研究者詳細 - 大石　充

論文 - 大石　充

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Kataoka T, Fukunaga K, Hiramine K, Nomoto Y, Matsumoto H, Sonoda K, Okino H, Tagata K, Kumamoto K, Kubota Y, Baba Y, Takasaki K, Nakashima H, Tanaka Y, Tokushige A, Ohishi M . Two-Year Clinical Outcomes Following SAPIEN3 20-mm Transcatheter Aortic Valve Implantation in Patients with Symptomatic Severe Aortic Stenosis-Comparison of the Smallest Size Valve against Larger Transcatheter Aortic Valve . J Transcatheter Valve Ther. 6 ( 1 ) 103 - 111 2024年7月査読

Kario K, Ohbayashi H, Hashimoto M, Itabashi N, Kato M, Uchiyama K, Hirano K, Nakamura N, Miyamoto T, Nagashima H, Kajiyama S, Ishida H, Imai E, Ebe Y, Ohishi M, Katsuya T, Taguchi T, Tanabe A, Shimosawa T; EXCITE-HT investigators . Home blood pressure-lowering effect of a non-steroidal mineralocorticoid receptor blocker, esaxerenone, versus trichlormethiazide for uncontrolled hypertension: the EXCITE-HT randomized controlled study . Hypertens Res.47 ( 9 ) 2435 - 2446 2024年7月査読

記述言語：日本語出版者・発行元：Hypertension Research

The EXCITE-HT study aimed to evaluate the efficacy and safety of esaxerenone versus thiazide diuretics (trichlormethiazide) as second-line treatment for Japanese patients with uncontrolled essential hypertension. This was a 12-week, multicenter, randomized, open-label, parallel-group study. The non-inferiority of esaxerenone to trichlormethiazide was confirmed if the upper limit of the two-sided 95% confidence interval (CI) for the difference in systolic blood pressure (SBP)/diastolic blood pressure (DBP) change between groups was below 3.9/2.1 mmHg. A total of 295 and 290 patients were included in the esaxerenone and trichlormethiazide groups, respectively. The non-inferiority of esaxerenone to trichlormethiazide was demonstrated: least squares mean change differences in morning home SBP/DBP at end of treatment (EOT) were −2.2 (95% CI, −3.6, −0.8) mmHg for SBP/−0.6 (−1.4, 0.2) mmHg for DBP. Morning home, bedtime home, and office BP significantly decreased (all p < 0.001) from baseline to EOT in both groups. The urinary albumin-to-creatinine ratio and N-terminal pro-brain natriuretic peptide level decreased from baseline to Week 12 in both groups, with no notable intergroup difference. Serum potassium elevations occurred more frequently with esaxerenone, while serum potassium reductions occurred more with trichlormethiazide. Uric acid elevations were observed in both groups, but more frequently with trichlormethiazide than esaxerenone. No cases of gout occurred in this study. Reductions in estimated glomerular filtration rate were similarly observed in both groups. EXCITE-HT is the first randomized controlled study to demonstrate evidence that esaxerenone is non-inferior to trichlormethiazide as second-line treatment for Japanese patients with uncontrolled essential hypertension, with no new safety concerns. (Figure presented.).

DOI： 10.1038/s41440-024-01762-z

Scopus

PubMed

Kiuchi Y, Makizako H, Kimura M, Nakai Y, Taniguchi Y, Akaida S, Tateishi M, Kubozono T, Takenaka T, Shimada H, Ohishi M . Association of combined low physical activity and low dietary diversity with mild cognitive impairment among community-dwelling Japanese older adults . Ann Geriatr Med Res. 2024年7月査読

吉野聡史, 伊東伸洋, 野崎圭吾, 兒玉世利汝, 神田大輔, 大石充 . OASによるdebulking後にVIPERWIREが抜去困難となり断裂しbailout困難となった一例 . 日本心血管インターベンション治療学会抄録集32回 MP38 - 9 2024年7月

Nakajo M., Hirahara D., Jinguji M., Ojima S., Hirahara M., Tani A., Takumi K., Kamimura K., Ohishi M., Yoshiura T. . Machine learning approach using 18F-FDG-PET-radiomic features and the visibility of right ventricle 18F-FDG uptake for predicting clinical events in patients with cardiac sarcoidosis . Japanese Journal of Radiology42 ( 7 ) 744 - 752 2024年7月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Radiology

Objectives: To investigate the usefulness of machine learning (ML) models using pretreatment 18F-FDG-PET-based radiomic features for predicting adverse clinical events (ACEs) in patients with cardiac sarcoidosis (CS). Materials and methods: This retrospective study included 47 patients with CS who underwent 18F-FDG-PET/CT scan before treatment. The lesions were assigned to the training (n = 38) and testing (n = 9) cohorts. In total, 49 18F-FDG-PET-based radiomic features and the visibility of right ventricle 18F-FDG uptake were used to predict ACEs using seven different ML algorithms (namely, decision tree, random forest [RF], neural network, k-nearest neighbors, Naïve Bayes, logistic regression, and support vector machine [SVM]) with tenfold cross-validation and the synthetic minority over-sampling technique. The ML models were constructed using the top four features ranked by the decrease in Gini impurity. The AUCs and accuracies were used to compare predictive performances. Results: Patients who developed ACEs presented with a significantly higher surface area and gray level run length matrix run length non-uniformity (GLRLM_RLNU), and lower neighborhood gray-tone difference matrix_coarseness and sphericity than those without ACEs (each, p < 0.05). In the training cohort, all seven ML algorithms had a good classification performance with AUC values of > 0.80 (range: 0.841–0.944). In the testing cohort, the RF algorithm had the highest AUC and accuracy (88.9% [8/9]) with a similar classification performance between training and testing cohorts (AUC: 0.945 vs 0.889). GLRLM_RLNU was the most important feature of the modeling process of this RF algorithm. Conclusion: ML analyses using 18F-FDG-PET-based radiomic features may be useful for predicting ACEs in patients with CS.

DOI： 10.1007/s11604-024-01546-y

Scopus

PubMed

Miyauchi Eiji, Arikawa Ryo, Oketani Naoya, Ohishi Mitsuru . 円錐枝閉塞によって生じた一過性ブルガダ型様心電図パターンを呈する患者における心室細動の一例(A Case of Ventricular Fibrillation in a Patient With a Transient Brugada-Like Electrocardiogram Pattern Caused by the Conus Branch Occlusion) . 日本心血管インターベンション治療学会抄録集32回 MO72 - 4 2024年7月

Nakajo Masatoyo, Hirahara Daisuke, Jinguji Megumi, Ojima Satoko, Hirahara Mitsuho, Tani Atsushi, Takumi Koji, Kamimura Kiyohisa, Ohishi Mitsuru, Yoshiura Takashi . 心サルコイドーシス患者の臨床有害事象を予測するために、18F-FDG-PET画像から得たラジオミクス特徴量と右室内18F-FDG集積の可視化による機械学習に基づいた手法(Machine learning approach using 18F-FDG-PET-radiomic features and the visibility of right ventricle 18F-FDG uptake for predicting clinical events in patients with cardiac sarcoidosis) . Japanese Journal of Radiology42 ( 7 ) 744 - 752 2024年7月

記述言語：英語出版者・発行元：(公社)日本医学放射線学会

心サルコイドーシス(CS)患者の臨床有害事象(ACE)の予測に、治療前18F-FDG-PET画像を用いた機械学習(ML)モデルが有用か検討した。MLモデルは7種類のMLアルゴリズムとジニ不純度の低下により最上位となった4つの特徴量を用いて構築した。治療前に18F-FDG-PET/CTが撮像されたCS患者47例(男性9例、女性38例、年齢39～81歳)を対象に、トレーニングコホート38例とテストコホート9例に分けて比較した。その結果、ACE発症患者では非発症患者に比べ、表面積とgray level run length matrix run length non-uniformityでは有意に大きかった一方、neighborhood gray-tone difference matrix_coarsenessおよび球形度は有意に小さかった。また、トレーニングコホートでは全てのMLアルゴリズムが良好な分類性能を示し、テストコホートではrandom forestアルゴリズムで、最も大きなROC曲線下面積と最も高い正確度が得られた。以上より、18F-FDG-PET画像をベースとしたラジオミクス特徴量によるML解析は、CS患者においてACEの予測に有用と判断された。

大迫将精, 下野洋和, 伊東伸洋, 田端宏之, 福元大地, 大牟禮健太, 神田大輔, 大石充 . 急性心筋梗塞に対するPCI後に,人工呼吸器離脱のための鎮静薬減量により引き起こされたと考えられる,たこつぼ型心筋症の1例 . 日本心血管インターベンション治療学会抄録集32回 MP35 - 4 2024年7月

Miyauchi Eiji, Arikawa Ryo, Oketani Naoya, Ohishi Mitsuru . 生検鉗子を用いた血管内治療の奏効した急性肢虚血の一例(A Case of Acute Limb Ischemia Successfully Managed by Endovascular Therapy Using Biopsy Forceps) . 日本心血管インターベンション治療学会抄録集32回 MP23 - 4 2024年7月

Sugimoto T, Araki A, Fujita H, Fujita K, Honda H, Inagaki N, Ishida T, Kato J, Kishi M, Kishino Y, Kobayashi K, Kouyama K, Kuroda Y, Kuwahata S, Matsumoto N, Murakami T, Noma H, Ogino J, Ogura M, Ohishi M, Shimada H, Sugimoto K, Takenaka T, Tamura Y, J-MIND-Diabetes study group . Multidomain Intervention Trial for Preventing Cognitive Decline among Older Adults with Type 2 Diabetes: J-MIND-Diabetes . J Prev Alzheimers Dis.11 ( 6 ) 1604 - 1614 2024年6月査読

Higuchi Koji, Ohishi Mitsuru . 慢性冠症候群患者における高血圧の進行・発症を抑制する最適な治療(Optimal Hypertensive Treatment for Reduction in Progression and Onset in Patients with Chronic Coronary Syndrome) . Journal of Coronary Artery Disease30 ( 2 ) 54 - 59 2024年6月

Kamada H, Iriki Y, Yoshimoto I, Ninomiya Y, Ichiki H, Maenosono R, Miyata M, Hamamoto Y, Horizoe Y, Ikeda Y, Ohishi M . Incidence and predictors of persistent iatrogenic atrial septal defect following catheter ablation . J Cardiol.84 ( 6 ) 372 - 378 2024年6月査読

Shimokihara S, Tabira T, Maruta M, Makizako H, Han G, Ikeda Y, Kamasaki T, Akasaki Y, Hidaka Y, Kumura Y, Kukizaki W, Nakahara R, Matsunaga S, Medina L, Kubozono T, Ohishi M . Smartphone Proficiency in Community-Dwelling Older Adults is Associated With Higher-Level Competence and Physical Function: A Population-Based Age-Specific Cross-Sectional Study . J Appl Gerontol. 2024年6月査読

Kanda D, Tokushige A, Ohishi M . Association between Estimated Small Dense Low-Density Lipoprotein Cholesterol and Occurrence of New Lesions after Percutaneous Coronary Intervention in Japanese Patients with Stable Angina and Receiving Statin Therapy . Reviews in Cardiovascular Medicine.25 ( 6 ) 218 2024年6月査読

Shimono H, Tokushige A, Kanda D, Ohno A, Arikawa R, Chaen H, Okui H, Oketani N, Ohishi M . Clinical impact of Academic Research Consortium for High Bleeding-Risk scores on clinical outcomes in patients with stable coronary artery disease undergoing percutaneous coronary intervention . Heart and Vessels. 2024年6月査読

Okamura T., Tsukamoto K., Arai H., Fujioka Y., Ishigaki Y., Koba S., Ohmura H., Shoji T., Yokote K., Yoshida H., Yoshida M., Deguchi J., Dobashi K., Fujiyoshi A., Hamaguchi H., Hara M., Harada-Shiba M., Hirata T., Iida M., Ikeda Y., Ishibashi S., Kanda H., Kihara S., Kitagawa K., Kodama S., Koseki M., Maezawa Y., Masuda D., Miida T., Miyamoto Y., Nishimura R., Node K., Noguchi M., Ohishi M., Saito I., Sawada S., Sone H., Takemoto M., Wakatsuki A., Yanai H. . Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022 . Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ31 ( 6 ) 641 - 853 2024年6月

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