研究者詳細 - 大石　充

論文 - 大石　充

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Shimamoto Kazuaki, Ando Katsuyuki, Fujita Toshiro, Hasebe Naoyuki, Higaki Jitsuo, Horiuchi Masatsugu, Imai Yutaka, Imaizumi Tsutomu, Ishimitsu Toshihiko, Ito Masaaki, Ito Sadayoshi, Itoh Hiroshi, Iwao Hiroshi, Kai Hisashi, Kario Kazuomi, Kashihara Naoki, Kawano Yuhei, Kim-Mitsuyama Shokei, Kimura Genjiro, Kohara Katsuhiko, Komuro Issei, Kumagai Hiroo, Matsuura Hideo, Miura Katsuyuki, Morishita Ryuichi, Naruse Mitsuhide, Node Koichi, Ohya Yusuke, Rakugi Hiromi, Saito Ikuo, Saitoh Shigeyuki, Shimada Kazuyuki, Shimosawa Tatsuo, Suzuki Hiromichi, Tamura Kouichi, Tanahashi Norio, Tsuchihashi Takuya, Uchiyama Makoto, Ueda Shinichiro, Umemura Satoshi, Maemura Koji, Okada Koichi, Katayama Shigehiro, Hisatome Ichiro, Arai Hidenori, Abe Isao, Akishita Masahiro, Adachi Kayoko, Arita Mikio, Arima Shuji, Ando Shinichi, Shimamoto Kazuaki, Minakami Hisanori, Matsumoto Masayasu, Ogawa Yoshihiro, Ouchi Yasuyoshi, Itakura Hiroshige, Ito Shinya, Ikeda Shunya, Iso Hiroyasu, Ichihara Atsuhiro, Ito Takayuki, Imai Enyu, Iwashima Yoshio, Uehara Yoshio, Uchiyama Shinichiro, Umemoto Seiji, Ura Nobuyuki, Urata Hidenori, Eguchi Kazuo, Ohishi Mitsuru, Okubo Ichiro, Ohkubo Takayoshi, Okura Takafumi, Okamura Tomonori, Ogawa Hisao, Kashiwagi Atsunori, Katsuya Tomohiro, Kato Norihiro, Kamide Kei, Kawashima Yukiko, Kikuchi Toru, Kitazono Takanari, Kitamura Kazuo, Kimura Kenjiro, Kihara Yasuki, Kiyohara Yutaka, Kusaka Miho, Kushiro Toshio, Kohno Masakazu, Kobayashi Shuzo, Goto Atsuo, Kokubo Yoshihiro, Saito Yoshihiko, Shibata Hirotaka, Sasamura Hiroyuki, Shimohama Shun, Suzuki Yoshikatsu, Abe Keishi, Arakawa Kikuo, Iimura Osamu, Omae Teruo, Ueshima Hirotsugu, Eto Tanenao, Ogihara Toshio, Kikuchi Kenjiro, Saruta Takao, Takishita Shuichi, Matsuoka Hiroaki, Takazawa Kenji, Takahashi Shori, Takahashi Hakuo, Takeda Kazuo, Takeda Yoshiyu, Tsutsui Hiroyuki, Tsubakihara Yoshiharu, Doi Yoshinori, Tomiyama Hirofumi, Tomino Yasuhiko, Toyoda Kazunori, Narita Ichiei, Nishikawa Tetsuo, Hayashi Koichi, Hirata Yasunobu, Hirawa Nobuhito, Hirooka Yoshitaka, Fukuda Noboru, Horio Takeshi, Hoshide Satoshi, Makino Hirofumi, Masuzaki Hiroaki, Matsumura Kiyoshi, Miura Shin-ichiro, Miura Tetsuji, Mukoyama Masashi, Murashima Atsuko, Murohara Toyoaki, Morimoto Shigeto, Yamakage Michiaki, Yamashina Akira, Yoshimura Michihiro, Watanabe Tsuyoshi, Kaneko Yoshihiro, Hiwada Kunio, Fukiyama Koshiro, Yazaki Yoshio, Shimizu Hideyuki, Yamaguchi Ikuko, Mikami Hiroshi, Yamamoto Wari, Nakao Masatoshi, Mori Hisao, The Japanese, Society of Hypertension Committee for Guidelines for the Management of Hypertension . 日本高血圧学会高血圧治療ガイドライン(JSH 2014)(The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014)) . Hypertension Research37 ( 4 ) 253 - 390 2014年4月

堀添善尚, 高崎州亜, 植屋奈美, 茶圓秀人, 窪田佳代子, 水上尚子, 湯浅敏典, 木佐貫彰, 大石充 . 肺高血圧症合併の単心房術後残存シャント根治術前後を心エコーで観察し得た一例 . 超音波医学41 ( Suppl. ) S502 - S502 2014年4月

大石充 . 巻頭言神様の作った｢生き物｣の仕組み . 呼吸と循環62 ( 3 ) 202 - 202 2014年3月

Kohno Y, Nakashima Y, Kitano T, Nakamura T, Takamura K, Akiyama M, Hara D, Yamamoto T, Motomura G, Ohishi M, Hamai S, Yukihide I . Subclinical bilateral involvement of the hip in patients with slipped capital femoral epiphysis: a multicentre study. . International orthopaedics38 ( 3 ) 477 - 82 2014年3月査読

赤崎雄一, 大石充 . 【家庭血圧-これからの高血圧個別治療へ-】白衣高血圧(低リスクと高リスク)の治療 . カレントテラピー32 ( 3 ) 254 - 258 2014年3月

Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB . Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. . Journal of the American College of Cardiology63 ( 7 ) 636 - 646 2014年2月査読

大石充 . 【日本人高血圧症患者の予後予測因子と治療の実際】 . Astellas Square: 明日の医療を考える10 ( 1 ) 6 - 12 2014年2月

Wang X, Sugimoto K, Fujisawa T, Shindo N, Minato S, Kamada Y, Hamano M, Ohishi M, Ikegami H, Rakugi H . Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse . Hepatology research44 ( 1 ) 102 - 113 2014年1月査読

茶圓秀人, 湯淺敏典, 植屋奈美, 堀添善尚, 川添晋, 窪田佳代子, 水上尚子, 高崎州亜, 木佐貫彰, 大石充 . 成人期まで外科的介入なく経過したShone症候群の一例 . 超音波医学41 ( 1 ) 93 - 93 2014年1月

Wang Xiang, Sugimoto Ken, Fujisawa Tomomi, Shindo Nobuyasu, Minato Satomi, Kamada Yoshihiro, Hamano Mina, Ohishi Mitsuru, Ikegami Hiroshi, Rakugi Hiromi . 脂肪肝シオノギ系マウスの非アルコール性脂肪性肝疾患の発症を阻害するエゼチミブの新規の作用(Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse) . Hepatology Research44 ( 1 ) 102 - 113 2014年1月

記述言語：英語出版者・発行元：John Wiley & Sons Australia, Ltd

エゼチミブが非アルコール性脂肪性肝疾患(NAFLD)の発症を抑制するかどうか明らかにし、その機序をNAFLD/非アルコール性脂肪性肝炎の自然発症モデルである脂肪肝シオノギ(FLS)系マウスを用いて解析した。20週齢の雄のFLS系マウスを2群に分割した(各7匹)。標準食であるCRF-1、またはCRF-1に0.005%(w/w)のエゼチミブ(1日7mg/kg)を4週間投与した。エゼチミブ投与の4週後に画分のマウスの組織学的な分析を行い分子機序について解析を行った。その結果、エゼチミブの摂取により標準食を摂取したマウスでは肝脂肪症と線維症の改善が見られた。エゼチミブは肝臓の活性酸素種の生成を抑制し、Skp2とCDC20のタンパク質量の低下を介して超低密度リポタンパク質の集合と輸送のための重要な分子であるミクロソームのトリグリセリド輸送タンパク質(MTP)のユビキチン化とタンパク質の分解を抑制した。以上の結果から、エゼチミブは肝臓における脂質の合成を低下させるだけでなく、肝臓からの脂質の放出を促進することが明らかとなり、この機序には肝臓の活性酸素種の生成の抑制を介したMTPの翻訳後の分解抑制が関与し、NAFLDの発症が防止されると考えられた。

MIYATA Masaaki, AKASAKI Yuichi, MIYAUCHI Takahiro, IKEDA Yoshiyuki, OHISHI Mitsuru . 02-2 Preventive effect of thermal therapy on heart failure due to pressure overload . The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine77 ( 5 ) 426 - 426 2014年

記述言語：英語出版者・発行元：The Japanese Society of Balneology, Climatology and Physical Medicine

Introduction: Long-term cardiac hypertrophy causes heart failure. One of the mechanisms of this transition from hypertrophy to heart failure is collapse of hypoxic response and angiogenesis. Heat shock protein 27 (HSP27) was found to act as an anti-apoptotic protein and its phosphorylation is responsible for the protection of cells against heat stress. HSP27 has been reported to regulate p53 expression, which contributes to down-regulate angiogenic factors through hypoxia inducible factor-1α(HIF-1α). We have reported that thermal therapy, namely Waon therapy, improves cardiac and vascular function in patients with chronic heart failure. However, the effect of this therapy on cardiac hypertrophy due to pressure overload is unknown. The purpose of this study is to investigate the effects and mechanisms of thermal therapy (Waon therapy) on the transition from cardiac hypertrophy to heart failure after pressure overload. Methods: Cardiac hypertrophy was induced by transverse aortic constriction (TAC) in C57BL/6 mice. At 2 weeks after TAC, all mice were examined by echocardiography and showed left ventricular hypertrophy. Then, mice were randomly divided into thermal therapy or untreated group. Thermal therapy group received thermal therapy using an experimental far infrared ray dry sauna, which elevates the core temperature by 1 degree Celsius for 30 minutes, daily for 4 weeks. Sham operated mice were used as control. At 6 weeks after TAC, we measured body weight, heart rate and blood pressure before sacrifice, and eviscerated heart and leg muscle. Western blot analysis of p53, phosphorylated HSP27, HIF-1α and vascular endothelial growth factor (VEGF) was performed using extracted protein form heart. Results: At 6 weeks after TAC, body weight, heart rate and blood pressure did not differ in three groups. Echocardiography showed that left ventricular fractional shortening of thermal therapy group was significantly larger than that of untreated group (Sham vs. Untreated vs. Thermal; 50.0±1.7 vs. 36.7±1.3 vs. 46.2±0.5, P<0.01, n=6 each). Heart weight/tibia length ratio of thermal therapy group was significantly smaller than that of untreated group (6.7±0.1 vs. 9.7±0.5 vs. 7.9±0.2, P<0.01, n=9 each). Western blot showed that thermal therapy increased phosphorylation of HSP27 and reduced p53. Thermal therapy also increased HIF-1α and VEGF at 6 weeks after TAC. Capillary/myofiber ratio was larger in thermal therapy group than that in untreated group (1.71±0.05 vs. 2.04±0.04 vs. 2.41±0.10, P<0.01, n=4 each). Conclusion: Thermal therapy, namely Waon therapy, prevented the transition from cardiac hypertrophy to heart failure induced by pressure overload in mice. As the mechanism, thermal therapy amplified the phosphorylation of HSP27 and inhibited p53, increased HIF-1α and VEGF, and then increased angiogenesis.

DOI： 10.11390/onki.77.426

CiNii Research

Kamide K, Asayama K, Katsuya T, Ohkubo T, Hirose T, Inoue R, Metoki H, Kikuya M, Obara T, Hanada H, Thijs L, Kuznetsova T, Noguchi Y, Sugimoto K, Ohishi M, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Higaki J, Matsuura H, Shinagawa T, Sasaguri T, Miki T, Takeda K, Shimamoto K, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Miyata T, Tomoike H, Kawano Y, Ogihara T, Rakugi H, Staessen JA, Imai Y. . Genome-Wide Pharmacogenomic Response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP Study. . Pharmacogenomics 14 ( 14 ) 1709 - 1721 2013年11月査読

Kawai T, Ohishi M, Takeya Y, Onishi M, Ito N, Oguro R, Yamamoto K, Kamide K, Rakugi H. . Carotid Plaque Score and Intima Media Thickness as Predictors of Stroke and Mortality in Hypertensive Patients. . Hypertens Res 36 902 - 909 2013年7月査読

Ohishi M, Kawai T, Hayashi N, Kitano S, Katsuya T, Nagano M, Hirotani A, Yamamoto K, Kamide K, Rakugi H. . Effect of tablets with a combination of telmisartan and amlodipine on patients with hypertension: The Cotalo study. . Hypertens Res 36 ( 7 ) 620 - 626 2013年7月査読

Kawai T, Ohishi M, Ito N, Onishi M, Takeya Y, Yamamoto K, Kamide K, Rakugi H. . Alteration of Vascular Function is Important Factor in the Correlation between Visit-to-visit Variability in Blood Pressure and Cardiovascular Disease. . J Hypertens 31 ( 7 ) 1387 - 1395 2013年7月査読

Takeuchi K, Yamamoto K, Ohishi M, Takeshita K, Hongyo K, Kawai T, Takeda M, Kamide K, Kurtz TW, Rakugi H . Telmisartan modulates mitochondrial function in vascular smooth muscle cells . Hypertens Res36 ( 5 ) 433 - 439 2013年5月査読

Kawai T, Ohishi M, Kamide K, Nakama C, Onishi M, Ito N, Takami Y, Takeya Y, Rakugi H. . Differences between daytime and night-time blood pressure variability regarding systemic atherosclerotic change and renal function . Hypertens Res36 ( 3 ) 232 - 239 2013年3月査読

Takeda M, Yamamoto K, Takemura Y, Takeshita H, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Oguro R, Takami Y, Tatara Y, Takeya Y, Sugimoto K, Kamide K, Ohishi M, Rakugi H. . Loss of Angiotensin-converting enzyme 2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice. . Diabetes62 ( 1 ) 223 - 233 2013年1月査読

Kawai T, Ohishi M, Onishi M, Ito N, Takeya Y, Maekawa Y, Rakugi H . Cut-off Value of Brachial-ankle Pulse Wave Velocity to Predict Cardiovascular Disease in Hypertensive Patients: A Cohort Study. . J Atheroscler Thromb 20 ( 4 ) 391 - 400 2013年査読

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