研究者詳細 - 大石　充

論文 - 大石　充

分割表示 1,236 件中 461 - 480 件目／全件表示 >>

Salim Anwar Ahmed, Kawasoe Shin, Kubozono Takuro, Ojima Satoko, Kawabata Takeko, Ikeda Yoshiyuki, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . BMIと腹囲・身長比の組み合わせを用いた将来の高血圧リスクの男女別評価(Assessment of Future Hypertension Risk by Sex Using Combined Body Mass Index and Waist-to-Height Ratio) . Circulation Reports4 ( 1 ) 9 - 16 2022年1月

記述言語：英語出版者・発行元：(一社)日本循環器学会

日本人一般集団の健康診断データを解析し、BMIと腹囲・身長比(WHtR)の組み合わせによって男女の高血圧リスクを評価できるか調べた。2008年10月1日～2019年3月31日に健康診断を受診した30～70歳の45921名(男性21570名、女性24351名、平均53.8±10.5歳)のデータを後ろ向きに解析した。BMIおよびWHtRの中央値を用いて受診者を4群に分類し、高血圧の5年発症率を男女別に評価した。平均BMIと平均WHtRは男性ではそれぞれ23.5±3.1kg/m2と0.50±0.05、女性では22.4±3.3kg/m2と0.53±0.06であった。ロジスティック回帰分析の結果、女性では高BMIと低WHtRの受診者は低BMIおよび低WHtRの受診者と比較して高血圧リスクが高かったが、男性では高BMIと低WHtRの受診者は高血圧発症リスクが増加しなかった。男女とも低BMIで高WHtRの受診者の方が低BMIで低WHtRの受診者よりも高血圧の発症率が高いことが示された。

濱元裕喜, 堀添善尚, 安田久代, 湯淺敏典, 大石充 . 膜様部心室中隔欠損症修復術にて右室流出路自由壁起源の心室期外収縮が軽減した1例 . 日本成人先天性心疾患学会雑誌11 ( 1 ) 223 - 223 2022年1月

湯淺敏典, 濱元裕喜, 堀添善尚, 安田久代, 池田義之, 大石充 . 高度チアノーゼを有する壮年期未修復成人先天性心疾患の2症例 . 日本成人先天性心疾患学会雑誌11 ( 1 ) 246 - 246 2022年1月

堀添善尚, 湯淺敏典, 濱元裕喜, 安田久代, 大石充 . 運動負荷試験にて呼吸困難の原因が房室ブロックと判明した両大血管右室起始の一例 . 日本成人先天性心疾患学会雑誌11 ( 1 ) 229 - 229 2022年1月

Sameshima K, Higo K, Hiwatari S, Shioura T, Torigoe T, Yoshimura A, Ohishi M . A case of Takotsubo cardiomyopathy with apical hypertrophic cardiomyopathy-like morphological changes during recovery. . Journal of rural medicine : JRM17 ( 3 ) 171 - 175 2022年査読

谷口善昭, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における骨量および筋量の低下と身体活動との関連性 . 理学療法学49 ( 2 ) 131 - 138 2022年査読

記述言語：日本語出版者・発行元：一般社団法人日本理学療法学会連合

<p>【目的】地域在住高齢者における骨量・筋量低下と身体活動との関連性を明らかにすることを目的とした。【方法】地域コホート研究（垂水研究2018）に参加した地域在住高齢者173 名を分析対象とした。骨量低下は％YAM が70% 以下とし，筋量低下は四肢骨格筋指数がサルコペニアの基準より低いものとした。身体活動量は3 軸加速度計を用いて，座位行動時間延長，中高強度身体活動時間低下，歩数低下の有無に分類した。骨量・筋量をもとに正常群，骨量低下群，筋量低下群，骨量・筋量低下群の4 群に分類し，基本情報および身体活動を比較した。【結果】骨量・筋量低下群は正常群と比べて中高強度身体活動時間が有意に減少していた（オッズ比3.29，p < 0.05，共変量：年齢（5 歳階級），性別，歩行速度低下，うつ傾向）。【結論】骨量・筋量低下を併存している高齢者は，中高強度身体活動時間が減少していることが示唆された。</p>

DOI： 10.15063/rigaku.12150

CiNii Research

Nakamura A., Maruta M., Makizako H., Miyata M., Miyata H., Han G., Ikeda Y., Shimokihara S., Tokuda K., Kubozono T., Ohishi M., Tabira T. . Meaningful activities and psychosomatic functions in japanese older adults after driving cessation . International Journal of Environmental Research and Public Health18 ( 24 ) 13270 2021年12月査読国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

The purpose of this cross-sectional study was to analyse the differences in meaningful activities and psychosomatic function depending on the driving status of community-dwelling older adults. Data from 594 older adults were obtained, including activities meaningful to individuals and psychosomatic functions, such as grip strength, depression, cognitive function, and ability of activity. Participants were divided into active driving (n = 549) and after driving cessation (n = 45) groups. In addition, the active driving group was operationally divided into three groups: high-frequency group (n = 387), medium group (n = 119), and infrequent group (n = 42). In the after driving cessation group, grip strength, and Japan Science and Technology Agency Index of Competence scores were significantly lower. Furthermore, the proportion of apathy and physical and social frailty was significantly higher in the after driving cessation group. Regarding meaningful activity, domestic life scores in the after driving cessation group were significantly higher than those of the active driving group. Decreased driving frequency in the active driving group was associated with weak muscle strength, lack of interest, and low activity. This study demonstrated that meaningful activity differed based on the driving status. Hence, we should support the activities of older adults who are considering driving cessation.

DOI： 10.3390/ijerph182413270

Scopus

PubMed

Ninomiya Yuichi, Inoue Koichi, Tanaka Nobuaki, Okada Masato, Tanaka Koji, Onishi Toshinari, Hirao Yuko, Oka Takafumi, Inoue Hiroyuki, Takayasu Kohtaro, Nakamura Ryo, Kitagaki Ryo, Koyama Yasushi, Okamura Atsunori, Iwakura Katsuomi, Ohishi Mitsuru, Fujii Kenshi . First pass isolationの不達成は肺静脈隔離の維持不良および心房細動アブレーションの予後不良と関連する(Absence of first-pass isolation is associated with poor pulmonary vein isolation durability and atrial fibrillation ablation outcomes) . Journal of Arrhythmia37 ( 6 ) 1468 - 1476 2021年12月

記述言語：英語出版者・発行元：(一社)日本不整脈心電学会

心房細動(AF)に対してカテーテルアブレーション(CA)を実施した患者446例(男性370例、女性76例、平均64±10歳)を対象に、1周の通電で肺静脈隔離の成功(First pass isolation)が転帰に及ぼす影響を検討した。対象は接触力(contact force)を指標として肺静脈隔離術を実施した薬剤抵抗性AF患者で、発作性AFは191例、持続性AFは175例、永続性AFは80例であった。患者を左右肺静脈のいずれかでFirst pass isolationに成功したFPI群383例(男性82%、平均64±11歳)と非FPI群63例(男性87%、平均63±9歳)の2群に分類した。患者背景は非FPI群でBMIが有意に高かった。CA治療後2年におけるAF再発回避率はFPI群(75%)の方が非FPI群(59%)より有意に高かった(P=0.032)。Cox比例ハザードモデルを使った多変量解析により、交絡因子で調整したところ、FPIの不達成はアブレーション治療後のAF再発を予測する独立因子であった(HR:1.65、95%CI:1.07～2.55、P=0.02)。

Nishi K., Kanouchi H., Tanaka A., Nakamura M., Hamada T., Mishima Y., Goto Y., Kume K., Beppu M., Hijioka H., Tabata H., Mori K., Uchino Y., Yamashiro K., Matsumura Y., Higashi Y., Makizako H., Kubozono T., Takenaka T., Ohishi M., Sugiura T. . Relationship between oral hypofunction, and protein intake: A cross-sectional study in local community-dwelling adults . Nutrients13 ( 12 ) 4377 2021年12月査読国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrients

Few studies have investigated the relationship between nutritional status and comprehensive assessment of oral hypofunction, especially protein intake-related sarcopenia. Thus, we explored these relationships in a large-scale cross-sectional cohort study using the seven-item evaluation for oral hypofunction and Diet History Questionnaire for nutritional assessment. We used the data from 1004 individuals who participated in the 2019 health survey of the residents of Tarumizu City, Kagoshima Prefecture, Japan for analysis. We found that individuals with oral hypofunction were significantly older with a lower skeletal muscle index. Although there were few foods that had a sig-nificant difference between the groups with and without oral hypofunction, the consumption of beans and meats was significantly lower in women and men in the oral hypofunction group, respectively. According to the lower limit of the tentative dietary goal defined in Japan, comprehensive evaluation of oral hypofunction was significantly and independently associated with protein intake in both men and women (odds ratio, 1.70; 95% confidence interval, 1.21–2.35). In conclusion, we found that oral hypofunction was associated with targeted protein intake for sarcopenia and frailty prevention in middle-aged and older community-dwelling adults. Comprehensive evaluation of oral function with intervention in cases of hypofunction could inform clinicians to better prevent sarcopenia.

DOI： 10.3390/nu13124377

Scopus

PubMed

窪薗琢郎, 大石充 . 【難治性高血圧Up-to-date 2021-診療と最新治療】難治性高血圧と心肥大・心房細動・心不全 . カレントテラピー39 ( 12 ) 1136 - 1140 2021年12月

記述言語：日本語出版者・発行元：(株)ライフメディコム

高血圧は、圧負荷の増大により心肥大や心筋間質の線維化といった心筋リモデリングをきたし、冠動脈内皮障害を引き起こす。左室内圧の上昇に伴い左房圧も上昇し、心房拡大につながり心房細動の発症リスクとなる。また、糖尿病や脂質異常症、肥満といった生活習慣病も加わると、虚血性心疾患のリスクにもなる。最終的に、高血圧により引き起こされた心肥大や心房細動、虚血性心疾患などにより、心不全の発症につながる。早期の治療介入により、それらの発症を抑制できることが報告されているが、多剤併用にもかかわらず降圧目標値に到達できない治療抵抗性高血圧の患者が存在する。治療抵抗性高血圧患者は、コントロールされた高血圧患者と比較し、持続的な高血圧に伴う臓器障害をきたす可能性が高い。近年、ミネラルコルチコイド受容体(MR)拮抗薬や腎交感神経デナベーションの有用性が報告され、適切な降圧薬の選択や腎交感神経デナベーションによる適切な血圧コントロールにより臓器合併症の予防や進展抑制が期待できる。(著者抄録)

Ninomiya Yuichi, Kawasoe Shin, Kubozono Takuro, Tokushige Akihiro, Ichiki Hitoshi, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 一般日本人集団における腹部肥満と新規発症心房細動との男女別にみた関係性(Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population) . Heart and Vessels36 ( 12 ) 1879 - 1884 2021年12月

記述言語：日本語出版者・発行元：シュプリンガー・ジャパン(株)

2008年4月～2016年3月の間に健康診断を2回以上受診した参加者67379名(男性49.8%、平均54.3±10.0歳)を対象に、腹部肥満と新規発症心房細動(AF)との関係を後ろ向きに検討した。参加者の腹囲に基づいて過大腹囲群と正常腹囲群に分けた。全体および男女別に腹部肥満と新規発症心房細動との関連の強度を判定した。過大腹囲群は男性16329名、女性6539名であった。経過観察期間中央値は5年で、280例で新規発症AFが記録された。単変量解析では過大腹囲は男性では新規発症AFと有意に関連したが、女性では関連しなかった。多変量解析では男性で過大腹囲が新規発症AFと有意に関連したが、女性では関連しなかった。腹部肥満は男性では新規発症AFのリスクの増加と関連していた。

Kanda D., Takumi T., Sonoda T., Arikawa R., Anzaki K., Sasaki Y., Ohishi M. . Coronary artery perforation secondary to lifesaving pericardiocentesis for cardiac tamponade: a case report . BMC Cardiovascular Disorders21 ( 1 ) 55 2021年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Cardiovascular Disorders

Background: Pericardiocentesis is frequently performed when fluid needs to be removed from the pericardial sac, for both therapeutic and diagnostic purposes, however, it can still be a high-risk procedure in inexperienced hands and/or an emergent setting. Case presentation: A 78-year-old male made an emergency call complaining of the back pain. When the ambulance crew arrived at his home, he was in a state of shock due to cardiac tamponade diagnosed by portable echocardiography. The pericardiocentesis was performed using a puncture needle on site, and the patient was immediately transferred to our hospital by helicopter. Contrast-enhanced computed tomography showed a small protrusion of contrast media on the inferior wall of the left ventricle, suggesting cardiac rupture due to acute myocardial infarction. Emergency coronary angiography was then performed, which confirmed occlusion of the posterior descending branch of the left circumflex coronary artery. In addition, extravasation of contrast medium due to coronary artery perforation was observed in the acute marginal branch of the right coronary artery. We considered that coronary artery perforation had occurred as a complication of the pericardial puncture. We therefore performed transcatheter coil embolization of the perforated branch, and angiography confirmed immediate vessel sealing and hemostasis. After the procedure, the patient made steady progress without a further increase in pericardial effusion, and was discharged on the 50th day after admission. Conclusions: When performing pericardial drainage, it is important that the physician recognizes the correct procedure and complications of pericardiocentesis, and endeavors to minimize the occurrence of serious complications. As with the patient presented, coil embolization is an effective treatment for distal coronary artery perforation caused by pericardiocentesis.

DOI： 10.1186/s12872-021-01875-0

Scopus

PubMed

Arikawa R., Kanda D., Ikeda Y., Tokushige A., Sonoda T., Anzaki K., Ohishi M. . Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage . BMC Cardiovascular Disorders21 ( 1 ) 479 - 479 2021年12月査読国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Cardiovascular Disorders

Background: Stable coronary artery disease (CAD) patients with myocardial damage have a poor prognosis compared to those without myocardial damage. Recently, malnutrition has been reported to affect the prognosis of cardiovascular diseases. However, the effects of malnutrition on prognosis of CAD patients with myocardial damage remains uncertain. We investigated the effects of malnutrition on prognosis of CAD patients with myocardial damage who received percutaneous coronary intervention (PCI). Methods: Subjects comprised 241 stable CAD patients with myocardial damage due to myocardial ischemia or infraction. Patients underwent successful revascularization for the culprit lesion by PCI using second-generation drug-eluting stents and intravascular ultrasound. The geriatric nutritional risk index (GNRI), which is widely used as a simple method for screening nutritional status using body mass index and serum albumin, was used to assess nutritional status. Associations between major cardiovascular and cerebrovascular events (MACCE) and patient characteristics were assessed. Results: Mean GNRI was 100 ± 13, and there were 55 malnourished patients (23%; GNRI < 92) and 186 non-malnourished patients (77%). MACCE occurred within 3 years after PCI in 42 cases (17%), including 34 deaths (14%), and the malnourished group showed a higher rate of MACCE (38%) compared with the non-malnourished group (11%, p < 0.001). Univariate Cox proportional hazards analyses showed that MACCE was associated with age [hazard ratio (HR), 1.04; 95% confidence interval (CI), 1.04–1.07; p = 0.004], prior heart failure (HR 2.35; 95% CI 1.10–5.01; p = 0.027), high-sensitivity C-reactive protein (HR 1.08; 95% CI 1.03–1.11; p < 0.001), hemodialysis (HR 2.63; 95% CI 1.51–4.58; p < 0.001) and malnutrition (HR 3.69; 95% CI 2.11–6.42; p < 0.001). Multivariate Cox proportional hazards analysis revealed hemodialysis (HR 2.17; 95% CI 1.19–3.93; p = 0.011) and malnutrition (HR 2.30; 95% CI 1.13–4.67; p = 0.020) as significantly associated with MACCE. Furthermore, Cox proportional hazards models using malnutrition and hemodialysis revealed that patients with malnutrition and hemodialysis were at greater risk of MACCE after PCI than patients with neither malnutrition nor hemodialysis (HR 6.91; 95% CI 3.29–14.54; p < 0.001). Conclusions: In CAD patients with myocardial damage, malnutrition (GNRI < 92) represents an independent risk factor for MACCE. Assessment of nutritional status may help stratify the risk of cardiovascular events and encourage improvements in nutritional status.

DOI： 10.1186/s12872-021-02296-9

Scopus

PubMed

記述言語：日本語出版者・発行元：(株)ライフメディコム

Salim Anwar A, Kawasoe S, Kubozono T, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M. . Assessment of future hypertension risk by sex using combined body mass index and waist-to-height ratio. . Circ Rep4 ( 1 ) 9 - 16 2021年11月査読

Uchikado Y, Ikeda Y, Sasaki Y, Iwabayashi M, Akasaki Y, Ohishi M. . Association of lectin-like oxidized low-density lipoprotein receptor-1 with angiotensin II type 1 receptor impacts mitochondrial quality control, offering promise for the treatment of vascular senescence. . Front Cardiovasc Med8 788655 2021年11月査読

記述言語：英語出版者・発行元：Frontiers in Cardiovascular Medicine

Lectin-like oxidized low-density lipoprotein (ox-LDL) causes vascular senescence and atherosclerosis. It has been reported that ox-LDL scavenger receptor-1 (LOX-1) is associated with the angiotensin II type 1 receptor (AT1R). While mitochondria play a crucial role in the development of vascular senescence and atherosclerosis, they also undergo quality control through mitochondrial dynamics and autophagy. The aim of this study was to investigate (1) whether LOX-1 associates with AT1R, (2) if this regulates mitochondrial quality control, and (3) whether AT1R inhibition using Candesartan might ameliorate ox-LDL-induced vascular senescence. We performed in vitro and in vivo experiments using vascular smooth muscle cells (VSMCs), and C57BL/6 and apolipoprotein E-deficient (ApoE KO) mice. Administration of oxidized low-density lipoprotein (ox-LDL) to VSMCs induced mitochondrial dysfunction and cellular senescence accompanied by excessive mitochondrial fission, due to the activation of fission factor Drp1, which was derived from the activation of the Raf/MEK/ERK pathway. Administration of either Drp1 inhibitor, mdivi-1, or AT1R blocker candesartan attenuated these alterations. Electron microscopy and immunohistochemistry of the co-localization of LAMP2 with TOMM20 signal showed that AT1R inhibition also increased mitochondrial autophagy, but this was not affected by Atg7 deficiency. Conversely, AT1R inhibition increased the co-localization of LAMP2 with Rab9 signal. Moreover, AT1R inhibition-induced mitochondrial autophagy was abolished by Rab9 deficiency, suggesting that AT1R signaling modulated mitochondrial autophagy derived from Rab9-dependent alternative autophagy. Inhibition of the Raf/MEK/ERK pathway also decreased the excessive mitochondrial fission, and Rab9-dependent mitochondrial autophagy, suggesting that AT1R signaling followed the Raf/MEK/ERK axis modulated both mitochondrial dynamics and autophagy. The degree of mitochondrial dysfunction, reactive oxygen species production, vascular senescence, atherosclerosis, and the number of fragmented mitochondria accompanied by Drp1 activation were all higher in ApoE KO mice than in C57BL/6 mice. These detrimental alterations were successfully restored, and mitochondrial autophagy was upregulated with the administration of candesartan to ApoE KO mice. The association of LOX-1 with AT1R was found to play a crucial role in regulating mitochondrial quality control, as cellular/vascular senescence is induced by ox-LDL, and AT1R inhibition improves the adverse effects of ox-LDL.

DOI： 10.3389/fcvm.2021.788655

Scopus

PubMed

Yoshimoto I., Oketani N., Ogawa M., Imamura S., Omure K., Chaen H., Miyata M., Hamasaki S., Yotsumoto G., Ohishi M. . Percutaneous Extraction for Misplacement of Pacemaker Leads Within the Coronary Artery and Left Ventricle . Jacc Case Reports3 ( 16 ) 1746 - 1752 2021年11月

記述言語：日本語出版者・発行元：Jacc Case Reports

A 75-year-old man, who underwent inadvertent misplacement of pacemaker leads into the left coronary artery and left ventricle through the subclavian artery, was referred to our hospital. We safely performed percutaneous lead extraction in collaboration with surgeons and with the patient under general anesthesia. (Level of Difficulty: Advanced.)

DOI： 10.1016/j.jaccas.2021.08.003

Scopus

PubMed

内門義博, 池田義之, 大石充 . 【糖尿病と循環器疾患update】糖尿病と血管合併症update . 循環器内科90 ( 5 ) 508 - 511 2021年11月

Arikawa R, Kanda D, Ikeda Y, Tokushige A, Sonoda T, Anzaki K, Ohishi M . Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage. . BMC Cardiovasc Disord21 ( 1 ) 479 - 479 2021年10月査読

　前のページ - 次のページ　

<大石 充>

論文 - 大石 充

<大石　充>

論文 - 大石　充