研究者詳細 - 大石　充

論文 - 大石　充

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Chaen H., Kinchiku S., Miyata M., Kajiya S., Uenomachi H., Yuasa T., Takasaki K., Ohishi M. . Validity of a novel method for estimation of low-density lipoprotein cholesterol levels in diabetic patients . Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ23 ( 12 ) 1355 - 1364 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本動脈硬化学会

Aim: Low-density lipoprotein cholesterol (LDL-C) is routinely estimated using the Friedewald equation [LDL-C(F)]. A novel method for LDL-C [LDL-C(M)] estimation recently proposed by Martin et al. was reported to be more accurate than the Friedewald formula in subjects in the United States. The validity of LDL-C(M) in different races and patients with diabetes mellitus (DM) has not been elucidated. The purpose of this study was to validate the LDL-C(M) estimates in Japanese population with type 2 DM by comparing with LDL-C(F) and directly measured LDL-C [LDL-C(D)]. Methods: Both LDL-C(M) and LDL-C(F) levels were compared against LDL-C(D) measured by selective solubilization method in 1,828 Japanese patients with type 2 DM. Results: On linear regression analysis, LDL-C(M) showed a stronger correlation than that shown by LDL-C(F) (R=0.979 vs. R=0.953, respectively) with LDL-C(D). We further analyzed the effect of serum triglyceride (TG) concentrations on the accuracy of LDL-C(F) and LDL-C(M). Although LDL-C levels showed a positive correlation with TG levels, the LDL-C(F) levels tended to show a greater divergence from LDL-C(D) levels than that shown by LDL-C(M) with changes in TG levels. Conclusion: We for the first time demonstrated a more useful measurement of LDL-C levels estimated by Martin’s method than that estimated by the Friedewald equation in Japanese patients with DM.

DOI： 10.5551/jat.35972

Scopus

PubMed

CiNii Research

Kawasoe S., Kubozono T., Yoshifuku S., Ojima S., Oketani N., Miyata M., Miyahara H., Maenohara S., Ohishi M. . Uric acid level and prevalence of atrial fibrillation in a Japanese general population of 285,882 . Circulation Journal80 ( 12 ) 2453 - 2459 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本循環器学会

Background: The association between serum uric acid (UA) levels and atrial fibrillation (AF) in the general population in Japan is not well known. Methods and Results: In total, 285,882 consecutive subjects (men, 130,897; women, 154,985; age, 58±15 years) not receiving treatment for hyperuricemia who underwent health checkups were enrolled. Subjects were stratified into deciles according to age, body mass index, estimated glomerular filtration rate, systolic blood pressure, and UA level. AF prevalence was calculated for each decile. The odds ratio that defined the decile with the lowest AF prevalence as reference was calculated in each sex. In men, the mean UA was 6.0±1.4 mg/dl; AF prevalence was 1.8% and was lowest in the decile with UA 4.4–4.9 mg/dl. Deciles with both high and low UA (5.4–5.6 mg/dl to >7.8 mg/dl and <4.3 mg/dl) were associated with significantly higher AF prevalence. In women, the mean UA was 4.5±1.1 mg/dl; AF prevalence was 0.7% and was lowest in the decile with UA 3.6–3.8 mg/dl. Deciles with highest UA (5.0–5.2 mg/dl to >5.9 mg/dl) were associated with significantly higher AF prevalence. The analysis adjusted for other clinical covariates demonstrated an independent association between UA and AF in both sexes. Conclusions: In a representative Japanese general population, UA level was significantly associated with AF, independently of other cardiovascular risk factors.

DOI： 10.1253/circj.cj-16-0766

Takumi T., Miyata M., Ohishi M. . Physiological assessment in peripheral artery disease: Going beyond angiography . Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ23 ( 1 ) 44 - 45 2016年

Kanda D., Takumi T., Miyata M., Tokushige A., Sonoda T., Yoshino S., Saihara K., Ohishi M. . Angiotensin-converting enzyme inhibitor prevents the worsening of renal function in the late phase after percutaneous coronary intervention . Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ23 ( 2 ) 233 - 240 2016年

記述言語：英語出版者・発行元：一般社団法人日本動脈硬化学会

Aim: The amount of contrast media and renal atheroemboli are risk factors for acute kidney injury after percutaneous coronary intervention (PCI). However, the chronic kidney injury after PCI has not been fully characterized. The purpose of this study was to investigate factors affecting renal function in the late phase after PCI by measuring serum Cystatin C (CysC).Methods: In 143 consecutive patients who underwent elective PCI, CysC was evaluated at baseline and at 9 months after PCI, and the percent change in CysC (%CysC) was calculated. The association between %CysC and baseline characteristics, including medication use, was assessed. Results: Of 143 patients, 86 had worsening renal function (WRF; %CysC ≥0), and 57 did not (non-WRF; %CysC ＜0). Only the use of angiotensin-converting enzyme inhibitor (ACEI) and baseline CysC were significantly different between WRF and non-WRF patients (15 vs. 40%, p=0.001 and 1.02±0.26 vs. 1.13±0.26 mg/L, p=0.015). In univariate analysis, the use of ACEI and CysC were negatively associated with WRF [Odds ratio (OR)=0.26, 95% confidence interval (CI)=0.12–0.57, p＜0.001 and OR=0.20, 95% CI=0.05–0.73, p=0.015]. Furthermore, multivariate analysis revealed that the use of ACEI and CysC significantly correlated with WRF (OR=0.26, 95% CI=0.11–0.57, p＜0.001 and OR=0.20, 95% CI=0.05–0.74, p=0.016). The %CysC in 36 patients with ACEI was significantly lower than that in 107 patients without ACEI [median: －3.8%; interquartile range (IQR), －11.0 to 4.2%; vs. median: 3.3%; IQR －2.9 to 11.0%, p=0.001].Conclusion: The use of ACEI was associated with lower CysC after PCI, suggesting that ACEI prevents worsening of renal function in late phase after PCI.

DOI： 10.5551/jat.33266

Scopus

PubMed

CiNii Research

Ohno S, Miyata M, Kohjitani A, Tohya A, Ohishi M, Sugiyama K . Associations between blood pressure responses to acute stress and impaired renal function and serum uric acid level. . Clin Exp Hypertens 37 ( 8 ) 656 - 660 2015年11月査読

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical and Experimental Hypertension

The study aimed to examine correlations between blood pressure (BP) responses to direct laryngoscopy and tracheal intubation and parameters of renal function, serum uric acid (SUA) level, and mean preoperative BP. Fifty-four patients (≥40 years) who were scheduled for oral surgery were analyzed. General anesthesia was induced by the rapid sequence method without opioid analgesics. Systolic and diastolic BP (SBP, DBP) in the operation room were measured when an electrocardiogram, a BP cuff, and a pulse oximetry probe were attached to the patients (T1) and immediately after the trachea was intubated (T2). The ΔSBP was defined as the difference between SBP at T2 and T1. The increasing rate of SBP (ΔSBPr) was defined as ΔSBP/SBP at T1. SBP at T2 was associated with increasing age (R = 0.44), serum creatinine (R = 0.32), SUA (R = 0.30), mean preoperative SBP and DBP (R = 0.54 and 0.37, respectively), and reduced estimated glomerular filtration rate (eGFR) (R =-0.44). Serum creatinine and SUA were positively associated, and eGFR was negatively associated with ΔSBP (R = 0.36, 0.34, and-0.29) and ΔSBPr (R = 0.39, 0.37, and-0.29). Multivariate regression analysis revealed that age and mean preoperative SBP was independently associated with SBP at T2, and serum creatinine was independently associated with ΔSBP and ΔSBPr. These findings suggested that elevated serum creatinine level, as well as elevated preoperative BP level, was associated with enhanced BP responses to acute stress in middle-aged to elderly patients.

DOI： 10.3109/10641963.2015.1047939

Web of Science

Scopus

PubMed

吉野聡史, 大牟禮健太, 福元大地, 田端宏之, 立石繁宜, 大石充 . SES留置後の冠動脈内皮機能障害に対する内科的治療と左主幹部病変に対するBES留置にて胸部症状消失した1例 . 日本冠疾患学会雑誌 ( Suppl. ) 174 - 174 2015年11月

池田義之, 大石充 . 【フレイルと心血管疾患:転倒・骨折との関わり】フレイルの心血管リスクについて . Progress in Medicine35 ( 11 ) 1683 - 1686 2015年11月

Lee Y, Motomura G, Yamamoto T, Nakashima Y, Ohishi M, Hamai S, Iura K, Iwamoto Y . Rapidly destructive arthrosis of the hip joint in a young adult with systemic lupus erythematosus. . Rheumatology international35 ( 10 ) 1753 - 7 2015年10月査読

湯淺敏典, 大石充, 竹中俊宏 . 【心筋症up-to-date 2015】二次性心筋症を見逃さない　教えて!心エコー診断のポイント　心Fabry病 . 心エコー16 ( 10 ) 974 - 979 2015年10月

Nomoto Y, Tsurugida M, Kihara K, Miyauchi E, Kosedo I, Yuasa T, Otsuji Y, Ohishi M . Attenuated early diastolic interventricular septum bulging by pulmonary hypertension due to later developed aortic regurgitation . Journal of Echocardiography13 ( 3 ) 110 - 112 2015年9月査読

Hirano M., Satake W., Ihara K., Tsuge I., Kondo S., Saida K., Betsui H., Okubo K., Sakamoto H., Ueno S., Ikuno Y., Ishihara R., Iwahashi H., Ohishi M., Mano T., Yamashita T., Suzuki Y., Nakamura Y., Kusunoki S., Toda T. . The first nationwide survey and genetic analyses of bardet-biedl syndrome in Japan . Plos One10 ( 9 ) e0136317 - e0136317 2015年9月査読

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Plos One

Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder characterized by central obesity, mental impairment, rod-cone dystrophy, polydactyly, hypogonadism in males, and renal abnormalities. The causative genes have been identified as BBS1-19. In Western countries, this disease is often reported, but remains undiagnosed in many patients until later in life, while only a few patients with no mutations identified have been reported in Japan. We thus conducted the first nationwide survey of BBS in Japan by sending questionnaires to 2,166 clinical departments with board-certified specialists and found 7 patients with clinically definite BBS. We performed exome analyses combined with analyses of mRNA and protein in these patients. We identified 2 novel mutations in the BBS5 gene (p. R89X and IVS7-27 T>G) in 2 sibling patients. The latter mutation that resided far from the authentic splicing site was associated with skipping of exon 8. We also found 3 previously reported mutations in the BBS2 (p.R413X and p.R480X) and BBS7 (p.C243Y) genes in 2 patients. To our knowledge, a nationwide survey of BBS has not been reported in any other country. In addition, this is the first study to identify genetic alterations in Japanese patients with BBS. Our results indicate that BBS in Japan is genetically heterogeneous and at least partly shares genetic features with BBS in other countries.

DOI： 10.1371/journal.pone.0136317

Web of Science

Scopus

PubMed

宮永直, 肥後建樹郎, 田中佳代子, 大石充 . IgG4高値を伴う肺高血圧症にステロイドが有効であった一例 . 日本心臓病学会学術集会抄録63回 1280 - 1280 2015年9月

吉野聡史, 大牟禮健太, 福元大地, 田端宏之, 立石繁宜, 大石充 . Sirolimus-eluting stent留置後の冠攣縮及び冠動脈内皮機能障害を診断し、左冠動脈主幹部病変に対してBiolimus-eluting stentを選択した1例 . 日本心臓病学会学術集会抄録63回 342 - 342 2015年9月

Nomoto Yutaro, Tsurugida Masanori, Kihara Koichi, Miyauchi Eiji, Kosedo Ippei, Yuasa Toshinori, Otsuji Yutaka, Ohishi Mitsuru . 大動脈弁閉鎖不全症に進展した肺高血圧症による減衰された拡張早期心室中隔伸展(Attenuated early diastolic interventricular septum bulging by pulmonary hypertension due to later developed aortic regurgitation) . Journal of Echocardiography13 ( 3 ) 110 - 112 2015年9月

記述言語：英語出版者・発行元：(一社)日本心エコー図学会

症例は50代女性で、経皮的腎造瘻術の施行歴を有する家族性肺高血圧症で、今回、呼吸困難のため入院となった。心エコーにて、典型的な肺高血圧症の所見を呈し、右室流出路ドップラーから収縮中期にノッチングパターンが描出された。アンブリセンタンとタダラフィル併用投与により、症状は著しく改善したが、5ヵ月後に発熱を伴い、呼吸困難が悪化し再入院となった。心エコーにより、重度の大動脈弁閉鎖不全症が認められ、異常な塊が大動脈弁に付着していた。血液および尿培養所見により、Staphylococcus lugdunensisが検出されたことから、感染性心内膜炎の治療として外科的処置を打診したが、患者に拒絶されたため、投薬治療を行ったが、症状が悪化し、2ヵ月後に急死した。

吉元一成, 濱元裕喜, 有川朋芳, 新里拓郎, 濱崎秀一, 大石充 . 心筋梗塞後心室中隔穿孔による心不全の急性期コントロールに対してトルバプタン早期導入が有用であった一例 . 日本心臓病学会学術集会抄録63回 51 - 51 2015年9月

茶圓秀人, 湯浅敏典, 堀添善尚, 植屋奈美, 水上尚子, 高崎州亜, 木佐貫彰, 宮田昌明, 大石充 . 甲状腺機能低下症に伴う多量の心嚢液貯留　経過の異なる2症例 . 日本心臓病学会学術集会抄録63回 1145 - 1145 2015年9月

記述言語：英語出版者・発行元：(一社)日本心エコー図学会

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