研究者詳細 - 大石　充

論文 - 大石　充

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椎葉竜平, 中井雄貴, 富岡一俊, 谷口善昭, 白土大成, 木内悠人, 竹中俊宏, 窪薗琢郎, 大石充, 牧迫飛雄馬 . 地域在住高齢者における前糖尿病および糖尿病と筋量、筋力、身体機能との関係 . 日本予防理学療法学会学術大会プログラム・抄録集1.Suppl.No.1 ( 0 ) 6 - 6 2022年12月

記述言語：日本語出版者・発行元：日本予防理学療法学会

【はじめに、目的】サルコペニアは転倒や死亡のリスクを増大させる要因であり、サルコペニアの危険因子のひとつには糖尿病が挙げられる。血糖値が糖尿病の基準には満たないが、正常より高い状態は前糖尿病と分類され、前糖尿病は糖尿病へ進行するリスクが高い。サルコペニアの割合はHbA1c値に比例して増加すると報告されており、前糖尿病の段階からサルコペニアの診断基準である筋量、筋力、身体機能が低下している可能性がある。これらを検討することは早期から機能低下を把握する上で重要である。本研究では、地域在住高齢者における前糖尿病および糖尿病と筋量、筋力、身体機能の関係を検討した。【方法】地域コホート研究（垂水研究2019）に参加した地域在住高齢者687名のうち、脳卒中、認知症の既往、要介護認定者を除く609名（平均74.0±6.3歳、女性62.1%）を対象とした。基礎情報として、年齢、性別、内服数、糖尿病の病歴を聴取した。四肢骨格筋指数（生体電気インピーダンス法）、握力、5回椅子立ち上がりテスト、HbA1c値を測定した。HbA1c値が5.7%未満を非糖尿病群、5.7～6.4%を前糖尿病群とし、6.5%以上または糖尿病の既往がある者を糖尿病群と分類した。四肢骨格筋指数は男性7.0kg/m 2 未満、女性5.7kg/m 2 未満を筋量低下、握力は男性28kg未満、女性18kg未満を筋力低下とした。また、5回椅子立ち上がりテストは12秒以上を身体機能低下とした。筋量低下、筋力低下、身体機能低下のそれぞれを従属変数とし、糖尿病分類（非糖尿病群、前糖尿病群、糖尿病群）を独立変数としたロジスティック回帰分析を行った。共変量は年齢、性別、多剤併用の有無および筋量低下の有無、筋力低下の有無または身体機能低下の有無とした。【結果】前糖尿病および糖尿病を有する者の割合はそれぞれ25.0%、15.1% であった。各群における筋量低下の割合は、非糖尿病群40.5%、前糖尿病群33.6%、糖尿病群23.9%であった。筋力低下の割合は、非糖尿病群20.3%、前糖尿病群25.7％、糖尿病群32.6%であった。また、身体機能低下の割合は、非糖尿病群6.6%、前糖尿病群7.9%、糖尿病群14.1%であった。非糖尿病群と比較して前糖尿病群では筋力低下のオッズ比が1.70（95%信頼区間：1.02-2.82）と有意に高かった。非糖尿病群と比較して糖尿病群では筋量低下のオッズ比が0.37（95%信頼区間：0.20-0.69）と有意に低かった。また、糖尿病群では筋力低下のオッズ比が2.10（95%信頼区間：1.15-3.85）、身体機能低下のオッズ比が2.28（95%信頼区間：1.00-5.17）と有意に高かった。【結論】非糖尿病の者と比較して、前糖尿病を有する者では筋力が低下しており、糖尿病を有する者では筋量は保持しているが、筋力および身体機能が低下していることが示唆された。筋力低下や身体機能低下は将来の日常生活動作能力の低下に影響するため、前糖尿病や糖尿病を有する者は早期から運動介入を検討することが必要だろう。【倫理的配慮、説明と同意】本研究は鹿児島大学疫学研究等倫理委員会の承認（170351疫）を得て実施した。ヘルシンキ宣言に基づき、対象者には研究内容について口頭と書面にて説明をし、同意を得た。

DOI： 10.57304/jsptpsuppl.1.suppl.no.1.0_6

CiNii Research

Kawabata T., Kubozono T., Ojima S., Kawasoe S., Akasaki Y., Salim A.A., Ikeda Y., Miyata M., Takenaka T., Ohishi M. . Insufficient blood pressure control is independently associated with increased arterial stiffness . Hypertension Research45 ( 12 ) 1861 - 1868 2022年12月査読

記述言語：日本語出版者・発行元：Hypertension Research

Hypertension is a risk factor for atherosclerosis. Achieving the therapeutic target value of blood pressure (BP) prevents the onset of cardiovascular events; however, it is not clear how antihypertensive drug use and BP control status relate to arterial stiffness. The purpose of this study is to investigate the relationship between BP control status with or without antihypertensive drugs and arterial stiffness. Nine hundred eighty individuals (mean age: 68 ± 11 years) who participated in a community-based cohort study were enrolled. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI). Higher BP was defined as a systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg. Participants were divided into four groups: normal, non higher BP without antihypertensive drugs (n = 421); untreated, higher BP without antihypertensive drugs (n = 174); good control, non higher BP with antihypertensive drugs (n = 209); and poor control, higher BP with antihypertensive drugs (n = 176). In multivariable logistic analysis adjusted for age, sex, dyslipidemia and diabetes mellitus medication use, obesity, smoking, alcohol drinking, and heart rate at the CAVI measurement for a high CAVI—using a borderline cutoff value of 8.0—the other three groups were significantly associated with a high CAVI when compared with the normal group. By contrast, multivariable logistic analysis of a high CAVI using an abnormal cutoff value of 9.0 demonstrated that the poor control and untreated groups were significantly associated with a high CAVI, whereas the good control group was not. In conclusion, even with antihypertensive drugs, poor BP control is independently associated with a high CAVI.

DOI： 10.1038/s41440-022-01039-3

Scopus

PubMed

Kanda D., Ikeda Y., Takumi T., Tokushige A., Sonoda T., Arikawa R., Anzaki K., Kosedo I., Ohishi M. . Impact of nutritional status on prognosis in acute myocardial infarction patients undergoing percutaneous coronary intervention . BMC Cardiovascular Disorders22 ( 1 ) 3 - 3 2022年12月査読国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Cardiovascular Disorders

Background: Malnutrition affects the prognosis of cardiovascular disease. Acute myocardial infarction (AMI) has been a major cause of death around the world. Thus, we investigated the impact of malnutrition as defined by Geriatric Nutritional Risk Index (GNRI) on mortality in AMI patients. Methods: In 268 consecutive AMI patients who underwent percutaneous coronary intervention (PCI), associations between all-cause death and baseline characteristics including malnutrition (GNRI < 92.0) and Global Registry of Acute Coronary Events (GRACE) risk score were assessed. Results: Thirty-three patients died after PCI. Mortality was higher in the 51 malnourished patients than in the 217 non-malnourished patients, both within 1 month after PCI (p < 0.001) and beyond 1 month after PCI (p = 0.017). Multivariate Cox proportional hazards regression modelling using age, left ventricular ejection fraction and GRACE risk score showed malnutrition correlated significantly with all-cause death within 1 month after PCI (hazard ratio [HR] 7.04; 95% confidence interval [CI] 2.30–21.51; p < 0.001) and beyond 1 month after PCI (HR 3.10; 95% CI 1.70–8.96; p = 0.037). There were no significant differences in area under the receiver-operating characteristic (ROC) curve between GRACE risk score and GNRI for predicting all-cause death within 1 month after PCI (0.90 vs. 0.81; p = 0.074) or beyond 1 month after PCI (0.69 vs. 0.71; p = 0.87). Calibration plots comparing actual and predicted mortality confirmed that GNRI (p = 0.006) was more predictive of outcome than GRACE risk score (p = 0.85) beyond 1 month after PCI. Furthermore, comparison of p-value for interaction of malnutrition and GRACE risk score for all-cause death within 1 month after PCI, beyond 1 month after PCI, and the full follow-up period after PCI were p = 0.62, p = 0.64 and p = 0.38, respectively. Conclusions: GNRI may have a potential for predicting the mortality in AMI patients especially in beyond 1 month after PCI, separate from GRACE risk score. Assessment of nutritional status may help stratify the risk of AMI mortality.

DOI： 10.1186/s12872-021-02448-x

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PubMed

Kawabata Takeko, Kubozono Takuro, Ojima Satoko, Kawasoe Shin, Akasaki Yuichi, Salim Anwar Ahmed, Ikeda Yoshiyuki, Miyata Masaaki, Takenaka Toshihiro, Ohishi Mitsuru . 【アジアにおける高血圧管理の現状と展望】不十分な血圧コントロールは動脈スティフネス増大と独立して関連する(【Current evidence and perspectives for hypertension management in Asia】Insufficient blood pressure control is independently associated with increased arterial stiffness) . Hypertension Research45 ( 12 ) 1861 - 1868 2022年12月

記述言語：英語出版者・発行元：Nature Publishing Group

垂水市で行われた地域住民を対象とするコホート研究に参加した980名を対象に、降圧薬を用いた場合と用いない場合の血圧コントロール状況と動脈スティフネスとの関連性を評価した。動脈スティフネスの評価には心臓足首血管指数(CAVI)を用いた。高血圧の定義は、収縮期血圧140mmHg以上または拡張期血圧90mmHg以上とした。未治療コントロール良好群421名(平均64±11歳)、未治療コントロール不良群174名(平均67±11歳)、治療コントロール良好群209名(平均73±9歳)、治療コントロール不良群176名(平均73±9歳)に分類した。CAVI評価時の年齢、性別、脂質異常症治療薬使用、糖尿病治療薬使用、肥満、喫煙、飲酒、心拍数を調整後、CAVI高値のカットオフ値を8.0とした場合は未治療コントロール良好群に比べて他の3群でCAVIが有意に高値であり、カットオフ値を9.0とした場合は治療コントロール不良群と未治療コントロール不良群でCAVIが有意に高値であった。降圧薬治療を行っても、血圧コントロール不良はCAVI高値と独立して関連することが示された。

Masumitsu Tomomi, Kubozono Takuro, Miyata Masaaki, Makizako Hyuma, Tabira Takayuki, Takenaka Toshihiro, Kawasoe Shin, Tokushige Akihiro, Niwa Sayoko, Ohishi Mitsuru . 地域在住高齢者での睡眠時間と心臓足首血管指数の関連性(Association of Sleep Duration and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults) . Journal of Atherosclerosis and Thrombosis29 ( 12 ) 1864 - 1871 2022年12月

記述言語：英語出版者・発行元：(一社)日本動脈硬化学会

65歳以上の地域住民を対象に、心臓足首血管指数(CAVI)と自己報告による睡眠の時間・質の関連性を横断的に調査した。2018～2019年に健康診断を受けた鹿児島県垂水市の高齢者コホート(垂水研究)から、65歳以上の997名(女性622名、年齢中央値74歳)を解析に組み入れた。睡眠時間で3群に分類した。その結果、睡眠時間が8時間以上であった長睡眠群は110名(女性56名、年齢中央値77歳)、6～8時間の中睡眠群は438名(女性269名、年齢中央値74歳)、6時間未満の短睡眠群は449名(女性297名、年齢中央値73歳)であった。この3群で平均CAVIを比較すると、長睡眠群では9.6±1.3となり、中睡眠群(9.1±1.2)または短睡眠群(9.1±1.1)よりも有意に高かった(P<0.001)。各種の因子(年齢、性別、収縮期血圧、現喫煙状態、BMI、運動頻度、学歴、フレイル、睡眠薬、睡眠の質、昼寝時間)で調整を行った多変量回帰分析の結果、長睡眠群のCAVIは中睡眠群よりも有意に高い(p=0.016)ことが証明された。こうした結果とは対照的に、睡眠の質とCAVIの有意な関連性は示されなかった。本解析結果から、高齢者では睡眠時間が長いことが動脈硬化度と相関し、睡眠の質は相関しないことが示唆された。

記述言語：英語出版者・発行元：Nature Publishing Group

Akasaki Y., Tabira T., Maruta M., Makizako H., Miyata M., Han G., Ikeda Y., Nakamura A., Shimokihara S., Hidaka Y., Kamasaki T., Kubozono T., Ohishi M. . Social Frailty and Meaningful Activities among Community-Dwelling Older Adults with Heart Disease . International Journal of Environmental Research and Public Health19 ( 22 ) 15167 2022年11月査読国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Patients with heart disease are more likely to experience social frailty due to physical inactivity, which may affect meaningful activities such as hobbies. This study aimed to investigate (1) the association between heart disease and social frailty in community-dwelling older adults and (2) the characteristics of meaningful activities in community-dwelling older adults with heart disease. Data from 630 older adults who participated in a community-based health survey were obtained, including clinical history, meaningful activities, social frailty and psychosomatic functions. Participants were divided into two groups: those with heart disease (n = 79) and those without (n = 551), and comparisons were made. Social frailty was observed in 23.7% of participants with heart disease, and logistic regression revealed significant associations with heart disease and social frailty after adjusting for potential covariates (OR, 1.97; 95% CI, 1.06 3.67; p = 0.032). Participants with heart disease did not differ significantly in terms of satisfaction or performance; their frequency of engagement in meaningful activities was significantly lower than without heart disease (p = 0.041). These results suggest that heart disease and social frailty are associated in community-dwelling older adults, and that this demographic is inclined to engage in meaningful activities less frequently.

DOI： 10.3390/ijerph192215167

Scopus

PubMed

Kubota K., Miyanaga S., Iwatani N., Ohishi M. . Unknown atrial septal defect was diagnosed during the course of treatment for portopulmonary hypertension: A case report . Journal of Cardiology Cases26 ( 5 ) 383 - 385 2022年11月

記述言語：日本語出版者・発行元：Journal of Cardiology Cases

Portopulmonary hypertension (POPH) is a condition defined by the development of pulmonary arterial hypertension (PAH) that is associated with liver disease or portal hypertension. Untreated POPH has a poor prognosis. POPH can be treated with PAH-targeted therapy and can sometimes resolve with liver transplantation (LT); however, poorly controlled POPH can preclude LT owing to an increased peri-operative risk. We report a case of POPH that was diagnosed as an unknown atrial septal defect during PAH-targeted therapy. As observed in our case, the same patient may have several causes of PAH. It is important to confirm an unknown shunt disease using echocardiography during PAH-targeted therapy. Learning objective: It is difficult to detect unknown shunt disease in patients who are diagnosed with pulmonary arterial hypertension (PAH) owing to other causes. We report a case of portopulmonary hypertension that was diagnosed as an unknown atrial septal defect during PAH-targeted therapy. This report highlights the same patient may have several causes of PAH. It is important to confirm an unknown shunt disease using echocardiography during PAH-targeted therapy.

DOI： 10.1016/j.jccase.2022.08.003

Scopus

PubMed

Kubota Kayoko, Miyanaga Sunao, Iwatani Noriko, Ohishi Mitsuru . 門脈肺高血圧症の治療中に検出され診断に至った心房中隔欠損症　1症例報告(Unknown atrial septal defect was diagnosed during the course of treatment for portopulmonary hypertension: A case report) . Journal of Cardiology Cases26 ( 5 ) 383 - 385 2022年11月

記述言語：英語出版者・発行元：(一社)日本心臓病学会

症例は51歳女性で、呼吸困難を主訴に近医を受診し、経胸壁心エコー検査で肺高血圧を指摘された。精査と加療を目的に当院へ紹介された。B型肝炎ウイルス感染による非代償性肝硬変の既往があった。受診時の心エコー検査で右室拡大を認め、推定右室収縮期圧は68mmHgであった。腹部CTで著明に拡張した上腸間膜静脈と脾腫を認めた。肺血流シンチグラフィーで肺血栓塞栓の所見はなかった。右心カテーテル検査で肺動脈圧は収縮期が68mmHg、拡張期が23mmHg、平均圧が41mmHg、心係数は5.49L/min/m2であった。門脈圧亢進症による門脈肺高血圧症と診断し、マシテンタンの投与を開始し、2ヵ月後にタダラフィルに切り替えた。4ヵ月後の心エコー検査で以前は見られなかったシャント血流が検出された。肺動脈圧は収縮期43mmHg、拡張期16mmHg、平均26mmHgに低下し、右房酸素飽和度は87.1%に上昇した。心房中隔欠損症と診断し、Amplatzer閉鎖栓を用いた経カテーテル閉鎖術を施行した。1年後に肝性脳症に対して肝移植が施行され、3年後の肺動脈圧は収縮期23mmHg、拡張期10mmHg、平均15mmHgであった。

Kubota Kayoko, Miyanaga Sunao, Iwatani Noriko, Ohishi Mitsuru . 門脈肺高血圧症の治療中に検出され診断に至った心房中隔欠損症 1症例報告(Unknown atrial septal defect was diagnosed during the course of treatment for portopulmonary hypertension: A case report) . Journal of Cardiology Cases26 ( 5 ) 383 - 385 2022年11月

記述言語：英語出版者・発行元：(一社)日本心臓病学会

Atsushi Tanaka, Masataka Sata, Yosuke Okada, Hiroki Teragawa, Kazuo Eguchi, Michio Shimabukuro, Isao Taguchi, Kazuo Matsunaga, Yumiko Kanzaki, Hisako Yoshida, Tomoko Ishizu, Shinichiro Ueda, Masafumi Kitakaze, Toyoaki Murohara, Koichi Node, Koichi Node, Masafumi Kitakaze, Yoshihiko Nishio, Mitsuru Ohishi, Kazuomi Kario, Masataka Sata, Michio Shimabukuro, Wataru Shimizu, Hideaki Jinnouchi, Isao Taguchi, Hirofumi Tomiyama, Koji Maemura, Makoto Suzuki, Shinichi Ando, Kazuo Eguchi, Haruo Kamiya, Tomohiro Sakamoto, Hiroki Teragawa, Mamoru Nanasato, Munehide Matsuhisa, Junya Ako, Yoshimasa Aso, Masaharu Ishihara, Kazuo Kitagawa, Akira Yamashina, Yumi Ikehara, Ayako Takamori, Atsushi Tanaka, Miki Mori, Kaori Yamaguchi, Machiko Asaka, Tetsuya Kaneko, Masashi Sakuma, Shigeru Toyoda, Takahisa Nasuno, Michiya Kageyama, Jojima Teruo, Iijima Toshie, Haruka Kishi, Hirotsugu Yamada, Kenya Kusunose, Daiju Fukuda, Shusuke Yagi, Koji Yamaguchi, Takayuki Ise, Yutaka Kawabata, Akio Kuroda, Yuichi Akasaki, Mihoko Kurano, Satoshi Hoshide, Takahiro Komori, Tomoyuki Kabutoya, Yukiyo Ogata, Yuji Koide, Hiroaki Kawano, Satoshi Ikeda, Satoki Fukae, Seiji Koga, Yukihito Higashi, Shinji Kishimoto, Masato Kajikawa, Tatsuya Maruhashi, Yoshiaki Kubota, Yoshisato Shibata, Nehiro Kuriyama, Ikuko Nakamura, Kanemitsu Hironori, Bonpei Takase, Yuichi Orita, Chikage Oshita, Yuko Uchimura, Ruka Yoshida, Yukihiko Yoshida, Hirohiko Suzuki, Yasuhiro Ogura, Mayuho Maeda, Masaki Takenaka, Takumi Hayashi, Mirai Hirose, Itaru Hisauchi, Toshiaki Kadokami, Ryo Nakamura, Junji Kanda, Kazuo Matsunaga, Masaaki Hoshiga, Koichi Sohmiya, Yumiko Kanzaki, Arihiro Koyosue, Hiroki Uehara, Naoto Miyagi, Toshiya Chinen, Kentaro Nakamura, Chikashi Nago, Suguru Chiba, Sho Hatano, Yoshikatsu Gima, Masami Abe, Masayoshi Ajioka, Hiroshi Asano, Yoshihiro Nakashima, Hiroyuki Osanai, Takahiro Kanbara, Yusuke Sakamoto, Mitsutoshi Oguri, Shiou Ohguchi, Kunihiko Takahara, Kazuhiro Izumi, Kenichiro Yasuda, Akihiro Kudo, Noritaka Machii, Ryota Morimoto, Yasuko Bando, Takahiro Okumura, Toru Kondo, Shin-Ichiro Miura, Yuhei Shiga, Joji Mirii, Makoto Sugihara, Tadaaki Arimura, Junko Nakano, Tomohiro Sakamoto, Kazuhisa Kodama, Nobuyuki Ohte, Tomonori Sugiura, Kazuaki Wakami, Yasuhiko Takemoto, Minoru Yoshiyama, Taichi Shuto, Kazuo Fukumoto, Yosuke Okada, Kenichi Tanaka, Satomi Sonoda, Akemi Tokutsu, Takashi Otsuka, Fumi Uemura, Kenji Koikawa, Megumi Miyazaki, Maiko Umikawa, Manabu Narisawa, Machi Furuta, Hiroshi Minami, Masaru Doi, Kazuhiro Sugimoto, Susumu Suzuki, Akira Kurozumi, Kosuke Nishio . Effect of ipragliflozin on carotid intima-media thickness in patients with type 2 diabetes: A multicenter, randomized, controlled trial. . European heart journal. Cardiovascular pharmacotherapy9 ( 2 ) 165 - 172 2022年10月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）

AIM: To examine the effects of 24-month treatment with ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients. METHODS: In this multicenter, prospective, randomized, open-label, blinded-endpoint investigator-initiated clinical trial, adults with type 2 diabetes and hemoglobin A1C (HbA1c) of 6.0%-10.0% (42-86 mmol/mol) were randomized equally to ipragliflozin (50 mg daily) and non-sodium-glucose cotransporter-2 (SGLT2) inhibitor use of standard-care (control group) for type 2 diabetes and were followed-up for 24 months. The primary endpoint was the change in mean common carotid artery IMT (CCA-IMT) from baseline to 24 months. RESULTS: A total of 482 patients were equally allocated to the ipragliflozin (N = 241) and control (N = 241) groups, and 464 patients (median age 68 years, female 31.7%, median type 2 diabetes duration 8 years, median HbA1c 7.3%) were included in the analyses. For the primary endpoint, the changes in the mean CCA-IMT from baseline to 24 months were 0.0013 (95% CI, -0.0155-0.0182) mm and 0.0015 (95% CI, -0.0155-0.0184) mm in the ipragliflozin and control groups, respectively, with an estimated group difference (ipragliflozin-control) of -0.0001 mm (95% CI, -0.0191-0.0189; P = 0.989). A group difference in HbA1c change at 24 months was also non-significant between the treatment groups (-0.1% [95% CI, -0.2-0.1]; P = 0.359). CONCLUSIONS: Twenty-four months of ipragliflozin treatment did not affect carotid IMT status in patients with type 2 diabetes recruited in the PROTECT study, relative to the non-SGLT2 inhibitor-use standard care for type 2 diabetes.

DOI： 10.1093/ehjcvp/pvac059

PubMed

Taniguchi Y., Makizako H., Nakai Y., Kiuchi Y., Akaida S., Tateishi M., Takenaka T., Kubozono T., Ohishi M. . Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults . Journal of Clinical Medicine11 ( 20 ) 6172 2022年10月査読国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Clinical Medicine

Bone and muscle mass loss are known to occur simultaneously. The alpha-actinin three (ACTN3) genotype has been shown to potentially affect bone and muscle mass. In this study, we investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged ≥ 60 years. This study was a cross-sectional analysis of data from 295 participants who participated in a community health checkup. The ACTN3 genotypes were classified as RR, RX, or XX types. Bone mass loss was defined as a calcaneal speed of sound T-score of <−1.32 and <−1.37, and muscle mass loss was defined as an appendicular skeletal muscle index of <7.0 kg/m2 and <5.7 kg/m2 in men and women, respectively. The percentages of XX, RX, and RR in the combined bone and muscle mass loss group were 33.8%, 30.8%, and 16.7%, respectively, with a significantly higher trend for XX. Multinomial logistic regression analysis showed that XX had an odds ratio of 3.00 (95% confidence interval 1.05–8.54) of being in the combined bone and muscle mass loss group compared to the RR group (covariates: age, sex, grip strength, and medications). The ACTN3 genotype of XX is associated with a higher rate of comorbid bone and muscle mass loss. Therefore, ACTN3 genotyping should be considered for preventing combined bone and muscle mass loss.

DOI： 10.3390/jcm11206172

Scopus

PubMed

入來泰久, 新山修平, 瀬尾浩希, 内山奈美, 永野祐志, 中條正典, 大石充, 垣花泰之 . MRI施行困難の急性期脳梗塞に対するPerfusion CTが診断・治療に有効であった1例 . 日本救急医学会雑誌33 ( 10 ) 816 - 816 2022年10月

Makizako H, Kiyama R, Nakai Y, Kawada M, Tomioka K, Taniguchi Y, Takenaka T, Kubozono T, Ohishi M . Reference values of chair stand test and associations of chair stand performance with cognitive function in older adults . Aging and Health Research2 ( 3 ) 100090. 2022年9月査読

Maruta M., Shimokihara S., Makizako H., Ikeda Y., Han G., Akasaki Y., Hidaka Y., Kamasaki T., Kubozono T., Ohishi M., Tabira T. . Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community-dwelling Japanese older adults . Psychogeriatrics22 ( 5 ) 651 - 658 2022年9月査読国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Psychogeriatrics

Background: Frailty is a multidimensional condition characterised by reduced physical and psychological resilience. Older adults also frequently demonstrate apathy, suggesting that it shares similar neuro-physiological pathways with frailty. This cross-sectional study aimed to investigate the association between apathy and frailty as defined by a comprehensive assessment. Methods: We analyzed 882 older adults (mean age: 74.4 ± 6.4 years; 62.1% female) who participated in a community-based health check survey (Tarumizu Study). Apathy was measured by the Geriatric Depression Scale-3A, a three-item subset of the Geriatric Depression Scale-15, and frailty by the Kihon Checklist of physical, psychological, functional, and social status. Associations were examined by multinomial logistic regression with frailty status (robust, pre-frailty, frailty) as the dependent variable, apathy as the independent variable, and sociodemographic factors, medications, cognitive function, functional capacity, and mood symptoms as potential confounders. Results: Apathy was observed in 23.7% of individuals, and logistic regression revealed significant associations with both pre-frailty and frailty after confounder adjustment (pre-frailty: odds ratio (OR) 1.80, 95% CI 1.22–2.64; frailty: OR 3.24, 95% CI 1.63–6.42). Participants with apathy also exhibited greater deficits in the Kihon Checklist subdomains instrumental activities of daily living (P = 0.022), physical function (P < 0.001), oral function (P < 0.001), and cognitive function (P = 0.001). Conclusions: Our findings underscore the importance of comprehensive frailty assessment and demonstrate that apathy can have pervasive deleterious effects on geriatric health.

DOI： 10.1111/psyg.12867

Scopus

PubMed

川畑孟子, 小島聡子, 窪薗琢郎, 川添晋, 池田義之, 大石充 . レンバチニブメシル酸塩による薬剤性心筋症を来した一例 . 日本心臓病学会学術集会抄録70回 C - 14 2022年9月

Maruta Michio, Shimokihara Suguru, Makizako Hyuma, Ikeda Yuriko, Han Gwanghee, Akasaki Yoshihiko, Hidaka Yuma, Kamasaki Taishiro, Kubozono Takuro, Ohishi Mitsuru, Tabira Takayuki . 地域在住日本人高齢者におけるアパシーと基本チェックリストにより包括的に評価されたフレイルとの関連(Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community-dwelling Japanese older adults) . Psychogeriatrics22 ( 5 ) 651 - 658 2022年9月

記述言語：英語出版者・発行元：John Wiley & Sons Australia, Ltd

地域在住高齢者におけるアパシーとフレイルとの横断的な関連について検討した。健康診断調査(垂水調査)に参加した地域在住高齢者882名(平均74.4±6.4歳、女性62.1%)を対象とした。アパシーはGeriatric Depression Scale-3Aで評価し、フレイルは基本チェックリスト(下位尺度;日常生活関連動作、運動器機能、低栄養状態、口腔機能、閉じこもり、認知機能)で評価した。その結果、209名(23.7%)でアパシーが認められた。交絡因子調整後の多項ロジスティック回帰分析の結果、アパシーはプレフレイルおよびフレイルと有意に関連していた。アパシーを有する高齢者では有さない高齢者と比較して、基本チェックリストの日常生活関連動作、運動器機能、口腔機能、認知機能に問題を呈する割合が有意に高かった。以上から、包括的なフレイル評価の重要性が示され、アパシーは老年期の健康に広範かつ有害な影響を及ぼす可能性が示唆された。

稲津真穂人, 片岡哲郎, 川畑深怜, 福崎篤, 新地秀也, 福元大地, 福永研吾, 高崎州亜, 永富脩二, 金城玉洋, 城ヶ崎倫久, 中島均, 大石充 . 卵円孔に管状静脈血栓が嵌頓した交通外傷後の1例 . 日本心臓病学会学術集会抄録70回 C - 11 2022年9月

濱元裕喜, 田島亜佳里, 内山洋太, 堀添善尚, 安田久代, 大石充 . 三尖弁置換後早期に三尖弁人工弁機能不全を来たした1例 . 日本心臓病学会学術集会抄録70回 C - 22 2022年9月

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