研究者詳細 - 大石　充

論文 - 大石　充

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Suematsu Yasunori, Morita Hidetaka, Abe Makiko, Uehara Yoshinari, Koyoshi Rie, Fujimi Kanta, Ideishi Akihito, Takata Kohei, Kato Yuta, Hirata Tetsuo, Yahiro Eiji, Morito Natsumi, Kitajima Ken, Yano Yuiko, Satoh Atsushi, Yoshimura Chikara, Ishida Shintaro, Okutsu Shota, Takahashi Koji, Shinohara Yukiko, Sakaguchi Takashi, Katsuki Shiori, Tada Kazuhiro, Fujii Takako, Funakoshi Shunsuke, Hu Yaopeng, Satoh Tomonori, Ohnishi Hirofumi, Okamura Keisuke, Mizuno Hiroyuki, Arakawa Kimika, Asayama Kei, Ohtsubo Toshio, Ishigami Tomoaki, Shibata Shigeru, Fujita Takayuki, Munakata Masanori, Ohishi Mitsuru, Ichihara Atsuhiro, Katsuya Tomohiro, Mukoyama Masashi, Rakugi Hiromi, Node Koichi, Arima Hisatomi, Miura Shin-ichiro . 血圧に対する運動の影響の差は、身体条件および運動のタイプに依存する系統的レビューおよびメタ解析(Differences in the effects of exercise on blood pressure depending on the physical condition of the subject and the type of exercise: a systematic review and meta-analysis) . Hypertension Research48 ( 2 ) 720 - 732 2025年2月

記述言語：英語出版者・発行元：Nature Publishing Group

運動の血圧(BP)低下効果を調べた無作為化対照試験4357件のアンブレラレビューおよびメタ解析を行った。ランダム効果モデルメタ解析により複数の試験を統合した効果量を推定した。運動は健常者の収縮期BP(SBP)を有意に低下させ、高血圧を含む生活習慣病患者でも同様であったが、心血管疾患患者では低下させなかった。地域に関して、オセアニアではSBP低下がみられず、アジアでは心血管疾患患者でもSBPが低下した。以上より、どんなタイプの運動でも健常者および生活習慣病患者のBPを低下させるが、心血管疾患患者のBPは低下させず、地域により運動の効果が異なると結論した。

地頭薗公宏, 桑波田聡, 大坪稔拓, 満留祐也, 川畑深怜, 長野綾香, 佐田千尋, 岩谷徳子, 軸丸美香, 竹中俊宏, 大石充 . 夜間血圧がnon-dipper/riser typeを呈した神経調節性失神の3例 . 日本病院総合診療医学会雑誌21 ( 臨増1 ) 158 - 158 2025年2月

津曲真二, 益満智美, 佐々木八千代, 宮田昌明, 竹ノ内千紗, 和田　麗, 窪薗琢郎, 竹中俊宏, 大石　充 . 地域在住高齢者における糖尿病予備群の座位時間 . 日健医誌33 ( 4 ) 528 - 533 2025年1月査読

Salim AA, Kawasoe S, Kubozono T, Ojima S, Yamaguchi S, Higuchi K, Ikeda Y, Miyahara H, Tokushige K, Ohishi M . Association between serum uric acid levels and left ventricular hypertrophy based on electrocardiographic findings: a sex-specific analysis across cardiometabolic diseases . Sci Rep15 ( 1 ) 2319 2025年1月査読

津曲真二, 益満智美, 佐々木八千代, 宮田昌明, 竹ノ内千紗, 和田麗, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における糖尿病予備群の座位時間 . 日本健康医学会雑誌33 ( 4 ) 528 - 533 2025年1月

記述言語：日本語出版者・発行元：日本健康医学会

鹿児島県垂水市で行われた地域コホート研究(垂水研究2021年度)に参加した551名のうち,65歳以上の198名をHbA1cが≧5.6%の糖尿病予備群(103名)とHbA1cが<5.6%の正常群(95名)の2群に分け,Body Mass Index(BMI),収縮期血圧,血清トリグリセリド(TG),HDLコレステロール(HDL-C),LDLコレステロール,総座位時間,10分以上の座位持続時間,中等度以上の活動時間(MVPA)を比較した。座位時間は,ActiGraphを用いて客観的に測定した。糖尿病予備群は,正常群と比較してBMI(p=0.001),TG(p=0.020),10分以上の座位持続時間(p=0.003)が有意に高値を示し,HDL-Cは有意に低値を示した(p=0.002)。糖尿病予備群/正常群という群分けを従属変数,10分以上の座位持続時間,年齢,性別,BMI,HDL-C,TG,MVPAを独立変数としたロジスティック回帰分析を行い,糖尿病予備群に対するオッズ比(OR)を算出したところ,10分以上の座位持続時間(OR,1.01;95%CI:1.01-1.02;p=0.012)とBMI(OR,1.12;95%CI:1.02-1.23;p=0.022)が有意な関連を示した。(著者抄録)

堀添善尚, 内山洋太, 田島亜佳里, 濱元裕喜, 窪薗琢郎, 大石充 . 小児期からの慢性的左室収縮不全に心不全基礎治療薬を導入し収縮能の改善を認めた一例 . 日本成人先天性心疾患学会雑誌14 ( 1 ) 226 - 226 2025年1月

Kario K., Katsuya T., Shimosawa T., Taguchi T., Tanabe A., Ohishi M. . Rationale and Design of a Randomized, Open-Label, Parallel-Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calcium Channel Blocker Monotherapy (ESCORT-HT) . Journal of Clinical Hypertension27 ( 1 ) e14947 2025年1月査読

記述言語：日本語出版者・発行元：Journal of Clinical Hypertension

Angiotensin II receptor blockers (ARBs) and calcium channel blockers (CCBs) are commonly prescribed as first- and second-line treatments for older Japanese patients with hypertension. However, due to age-related decline in renin activity, the effectiveness of ARBs may decrease. This highlights the need for other antihypertensive agents to be used in combination with CCBs to replace ARBs for more effective blood pressure (BP) control. The ESCORT-HT study is a multicenter, randomized, controlled, open-label, parallel-group study with a 4-week run-in period and 12-week treatment period. This study aims to evaluate the efficacy of esaxerenone as a second-line treatment for hypertension and to determine whether its BP-lowering effect is noninferior to that of ARBs in older patients with uncontrolled hypertension on CCB monotherapy. The safety profiles of esaxerenone and ARBs will also be evaluated. Patients will be randomly assigned in a 1:1 ratio to receive either esaxerenone or an ARB. The primary efficacy endpoint will be the change from baseline in morning home systolic BP at the end of the treatment period. The BP-lowering effect of esaxerenone will be considered noninferior to that of ARBs if the upper limit of the two-sided 95% confidence interval (CI) for the difference in systolic BP change between esaxerenone and ARB is <3.8 mmHg, and will be considered superior if the upper limit of the two-sided 95% CI is <0. The findings may elucidate the possible benefits of earlier use of mineralocorticoid receptor blockers in combination with CCBs in older patients with essential hypertension.

DOI： 10.1111/jch.14947

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Ohmure Kenta, Kanda Daisuke, Ikeda Yoshiyuki, Tokushige Akihiro, Sonoda Takeshi, Arikawa Ryo, Anzaki Kazuhiro, Ohishi Mitsuru . 血管内治療後の下肢動脈疾患患者における予後に対する低栄養-炎症-アテローム性動脈硬化因子の併存の影響(Impact of co-presence of malnutrition-inflammation-atherosclerosis factors on prognosis in lower extremity artery disease patients after endovascular therapy) . Cardiovascular Intervention and Therapeutics40 ( 1 ) 102 - 111 2025年1月

記述言語：英語出版者・発行元：(一社)日本心血管インターベンション治療学会

2015年1月～2022年2月に単一施設で血管内治療(EVT)を行った下肢動脈疾患(LEAD)患者284例を対象に、低栄養-炎症-アテローム性動脈硬化(MIA)因子の予後的影響を後ろ向きに評価した。MIA因子は、Geriatric Nutritional Risk Index 92未満、高感度C反応性タンパク0.1mg/dL以上、冠動脈血行再建術・ラクナまたはアテローム血栓性脳梗塞の既往とした。62例(22%)が死亡し、72例(25%)で主要有害心血管・脳血管イベント(MACCE;全死亡、非致死的心筋梗塞、脳卒中)を認めた。44例(16%)が3つ全てのMIA(3-MIA)因子を有していた。追跡期間は平均737日であった。多変量Cox比例ハザード回帰分析において、3-MIA因子は全死亡およびMACCEと有意に関連した(ハザード比、95%CIはそれぞれ3.46、1.89～6.34、2.91、1.62～5.22)。Kaplan-Meier法において、複数のMIA因子を有する患者および包括的高度慢性下肢虚血患者では、全死亡およびMACCEの発生率が有意に高かった。EVT後のLEAD患者において、MIA因子の併存は全死亡およびMACCEの独立したリスク因子であることが示された。

Hidaka Y., Shimokihara S., Akasaki Y., Maruta M., Han G., Kamasaki T., Kumura Y., Kukizaki W., Nakahara R., Makizako H., Kubozono T., Ohishi M., Tabira T. . Longitudinal Relationship Between Grave Visitation and Depressive Symptoms Among Community-Dwelling Older Adults . Clinical Gerontologist 1 - 12 2025年

記述言語：日本語出版者・発行元：Clinical Gerontologist

Objectives: Participating in religious activities benefits older adults’ mental health; however, the effects of grave visitation, a significant religious practice in Japan, on older adults’ mental health remain unclear. Therefore, this study examined the relationship between grave visitation frequency and depressive symptoms. Methods: A prospective cohort study of 273 community-dwelling older adults in Japan was conducted with baseline (2018) and follow-up (2022) assessments. Participants were categorized by visitation frequency: more or less than once a week. Changes in visitation frequency were classified as continued high, decreased, continued low, or increased. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Multivariable linear regressions were used to examine the association between visitation and depressive symptoms. Results: Lower visitation at baseline was associated with worse GDS-15 scores in the follow-up. Those with decreased or continued low visitation had significantly worse depressive symptoms. After adjusting for baseline GDS-15 scores and covariates, the decreased group had significantly worse depressive symptoms than the continued high group. Conclusions: The findings indicate that changes in grave visitation frequency are significantly associated with depressive symptoms. Clinical Implications: Supporting older adults’ access to grave visitation through transportation or community programs may help maintain their well-being and emotional health.

DOI： 10.1080/07317115.2025.2538105

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Kario K., Ohishi M., Katsuya T., Shimosawa T., Shiosakai K., Furugori T., Taguchi T. . Effect of N-terminal pro B-type natriuretic peptide levels on the efficacy and safety of esaxerenone vs trichlormethiazide for the treatment of Japanese patients with uncontrolled essential hypertension: a subanalysis of the EXCITE-HT study . Hypertension Research49 ( 2 ) 431 - 443 2025年

記述言語：日本語出版者・発行元：Hypertension Research

It is currently unknown whether baseline N-terminal pro B-type natriuretic peptide (NT-proBNP) levels, a marker of pressure-related cardiac stress, affect the efficacy and safety of esaxerenone vs trichlormethiazide. This exploratory subanalysis of the EXCITE-HT study aimed to compare the antihypertensive efficacy and safety of esaxerenone vs trichlormethiazide in Japanese patients with uncontrolled essential hypertension stratified by baseline NT-proBNP. EXCITE-HT was a randomized, open-label, parallel-group study. In this subanalysis, patients were divided into low and high NT-proBNP subgroups based on their baseline levels (<125 pg/mL and ≥125 pg/mL, respectively). The low NT-proBNP subgroup included 188 and 212 patients and the high NT-proBNP subgroup included 49 and 41 patients in the esaxerenone and trichlormethiazide groups, respectively. A significant decrease in morning home systolic/diastolic blood pressure (SBP/DBP; the primary endpoint) was observed from baseline to the end of treatment in both NT-proBNP subgroups. In the low NT-proBNP subgroup, esaxerenone was superior to trichlormethiazide in lowering SBP and non-inferior in lowering DBP. Non-inferiority could not be confirmed in the high NT-proBNP subgroup. The geometric mean urinary albumin-to-creatinine ratio significantly decreased from baseline to Week 12 in all subgroups (all P < 0.001 vs baseline). No cases of serum potassium level ≥6.0 mEq/L were reported. These findings suggest that esaxerenone is efficacious across a wide range of baseline NT-proBNP levels, while also supporting its favorable safety profile. (Figure presented.)

DOI： 10.1038/s41440-025-02412-8

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Noguchi Y, Kawasoe S, Miyata M, Horizoe Y, Hamamoto Y, Tajima A, Uchiyama Y, Kubozono T, Nakamura Y, Kobayashi S, Yunoue S, Ozono N, Nakashima K, Higashi F, Ohishi M . Characteristics of Myocardial Work Indices in Patients with Aortic Valve Stenosis . Int Heart J.66 ( 5 ) 754 - 762 2025年査読

Kanda D., Ito N., Ohishi M. . Coronary Pseudoaneurysm and Stent Disruption Caused by Infective Endocarditis . Jacc Case Reports31 ( 6 ) 106337 2025年

記述言語：日本語出版者・発行元：Jacc Case Reports

Images: Intravascular imaging (optical coherence tomography and intravascular ultrasound) demonstrating coronary pseudoaneurysm and stent disruption. Case Summary: A 65-year-old man undergoing hemodialysis for diabetic nephropathy developed methicillin-resistant Staphylococcus aureus infective endocarditis complicated by coronary pseudoaneurysm and stent disruption, resulting in cardiac tamponade. Intravascular imaging confirmed the complete destruction of the arterial wall. Emergency covered stent implantation and pericardiocentesis stabilized the patient, followed by a multidisciplinary treatment approach, including prolonged antibiotics and surgical source control, leading to survival. Take-Home Message: Timely imaging-guided diagnosis and a stepwise multidisciplinary strategy were lifesaving in this extremely rare and complex case.

DOI： 10.1016/j.jaccas.2025.106337

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Akasaki Y., Shimokihara S., Hidaka Y., Maruta M., Han G., Kamasaki T., Kumura Y., Kukizaki W., Nakahara R., Makizako H., Kubozono T., Ohishi M., Tabira T. . Changes in satisfaction with meaningful activities and subsequent subjective memory complaints: a two-wave longitudinal analysis of Japanese older adults . Aging and Mental Health 1 - 12 2025年

記述言語：日本語出版者・発行元：Aging and Mental Health

Objectives: This two-wave longitudinal study examined whether changes in satisfaction with meaningful activities (MA) were associated with subsequent subjective memory complaints (SMC) among community-dwelling older adults between 2019 and 2021. Method: Health surveys were conducted among local people at two time points: baseline (2019, before the COVID-19 pandemic) and follow-up (2021, during the pandemic). The participants were 275 community-dwelling older adults aged ≥65 years without cognitive decline at baseline. Satisfaction with MA was assessed using the Aid for Decision-Making in Occupation Choice and categorized as maintained/improved or decreased at follow-up. SMC was measured using four items developed by Tsutsumimoto and quantified according to the total number of complaints. Results: Older adults who maintained or improved satisfaction with MA showed no significant increase in SMC (p = 0.30), whereas those who demonstrated decreased satisfaction experienced a significant increase in SMC (p = 0.02). In the generalized linear mixed-effects model adjusted for covariates, a significant association was observed between decreased satisfaction with MA and increased SMC scores (β = 0.32, 95% CI = 0.09–0.55, p < 0.01). Conclusion: Maintaining and improving satisfaction with MA may be associated with a reduced risk of SMC increase in older adults.

DOI： 10.1080/13607863.2025.2570823

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Shimono H., Kanda D., Tokushige A., Ito N., Nomoto Y., Tabata H., Ohmure K., Kubozono T., Ohishi M. . Association between the modified Japanese Version of High Bleeding Risk scores and clinical outcomes in Japanese patients with lower extremity artery disease undergoing endovascular treatment . Heart and Vessels 2025年

記述言語：日本語出版者・発行元：Heart and Vessels

This study aimed to investigate the association between the modified Japanese Version of High Bleeding Risk (J-HBR) criteria and the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria with clinical outcomes in patients with lower extremity artery disease (LEAD) undergoing endovascular treatment (EVT). We enrolled 305 consecutive patients with LEAD who underwent EVT. Each modified J-HBR and ARC-HBR score was calculated by assigning 1 and 0.5 points to each major and minor criterion, respectively. Coronary artery disease was included as a major criterion in the modified J-HBR criteria, replacing peripheral vascular disease. The cut-off values for ARC-HBR and modified J-HBR scores were determined using the survival classification and regression tree (CART) model to predict all-cause mortality. A novel bleeding risk score associated with major bleeding events was developed from this dataset, with its cut-off determined by the CART model. The primary outcome was all-cause mortality; the secondary outcome was major bleeding events defined as Bleeding Academic Research Consortium type 3 or 5 following EVT. We also compared the discriminatory ability of the modified J-HBR, ARC-HBR, and novel bleeding risk scores. During a median follow-up of 1085 (435–1951) days, 116 patients died and 36 had major bleeding events. The CART model classified patients into low (modified J-HBR < 2, ARC-HBR < 1, novel bleeding risk 0), intermediate (modified J-HBR 2–2.5, ARC-HBR 1–1.5, novel bleeding risk 1), and high (modified J-HBR ≥ 3, ARC-HBR ≥ 2, novel bleeding risk ≥ 2) risk groups. Kaplan–Meier curves demonstrated a significant increase in mortality with higher modified J-HBR and ARC-HBR scores (log-rank p < 0.001) and in major bleeding events with higher novel bleeding risk scores (log-rank p < 0.001). Time-dependent receiver operating characteristic analysis for 1- and 3-year all-cause mortality showed modified J-HBR had a higher area under the curve (AUC) than ARC-HBR at 1 year (0.72 vs. 0.66, p = 0.040) and 3 years (0.66 vs. 0.61, p = 0.024). The novel bleeding risk score tended to have a higher AUC for predicting major bleeding events at 1 year than modified J-HBR (0.77 vs. 0.69, p = 0.068) and ARC-HBR (0.77 vs. 0.67, p = 0.067). The modified J-HBR and ARC-HBR scores effectively stratified the mortality risk, whereas the novel bleeding risk score effectively stratified bleeding risk in patients with LEAD undergoing EVT. The modified J-HBR score demonstrated superior discriminative ability in predicting mid- and long-term mortality compared to the ARC-HBR score.

DOI： 10.1007/s00380-025-02629-0

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Hidaka Y., Tabira T., Maruta M., Makizako H., Han G., Shimokihara S., Akasaki Y., Kamasaki T., Kukizaki W., Nakahara R., Kubozono T., Ohishi M. . Satisfaction with grave visitation and depressive symptoms among community-dwelling older Japanese adults . Mental Health Religion and Culture 2025年

記述言語：日本語出版者・発行元：Mental Health Religion and Culture

This cross-sectional observational study aimed to clarify the relationship between satisfaction with grave visitation and depressive symptoms among Japanese older adults. We analysed older adults who participated in a community health survey (n = 1025). Participants selected meaningful activities from the 95-item Aid for Decision-Making in Occupation Choice and rated their satisfaction on a five-point scale. Depression symptoms were assessed using the 15-item Geriatric Depression Scale. Grave visitation ranked fourth among all activities and was the most frequently chosen social activity. Higher satisfaction with grave visitation was associated with a significantly lower prevalence of depression, particularly in the hopelessness dimension. After adjusting for potential covariates in a Poisson regression analysis, satisfaction with grave visitation was significantly related to depression symptoms (prevalence ratio,.58; 95% confidence interval,.35–.96). Discussing beliefs about the deceased and ancestors and helping to increase satisfaction with grave visitation may help alleviate depressive symptoms.

DOI： 10.1080/13674676.2025.2516583

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宮田昌明, 窪薗琢郎, 大石充 . 地域在住高齢者における糖尿病予備群の座位時間 . 日本健康医学会33 528 - 533 2025年査読

Ohno A, Higo K, Hiwatari S, Kawabata T, Nakashima H, Ohishi M . Visualization of Vascular Inflammation Using Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression. . Annals of vascular diseases18 ( 1 ) n/a 2025年

Ohno Ayaka, Higo Kenjuro, Hiwatari Sawako, Kawabata Takeko, Nakashima Hitoshi, Ohishi Mitsuru . Visualization of Vascular Inflammation Using Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression(タイトル和訳中) . Annals of Vascular Diseases18 ( 1 ) avd.cr.25 - 00030 2025年

Akasaki Y., Shimokihara S., Hidaka Y., Maruta M., Han G., Kamasaki T., Kumura Y., Kukizaki W., Nakahara R., Makizako H., Kubozono T., Ohishi M., Tabira T. . Satisfaction with Meaningful Activities and Sleep in Community-Dwelling Older Adults: Cross-Sectional Study . Clinical Gerontologist 1 - 15 2025年

記述言語：日本語出版者・発行元：Clinical Gerontologist

Objectives: To examine whether satisfaction with meaningful activities (MA) is associated with self-rated sleep quality and sleep duration among community-dwelling older adults. Methods: Data were drawn from 833 individuals aged ≥65 years who participated in a health survey between 2018 and 2019 in Japan. Sleep quality (good, moderate, or poor) and duration (< 6, 6–8, or ≥8 h) were assessed through a questionnaire. Participants selected the MA they considered most meaningful from a list of 95 activities in the Aid for Decision-Making in Occupation Choice, and their satisfaction with these MA were measured. Results: Ordinal logistic regression analysis, with sleep quality or duration as the dependent variable and satisfaction with MA as the independent variable, showed that higher satisfaction with MA was significantly associated with lower odds of poor sleep quality (OR: 0.84, 95% CI: 0.72–0.97, p =.03), but not with sleep duration. However, the association was not significant in sensitivity analyses that reversed the model. Conclusions: Satisfaction with MA may be associated with better sleep quality in older adults. Clinical Implications: Evaluating and enhancing satisfaction with MA may help identify older adults at risk of poor sleep quality, indicating that MA may be useful in supporting sleep.

DOI： 10.1080/07317115.2025.2597956

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