研究者詳細 - 大石　充

論文 - 大石　充

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Tezuka A, Kubozono T, Kawabata T, Kawasoe S, Ojima S, Yamaguchi S, Akasaki Y, Higuchi K, Kuwahata S, Takenaka T, Nishi K, Nakamura M, Okui T, Ohishi M. . Association between toothbrushing habits and hypertension in the general population . Sci Rep. 15 ( 1 ) 35333 2025年10月査読

Ninomiya Y., Enokizono K., Kawasoe S., Kubozono T., Kamada H., Iriki Y., Ikeda Y., Miyahara H., Tokushige K., Ohishi M. . QT prolongation and excessive variability predicts new-onset atrial fibrillation in the health screening data of Japanese adults . Plos One20 ( 10 October ) e0333169 2025年10月

記述言語：日本語出版者・発行元：Plos One

Background A prolonged QT interval (QTc) is associated with the development of atrial fibrillation. However, reports linking QTc variability and atrial fibrillation are limited. Purpose To investigate the relationship linking prolongation and variability of QTc with new-onset atrial fibrillation in Japanese adults. Methods This retrospective study analyzed the annual health screening data of 103,304 adults (50,438 males; mean age, 54 years) who did not exhibit atrial fibrillation at baseline between April 2005 and October 2018. The majority of the study population underwent annual health examinations according to Japan’s health welfare policy. We calculated QTc times using the Bazett formula (QTc = QT/√RR). QTc variability is indicated by the gap between the maximum and minimum QTc values. Atrial fibrillation was diagnosed by 12-lead surface electrocardiography. The association between QT prolongation and variability in new-onset atrial fibrillation was ascertained by logistic regression analysis. The strength of the association was further analyzed using multivariable analyses adjusted for sex, age, dyslipidemia, diabetes, hypertension, obesity, estimated glomerular filtration rate, and alcohol consumption. Results During the follow-up (median six years), we recorded 341 (0.3%) new atrial fibrillation cases. Univariable analysis showed a significant association between QTc prolongation and variability with new-onset atrial fibrillation (odds ratio [OR] per 10 ms, 1.08 and 1.15; 95% confidence interval [CI], 1.03–1.13 and 1.07–1.23, respectively; P<0.001). Multivariable analysis suggested increased risk of new-onset atrial fibrillation with QTc prolongation and QT variability (OR per 10 ms, 1.09 and 1.16; 95% CI, 1.04–1.14 and 1.09–1.24, respectively; P<0.001). Conclusion In the general Japanese population, QTc prolongation and large QT variability are risk factors for new-onset atrial fibrillation. QT prolongation and large QT variability during sinus rhythm may be good markers for predicting not only ventricular but also atrial arrhythmias such as atrial fibrillation.

DOI： 10.1371/journal.pone.0333169

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Beppu Risa, Kubota Kayoko, Iwatani Noriko, Miyanaga Sunao, Kirishima Mari, Tanimoto Akihide, Ohishi Mitsuru . Pulmonary tumor thrombotic microangiopathy associated with endometrial carcinoma: A case report(タイトル和訳中) . Journal of Cardiology Cases32 ( 4 ) 160 - 162 2025年10月

Beppu R., Kubota K., Iwatani N., Miyanaga S., Kirishima M., Tanimoto A., Ohishi M. . Pulmonary tumor thrombotic microangiopathy associated with endometrial carcinoma: A case report . Journal of Cardiology Cases32 ( 4 ) 160 - 162 2025年10月

記述言語：日本語出版者・発行元：Journal of Cardiology Cases

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive fatal cancer-related complication. Diagnosing PTTM is challenging, with most cases diagnosed postmortem. Gastric, breast, and lung cancers are the most common primary tumors associated with PTTM. To the best of our knowledge, this is the first case report of PTTM arising from an endometrial carcinoma. A patient with advanced respiratory failure and pulmonary hypertension was diagnosed with endometrial carcinoma. This case highlights the importance of suspecting PTTM in patients with pulmonary hypertension accompanied by rapidly progressive dyspnea when pulmonary embolism has been excluded. In such cases, identifying the primary cancer is crucial for establishing an appropriate treatment plan. It also emphasizes the importance of investigating systemic cancers, extending beyond the frequently encountered cancers, even in the absence of active cancer. Learning objective: Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly fatal complication of cancer. This is the first case report of PTTM arising from an endometrial carcinoma. Clinicians should consider PTTM in patients with respiratory failure and pulmonary hypertension, even in the absence of active cancer. Early investigation for underlying malignancy and prompt pathological evaluation are essential for the rapid diagnosis of PTTM.

DOI： 10.1016/j.jccase.2025.06.013

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長野綾香, 桑波田聡, 大坪稔拓, 満留祐也, 川畑深怜, 佐田千尋, 岩谷徳子, 軸丸美香, 竹中俊宏, 大石充 . 夜間血圧がnon-dipper/riser typeを呈した神経調節性失神の2症例 . 日本老年医学会雑誌62 ( 4 ) 464 - 464 2025年10月

Ogawa S, Ishii M, Saito S, Seki H, Ikeda K, Yasui Y, Komatsu T, Sato G, Tabata N, Ohishi M, Kubozono T, Saito N, Kato ET, Song X, Yamada M, Natori S, Kunikane Y, Yokomatsu T, Kato M, Sagara Y, Uchiyama N, Atsuchi N, Kawahara S, Natsugoe S, Tsujita K . Deep Learning for Cardiac Overload Estimation- Predicting B-Type Natriuretic Peptide (BNP) Levels From Heart Sounds and Electrocardiogram . Circ J.89 ( 10 ) 1684 - 1692 2025年9月査読

Shiratsuchi D, Makizako H, Akaida S, Miyake Y, Kiyama R, Tabira T, Tateishi M, Otsuka R, Takenaka T, Kubozono T, Ohishi M . Combinations of intrinsic capacity and frailty and their associations with self-rated health in community-dwelling older adults . Aging Clin Exp Res.37 ( 1 ) 275 2025年9月査読

Ogawa Shimpei, Ishii Masanobu, Saito Shumpei, Seki Hiroshi, Ikeda Koshiro, Yasui Yuhei, Komatsu Tomohiro, Sato Ginga, Tabata Noriaki, Ohishi Mitsuru, Kubozono Takuro, Saito Naritatsu, Toda Kato Eri, Song Xiaoyang, Yamada Masahiro, Natori Shunsuke, Kunikane Yuki, Yokomatsu Takafumi, Kato Masashi, Sagara Yasuaki, Uchiyama Nami, Atsuchi Nobuhiko, Kawahara Shota, Natsugoe Shoji, Tsujita Kenichi . Deep Learning for Cardiac Overload Estimation: Predicting B-Type Natriuretic Peptide(BNP) Levels From Heart Sounds and Electrocardiogram(タイトル和訳中) . Circulation Journal89 ( 10 ) 1684 - 1692 2025年9月

Noguchi Yoshihisa, Kawasoe Shin, Miyata Masaaki, Horizoe Yoshihisa, Hamamoto Yuki, Tajima Akari, Uchiyama Yota, Kubozono Takuro, Nakamura Yukimi, Kobayashi Saori, Yunoue Shingo, Ozono Nanase, Nakashima Kaori, Higashi Fuyuki, Ohishi Mitsuru . Characteristics of Myocardial Work Indices in Patients with Aortic Valve Stenosis(タイトル和訳中) . International Heart Journal66 ( 5 ) 754 - 762 2025年9月

柴田啓佑, 寺園逸正, 小島聡子, 篠原直弘, 川添晋, 窪薗琢郎, 大石充 . アントラサイクリン投与の1年後にがん治療関連心機能障害を来した骨軟部肉腫の一例 . 日本心臓病学会学術集会抄録73回 675 - 675 2025年9月

神田大輔, 堀添善尚, 田端宏之, 内山洋太, 大牟禮健太, 下野洋和, 野元祐太朗, 伊東伸洋, 田島亜佳里, 大石充 . Buddy wireテクニックでSteerable Guide Catheterのデリバリーに成功したMitraClipの一例 . 日本心臓病学会学術集会抄録73回 393 - 393 2025年9月

伊東伸洋, 神田大輔, 横峯辰生, 野元裕太朗, 田端宏之, 下野洋和, 大牟禮健太, 窪薗琢郎, 大石充 . 石灰化結節病変に対しIntravascular lithotripsy(IVL)による処置後に薬剤溶出性ステント留置し、その後の経過が良好であった1例 . 日本心臓病学会学術集会抄録73回 713 - 713 2025年9月

Yokomine T, Enokida Y, Kajiya T, Takei T, Ninomiya T, Atsuchi N, Ohishi M . Intravascular ultrasound-detected intimal flap predicts acute diagonal branch occlusion after drug-eluting stent implantation. . The Journal of invasive cardiology 2025年8月

Kanda D., Horizoe Y., Tabata H., Uchiyama Y., Ohishi M. . Crossover Buddy Wire–Assisted Delivery of Steerable Guide Catheter . Jacc Case Reports30 ( 22 ) 104570 2025年8月

記述言語：日本語出版者・発行元：Jacc Case Reports

Background: Transfemoral venous access is the standard for MitraClip procedures, but anatomic variations can hinder device delivery. Case Summary: An 88-year-old man with severe mitral regurgitation underwent MitraClip therapy via the right femoral vein. During the procedure, compression by a calcified right iliac artery caused severe tortuosity of the iliac vein, preventing the advancement of the steerable guide catheter. A buddy wire was introduced through a left femoral crossover approach using a Radifocus guidewire into the right iliac vein, allowing successful catheter advancement and device deployment. Discussion: This case highlights the importance of adaptive strategies to overcome anatomic challenges. The buddy wire technique allows for more controlled catheter manipulation and may have reduced the risk of venous injury. Take-Home Message: The crossover buddy wire technique may be a useful bailout strategy with only minimal additional equipment to facilitate steerable guide catheter delivery in cases of venous compression.

DOI： 10.1016/j.jaccas.2025.104570

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PubMed

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