Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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光吉こころ, 宮永直, 窪田佳代子, 大石充 . 病理解剖にて特発性多中心性キャッスルマン病と診断した重症肺高血圧症の一例 . 日本心臓病学会学術集会抄録72回 C - 2 2024.9

神田大輔, 大牟禮健太, 下野洋和, 田端宏之, 伊東伸洋, 大石充 . Orbital Atherectomyとロータブレーターを使用しコンビネーション治療を行った高度石灰化LMT病変 . 日本心臓病学会学術集会抄録72回 P - 1 2024.9

伊東伸洋, 神田大輔, 大牟禮健太, 下野洋和, 田端宏之, 大石充 . 生体腎移植後で免疫抑制剤内服下の高出血リスクST上昇型心筋梗塞患者にperfusion balloonでstentless治療した一例 . 日本心臓病学会学術集会抄録72回 P - 7 2024.9

Kario Kazuomi, Ohbayashi Hiroyuki, Hashimoto Masami, Itabashi Naoki, Kato Mitsutoshi, Uchiyama Kazuaki, Hirano Kunio, Nakamura Noriko, Miyamoto Takahide, Nagashima Hirotaka, Kajiyama Shizuo, Ishida Hidenori, Imai Enyu, Ebe Yusuke, Ohishi Mitsuru, Katsuya Tomohiro, Taguchi Takashi, Tanabe Ayumi, Shimosawa Tatsuo . コントロール不良の高血圧に対する非ステロイド性ミネラルコルチコイド受容体拮抗薬エサキセレノンとトリクロルメチアジドの家庭血圧低下効果の比較 EXCITE-HT無作為化比較試験(Home blood pressure-lowering effect of a non-steroidal mineralocorticoid receptor blocker, esaxerenone, versus trichlormethiazide for uncontrolled hypertension: the EXCITE-HT randomized controlled study) . Hypertension Research47 ( 9 ) 2435 - 2446 2024.9

Language：English Publisher：Nature Publishing Group

アンジオテンシンII受容体拮抗薬またはカルシウム拮抗薬で降圧不十分な日本人本態性高血圧患者のセカンドライン治療としてのエサキセレノンとトリクロルメチアジドの有効性および安全性を評価するため、12週間の多施設共同無作為化オープンラベル並行群間比較試験(EXCITE-HT試験)を行った。Full analysis setはエサキセレノン群295例(平均65.2±11.5歳)、トリクロルメチアジド群290例(平均64.7±12.1歳)であった。治療終了時における早朝家庭血圧の変化量の最小二乗平均の群間差は収縮期血圧で-2.2mmHg(95%CI -3.6～-0.8mmHg)、拡張期血圧で-0.6mmHg(-1.4～0.2mmHg)であり、両側95%信頼区間の上限がそれぞれ3.9mmHg、2.1mmHgより小さかったことから、エサキセレノンのトリクロルメチアジドに対する非劣性が示された。安全性について新たな懸念は認めなかった。

下野洋和, 神田大輔, 伊東伸洋, 田端宏之, 福元大地, 大牟禮健太, 大石充 . 補助循環使用困難な高度石灰化病変の急性冠症候群症例に対してIntravascular LithotripsyによるPCIを行い救命できた1例 . 日本心臓病学会学術集会抄録72回 P - 2 2024.9

徳武大輔, 宮内栄治, 有川亮, 桶谷直也, 大石充 . 長期留置の下大静脈フィルターを血管内治療にて回収に成功した一例 . 日本心臓病学会学術集会抄録72回 C - 3 2024.9

大迫将精, 下野洋和, 伊東伸洋, 田端宏之, 福元大地, 大牟禮健太, 神田大輔, 大石充 . 鎮静薬減量がストレスとなり、たこつぼ型心筋症を発症したと考えられる1例 . 日本心臓病学会学術集会抄録72回 P - 14 2024.9

吉元一成, 大石充 . 【不整脈診療up to date】不整脈診断のための検査法　12誘導心電図での不整脈診断 . 臨牀と研究101 ( 8 ) 931 - 937 2024.8

吉元一成, 大石充 . 【不整脈診療up to date】不整脈診断のための検査法 12誘導心電図での不整脈診断 . 臨牀と研究101 ( 8 ) 931 - 937 2024.8

Kataoka T, Fukunaga K, Hiramine K, Nomoto Y, Matsumoto H, Sonoda K, Okino H, Tagata K, Kumamoto K, Kubota Y, Baba Y, Takasaki K, Nakashima H, Tanaka Y, Tokushige A, Ohishi M . Two-Year Clinical Outcomes Following SAPIEN3 20-mm Transcatheter Aortic Valve Implantation in Patients with Symptomatic Severe Aortic Stenosis-Comparison of the Smallest Size Valve against Larger Transcatheter Aortic Valve . J Transcatheter Valve Ther. 6 ( 1 ) 103 - 111 2024.7Reviewed

Kario K, Ohbayashi H, Hashimoto M, Itabashi N, Kato M, Uchiyama K, Hirano K, Nakamura N, Miyamoto T, Nagashima H, Kajiyama S, Ishida H, Imai E, Ebe Y, Ohishi M, Katsuya T, Taguchi T, Tanabe A, Shimosawa T; EXCITE-HT investigators . Home blood pressure-lowering effect of a non-steroidal mineralocorticoid receptor blocker, esaxerenone, versus trichlormethiazide for uncontrolled hypertension: the EXCITE-HT randomized controlled study . Hypertens Res.47 ( 9 ) 2435 - 2446 2024.7Reviewed

Language：Japanese Publisher：Hypertension Research

The EXCITE-HT study aimed to evaluate the efficacy and safety of esaxerenone versus thiazide diuretics (trichlormethiazide) as second-line treatment for Japanese patients with uncontrolled essential hypertension. This was a 12-week, multicenter, randomized, open-label, parallel-group study. The non-inferiority of esaxerenone to trichlormethiazide was confirmed if the upper limit of the two-sided 95% confidence interval (CI) for the difference in systolic blood pressure (SBP)/diastolic blood pressure (DBP) change between groups was below 3.9/2.1 mmHg. A total of 295 and 290 patients were included in the esaxerenone and trichlormethiazide groups, respectively. The non-inferiority of esaxerenone to trichlormethiazide was demonstrated: least squares mean change differences in morning home SBP/DBP at end of treatment (EOT) were −2.2 (95% CI, −3.6, −0.8) mmHg for SBP/−0.6 (−1.4, 0.2) mmHg for DBP. Morning home, bedtime home, and office BP significantly decreased (all p < 0.001) from baseline to EOT in both groups. The urinary albumin-to-creatinine ratio and N-terminal pro-brain natriuretic peptide level decreased from baseline to Week 12 in both groups, with no notable intergroup difference. Serum potassium elevations occurred more frequently with esaxerenone, while serum potassium reductions occurred more with trichlormethiazide. Uric acid elevations were observed in both groups, but more frequently with trichlormethiazide than esaxerenone. No cases of gout occurred in this study. Reductions in estimated glomerular filtration rate were similarly observed in both groups. EXCITE-HT is the first randomized controlled study to demonstrate evidence that esaxerenone is non-inferior to trichlormethiazide as second-line treatment for Japanese patients with uncontrolled essential hypertension, with no new safety concerns. (Figure presented.).

DOI： 10.1038/s41440-024-01762-z

Scopus

PubMed

Kiuchi Y, Makizako H, Kimura M, Nakai Y, Taniguchi Y, Akaida S, Tateishi M, Kubozono T, Takenaka T, Shimada H, Ohishi M . Association of combined low physical activity and low dietary diversity with mild cognitive impairment among community-dwelling Japanese older adults . Ann Geriatr Med Res. 2024.7Reviewed

吉野聡史, 伊東伸洋, 野崎圭吾, 兒玉世利汝, 神田大輔, 大石充 . OASによるdebulking後にVIPERWIREが抜去困難となり断裂しbailout困難となった一例 . 日本心血管インターベンション治療学会抄録集32回 MP38 - 9 2024.7

Masatoyo Nakajo, Daisuke Hirahara, Megumi Jinguji, Satoko Ojima, Mitsuho Hirahara, Atsushi Tani, Koji Takumi, Kiyohisa Kamimura, Mitsuru Ohishi, Takashi Yoshiura . Machine learning approach using <sup>18</sup>F-FDG-PET-radiomic features and the visibility of right ventricle <sup>18</sup>F-FDG uptake for predicting clinical events in patients with cardiac sarcoidosis . Japanese Journal of Radiology42 ( 7 ) 744 - 752 2024.7

Language：Japanese Publishing type：Research paper (scientific journal)

OBJECTIVES: To investigate the usefulness of machine learning (ML) models using pretreatment 18F-FDG-PET-based radiomic features for predicting adverse clinical events (ACEs) in patients with cardiac sarcoidosis (CS). MATERIALS AND METHODS: This retrospective study included 47 patients with CS who underwent 18F-FDG-PET/CT scan before treatment. The lesions were assigned to the training (n = 38) and testing (n = 9) cohorts. In total, 49 18F-FDG-PET-based radiomic features and the visibility of right ventricle 18F-FDG uptake were used to predict ACEs using seven different ML algorithms (namely, decision tree, random forest [RF], neural network, k-nearest neighbors, Naïve Bayes, logistic regression, and support vector machine [SVM]) with tenfold cross-validation and the synthetic minority over-sampling technique. The ML models were constructed using the top four features ranked by the decrease in Gini impurity. The AUCs and accuracies were used to compare predictive performances. RESULTS: Patients who developed ACEs presented with a significantly higher surface area and gray level run length matrix run length non-uniformity (GLRLM_RLNU), and lower neighborhood gray-tone difference matrix_coarseness and sphericity than those without ACEs (each, p < 0.05). In the training cohort, all seven ML algorithms had a good classification performance with AUC values of > 0.80 (range: 0.841-0.944). In the testing cohort, the RF algorithm had the highest AUC and accuracy (88.9% [8/9]) with a similar classification performance between training and testing cohorts (AUC: 0.945 vs 0.889). GLRLM_RLNU was the most important feature of the modeling process of this RF algorithm. CONCLUSION: ML analyses using 18F-FDG-PET-based radiomic features may be useful for predicting ACEs in patients with CS.

DOI： 10.1007/s11604-024-01546-y

Scopus

PubMed

Miyauchi Eiji, Arikawa Ryo, Oketani Naoya, Ohishi Mitsuru . 円錐枝閉塞によって生じた一過性ブルガダ型様心電図パターンを呈する患者における心室細動の一例(A Case of Ventricular Fibrillation in a Patient With a Transient Brugada-Like Electrocardiogram Pattern Caused by the Conus Branch Occlusion) . 日本心血管インターベンション治療学会抄録集32回 MO72 - 4 2024.7

Nakajo Masatoyo, Hirahara Daisuke, Jinguji Megumi, Ojima Satoko, Hirahara Mitsuho, Tani Atsushi, Takumi Koji, Kamimura Kiyohisa, Ohishi Mitsuru, Yoshiura Takashi . 心サルコイドーシス患者の臨床有害事象を予測するために、18F-FDG-PET画像から得たラジオミクス特徴量と右室内18F-FDG集積の可視化による機械学習に基づいた手法(Machine learning approach using 18F-FDG-PET-radiomic features and the visibility of right ventricle 18F-FDG uptake for predicting clinical events in patients with cardiac sarcoidosis) . Japanese Journal of Radiology42 ( 7 ) 744 - 752 2024.7

Language：English Publisher：(公社)日本医学放射線学会

心サルコイドーシス(CS)患者の臨床有害事象(ACE)の予測に、治療前18F-FDG-PET画像を用いた機械学習(ML)モデルが有用か検討した。MLモデルは7種類のMLアルゴリズムとジニ不純度の低下により最上位となった4つの特徴量を用いて構築した。治療前に18F-FDG-PET/CTが撮像されたCS患者47例(男性9例、女性38例、年齢39～81歳)を対象に、トレーニングコホート38例とテストコホート9例に分けて比較した。その結果、ACE発症患者では非発症患者に比べ、表面積とgray level run length matrix run length non-uniformityでは有意に大きかった一方、neighborhood gray-tone difference matrix_coarsenessおよび球形度は有意に小さかった。また、トレーニングコホートでは全てのMLアルゴリズムが良好な分類性能を示し、テストコホートではrandom forestアルゴリズムで、最も大きなROC曲線下面積と最も高い正確度が得られた。以上より、18F-FDG-PET画像をベースとしたラジオミクス特徴量によるML解析は、CS患者においてACEの予測に有用と判断された。

Miyauchi Eiji, Arikawa Ryo, Oketani Naoya, Ohishi Mitsuru . 生検鉗子を用いた血管内治療の奏効した急性肢虚血の一例(A Case of Acute Limb Ischemia Successfully Managed by Endovascular Therapy Using Biopsy Forceps) . 日本心血管インターベンション治療学会抄録集32回 MP23 - 4 2024.7

大迫将精, 下野洋和, 伊東伸洋, 田端宏之, 福元大地, 大牟禮健太, 神田大輔, 大石充 . 急性心筋梗塞に対するPCI後に,人工呼吸器離脱のための鎮静薬減量により引き起こされたと考えられる,たこつぼ型心筋症の1例 . 日本心血管インターベンション治療学会抄録集32回 MP35 - 4 2024.7

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Papers - OHISHI Mitsuru