Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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Miyauchi Eiji, Arikawa Ryo, Oketani Naoya, Ohishi Mitsuru . 生検鉗子を用いた血管内治療の奏効した急性肢虚血の一例(A Case of Acute Limb Ischemia Successfully Managed by Endovascular Therapy Using Biopsy Forceps) . 日本心血管インターベンション治療学会抄録集32回 MP23 - 4 2024.7

大迫将精, 下野洋和, 伊東伸洋, 田端宏之, 福元大地, 大牟禮健太, 神田大輔, 大石充 . 急性心筋梗塞に対するPCI後に,人工呼吸器離脱のための鎮静薬減量により引き起こされたと考えられる,たこつぼ型心筋症の1例 . 日本心血管インターベンション治療学会抄録集32回 MP35 - 4 2024.7

Miyauchi Eiji, Arikawa Ryo, Oketani Naoya, Ohishi Mitsuru . 円錐枝閉塞によって生じた一過性ブルガダ型様心電図パターンを呈する患者における心室細動の一例(A Case of Ventricular Fibrillation in a Patient With a Transient Brugada-Like Electrocardiogram Pattern Caused by the Conus Branch Occlusion) . 日本心血管インターベンション治療学会抄録集32回 MO72 - 4 2024.7

Sugimoto T, Araki A, Fujita H, Fujita K, Honda H, Inagaki N, Ishida T, Kato J, Kishi M, Kishino Y, Kobayashi K, Kouyama K, Kuroda Y, Kuwahata S, Matsumoto N, Murakami T, Noma H, Ogino J, Ogura M, Ohishi M, Shimada H, Sugimoto K, Takenaka T, Tamura Y, J-MIND-Diabetes study group . Multidomain Intervention Trial for Preventing Cognitive Decline among Older Adults with Type 2 Diabetes: J-MIND-Diabetes . J Prev Alzheimers Dis.11 ( 6 ) 1604 - 1614 2024.6Reviewed

Higuchi Koji, Ohishi Mitsuru . Optimal Hypertensive Treatment for Reduction in Progression and Onset in Patients with Chronic Coronary Syndrome . Journal of Coronary Artery Disease30 ( 2 ) 54 - 59 2024.6

Language：English Publisher：The Japanese Coronary Association

The importance of optimal medical therapy for chronic coronary syndrome was demonstrated in the COURAGE and ISCHEMIA trials. Hypertension is an important risk factor for atherosclerotic disease; however, it has not garnered as much attention as low-density lipoprotein cholesterol in coronary artery diseases. Blood pressure contributes significantly to the development of atherosclerosis, an underlying pathological mechanism of chronic coronary syndrome. This is due to shear stress, which causes endothelial dysfunction and angiotensin II-induced intimal smooth muscle cell proliferation. Although the renin-angiotensin system plays an important role in atherosclerosis, the strong expression of angiotensin-converting enzyme in macrophages and angiotensin II type 1 receptors in smooth muscle cells suggests that this pathway may be involved in different local pathologies. Furthermore, an imbalance between myocardial oxygen demand and supply contributes to chronic coronary syndromes. An elevated systolic blood pressure also has a significant impact on increased myocardial oxygen consumption. Therefore, adequate blood pressure reduction is important to prevent the development of chronic coronary syndrome. Percutaneous coronary intervention, which significantly contributes to the treatment of chronic coronary syndrome, requires aggressive antithrombotic therapy. Although antithrombotic therapy has significantly increased the success rate, it is also associated with an increase in the incidence of serious adverse bleeding events. A bleeding with antithrombotic therapy study conducted in Japan reported that a robust antihypertensive regimen could reduce the incidence of intracranial hemorrhaging. Percutaneous coronary intervention for chronic coronary syndrome is an elective procedure that should be performed only after adequate blood pressure reduction has been achieved.

DOI： 10.7793/jcad.30.24-00007

CiNii Research

Kamada H, Iriki Y, Yoshimoto I, Ninomiya Y, Ichiki H, Maenosono R, Miyata M, Hamamoto Y, Horizoe Y, Ikeda Y, Ohishi M . Incidence and predictors of persistent iatrogenic atrial septal defect following catheter ablation . J Cardiol.84 ( 6 ) 372 - 378 2024.6Reviewed

Shimokihara S, Tabira T, Maruta M, Makizako H, Han G, Ikeda Y, Kamasaki T, Akasaki Y, Hidaka Y, Kumura Y, Kukizaki W, Nakahara R, Matsunaga S, Medina L, Kubozono T, Ohishi M . Smartphone Proficiency in Community-Dwelling Older Adults is Associated With Higher-Level Competence and Physical Function: A Population-Based Age-Specific Cross-Sectional Study . J Appl Gerontol. 2024.6Reviewed

Kanda D, Tokushige A, Ohishi M . Association between Estimated Small Dense Low-Density Lipoprotein Cholesterol and Occurrence of New Lesions after Percutaneous Coronary Intervention in Japanese Patients with Stable Angina and Receiving Statin Therapy . Reviews in Cardiovascular Medicine.25 ( 6 ) 218 2024.6Reviewed

Shimono H, Tokushige A, Kanda D, Ohno A, Arikawa R, Chaen H, Okui H, Oketani N, Ohishi M . Clinical impact of Academic Research Consortium for High Bleeding-Risk scores on clinical outcomes in patients with stable coronary artery disease undergoing percutaneous coronary intervention . Heart and Vessels. 2024.6Reviewed

Kubota K., Miyanaga S., Akao M., Mitsuyoshi K., Iwatani N., Higo K., Ohishi M. . Association of delayed diagnosis of pulmonary arterial hypertension with its prognosis . Journal of Cardiology83 ( 6 ) 365 - 370 2024.6

Language：Japanese Publisher：Journal of Cardiology

Background: Currently, pulmonary hypertension-targeted therapy has been shown to improve the survival of patients with pulmonary artery hypertension (PAH). However, the importance of early diagnosis has not been investigated. Therefore, this study aimed to investigate whether a delayed diagnosis of PAH is associated with its prognosis. Methods and results: A total of 66 consecutive untreated patients were diagnosed with PAH from January 2008 to December 2021 at the Kagoshima University Hospital. The time from symptom onset to diagnosis correlated with brain natriuretic peptide levels (p < 0.001), right ventricle (RV) Tei index (p < 0.001), and the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio (p = 0.003). These findings suggest that in patients with PAH, RV function declines with increasing time from symptom onset to diagnosis. Furthermore, older patients with PAH appeared to have a longer time from symptom onset to diagnosis. Next, patients were divided into delayed diagnosis (>3 months) and early diagnosis (≤3 months) groups based on the time from symptom onset to diagnosis. Patients were categorized into three groups according to the European Society of Cardiology (or the European Respiratory Society) risk stratification guidelines. Patients diagnosed with PAH within 3 months of symptom onset were significantly in the low- or intermediate-risk groups (p < 0.001). A Kaplan-Meier analysis revealed that the cumulative event-free rate was significantly lower (p < 0.01) in the delayed diagnosis group than in the early diagnosis group. A delayed diagnosis was significantly associated with a worse outcome than an early diagnosis, after adjusting for different sets of confounding factors. Conclusions: A delayed PAH diagnosis is associated with a poor prognosis. Early diagnosis of PAH may lead to a low-risk treatment. Furthermore, older patients need more careful screening for PAH.

DOI： 10.1016/j.jjcc.2023.08.004

Scopus

PubMed

Okamura Tomonori, Tsukamoto Kazuhisa, Arai Hidenori, Fujioka Yoshio, Ishigaki Yasushi, Koba Shinji, Ohmura Hirotoshi, Shoji Tetsuo, Yokote Koutaro, Yoshida Hiroshi, Yoshida Masayuki, Deguchi Juno, Dobashi Kazushige, Fujiyoshi Akira, Hamaguchi Hirotoshi, Hara Masumi, Harada-Shiba Mariko, Hirata Takumi, Iida Mami, Ikeda Yoshiyuki, Ishibashi Shun, Kanda Hideyuki, Kihara Shinji, Kitagawa Kazuo, Kodama Satoru, Koseki Masahiro, Maezawa Yoshiro, Masuda Daisaku, Miida Takashi, Miyamoto Yoshihiro, Nishimura Rimei, Node Koichi, Noguchi Midori, Ohishi Mitsuru, Saito Isao, Sawada Shojiro, Sone Hirohito, Takemoto Minoru, Wakatsuki Akihiko, Yanai Hidekatsu, Fujihara Kazuya, Hasegawa Koji, Hiraishi Chika, Honda Takanori, Horiuchi Hisanori, Katsuyama Hisayuki, Kuwabara Akiko, Matsui Sadako, Matsuki Kota, Mianamino Tetsuo, Morishita Eriko, Nakao Yoko M., Natsuaki Masahiro, Nishikido Toshiyuki, Ohtake Akira, Okazaki Hiroaki, Sugiyama Daisuke, Tada Hayato, Taketani Yutaka, Tamori Yoshikazu, Tanaka Atsushi, Yamamoto Yukiyo, Yamashita Shizuya, Yamato Hiroshi, Yoshizumi Toru, Ando Koichi, Chiba Hiraku, Doi Takahito, Emori Hiroki, Fukushima Yoshifumi, Hayashi Aiko, Higashiyama Aya, Hirata Aya, Hirayama Satoshi, Inagaki Kyoko, Ishikawa Takahiro, Iso-o Naoyuki, Kanno Kotaro, Kataoka Yu, Kinoshita Daisuke, Kinuta Minako, Kohmo Kyoko, Koshizaka Masaya, Kubota Yoshimi, Makino Hisashi, Maruyama Koutatsu, Matsubara Masaki, Nakagawa-Tsutsui Wao, Nakai Yasuo, Nakamoto Mariko, Narumi-Hyakutake Aiko, Nishikawa Tetsuo, Nomura Akihiro, Oda Tomoyasu, Ogura Masatsune, Oohira Hideo, Ohminami Hirokazu, Okada Takeshi, Okada Hirofumi, Okajima Fumitaka, Okamoto Rie, Okazaki Sachiko, Omote Shizuko, Saiki Atsuhito, Sakamoto Kaori, Sata Mizuki, Sato Kayoko, Shiratori Yoshitaka, Shoji Mayumi, Suganuma Yuka, Suzuki Daisuke, Suzuki Harumitsu, Suzuki Nobuaki, Takahashi Hiroshi, Takahashi Yutaro, Takanashi Mikio, Takase Satoru, Takebe Noriko, Tamura Yukinori, Tanaka Kaki, Tanaka Katsunao, Tanaka Sarasa, Tanaka Yoshihiro, Terada Kousei, Teramoto Naoya, Tsukagoshi-Yamaguchi Ayano, Wakasa Hana, Yako Rie, Yamada Eri, Yamamoto Masashi, Yashiro Satoshi, Yokota Yuya, Yoshimura Yukihiro, Yan Zhang, Akishita Masahiro, Ako Junya, Bujo Hideaki, Emoto Masanori, Goto Shinya, Hanada Hiroyuki, Hosomi Naohisa, Hozawa Atsushi, Ikewaki Katsunori, Ishida Tatsurou, Kajinami Kouji, Kameyama Noriko, Kikuchi Toru, Kozaki Koichi, Kuwabara Kazuyo, Masuzaki Hiroaki, Matoba Tetsuya, Matoba Yuka, Miyata Masaaki, Ninomiya Toshiharu, Ogura Masatsune, Ohtsuki Toshiho, Ohya Yusuke, Okuda Nagako, Saitoh Shigeyuki, Shimano Hitoshi, Tomiyama Hirofumi, Toyoda Kazunori, Tsushita Kazuyo, Ueda Yukihiko, Umemoto Seiji, Yahagi Naoya, Yamagishi Kazumasa, Yamashita Tomoya, Daida Hiroyuki, Kinoshita Makoto, Yokode Masayuki, Japan Atherosclerosis Society . 日本動脈硬化学会(JAS)　動脈硬化性疾患予防ガイドライン2022年版(Japan Atherosclerosis Society(JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022) . Journal of Atherosclerosis and Thrombosis31 ( 6 ) 641 - 853 2024.6

Kawasoe Shin, Kubozono Takuro, Salim Anwar Ahmed, Ojima Satoko, Yamaguchi Satoshi, Ikeda Yoshiyuki, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 血清尿酸値と腎機能低下の有病率におけるJ字型の関連　日本の健康診断データを用いた横断研究(J-shaped Association between Serum Uric Acid Levels and the Prevalence of a Reduced Kidney Function: A Cross-sectional Study Using Japanese Health Examination Data) . Internal Medicine63 ( 11 ) 1539 - 1548 2024.6

Language：English Publisher：(一社)日本内科学会

日本の健康診断データセットを用いて、血清尿酸(SUA)値と腎機能低下の関連を多変量ロジスティック回帰分析で検討した。2001年から2018年までに健診を受けた227,672例(男性46.1%)を対象に、SUA値で5群に分類し、第2群を基準とした。尿酸値には性差があるため、分析はすべて男女別に行った。男性は平均年齢55.9歳、平均SUA値5.9mgdL、平均eGFR値80.0mL/min/1.73m2、女性は平均年齢57.3歳、平均SUA値4.5mgdL、平均eGFR値81.2mL/min/1.73m2で、男女とも9.4%が腎機能低下(eGFR値60.0mL/min/1.73m2)を有していた。多変量解析において、男女ともに、SUA値が高い第3～5群だけでなく、第1群においても腎機能低下の有病率は有意に高かった。以上より、男女ともSUA値と腎機能低下の有病率はJ字型の関連を示し、高尿酸血症だけではなく低尿酸血症も腎機能低下のリスクと関連することが示唆された。

Kubota Kayoko, Miyanaga Sunao, Akao Mitsumasa, Mitsuyoshi Kokoro, Iwatani Noriko, Higo Kenjuro, Ohishi Mitsuru . 肺動脈性肺高血圧症の診断遅延と予後との関連(Association of delayed diagnosis of pulmonary arterial hypertension with its prognosis) . Journal of Cardiology83 ( 5-6 ) 365 - 370 2024.6

Language：English Publisher：(一社)日本心臓病学会

肺動脈性肺高血圧症(PAH)の診断遅延が予後と関連するかについて検討するため、2008年1月～2021年12月に当院でPAHと診断された未治療患者を後ろ向きに調べた。患者をリスク層別化基準に従って低、中、高リスクの3群に分類した。全患者は診断後に至適薬物治療を受けた。追跡期間中の全死因死亡とPAHによる再入院を評価した。患者66例(平均54±15歳、女性87.9%)を解析した。症状発症から診断までの時間は、脳ナトリウム利尿ペプチド値(p<0.001)、右室Tei index(p<0.001)、三尖弁輪の収縮期変動/収縮期肺動脈圧比(p=0.003)と相関し、症状発症から診断までの時間の増加に伴い右室機能が低下することが示唆された。症状発症から診断までの時間と年齢にも弱い相関が認められた。症状発症から診断までの時間が3ヵ月超であった患者(診断遅延群)と3ヵ月以下であった患者(早期診断群)では、リスク層別化に有意差がみられ(p<0.001)、高リスク群は診断遅延群の12%、早期診断群の34%であった。カプランマイヤー解析で、診断遅延群の累積無イベント率は早期診断群より有意に低かった(p<0.01)。交絡因子調整後、診断遅延は予後不良と有意に関連した。以上より、PAHの診断遅延は予後不良につながり、特に高齢患者ではより慎重なPAHのスクリーニングが必要と考えられた。

Okamura Tomonori, Tsukamoto Kazuhisa, Arai Hidenori, Fujioka Yoshio, Ishigaki Yasushi, Koba Shinji, Ohmura Hirotoshi, Shoji Tetsuo, Yokote Koutaro, Yoshida Hiroshi, Yoshida Masayuki, Deguchi Juno, Dobashi Kazushige, Fujiyoshi Akira, Hamaguchi Hirotoshi, Hara Masumi, Harada-Shiba Mariko, Hirata Takumi, Iida Mami, Ikeda Yoshiyuki, Ishibashi Shun, Kanda Hideyuki, Kihara Shinji, Kitagawa Kazuo, Kodama Satoru, Koseki Masahiro, Maezawa Yoshiro, Masuda Daisaku, Miida Takashi, Miyamoto Yoshihiro, Nishimura Rimei, Node Koichi, Noguchi Midori, Ohishi Mitsuru, Saito Isao, Sawada Shojiro, Sone Hirohito, Takemoto Minoru, Wakatsuki Akihiko, Yanai Hidekatsu, Fujihara Kazuya, Hasegawa Koji, Hiraishi Chika, Honda Takanori, Horiuchi Hisanori, Katsuyama Hisayuki, Kuwabara Akiko, Matsui Sadako, Matsuki Kota, Mianamino Tetsuo, Morishita Eriko, Nakao Yoko M., Natsuaki Masahiro, Nishikido Toshiyuki, Ohtake Akira, Okazaki Hiroaki, Sugiyama Daisuke, Tada Hayato, Taketani Yutaka, Tamori Yoshikazu, Tanaka Atsushi, Yamamoto Yukiyo, Yamashita Shizuya, Yamato Hiroshi, Yoshizumi Toru, Ando Koichi, Chiba Hiraku, Doi Takahito, Emori Hiroki, Fukushima Yoshifumi, Hayashi Aiko, Higashiyama Aya, Hirata Aya, Hirayama Satoshi, Inagaki Kyoko, Ishikawa Takahiro, Iso-o Naoyuki, Kanno Kotaro, Kataoka Yu, Kinoshita Daisuke, Kinuta Minako, Kohmo Kyoko, Koshizaka Masaya, Kubota Yoshimi, Makino Hisashi, Maruyama Koutatsu, Matsubara Masaki, Nakagawa-Tsutsui Wao, Nakai Yasuo, Nakamoto Mariko, Narumi-Hyakutake Aiko, Nishikawa Tetsuo, Nomura Akihiro, Oda Tomoyasu, Ogura Masatsune, Oohira Hideo, Ohminami Hirokazu, Okada Takeshi, Okada Hirofumi, Okajima Fumitaka, Okamoto Rie, Okazaki Sachiko, Omote Shizuko, Saiki Atsuhito, Sakamoto Kaori, Sata Mizuki, Sato Kayoko, Shiratori Yoshitaka, Shoji Mayumi, Suganuma Yuka, Suzuki Daisuke, Suzuki Harumitsu, Suzuki Nobuaki, Takahashi Hiroshi, Takahashi Yutaro, Takanashi Mikio, Takase Satoru, Takebe Noriko, Tamura Yukinori, Tanaka Kaki, Tanaka Katsunao, Tanaka Sarasa, Tanaka Yoshihiro, Terada Kousei, Teramoto Naoya, Tsukagoshi-Yamaguchi Ayano, Wakasa Hana, Yako Rie, Yamada Eri, Yamamoto Masashi, Yashiro Satoshi, Yokota Yuya, Yoshimura Yukihiro, Yan Zhang, Akishita Masahiro, Ako Junya, Bujo Hideaki, Emoto Masanori, Goto Shinya, Hanada Hiroyuki, Hosomi Naohisa, Hozawa Atsushi, Ikewaki Katsunori, Ishida Tatsurou, Kajinami Kouji, Kameyama Noriko, Kikuchi Toru, Kozaki Koichi, Kuwabara Kazuyo, Masuzaki Hiroaki, Matoba Tetsuya, Matoba Yuka, Miyata Masaaki, Ninomiya Toshiharu, Ogura Masatsune, Ohtsuki Toshiho, Ohya Yusuke, Okuda Nagako, Saitoh Shigeyuki, Shimano Hitoshi, Tomiyama Hirofumi, Toyoda Kazunori, Tsushita Kazuyo, Ueda Yukihiko, Umemoto Seiji, Yahagi Naoya, Yamagishi Kazumasa, Yamashita Tomoya, Daida Hiroyuki, Kinoshita Makoto, Yokode Masayuki, Japan Atherosclerosis Society . 日本動脈硬化学会(JAS) 動脈硬化性疾患予防ガイドライン2022年版(Japan Atherosclerosis Society(JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022) . Journal of Atherosclerosis and Thrombosis31 ( 6 ) 641 - 853 2024.6

Language：English Publisher：(一社)日本心臓病学会

Kawasoe Shin, Kubozono Takuro, Salim Anwar Ahmed, Ojima Satoko, Yamaguchi Satoshi, Ikeda Yoshiyuki, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 血清尿酸値と腎機能低下の有病率におけるJ字型の関連日本の健康診断データを用いた横断研究(J-shaped Association between Serum Uric Acid Levels and the Prevalence of a Reduced Kidney Function: A Cross-sectional Study Using Japanese Health Examination Data) . Internal Medicine63 ( 11 ) 1539 - 1548 2024.6

Language：English Publisher：(一社)日本内科学会

Imamura S, Miyata M, Ogawa M, Oketani N, Hamasaki S, Hirahara N, Ninomiya Y, Ohishi M . Effect of Oral Care on Endothelial Dysfunction in Patients with Acute Coronary Syndrome . International Heart Journal.65 ( 3 ) 386 - 394 2024.5Reviewed

Ninomiya Yuichi, Kawasoe Shin, Kubozono Takuro, Tokushige Akihiro, Ichiki Hitoshi, Salim Anwar Ahmed, Ikeda Yoshiyuki, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 【アジアにおける高血圧治療に関する現在のエビデンスと展望】禁煙後の体重増加と将来の高血圧発症の関連(【Current evidence and perspectives for hypertension management in Asia】Association between weight gain following smoking cessation and development of hypertension in the future) . Hypertension Research47 ( 5 ) 1167 - 1174 2024.5

Language：English Publisher：Nature Publishing Group

禁煙後の体重増加が高血圧発症に与える影響について検討した。定期健診者から禁煙者856名を抽出し、禁煙1年後の体重増加量により中央値1.8kg未満の軽度増加(L)群と中央値以上の高度増加(H)群に分け、禁煙6年後の体重および血圧の変化を比較した。ベースライン時の体重は群間で差がなかったが、禁煙6年後はH群で高値を示した(P<0.01)。H群はL群に比べて禁煙6年後のベースラインからの血圧上昇が大きかった(P<0.001)。降圧薬処方率と高血圧の頻度には差がなかった。重回帰分析の結果、高度体重増加は禁煙後の血圧変化の影響因子であった。禁煙者は、背景因子を一致させた喫煙継続者(854名)と比較して、ベースラインから6年後までの体重増加と血圧上昇が大きかった(各P<0.001)。以上より、禁煙後の体重増加は血圧上昇につながる可能性があり、禁煙希望者に対する減量指導の有用性が示唆された。

Salim Anwar Ahmed, Kawasoe Shin, Kubozono Takuro, Ojima Satoko, Kawabata Takeko, Ikeda Yoshiyuki, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 【アジアにおける高血圧治療に関する現在のエビデンスと展望】血清尿酸値と各種高血圧基準値に基づく高血圧症のリスクとの関連の性差(【Current evidence and perspectives for hypertension management in Asia】Sex-specific associations between serum uric acid levels and risk of hypertension for different diagnostic reference values of high blood pressure) . Hypertension Research47 ( 5 ) 1120 - 1132 2024.5

Language：English Publisher：Nature Publishing Group

血清尿酸値(UA)と高血圧発症の関連について、2種類の血圧基準を用いて検討した。対象は健診時血圧が140/90未満の21443名(男性39.8%、集団1)と130/80未満の15245名(同36.5%、集団2)である。5年後の高血圧症有病率(各基準値を超過した者の割合)は、集団1で男性16.3%、女性10.9%、集団2で男性29.7%、女性21.4%であった。多変量解析の結果、全体として、UA(四分位)および高尿酸血症(有無)は5年後の高血圧症と有意に関連した。性別では、UAは男性でのみ高血圧症と関連し、第4四分位群におけるオッズ比は集団1で1.36、集団2で1.31であった(各P<0.01)。高尿酸血症と高血圧症の有意な関連は、集団1では男性(オッズ比1.23、P=0.02)、集団2では女性(1.57、P<0.01)でのみ維持された。UAと高血圧発症の関連には性差があると考えられた。

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Papers - OHISHI Mitsuru