Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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志岐健三郎, 下舞浩二, 大場一郎, 大石充 . 低ナトリウム血症の治療に漢方治療が有用であった高度大動脈弁狭窄症の高齢者の1例 . 日本老年医学会雑誌55 ( 4 ) 724 - 724 2018.10

米澤英之, 桑波田聡, 新地秀也, 川島吉博, 毛利翔悟, 安部智, 竹中俊宏, 大石充 . 致死性不整脈の原因として抗認知症薬の関与が疑われた超高齢者の2例 . 日本老年医学会雑誌55 ( 4 ) 725 - 725 2018.10

荒木厚, 横手幸太郎, 井藤英喜, 楽木宏実, 山本浩一, 荒井秀典, 大石充, 小林一貴, 櫻井孝, 田村嘉章, 林登志雄, 石川崇広, 小川純人, 加藤尚也, 杉本研, 千葉優子, 矢加部満高, 小川渉, 津下一代, 岡本芳久, 高本偉碩, 石井好二郎, 日本老年医学会「高齢者の生活習慣病管理ガイドライン」作成ワーキング . 高齢者肥満症診療ガイドライン2018 . 日本老年医学会雑誌55 ( 4 ) 464 - 538 2018.10

赤崎雄一, 大石充 . 【血圧変動と臓器合併症】血圧変動と臓器合併症のUpDate . 血圧25 ( 10 ) 682 - 685 2018.10

Language：Japanese Publisher：(株)先端医学社

コホート研究、ランダム化比較試験のサブ解析、システマティックレビューおよびメタ解析の結果から、受診間血圧変動(VVV)は、心血管疾患イベントのリスクとなり、死亡率に相関する。またVVVは、血管硬化度および血管抵抗に相関し、また脳萎縮や認知機能低下に関係する。VVV以外でも、日間血圧変動は心血管疾患のみならず、認知機能低下にも関連し、24時間血圧変動は、心血管病のリスクであり、認知機能低下や呼吸機能とも関係していた。動物実験でも、血圧変動と臓器障害について、その機序が報告されている。今後も、様々な血圧変動と臓器障害の機序が解明されることによって、臓器障害の進展抑制につながる研究が期待される。(著者抄録)

中村幸美, 水上尚子, 大園七瀬, 湯之上真吾, 前之園隆一, 野口慶久, 堀添善尚, 湯浅敏典, 林完勇, 瀬之口輝寿, 大石充, 橋口照人 . Aneurysmal typeの腎動静脈瘤の2症例 . 脈管学58 ( Suppl. ) S237 - S237 2018.9

肥後建樹郎, 窪田佳代子, 宮永直, 岩谷徳子, 大石充 . PGI2製剤の切り替えが有効であったPAHの一症例 . 日本心臓病学会学術集会抄録66回 EP - 216 2018.9

田端宏之, 吉野聡史, 安崎和博, 大牟禮健太, 内門義博, 福元大地, 沖野秀人, 大石充 . PCI中にステントバルーン拡張不良に陥りbail outし得た2症例 . 日本心臓病学会学術集会抄録66回 EP - 163 2018.9

安崎和博, 大牟禮健太, 沖野秀人, 田端宏之, 福元大地, 吉野聡史, 大石充 . BiolimusA9 coated stent留置の際、カテーテルシャフト断裂をきたし、回収し得た一例 . 日本心臓病学会学術集会抄録66回 EP - 068 2018.9

肥後建樹郎, 窪田佳代子, 宮永直, 岩谷徳子, 大石充 . PGI2製剤の切り替えが有効であったPAHの一症例 . 日本心臓病学会学術集会抄録66回 EP - 216 2018.9

Kobayashi Saori, Mizukami Naoko, Ozono Nanase, Yunoue Shingo, Maenosono Ryuichi, Horizoe Yoshihisa, Chaen Hideto, Takasaki Kunitugu, Yuasa Toshinori, Kisanuki Akira, Ohishi Mitsuru . Analysis of the Influence by Visualized Direction on the Right Ventricular Outflow Doppler Waveform in Patients with Pulmonary Hypertension . Japanese Journal of Medical Ultrasound Technology43 ( 4 ) 440 - 449 2018.8

Language：Japanese Publisher：Japanese Society of Sonographers

Background: In evaluating pulmonary hypertension by echocardiography, the biphasic waveform and shortening of acceleration time of the right ventricular outflow tract Doppler flow (RVOF) are frequently seen in accordance with increasing of pulmonary artery pressure. In addition, it has been reported that the biphasic waveform of RVOF relates to the highly elevated pulmonary vascular resistance (PVR). Therefore, it is important to analyze the RVOF waveform in evaluation of pulmonary hypertension. However, the RVOF waveform often varies, depending on the visualized direction. The purpose of this study was to analyze the influence by the visualized direction on the RVOF Doppler waveform in patients with pulmonary hypertension.Subjects and Methods: Sixty-nine consecutive patients (12 males, 57 females, average age 59±15 years) who underwent echocardiographic examination for evaluation of pulmonary hypertension were in the study. RVOF was acquired by the pulsed wave Doppler method from three directions: the aortic valve short-axis view, the right ventricular outflow tract view, and the epigastrium view. In 40 patients who underwent right heart catheterization (RHC), the RVOF was compared with the PVR calculated by the RHC.Results and Discussion: Impossible evaluation rate of RVOF and was significantly high for the epigastric view (p＜0.01). The detection rate of the biphasic waveform reflecting the increasing PVR was significantly low for the epigastric view (p＜0.05). In patients with the biphasic waveform of the RVOF from all directions except the epigastric view, PVR significantly increased compared to the patients without the biphasic waveform of the RVOF (p＜0.05). Therefore, it was difficult to estimate the increasing of PVR by the RVOF from the epigastric view. On the other hand, the velocity time integral (VTI) of the RVOF reflecting the flow volume from all three directions correlated with the PVR calculated by the RHC (aortic valve short-axis view r＝－0.47, right ventricular outflow tract view r＝－0.52, epigastric view r＝－0.56). Therefore, independent of the visualized direction, the VTI of the RVOF was considered to be useful for an index to reflect PVR.Conclusion: In RVOF from the epigastric view, the VTI reflecting the flow volume was shown to have a good correlation with the PVR, but there was a limitation to detect the biphasic waveform reflecting the increasing PVR.

DOI： 10.11272/jss.43.440

CiNii Research

Yunoue Shingo, Mizukami Naoko, Ozono Nanase, Kobayashi Saori, Maenosono Ryuichi, Horizoe Yoshihisa, Cyaen Hideto, Takasaki Kunitsugu, Yuasa Toshinori, Kisanuki Akira, Ohishi Mitsuru . A Case of Carcinoid Syndrome Associated with Primary Ovarian Tumor Diagnosed by Echocardiography . Japanese Journal of Medical Ultrasound Technology43 ( 4 ) 464 - 470 2018.8

Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A; collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI). . Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. . Atherosclerosis275 141 - 148 2018.8Reviewed

池田義之, 大石充 . 【老年医学(下)-基礎・臨床研究の最新動向-】高齢者の生活習慣病　高血圧 . 日本臨床76 ( 増刊7 老年医学(下) ) 111 - 115 2018.8

Toshiaki Ohkuma, Toshiharu Ninomiya, Hirofumi Tomiyama, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Victor Aboyans, Akira Yamashina . Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. . Atherosclerosis275 141 - 148 2018.8Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND AND AIMS: The ankle-brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes. METHODS: We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality. RESULTS: During an average of 7.8 years of follow-up, 720 participants experienced the primary outcome. The multivariable-adjusted hazard ratios (HRs) of the primary outcome significantly increased with a lower ABI. The HRs were 1.07 (95% confidence interval [CI] 0.91-1.27) for ABI of 1.00-1.09, HR 1.37 (95% CI 1.04-1.81) for ABI of 0.91-0.99, and HR 1.60 (95% CI 1.06-2.41) for ABI of ≤0.90, compared with ABI of 1.10-1.19. Furthermore, a high ABI (≥1.30) was associated with a greater risk of outcome (HR 2.42 [95% CI 1.14-5.13]). Similar tendencies were observed for CVD events alone and all-cause mortality alone. Addition of ABI to a model with the Framingham risk score marginally improved the c-statistics (p = 0.08) and integrated discrimination improvement (p < 0.05) for the primary outcome. CONCLUSIONS: The present study suggests that lower and higher ABI are significantly associated with an increased risk of CVD and all-cause mortality in the Japanese population. The ABI, which is easily measured by oscillometry, may be incorporated into daily clinical practice to identify high-risk populations.

DOI： 10.1016/j.atherosclerosis.2018.05.048

Scopus

PubMed

田端宏之, 吉野聡史, 内門義博, 大牟禮健太, 安崎和博, 大石充 . 地域医療における心血管インターベンションのあるべき姿とは　当地域におけるPCIの現状　高次医療機関とのスムーズな連携と迅速な搬送手段により救命し得た急性冠症候群の一例 . 日本心血管インターベンション治療学会抄録集27回 SY6 - 4 2018.8

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