Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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Ojima S, Kubozono T, Kawabata T, Kawasoe S, Yamaguchi S, Enokida Y, Mukai S, Kanda D, Ohishi M . Prolonged ventricular fibrillation treated with nifekalant in fulminant myocarditis following late-onset coronavirus disease 2019 . BMJ case reports19 ( 5 ) 2026.5Reviewed

Kario K, Ohbayashi H, Ishii H, Kato M, Nozaki M, Abiru N, Fukui T, Nomura K, Fukushima Y, Itabashi N, Uchiyama K, Nishizawa M, Hata Y, Nakamura N, Kodono S, Hirano K, Katsuya T, Shimosawa T, Shiosakai K, Kato G, Taguchi T, Ohishi M, ESCORT-HT investigators . Esaxerenone versus angiotensin II receptor blockers as second-line therapy in older Japanese patients with uncontrolled hypertension on calcium channel blockers: the randomized, open-label ESCORT-HT study. . Hypertension research : official journal of the Japanese Society of Hypertension 2026.4

Araki Y, Kawasoe S, Kubozono T, Yoshimoto J, Kishi M, Suzuki S, Makizako H, Ohishi M . Habitual natto consumption is inversely associated with mild cognitive impairment and depressive symptoms in older Japanese adults: A cross-sectional study. . Nutrition research (New York, N.Y.)150 174 - 183 2026.4

Kawai Shotaro, Nishihira Kensaku, Kimura Toshiyuki, Takamatsu Makoto, Honda Yasuhiro, Yamamoto Keisuke, Kadooka Kosuke, Nishino Shun, Kudo Takeaki, Ogata Kenji, Kuriyama Nehiro, Ohishi Mitsuru, Shibata Yoshisato . Prognostic Utility of Pulmonary Arterial Elastance in Patients With ST-Segment Elevation Myocardial Infarction Classified as Killip Classes 3–4 . Circulation Reportsadvpub ( 0 ) 2026.4

Language：English Publisher：The Japanese Circulation Society

Background: Invasive hemodynamic assessment is critical in patients with ST-segment elevation myocardial infarction (STEMI) classified as Killip classes 3–4. However, the prognostic utility of pulmonary arterial elastance (PaE) remains unclear.Methods and Results: We retrospectively analyzed 145 consecutive patients with STEMI classified as Killip classes 3–4 undergoing primary percutaneous coronary intervention, all with complete pulmonary artery catheter data. PaE was calculated as systolic pulmonary artery pressure divided by stroke volume. In total, 27 patients died in hospital (18.6%), and 118 patients (81.4%) survived to discharge. Non-survivors were older, more often women, and had lower estimated glomerular filtration rate and left ventricular ejection fraction than survivors. PaE was significantly higher in non-survivors than in survivors (1.40 vs. 0.81 mmHg/mL, P<0.001). After adjusting for confounders, PaE was independently associated with in-hospital death (P<0.05). In the receiver operating characteristic curve analyses, PaE showed superior discriminative ability (area under the curve [AUC], 0.729) than pulmonary vascular resistance (AUC, 0.648) and pulmonary arterial pulsatility index (PAPI; AUC, 0.501; both, P<0.05) but was comparable to cardiac power output (AUC, 0.705; P=0.351). Furthermore, the in-hospital mortality rate increased with increasing PaE, consistently across PAPI strata.Conclusions: PaE independently predicts in-hospital death of patients with STEMI classified as Killip classes 3–4. Its robust performance across subgroups and ease of calculation support its use in early risk stratification.

DOI： 10.1253/circrep.cr-26-0053

CiNii Research

Kawasoe S, Kubozono T, Akasaki Y, Tokutake D, Shinchi S, Ojima S, Yamaguchi S, Mukai S, Miyahara H, Tokushige K, Miyata M, Ohishi M . Sex-specific trajectories of blood pressure and pulse pressure across body mass index categories: a descriptive study based on 13-year health checkup data. . Hypertension research : official journal of the Japanese Society of Hypertension 2026.3Reviewed

Shiratsuchi D, Makizako H, Tabira K, Miyake Y, Kubozono T, Ohishi M. . Association Between Sarcopenia Defined by the Asian Working Group for Sarcopenia 2025 Criteria and Cognitive Function in Middle-Aged Community-Dwelling Adults. . Geriatrics & gerontology international26 ( 3 ) e70426 2026.3Reviewed

Arima H, Itoh H, Ohkubo T, Ohya Y, Kabayama M, Kishi T, Hirawa N, Miura K, Miura SI, Yamamoto K, Yoshimura C, Rakugi H, Asayama K, Inoue T, Ohishi M, Kusaka M, Goto K, Shimosawa T, Nishiyama A, Hoshide S, Yano Y, Kaneko K, Uesugi F, Shigyo M, Suenaga E, Masujima T, Kawachi S, Okayama A, Miyakawa M, Miyamatsu N, Nakamura K, Saito I, Murakami Y, Ishida M, Kitagawa K, Ohnishi H, Okada H, Fujioka Y, Ogawa Y, Shide K, Inoue S, Japanese Society of Hypertension Committee on the Guidelines for Blood Pressure Control Using Digital Technologies . The Japanese Society of Hypertension Guidelines for blood pressure control using digital technologies. . Hypertension research : official journal of the Japanese Society of Hypertension 2026.2

Ohta M, Kaimoto K, Makizako H, Aburada S, Imamura K, Manabe H, Takenaka T, Kubozono T, Ohishi M, Kuwabara A, Kanouchi H . Association Between Serum Pyridoxal 5'-Phosphate and Frailty Risk in Community-Dwelling Older Japanese Adults . Geriatrics & gerontology international26 ( 2 ) e70412 2026.2Reviewed

大石充 . 【行動変容をもたらす患者指導】各種疾患・病態と生活習慣　高血圧 . 臨牀と研究103 ( 2 ) 164 - 166 2026.2

Ohishi Mitsuru, Kario Kazuomi, Katsuya Tomohiro, Shimosawa Tatsuo, Shiosakai Kazuhito, Furugori Taketoshi, Taguchi Takashi . Efficacy and safety of esaxerenone vs trichlormethiazide for the treatment of uncontrolled essential hypertension in Japanese patients with type 2 diabetes mellitus: a subanalysis of the EXCITE-HT study(タイトル和訳中) . Hypertension Research49 ( 2 ) 444 - 456 2026.2

大石充 . 【行動変容をもたらす患者指導】各種疾患・病態と生活習慣　高血圧 . 臨牀と研究103 ( 2 ) 164 - 166 2026.2

Kanda D., Horizoe Y., Tajima A., Tabata H., Uchiyama Y., Ohishi M. . Successful Transcatheter Mitral Valve Repair for Iatrogenic Chordal Rupture in Cardiac Amyloidosis . Jacc Case Reports31 ( 2 ) 106137 2026.1

Language：Japanese Publisher：Jacc Case Reports

Background: Cardiac amyloidosis is associated with poor prognosis. Biopsy-induced severe mitral regurgitation (MR) secondary to chordal rupture is a rare but critical complication, and its optimal management remains uncertain. Case Summary: A 78-year-old man with transthyretin cardiac amyloidosis developed acute severe MR after left ventricular myocardial biopsy, which caused rupture of the chordae tendineae. He presented with NYHA functional class IV heart failure. Given his condition, transcatheter edge-to-edge mitral valve repair (M-TEER) was prioritized. A MitraClip was successfully deployed, reducing the severe MR to mild without complications, and his symptoms markedly improved. Discussion: This is to our knowledge the first reported case of biopsy-induced MR in cardiac amyloidosis successfully managed using M-TEER. This case demonstrates the safety and efficacy of M-TEER in frail patients with iatrogenic mechanical complications. Take-Home Message: M-TEER may be a life-saving therapy for severe iatrogenic MR in patients with advanced cardiac amyloidosis.

DOI： 10.1016/j.jaccas.2025.106137

Scopus

PubMed

Kanda D, Tokushige A, Ohmure K, Shimono H, Tabata H, Ito N, Kubozono T, Ohishi M . Impact of cancer history on coronary calcification and clinical outcomes in intravascular ultrasound-guided percutaneous coronary intervention. . Coronary artery disease 2026.1

Mitsuyoshi K, Kubota K, Miyanaga S, Akao M, Ohishi M. . Association of peak expiratory flow rate with clinical outcomes in pulmonary arterial hypertension . Hypertension Research49 1509 - 1516 2026.1Reviewed

Language：Japanese Publisher：Hypertension Research

Pulmonary arterial hypertension (PAH) is a rare disease characterized by a progressive increase in pulmonary arterial pressure, leading to right heart failure. In clinical practice, reduced exercise tolerance is commonly observed in patients with PAH. Several studies have identified skeletal muscle abnormalities and muscle weakness as factors contributing to impaired exercise capacity in these patients. Recently, peak expiratory flow rate (PEFR) has been shown to correlate with skeletal muscle mass. Given that PEFR can be easily and noninvasively measured using respiratory function tests, we investigated the relationship between PEFR and prognosis in patients with PAH. We enrolled consecutive untreated patients diagnosed with PAH at Kagoshima University Hospital between July 2005 and July 2024. A total of 85 patients were included and divided into the preserved PEFR group and the reduced PEFR group. There were no significant differences in hemodynamic parameters between the two groups; however, the 6-minute walk distance was significantly shorter (p = 0.0062) in the reduced PEFR group. Kaplan–Meier analysis revealed that the cumulative event-free rate was significantly lower in the reduced PEFR group (Log-rank p = 0.0048). Reduced PEFR was independently associated with poorer outcomes after adjusting for age, plus each of right atrial pressure, cardiac index, and pulmonary vascular resistance. In conclusion, PEFR, a method for measuring skeletal muscle, was associated with poor prognosis in patients with PAH when assessed at the time of diagnosis. PEFR can be easily and repeatedly measured, making it potentially useful for prognostic prediction and exercise rehabilitation in these patients. (Figure presented.)

DOI： 10.1038/s41440-025-02511-6

Scopus

PubMed

Shimokihara S., Tabira T., Maruta M., Makizako H., Han G., Kamasaki T., Akasaki Y., Hidaka Y., Kumura Y., Kukizaki W., Kubozono T., Ohishi M. . Associations Between the Diverse Aspects of Psychological Frailty and Health-Related Outcomes in Community-Dwelling Older Adults: A Cross-Sectional Study . Psychogeriatrics.26 ( 1 ) e70115 2026.1Reviewed

Language：Japanese Publisher：Psychogeriatrics

Background: Psychological frailty (PsF), encompassing cognitive and emotional vulnerabilities, remains understudied despite its potential impact on health outcomes in older adults. This cross-sectional study aimed to explore the characteristics of diverse aspects of PsF, including cognitive frailty (CF), lower cognitive function, and affective frailty (AF), and to examine their associations with health-related outcomes in community-dwelling older adults. Methods: Data were analysed from 420 community-dwelling older adults participating in the Tarumizu Study in Japan, excluding those exhibiting physical or social frailty. Participants were categorised into Robust, Lower cognitive function, CF, AF, and Multi-domain PsF groups. AF was assessed using five items from the Geriatric Depression Scale, focusing on emotional vulnerability. Health outcomes included self-rated health, subjective memory complaints (SMC), and functional ability of daily living. Associations were analysed using adjusted multiple regression models controlling for covariates. Results: PsF was present in 39.5% of the cohort (lower cognitive function: 18.1%, CF: 7.6%, AF: 11.0%, Multi-domain PsF: 2.9%). In the adjusted models, only AF showed a significant positive association with SMC (adjusted risk ratio = 1.62, 95% CI: 1.06–2.42, p = 0.023). No significant associations were found between any PsF domain and subjective health or daily functional ability in the adjusted models. Conclusions: AF, characterised by emotional vulnerability, was uniquely associated with SMC, suggesting emotional factors may play a more central role than cognitive decline in shaping perceptions of memory problems. These findings highlight the heterogeneous nature of PsF and underscore the need for nuanced assessments to inform targeted prevention and intervention strategies.

DOI： 10.1111/psyg.70115

Scopus

PubMed

Shimokihara S., Tabira T., Maruta M., Makizako H., Han G., Kamasaki T., Akasaki Y., Hidaka Y., Kumura Y., Kukizaki W., Kubozono T., Ohishi M. . Longitudinal associations between satisfaction with meaningful activities and domains of frailty in community-dwelling older adults: A 2-year prospective cohort study . British Journal of Occupational Therapy 2026

Language：Japanese Publisher：British Journal of Occupational Therapy

Introduction: Frailty in older adults is a multidimensional condition that affects healthy life expectancy. Engagement in meaningful activities (MA) is thought to support healthy aging, but the specific relationship between satisfaction with MA and frailty remains underexplored. This study investigated the longitudinal association between satisfaction with MA and frailty (physical, social, and cognitive domains) in community-dwelling older adults. Method: A total of 231 community-dwelling older adults who completed a 2-year follow-up were analyzed. Frailty in each domain was assessed at baseline and at 1- and 2-years. Participants’ MA and satisfaction were obtained through face-to-face interviews. Mixed-effects logistic regression models were used to examine the longitudinal associations between satisfaction with MA and frailty status trajectories. Results: At follow-up, changes in physical frailty status were observed in most participants. Robust status was commonly maintained in the social and cognitive frailty domain. Participants’ MA primarily involved leisure, sports, and domestic activities. Mixed-effects logistic regression analysis showed that satisfaction with MA was significantly associated with physical frailty, even after adjusting for potential covariates (odds ratio 0.68; 95% confidence interval 0.45, 0.99, p = 0.045). However, this association was not significant for social or cognitive frailty. Conclusion: Satisfaction with MA was longitudinally associated with physical frailty, but not with social or cognitive frailty.

DOI： 10.1177/03080226261417513

Scopus

Ohishi M, Kario K, Katsuya T, Shimosawa T, Shiosakai K, Furugori T, Taguchi T, EXCITE-HT investigators . Efficacy and safety of esaxerenone vs trichlormethiazide for the treatment of uncontrolled essential hypertension in Japanese patients with type 2 diabetes mellitus: a subanalysis of the EXCITE-HT study. . Hypertension research : official journal of the Japanese Society of Hypertension.49 ( 2 ) 444 - 456 2025.12Reviewed

Language：English Publisher：Hypertension Research

This subgroup analysis of the randomized, open-label, parallel-group EXCITE-HT study explored the antihypertensive efficacy and safety of esaxerenone vs trichlormethiazide in patients with type 2 diabetes mellitus (T2DM), stratified by baseline antihypertensive agent (angiotensin receptor blocker [ARB] or calcium channel blocker [CCB]) and urinary albumin-to-creatinine ratio (UACR; <30 or ≥30 mg/gCr). Using thresholds consistent with those used in the main study to interpret the difference in systolic/diastolic blood pressure (SBP/DBP), the between-group difference in least squares mean change (95% confidence interval [CI]) in morning home SBP/DBP at the end of treatment was −2.5 (−4.8, −0.2)/ − 0.7 (−2.0, 0.6) mmHg. Trends were consistent across all subgroups. The geometric mean UACR significantly decreased from baseline to Week 12 in the overall population, ARB subgroup (except for esaxerenone-treated patients), CCB subgroup, and both UACR subgroups. The overall incidence of serum potassium ≥5.5 mEq/L was 2.5% with esaxerenone and 0.9% with trichlormethiazide, with no cases of serum potassium ≥6.0 mEq/L. In this patient population, esaxerenone had a favorable safety profile, achieved blood pressure lowering similar to trichlormethiazide, and elicited a reduction of kidney damage (based on UACR), regardless of baseline antihypertensive agent or UACR. (Figure presented.)

DOI： 10.1038/s41440-025-02437-z

Scopus

PubMed

Akasaki Y, Shimokihara S, Hidaka Y, Maruta M, Han G, Kamasaki T, Kumura Y, Kukizaki W, Nakahara R, Makizako H, Kubozono T, Ohishi M, Tabira T . Satisfaction with Meaningful Activities and Sleep in Community-Dwelling Older Adults: Cross-Sectional Study. . Clinical gerontologist 1 - 15 2025.12Reviewed

Hirokazu Shimono, Daisuke Kanda, Akihiro Tokushige, Nobuhiro Ito, Yutaro Nomoto, Hiroyuki Tabata, Kenta Ohmure, Takuro Kubozono, Mitsuru Ohishi . Association between the modified Japanese Version of High Bleeding Risk scores and clinical outcomes in Japanese patients with lower extremity artery disease undergoing endovascular treatment . Heart and Vessels 2025.11Reviewed

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Papers - OHISHI Mitsuru