Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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Sasaguri M., Hak M.S., Nakamura N., Suzuki A., Sulaiman F.K., Nakamura S., Ohishi M. . Effects of Hotz's plate and lip adhesion on maxillary arch in patients with complete unilateral cleft lip and palate until 5 years of age . Journal of Oral and Maxillofacial Surgery Medicine and Pathology26 ( 3 ) 292 - 300 2014.7

Language：Japanese Publisher：Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Purpose: The purpose of this study was to evaluate the effect of infant orthopedic treatment using Hotz's plate and lip adhesion (LA) on maxillary arch of the patients with complete unilateral cleft lip and palate (UCLP) until 5 years of age. Patients and methods: Fifty patients with complete UCLP who were treated in Cleft Lip and Palate Center of Harapan Kita Children and Maternity Hospital, Indonesia, were divided into three groups. Hotz (+) group: 22 patients treated with Hotz's plate until palatoplasty. Hotz-LA group: 14 patients treated with LA at one or two months of age and with Hotz plate until palatoplasty. Hotz (-) group: 14 patients treated without Hotz's plate and LA. Serial dental casts were obtained from each patient at following four time points: first visit, cheiloplasty, palatoplasty, and 5 years of age. Each maxillary dental cast was scanned, and the linear and angular dimensions were measured. Results: Maxillary arch width and length of anterior part were larger in the Hotz (+) group than in the Hotz-LA and Hotz (-) groups at the palatoplasty and 5 years of age. The anterior part of the maxillary arch in the Hotz-LA and Hotz (-) groups was smaller and more flattened than that in the Hotz (+) group. Conclusions: This study suggests that Hotz's plate prevents the maxillary arch from collapsing after cheiloplasty to the palatoplasty. This effect remained up to 5 years of age. However, the effects of Hotz's plate are negated in patients who underwent LA. © 2013 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI.

DOI： 10.1016/j.ajoms.2013.03.002

Scopus

大石充 . 【Ca拮抗薬と降圧治療の20年を振り返る】臓器保護を考慮した降圧治療におけるアムロジピンの役割　脳保護 . 血圧21 ( 7 ) 590 - 594 2014.7

Language：Japanese Publisher：(株)先端医学社

脳保護のためには"the lower、the better"が重要であるが、アムロジピンは安定した確実な降圧力を介して、ALLHATやASCOT-BPLAといった大規模臨床試験において脳卒中抑制に有用であることが報告されている。近年、visit-to-visit variability(来院時ごと血圧変動)という概念が提唱され、アムロジピンを代表とするCa拮抗薬は血圧そのものの抑制作用に加えて、この変動性を抑制することにより脳卒中抑制効果を示している可能性が高い。(著者抄録)

赤崎雄一, 大石充 . 【高齢者の高血圧-新しいガイドラインをめぐって-】高齢者高血圧のエビデンス . Geriatric Medicine52 ( 6 ) 637 - 640 2014.6

Language：Japanese Publisher：(株)ライフ・サイエンス

加齢に伴う様々な疾患の合併や動脈硬化の進展により、高齢者の血行動態は、若年・中高年者とは大きく異なっており、血圧管理に苦労する症例が多い。高齢者高血圧の降圧目標に対するエビデンスは少ないが、2008年のHYVET(The HYpertension in the Very Elderly Trial)が80歳以上の比較的元気な高齢者高血圧に対する降圧の有効性を検証して以降、高齢者高血圧の治療意義についての大規模臨床試験が散見されるようになった。本稿では、HYVETおよびわが国からのエビデンスとしてJATOSとVALISHについて解説する。(著者抄録)

Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H. . Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis. . PLoS One9 ( 4 ) e94930 - e94930 2014.4Reviewed

Ohishi M . [Hypertension]. . Nihon rinsho. Japanese journal of clinical medicine72 ( 4 ) 687 - 91 2014.4

大石充 . 【レニン・アンジオテンシン・アルドステロン系研究の新展開】ACE2、アンジオテンシン(1-7)、mas受容体研究の最前線 . Angiology Frontier13 ( 1 ) 36 - 41 2014.4

Language：Japanese Publisher：(株)メディカルレビュー社

2002年に発表されたアンジオテンシン変換酵素(ACE)2欠損マウスが心不全を発症するという論文で、ACE2/アンジオテンシン(1-7)/mas軸が一躍脚光を浴びた。その後非常に多くの研究がなされて、さまざまな疾患群においてACE/アンジオテンシンII/アンジオテンシンIIタイプ1(AT1)受容体軸と拮抗する役割を果たしていることが明らかにされてきた。一方で、近年の報告により糖代謝を中心としてmas受容体独自の作用が明らかになりつつあり、新規治療薬の開発にも結びつく可能性が示唆されている。(著者抄録)

大石充 . 【生活習慣病と認知機能-認知症の予防を見据えた生活習慣病の治療を目指して-】生活習慣病と認知機能　予防と治療　高血圧症 . 日本臨床72 ( 4 ) 687 - 691 2014.4

福森優司, 前川佳敬, 大石充 . 【生活習慣病対策から認知症予防を考える】認知症診療に対するチーム医療　多職種連携 . 月刊糖尿病6 ( 3 ) 73 - 82 2014.4

Shimamoto Kazuaki, Ando Katsuyuki, Fujita Toshiro, Hasebe Naoyuki, Higaki Jitsuo, Horiuchi Masatsugu, Imai Yutaka, Imaizumi Tsutomu, Ishimitsu Toshihiko, Ito Masaaki, Ito Sadayoshi, Itoh Hiroshi, Iwao Hiroshi, Kai Hisashi, Kario Kazuomi, Kashihara Naoki, Kawano Yuhei, Kim-Mitsuyama Shokei, Kimura Genjiro, Kohara Katsuhiko, Komuro Issei, Kumagai Hiroo, Matsuura Hideo, Miura Katsuyuki, Morishita Ryuichi, Naruse Mitsuhide, Node Koichi, Ohya Yusuke, Rakugi Hiromi, Saito Ikuo, Saitoh Shigeyuki, Shimada Kazuyuki, Shimosawa Tatsuo, Suzuki Hiromichi, Tamura Kouichi, Tanahashi Norio, Tsuchihashi Takuya, Uchiyama Makoto, Ueda Shinichiro, Umemura Satoshi, Maemura Koji, Okada Koichi, Katayama Shigehiro, Hisatome Ichiro, Arai Hidenori, Abe Isao, Akishita Masahiro, Adachi Kayoko, Arita Mikio, Arima Shuji, Ando Shinichi, Shimamoto Kazuaki, Minakami Hisanori, Matsumoto Masayasu, Ogawa Yoshihiro, Ouchi Yasuyoshi, Itakura Hiroshige, Ito Shinya, Ikeda Shunya, Iso Hiroyasu, Ichihara Atsuhiro, Ito Takayuki, Imai Enyu, Iwashima Yoshio, Uehara Yoshio, Uchiyama Shinichiro, Umemoto Seiji, Ura Nobuyuki, Urata Hidenori, Eguchi Kazuo, Ohishi Mitsuru, Okubo Ichiro, Ohkubo Takayoshi, Okura Takafumi, Okamura Tomonori, Ogawa Hisao, Kashiwagi Atsunori, Katsuya Tomohiro, Kato Norihiro, Kamide Kei, Kawashima Yukiko, Kikuchi Toru, Kitazono Takanari, Kitamura Kazuo, Kimura Kenjiro, Kihara Yasuki, Kiyohara Yutaka, Kusaka Miho, Kushiro Toshio, Kohno Masakazu, Kobayashi Shuzo, Goto Atsuo, Kokubo Yoshihiro, Saito Yoshihiko, Shibata Hirotaka, Sasamura Hiroyuki, Shimohama Shun, Suzuki Yoshikatsu, Abe Keishi, Arakawa Kikuo, Iimura Osamu, Omae Teruo, Ueshima Hirotsugu, Eto Tanenao, Ogihara Toshio, Kikuchi Kenjiro, Saruta Takao, Takishita Shuichi, Matsuoka Hiroaki, Takazawa Kenji, Takahashi Shori, Takahashi Hakuo, Takeda Kazuo, Takeda Yoshiyu, Tsutsui Hiroyuki, Tsubakihara Yoshiharu, Doi Yoshinori, Tomiyama Hirofumi, Tomino Yasuhiko, Toyoda Kazunori, Narita Ichiei, Nishikawa Tetsuo, Hayashi Koichi, Hirata Yasunobu, Hirawa Nobuhito, Hirooka Yoshitaka, Fukuda Noboru, Horio Takeshi, Hoshide Satoshi, Makino Hirofumi, Masuzaki Hiroaki, Matsumura Kiyoshi, Miura Shin-ichiro, Miura Tetsuji, Mukoyama Masashi, Murashima Atsuko, Murohara Toyoaki, Morimoto Shigeto, Yamakage Michiaki, Yamashina Akira, Yoshimura Michihiro, Watanabe Tsuyoshi, Kaneko Yoshihiro, Hiwada Kunio, Fukiyama Koshiro, Yazaki Yoshio, Shimizu Hideyuki, Yamaguchi Ikuko, Mikami Hiroshi, Yamamoto Wari, Nakao Masatoshi, Mori Hisao, The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension . 日本高血圧学会高血圧治療ガイドライン(JSH 2014)(The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014)) . Hypertension Research37 ( 4 ) 253 - 390 2014.4

堀添善尚, 高崎州亜, 植屋奈美, 茶圓秀人, 窪田佳代子, 水上尚子, 湯浅敏典, 木佐貫彰, 大石充 . 肺高血圧症合併の単心房術後残存シャント根治術前後を心エコーで観察し得た一例 . 超音波医学41 ( Suppl. ) S502 - S502 2014.4

Ohishi M. . [Hypertension]. . Nihon rinsho. Japanese journal of clinical medicine72 ( 4 ) 687 - 91 2014.4

Shimamoto Kazuaki, Ando Katsuyuki, Fujita Toshiro, Hasebe Naoyuki, Higaki Jitsuo, Horiuchi Masatsugu, Imai Yutaka, Imaizumi Tsutomu, Ishimitsu Toshihiko, Ito Masaaki, Ito Sadayoshi, Itoh Hiroshi, Iwao Hiroshi, Kai Hisashi, Kario Kazuomi, Kashihara Naoki, Kawano Yuhei, Kim-Mitsuyama Shokei, Kimura Genjiro, Kohara Katsuhiko, Komuro Issei, Kumagai Hiroo, Matsuura Hideo, Miura Katsuyuki, Morishita Ryuichi, Naruse Mitsuhide, Node Koichi, Ohya Yusuke, Rakugi Hiromi, Saito Ikuo, Saitoh Shigeyuki, Shimada Kazuyuki, Shimosawa Tatsuo, Suzuki Hiromichi, Tamura Kouichi, Tanahashi Norio, Tsuchihashi Takuya, Uchiyama Makoto, Ueda Shinichiro, Umemura Satoshi, Maemura Koji, Okada Koichi, Katayama Shigehiro, Hisatome Ichiro, Arai Hidenori, Abe Isao, Akishita Masahiro, Adachi Kayoko, Arita Mikio, Arima Shuji, Ando Shinichi, Shimamoto Kazuaki, Minakami Hisanori, Matsumoto Masayasu, Ogawa Yoshihiro, Ouchi Yasuyoshi, Itakura Hiroshige, Ito Shinya, Ikeda Shunya, Iso Hiroyasu, Ichihara Atsuhiro, Ito Takayuki, Imai Enyu, Iwashima Yoshio, Uehara Yoshio, Uchiyama Shinichiro, Umemoto Seiji, Ura Nobuyuki, Urata Hidenori, Eguchi Kazuo, Ohishi Mitsuru, Okubo Ichiro, Ohkubo Takayoshi, Okura Takafumi, Okamura Tomonori, Ogawa Hisao, Kashiwagi Atsunori, Katsuya Tomohiro, Kato Norihiro, Kamide Kei, Kawashima Yukiko, Kikuchi Toru, Kitazono Takanari, Kitamura Kazuo, Kimura Kenjiro, Kihara Yasuki, Kiyohara Yutaka, Kusaka Miho, Kushiro Toshio, Kohno Masakazu, Kobayashi Shuzo, Goto Atsuo, Kokubo Yoshihiro, Saito Yoshihiko, Shibata Hirotaka, Sasamura Hiroyuki, Shimohama Shun, Suzuki Yoshikatsu, Abe Keishi, Arakawa Kikuo, Iimura Osamu, Omae Teruo, Ueshima Hirotsugu, Eto Tanenao, Ogihara Toshio, Kikuchi Kenjiro, Saruta Takao, Takishita Shuichi, Matsuoka Hiroaki, Takazawa Kenji, Takahashi Shori, Takahashi Hakuo, Takeda Kazuo, Takeda Yoshiyu, Tsutsui Hiroyuki, Tsubakihara Yoshiharu, Doi Yoshinori, Tomiyama Hirofumi, Tomino Yasuhiko, Toyoda Kazunori, Narita Ichiei, Nishikawa Tetsuo, Hayashi Koichi, Hirata Yasunobu, Hirawa Nobuhito, Hirooka Yoshitaka, Fukuda Noboru, Horio Takeshi, Hoshide Satoshi, Makino Hirofumi, Masuzaki Hiroaki, Matsumura Kiyoshi, Miura Shin-ichiro, Miura Tetsuji, Mukoyama Masashi, Murashima Atsuko, Murohara Toyoaki, Morimoto Shigeto, Yamakage Michiaki, Yamashina Akira, Yoshimura Michihiro, Watanabe Tsuyoshi, Kaneko Yoshihiro, Hiwada Kunio, Fukiyama Koshiro, Yazaki Yoshio, Shimizu Hideyuki, Yamaguchi Ikuko, Mikami Hiroshi, Yamamoto Wari, Nakao Masatoshi, Mori Hisao, The Japanese, Society of Hypertension Committee for Guidelines for the Management of Hypertension . 日本高血圧学会高血圧治療ガイドライン(JSH 2014)(The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014)) . Hypertension Research37 ( 4 ) 253 - 390 2014.4

大石充 . 巻頭言神様の作った｢生き物｣の仕組み . 呼吸と循環62 ( 3 ) 202 - 202 2014.3

Kohno Y, Nakashima Y, Kitano T, Nakamura T, Takamura K, Akiyama M, Hara D, Yamamoto T, Motomura G, Ohishi M, Hamai S, Yukihide I . Subclinical bilateral involvement of the hip in patients with slipped capital femoral epiphysis: a multicentre study. . International orthopaedics38 ( 3 ) 477 - 82 2014.3Reviewed

赤崎雄一, 大石充 . 【家庭血圧-これからの高血圧個別治療へ-】白衣高血圧(低リスクと高リスク)の治療 . カレントテラピー32 ( 3 ) 254 - 258 2014.3

Yoav Ben-Shlomo, Melissa Spears, Chris Boustred, Margaret May, Simon G. Anderson, Emelia J. Benjamin, Pierre Boutouyrie, James Cameron, Chen-Huan Chen, J. Kennedy Cruickshank, Shih-Jen Hwang, Edward G. Lakatta, Stephane Laurent, Joao Maldonado, Gary F. Mitchell, Samer S. Najjar, Anne B. Newman, Mitsuru Ohishi, Bruno Pannier, Telmo Pereira, Ramachandran S. Vasan, Tomoki Shokawa, Kim Sutton-Tyrell, Francis Verbeke, Kang-Ling Wang, David J. Webb, Tine Willum Hansen, Sophia Zoungas, Carmel M. McEniery, John R. Cockcroft, Ian B. Wilkinson . Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction An Individual Participant Meta-Analysis of Prospective Observational Data From 17,635 Subjects . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY63 ( 7 ) 636 - 646 2014.2Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Objectives The goal of this study was to determine whether aortic pulse wave velocity (aPWV) improves prediction of cardiovascular disease (CVD) events beyond conventional risk factors.
Background Several studies have shown that aPWV may be a useful risk factor for predicting CVD, but they have been underpowered to examine whether this is true for different subgroups.
Methods We undertook a systematic review and obtained individual participant data from 16 studies. Study-specific associations of aPWV with CVD outcomes were determined using Cox proportional hazard models and random effect models to estimate pooled effects.
Results Of 17,635 participants, a total of 1,785 (10%) had a CVD event. The pooled age-and sex-adjusted hazard ratios (HRs) per 1-SD change in loge aPWV were 1.35 (95% confidence interval [CI]: 1.22 to 1.50; p < 0.001) for coronary heart disease, 1.54 (95% CI: 1.34 to 1.78; p < 0.001) for stroke, and 1.45 (95% CI: 1.30 to 1.61; p < 0.001) for CVD. Associations stratified according to sex, diabetes, and hypertension were similar but decreased with age (1.89, 1.77, 1.36, and 1.23 for age <= 50, 51 to 60, 61 to 70, and > 70 years, respectively; pinteraction < 0.001). After adjusting for conventional risk factors, aPWV remained a predictor of coronary heart disease (HR: 1.23 [95% CI: 1.11 to 1.35]; p < 0.001), stroke (HR: 1.28 [95% CI: 1.16 to 1.42]; p < 0.001), and CVD events (HR: 1.30 [95% CI: 1.18 to 1.43]; p < 0.001). Reclassification indices showed that the addition of aPWV improved risk prediction (13% for 10-year CVD risk for intermediate risk) for some subgroups.
Conclusions Consideration of aPWV improves model fit and reclassifies risk for future CVD events in models that include standard risk factors. aPWV may enable better identification of high-risk populations that might benefit from more aggressive CVD risk factor management. (C) 2014 by the American College of Cardiology Foundation

DOI： 10.1016/j.jacc.2013.09.063

Web of Science

PubMed

大石充 . 【日本人高血圧症患者の予後予測因子と治療の実際】 . Astellas Square: 明日の医療を考える10 ( 1 ) 6 - 12 2014.2

Wang X, Sugimoto K, Fujisawa T, Shindo N, Minato S, Kamada Y, Hamano M, Ohishi M, Ikegami H, Rakugi H . Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse . Hepatology research44 ( 1 ) 102 - 113 2014.1Reviewed

茶圓秀人, 湯淺敏典, 植屋奈美, 堀添善尚, 川添晋, 窪田佳代子, 水上尚子, 高崎州亜, 木佐貫彰, 大石充 . 成人期まで外科的介入なく経過したShone症候群の一例 . 超音波医学41 ( 1 ) 93 - 93 2014.1

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Papers - OHISHI Mitsuru