Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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Uebo S, Ikeda Y, Uchikado Y, Sasaki Y, Akasaki Y, Kubozono T, Ohishi M . Disruption of Rab9-dependent mitophagy contributes to menopause-induced sarcopenia. . Experimental gerontology.213 112970 2025.11Reviewed

Shirakabe A., Ikeda Y., Uchikado Y., Okazaki H., Matsushita M., Sawatani T., Shigihara S., Tani K., Morooka M., Takahashi M., Kobayashi N., Ohishi M., Sadoshima J., Asai K. . Prognostic impact of mitochondrial dynamics-related miRNA levels during the treatment of acute heart failure in the hospital . Scientific Reports15 ( 1 ) 39938 2025.11Reviewed

Language：Japanese Publisher：Scientific Reports

Mitochondrial dynamics-related RNAs during hospitalization for acute heart failure (AHF) were rarely evaluated in various points. In total, 234 patients who visited the emergency room for AHF were retrospectively evaluated. Blood samples were collected within 15 min of admission (day 1), after 48–72 h, and between days 7 and 21. Low miR-140-3p during hospitalization was defined as the level being categorized as Q1 more than once (on days 1, 3 and/or 14), and normal-140-3p during hospitalization as the level never being categorized as Q1. The median miR-140-3p levels were significantly decreased on days 3 and 14 (2.53 [1.06–6.42] and 3.65 [1.41–9.05], respectively) in comparison to the value on day 1 (6.71 [2.66–14.0]). Kaplan–Meier curves indicated that all-cause mortality within 1000 days was significantly higher in the low-miR-140-3p group than in the other-miR-140-3p group on days 1 and 14. Moreover, the survival rate was significantly lower and the rate of HF events was significantly higher in the low-miR-140-3p group than in the normal-miR-140-3p group. The miRNA levels of patients further decreased during treatment for AHF. Low levels of mitochondrial fission-related miRNAs during AHF treatment were independently associated with an increased risk of long-term adverse outcomes.

DOI： 10.1038/s41598-025-23792-4

Scopus

PubMed

Tokutake Daisuke, Akasaki Yuichi, Shinchi Shuya, Uebo Shota, Kawasoe Shin, Kubozono Takuro, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . Association Between Fatty Liver Index and Brachial-Ankle Pulse Wave Velocity in the General Population　― A Cross-Sectional Study ― . Circulation Reports8 ( 1 ) 118 - 126 2025.11Reviewed

Language：English Publisher：The Japanese Circulation Society

Background: Although metabolic dysfunction-associated fatty liver disease is typically diagnosed using ultrasonography, the fatty liver index (FLI) offers a simple alternative. Brachial-ankle pulse wave velocity (baPWV) is an established marker of arterial stiffness and a predictor of cardiovascular events. This study investigated the association between FLI and baPWV in a general Japanese population.Methods and Results: This cross-sectional study included participants aged ≥18 years, excluding those with atrial fibrillation, lower extremity artery disease, severe aortic stenosis, or missing data. The primary outcome was an elevated baPWV (≥1,800 cm/s). Multivariable logistic regression analysis was performed to assess the association between FLI and elevated baPWV, considering FLI both as a categorical variable (low risk: FLI <30; moderate risk: FLI ≥30 and <60; high risk: FLI ≥60) and as a continuous variable (per 10-unit increase). The analysis included 10,122 individuals (mean age 54.3 years; 55% male). In multivariable-adjusted models, the odds of elevated baPWV were significantly higher in the moderate-risk (odds ratio [OR] 1.47; 95% confidence interval [CI] 1.20–1.79) and high-risk (OR 1.78; 95% CI 1.33–2.38) groups, using the low-risk group as the reference category. Each 10-unit increase in FLI was associated with significantly higher odds of the outcome (OR 1.16; 95% CI 1.10–1.22).Conclusions: FLI showed a significant association with arterial stiffness in the general Japanese population.

DOI： 10.1253/circrep.cr-25-0218

PubMed

CiNii Research

Kario K, Ohishi M, Katsuya T, Shimosawa T, Shiosakai K, Furugori T, Taguchi T. . Effect of N-terminal pro B-type natriuretic peptide levels on the efficacy and safety of esaxerenone vs trichlormethiazide for the treatment of Japanese patients with uncontrolled essential hypertension: a subanalysis of the EXCITE-HT study . Hypertension Research49 ( 2 ) 431 - 443 2025.11Reviewed

Shirakabe Akihiro, Ikeda Yoshiyuki, Uchikado Yoshihiro, Matsushita Masato, Sawatani Tomofumi, Shigihara Shota, Tani Kenichi, Morooka Masaki, Takahashi Masahito, Kobayashi Nobuaki, Ohishi Mitsuru, Sadoshima Junichi, Asai Kuniya . Prognostic impact of excessive mitochondrial fission in patients with heart failure and evaluation of mitochondrial dynamics-related miRNAs in heart failure(タイトル和訳中) . Hypertension Research48 ( 11 ) 2950 - 2960 2025.11

Akasaki Y, Shimokihara S, Hidaka Y, Maruta M, Han G, Kamasaki T, Kumura Y, Kukizaki W, Nakahara R, Makizako H, Kubozono T, Ohishi M, Tabira T . Changes in satisfaction with meaningful activities and subsequent subjective memory complaints: a two-wave longitudinal analysis of Japanese older adults . Aging & mental health30 ( 3 ) 492 - 503 2025.10Reviewed

Ninomiya Y., Enokizono K., Kawasoe S., Kubozono T., Kamada H., Iriki Y., Ikeda Y., Miyahara H., Tokushige K., Ohishi M. . QT prolongation and excessive variability predicts new-onset atrial fibrillation in the health screening data of Japanese adults . Plos One20 ( 10 ) e0333169 2025.10Reviewed

Language：Japanese Publisher：Plos One

Background A prolonged QT interval (QTc) is associated with the development of atrial fibrillation. However, reports linking QTc variability and atrial fibrillation are limited. Purpose To investigate the relationship linking prolongation and variability of QTc with new-onset atrial fibrillation in Japanese adults. Methods This retrospective study analyzed the annual health screening data of 103,304 adults (50,438 males; mean age, 54 years) who did not exhibit atrial fibrillation at baseline between April 2005 and October 2018. The majority of the study population underwent annual health examinations according to Japan’s health welfare policy. We calculated QTc times using the Bazett formula (QTc = QT/√RR). QTc variability is indicated by the gap between the maximum and minimum QTc values. Atrial fibrillation was diagnosed by 12-lead surface electrocardiography. The association between QT prolongation and variability in new-onset atrial fibrillation was ascertained by logistic regression analysis. The strength of the association was further analyzed using multivariable analyses adjusted for sex, age, dyslipidemia, diabetes, hypertension, obesity, estimated glomerular filtration rate, and alcohol consumption. Results During the follow-up (median six years), we recorded 341 (0.3%) new atrial fibrillation cases. Univariable analysis showed a significant association between QTc prolongation and variability with new-onset atrial fibrillation (odds ratio [OR] per 10 ms, 1.08 and 1.15; 95% confidence interval [CI], 1.03–1.13 and 1.07–1.23, respectively; P<0.001). Multivariable analysis suggested increased risk of new-onset atrial fibrillation with QTc prolongation and QT variability (OR per 10 ms, 1.09 and 1.16; 95% CI, 1.04–1.14 and 1.09–1.24, respectively; P<0.001). Conclusion In the general Japanese population, QTc prolongation and large QT variability are risk factors for new-onset atrial fibrillation. QT prolongation and large QT variability during sinus rhythm may be good markers for predicting not only ventricular but also atrial arrhythmias such as atrial fibrillation.

DOI： 10.1371/journal.pone.0333169

Scopus

PubMed

Hidaka Y, Tabira T, Maruta M, Makizako H, Han G, Shimokihara S, Akasaki Y, Kamasaki T, Kukizaki W, Nakahara R, Kubozono T, Ohishi, M. . Satisfaction with grave visitation and depressive symptoms among community-dwelling older Japanese adults . Mental Health, Religion & Culture.28 95 - 109 2025.10Reviewed

Shirakabe A., Ikeda Y., Uchikado Y., Okazaki H., Matsushita M., Sawatani T., Shigihara S., Tani K., Morooka M., Kobayashi N., Ohishi M., Sadoshima J., Asai K. . Clinical significance of mitochondrial dynamics-related miRNAs in the superacute phase of acute heart failure in patients presenting to the emergency department . International Journal of Cardiology444 133967 2025.10Reviewed

Language：Japanese Publisher：International Journal of Cardiology

Background: Mitochondria are dynamic organelles whose morphology can change through fusion and fission. The role of these mitochondrial dynamics in cardiomyocytes has not been evaluated in patients with acute heart failure (AHF). Methods and results: Two hundred seventy-three AHF patients and 374 control patients who attended a cardiovascular outpatient clinic were prospectively analyzed. Blood samples were collected within 15 min of admission from AHF patients (AHF group) and control patients who visited a daily cardiovascular outpatient clinic (control group). Mitochondrial dynamics-related RNAs were compared between the two groups, and long-term prognosis (1000-day mortality) was evaluated across RNA quartiles. The miR-140-3p and miR-485-3p levels in the AHF group (median 6.73, range 2.75–14.55; median 0.45, range 0.13–1.86) were significantly (p = 0.002 and p = 0.049) lower than those in the control group (median 8.61, range 3.37–34.12; median 0.78, range 0.15–3.52), respectively. Cardiac biomarkers, including N-terminal pro-BNP, heart-type fatty acid-binding protein, and high-sensitivity troponin, were significantly higher in the low-miR-140-3p group than in the middle- and high-miR-140-3p groups. Kaplan–Meier curve analysis revealed that all-cause mortality within 1000 days was significantly higher in the low-140-3p group than in the middle- and high-miR-140-3p groups. Cox regression analysis revealed that the low-140-3p group was an independent predictor of 1000-day mortality (hazard ratio 1.567; 95 % confidence interval 1.004–2.444; p = 0.048). Conclusion: Impaired mitochondrial dynamics were observed in the acute phase of AHF. In particular, a mitochondrial fission-related miRNA (miR-140-3p) was independently associated with adverse outcomes.

DOI： 10.1016/j.ijcard.2025.133967

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PubMed

Tezuka A, Kubozono T, Kawabata T, Kawasoe S, Ojima S, Yamaguchi S, Akasaki Y, Higuchi K, Kuwahata S, Takenaka T, Nishi K, Nakamura M, Okui T, Ohishi M. . Association between toothbrushing habits and hypertension in the general population . Sci Rep. 15 ( 1 ) 35333 2025.10Reviewed

Beppu Risa, Kubota Kayoko, Iwatani Noriko, Miyanaga Sunao, Kirishima Mari, Tanimoto Akihide, Ohishi Mitsuru . Pulmonary tumor thrombotic microangiopathy associated with endometrial carcinoma: A case report(タイトル和訳中) . Journal of Cardiology Cases32 ( 4 ) 160 - 162 2025.10

Beppu R., Kubota K., Iwatani N., Miyanaga S., Kirishima M., Tanimoto A., Ohishi M. . Pulmonary tumor thrombotic microangiopathy associated with endometrial carcinoma: A case report . Journal of Cardiology Cases32 ( 4 ) 160 - 162 2025.10

Language：Japanese Publisher：Journal of Cardiology Cases

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive fatal cancer-related complication. Diagnosing PTTM is challenging, with most cases diagnosed postmortem. Gastric, breast, and lung cancers are the most common primary tumors associated with PTTM. To the best of our knowledge, this is the first case report of PTTM arising from an endometrial carcinoma. A patient with advanced respiratory failure and pulmonary hypertension was diagnosed with endometrial carcinoma. This case highlights the importance of suspecting PTTM in patients with pulmonary hypertension accompanied by rapidly progressive dyspnea when pulmonary embolism has been excluded. In such cases, identifying the primary cancer is crucial for establishing an appropriate treatment plan. It also emphasizes the importance of investigating systemic cancers, extending beyond the frequently encountered cancers, even in the absence of active cancer. Learning objective: Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly fatal complication of cancer. This is the first case report of PTTM arising from an endometrial carcinoma. Clinicians should consider PTTM in patients with respiratory failure and pulmonary hypertension, even in the absence of active cancer. Early investigation for underlying malignancy and prompt pathological evaluation are essential for the rapid diagnosis of PTTM.

DOI： 10.1016/j.jccase.2025.06.013

Scopus

PubMed

長野綾香, 桑波田聡, 大坪稔拓, 満留祐也, 川畑深怜, 佐田千尋, 岩谷徳子, 軸丸美香, 竹中俊宏, 大石充 . 夜間血圧がnon-dipper/riser typeを呈した神経調節性失神の2症例 . 日本老年医学会雑誌62 ( 4 ) 464 - 464 2025.10

Noguchi Yoshihisa, Kawasoe Shin, Miyata Masaaki, Horizoe Yoshihisa, Hamamoto Yuki, Tajima Akari, Uchiyama Yota, Kubozono Takuro, Nakamura Yukimi, Kobayashi Saori, Yunoue Shingo, Ozono Nanase, Nakashima Kaori, Higashi Fuyuki, Ohishi Mitsuru . Characteristics of Myocardial Work Indices in Patients with Aortic Valve Stenosis(タイトル和訳中) . International Heart Journal66 ( 5 ) 754 - 762 2025.9Reviewed

Ogawa S, Ishii M, Saito S, Seki H, Ikeda K, Yasui Y, Komatsu T, Sato G, Tabata N, Ohishi M, Kubozono T, Saito N, Kato ET, Song X, Yamada M, Natori S, Kunikane Y, Yokomatsu T, Kato M, Sagara Y, Uchiyama N, Atsuchi N, Kawahara S, Natsugoe S, Tsujita K . Deep Learning for Cardiac Overload Estimation- Predicting B-Type Natriuretic Peptide (BNP) Levels From Heart Sounds and Electrocardiogram . Circ J.89 ( 10 ) 1684 - 1692 2025.9Reviewed

Shiratsuchi D, Makizako H, Akaida S, Miyake Y, Kiyama R, Tabira T, Tateishi M, Otsuka R, Takenaka T, Kubozono T, Ohishi M . Combinations of intrinsic capacity and frailty and their associations with self-rated health in community-dwelling older adults . Aging Clin Exp Res.37 ( 1 ) 275 2025.9Reviewed

Shirakabe A., Ikeda Y., Uchikado Y., Matsushita M., Sawatani T., Shigihara S., Tani K., Morooka M., Takahashi M., Kobayashi N., Ohishi M., Sadoshima J., Asai K. . Prognostic impact of excessive mitochondrial fission in patients with heart failure and evaluation of mitochondrial dynamics-related miRNAs in heart failure . Hypertension Research48 ( 11 ) 2950 - 2960 2025.9Reviewed

Language：Japanese Publisher：Hypertension Research

Mitochondria are dynamic organelles that can change their morphology. The role of these mitochondrial dynamics in cardiomyocytes remains obscure in patients with heart failure (HF). Endomyocardial biopsies were performed consecutively in 127 HF patients, and mitochondrial morphology data were obtained from 111 patients by electron microscopy. The patients were divided into three groups according to mitochondrial area quartiles (fission [Q1, area ≤ 0.119 μm2, n = 27], normal [Q2/Q3, 0.120 μm2 ≤ area ≤ 0.178 μm2, n = 55], and fusion [Q4, area ≥ 0.179 μm2, n = 28]). In the fission group, the serum N-terminal pro-brain natriuretic peptide and B-type natriuretic peptide (BNP) levels were significantly higher, and patients with HF and a reduced left ventricular ejection fraction were more common, than in the other groups. A multivariate logistic regression model showed that diabetes mellitus was independently associated with placement in the fission group (odds ratio: 2.835, 95%confidence interval [CI]: 1.037–7.752). A Kaplan–Meier curve analysis showed that the prognosis was significantly poorer in the fission group than in the other groups, and a multivariate Cox regression model revealed fission to be an independent predictor of 1500-day mortality (hazard ratio: 4.365, 95%CI: 1.198–15.909). The circulating levels of miR-140-5p (≥2500) were independently associated with the presence of mitochondrial fission (OR: 3.622, 95%CI: 1.260–10.413). Excessive mitochondrial fission was observed in patients with severe HF status, and was independently associated with adverse outcomes in HF patients. Circulating mitochondrial dynamics-related miRNA levels might be of use in detecting mitochondrial fission in the cardiomyocytes of HF patients. (Figure presented.)

DOI： 10.1038/s41440-025-02338-1

Scopus

PubMed

Ogawa Shimpei, Ishii Masanobu, Saito Shumpei, Seki Hiroshi, Ikeda Koshiro, Yasui Yuhei, Komatsu Tomohiro, Sato Ginga, Tabata Noriaki, Ohishi Mitsuru, Kubozono Takuro, Saito Naritatsu, Toda Kato Eri, Song Xiaoyang, Yamada Masahiro, Natori Shunsuke, Kunikane Yuki, Yokomatsu Takafumi, Kato Masashi, Sagara Yasuaki, Uchiyama Nami, Atsuchi Nobuhiko, Kawahara Shota, Natsugoe Shoji, Tsujita Kenichi . Deep Learning for Cardiac Overload Estimation: Predicting B-Type Natriuretic Peptide(BNP) Levels From Heart Sounds and Electrocardiogram(タイトル和訳中) . Circulation Journal89 ( 10 ) 1684 - 1692 2025.9

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Papers - OHISHI Mitsuru