Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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Kubota Kayoko, Miyanaga Sunao, Iwatani Noriko, Ohishi Mitsuru . 門脈肺高血圧症の治療中に検出され診断に至った心房中隔欠損症 1症例報告(Unknown atrial septal defect was diagnosed during the course of treatment for portopulmonary hypertension: A case report) . Journal of Cardiology Cases26 ( 5 ) 383 - 385 2022.11

Language：English Publisher：(一社)日本心臓病学会

症例は51歳女性で、呼吸困難を主訴に近医を受診し、経胸壁心エコー検査で肺高血圧を指摘された。精査と加療を目的に当院へ紹介された。B型肝炎ウイルス感染による非代償性肝硬変の既往があった。受診時の心エコー検査で右室拡大を認め、推定右室収縮期圧は68mmHgであった。腹部CTで著明に拡張した上腸間膜静脈と脾腫を認めた。肺血流シンチグラフィーで肺血栓塞栓の所見はなかった。右心カテーテル検査で肺動脈圧は収縮期が68mmHg、拡張期が23mmHg、平均圧が41mmHg、心係数は5.49L/min/m2であった。門脈圧亢進症による門脈肺高血圧症と診断し、マシテンタンの投与を開始し、2ヵ月後にタダラフィルに切り替えた。4ヵ月後の心エコー検査で以前は見られなかったシャント血流が検出された。肺動脈圧は収縮期43mmHg、拡張期16mmHg、平均26mmHgに低下し、右房酸素飽和度は87.1%に上昇した。心房中隔欠損症と診断し、Amplatzer閉鎖栓を用いた経カテーテル閉鎖術を施行した。1年後に肝性脳症に対して肝移植が施行され、3年後の肺動脈圧は収縮期23mmHg、拡張期10mmHg、平均15mmHgであった。

Atsushi Tanaka, Masataka Sata, Yosuke Okada, Hiroki Teragawa, Kazuo Eguchi, Michio Shimabukuro, Isao Taguchi, Kazuo Matsunaga, Yumiko Kanzaki, Hisako Yoshida, Tomoko Ishizu, Shinichiro Ueda, Masafumi Kitakaze, Toyoaki Murohara, Koichi Node, Koichi Node, Masafumi Kitakaze, Yoshihiko Nishio, Mitsuru Ohishi, Kazuomi Kario, Masataka Sata, Michio Shimabukuro, Wataru Shimizu, Hideaki Jinnouchi, Isao Taguchi, Hirofumi Tomiyama, Koji Maemura, Makoto Suzuki, Shinichi Ando, Kazuo Eguchi, Haruo Kamiya, Tomohiro Sakamoto, Hiroki Teragawa, Mamoru Nanasato, Munehide Matsuhisa, Junya Ako, Yoshimasa Aso, Masaharu Ishihara, Kazuo Kitagawa, Akira Yamashina, Yumi Ikehara, Ayako Takamori, Atsushi Tanaka, Miki Mori, Kaori Yamaguchi, Machiko Asaka, Tetsuya Kaneko, Masashi Sakuma, Shigeru Toyoda, Takahisa Nasuno, Michiya Kageyama, Jojima Teruo, Iijima Toshie, Haruka Kishi, Hirotsugu Yamada, Kenya Kusunose, Daiju Fukuda, Shusuke Yagi, Koji Yamaguchi, Takayuki Ise, Yutaka Kawabata, Akio Kuroda, Yuichi Akasaki, Mihoko Kurano, Satoshi Hoshide, Takahiro Komori, Tomoyuki Kabutoya, Yukiyo Ogata, Yuji Koide, Hiroaki Kawano, Satoshi Ikeda, Satoki Fukae, Seiji Koga, Yukihito Higashi, Shinji Kishimoto, Masato Kajikawa, Tatsuya Maruhashi, Yoshiaki Kubota, Yoshisato Shibata, Nehiro Kuriyama, Ikuko Nakamura, Kanemitsu Hironori, Bonpei Takase, Yuichi Orita, Chikage Oshita, Yuko Uchimura, Ruka Yoshida, Yukihiko Yoshida, Hirohiko Suzuki, Yasuhiro Ogura, Mayuho Maeda, Masaki Takenaka, Takumi Hayashi, Mirai Hirose, Itaru Hisauchi, Toshiaki Kadokami, Ryo Nakamura, Junji Kanda, Kazuo Matsunaga, Masaaki Hoshiga, Koichi Sohmiya, Yumiko Kanzaki, Arihiro Koyosue, Hiroki Uehara, Naoto Miyagi, Toshiya Chinen, Kentaro Nakamura, Chikashi Nago, Suguru Chiba, Sho Hatano, Yoshikatsu Gima, Masami Abe, Masayoshi Ajioka, Hiroshi Asano, Yoshihiro Nakashima, Hiroyuki Osanai, Takahiro Kanbara, Yusuke Sakamoto, Mitsutoshi Oguri, Shiou Ohguchi, Kunihiko Takahara, Kazuhiro Izumi, Kenichiro Yasuda, Akihiro Kudo, Noritaka Machii, Ryota Morimoto, Yasuko Bando, Takahiro Okumura, Toru Kondo, Shin-Ichiro Miura, Yuhei Shiga, Joji Mirii, Makoto Sugihara, Tadaaki Arimura, Junko Nakano, Tomohiro Sakamoto, Kazuhisa Kodama, Nobuyuki Ohte, Tomonori Sugiura, Kazuaki Wakami, Yasuhiko Takemoto, Minoru Yoshiyama, Taichi Shuto, Kazuo Fukumoto, Yosuke Okada, Kenichi Tanaka, Satomi Sonoda, Akemi Tokutsu, Takashi Otsuka, Fumi Uemura, Kenji Koikawa, Megumi Miyazaki, Maiko Umikawa, Manabu Narisawa, Machi Furuta, Hiroshi Minami, Masaru Doi, Kazuhiro Sugimoto, Susumu Suzuki, Akira Kurozumi, Kosuke Nishio . Effect of ipragliflozin on carotid intima-media thickness in patients with type 2 diabetes: A multicenter, randomized, controlled trial. . European heart journal. Cardiovascular pharmacotherapy9 ( 2 ) 165 - 172 2022.10Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

AIM: To examine the effects of 24-month treatment with ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients. METHODS: In this multicenter, prospective, randomized, open-label, blinded-endpoint investigator-initiated clinical trial, adults with type 2 diabetes and hemoglobin A1C (HbA1c) of 6.0%-10.0% (42-86 mmol/mol) were randomized equally to ipragliflozin (50 mg daily) and non-sodium-glucose cotransporter-2 (SGLT2) inhibitor use of standard-care (control group) for type 2 diabetes and were followed-up for 24 months. The primary endpoint was the change in mean common carotid artery IMT (CCA-IMT) from baseline to 24 months. RESULTS: A total of 482 patients were equally allocated to the ipragliflozin (N = 241) and control (N = 241) groups, and 464 patients (median age 68 years, female 31.7%, median type 2 diabetes duration 8 years, median HbA1c 7.3%) were included in the analyses. For the primary endpoint, the changes in the mean CCA-IMT from baseline to 24 months were 0.0013 (95% CI, -0.0155-0.0182) mm and 0.0015 (95% CI, -0.0155-0.0184) mm in the ipragliflozin and control groups, respectively, with an estimated group difference (ipragliflozin-control) of -0.0001 mm (95% CI, -0.0191-0.0189; P = 0.989). A group difference in HbA1c change at 24 months was also non-significant between the treatment groups (-0.1% [95% CI, -0.2-0.1]; P = 0.359). CONCLUSIONS: Twenty-four months of ipragliflozin treatment did not affect carotid IMT status in patients with type 2 diabetes recruited in the PROTECT study, relative to the non-SGLT2 inhibitor-use standard care for type 2 diabetes.

DOI： 10.1093/ehjcvp/pvac059

PubMed

Yoshiaki Taniguchi, Hyuma Makizako, Yuki Nakai, Yuto Kiuchi, Shoma Akaida, Mana Tateishi, Toshihiko Takenaka, Takuro Kubozono, Mitsuru Ohishi . Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults. . Journal of clinical medicine11 ( 20 ) 6172 2022.10Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

Bone and muscle mass loss are known to occur simultaneously. The alpha-actinin three (ACTN3) genotype has been shown to potentially affect bone and muscle mass. In this study, we investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged ≥ 60 years. This study was a cross-sectional analysis of data from 295 participants who participated in a community health checkup. The ACTN3 genotypes were classified as RR, RX, or XX types. Bone mass loss was defined as a calcaneal speed of sound T-score of <−1.32 and <−1.37, and muscle mass loss was defined as an appendicular skeletal muscle index of <7.0 kg/m2 and <5.7 kg/m2 in men and women, respectively. The percentages of XX, RX, and RR in the combined bone and muscle mass loss group were 33.8%, 30.8%, and 16.7%, respectively, with a significantly higher trend for XX. Multinomial logistic regression analysis showed that XX had an odds ratio of 3.00 (95% confidence interval 1.05−8.54) of being in the combined bone and muscle mass loss group compared to the RR group (covariates: age, sex, grip strength, and medications). The ACTN3 genotype of XX is associated with a higher rate of comorbid bone and muscle mass loss. Therefore, ACTN3 genotyping should be considered for preventing combined bone and muscle mass loss.

DOI： 10.3390/jcm11206172

Scopus

PubMed

入來泰久, 新山修平, 瀬尾浩希, 内山奈美, 永野祐志, 中條正典, 大石充, 垣花泰之 . MRI施行困難の急性期脳梗塞に対するPerfusion CTが診断・治療に有効であった1例 . 日本救急医学会雑誌33 ( 10 ) 816 - 816 2022.10

Makizako H, Kiyama R, Nakai Y, Kawada M, Tomioka K, Taniguchi Y, Takenaka T, Kubozono T, Ohishi M . Reference values of chair stand test and associations of chair stand performance with cognitive function in older adults . Aging and Health Research2 ( 3 ) 100090. 2022.9Reviewed

Michio Maruta, Suguru Shimokihara, Hyuma Makizako, Yuriko Ikeda, Gwanghee Han, Yoshihiko Akasaki, Yuma Hidaka, Taishiro Kamasaki, Takuro Kubozono, Mitsuru Ohishi, Takayuki Tabira . Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community-dwelling Japanese older adults. . Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society22 ( 5 ) 651 - 658 2022.9Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Frailty is a multidimensional condition characterised by reduced physical and psychological resilience. Older adults also frequently demonstrate apathy, suggesting that it shares similar neuro-physiological pathways with frailty. This cross-sectional study aimed to investigate the association between apathy and frailty as defined by a comprehensive assessment. METHODS: We analyzed 882 older adults (mean age: 74.4 ± 6.4 years; 62.1% female) who participated in a community-based health check survey (Tarumizu Study). Apathy was measured by the Geriatric Depression Scale-3A, a three-item subset of the Geriatric Depression Scale-15, and frailty by the Kihon Checklist of physical, psychological, functional, and social status. Associations were examined by multinomial logistic regression with frailty status (robust, pre-frailty, frailty) as the dependent variable, apathy as the independent variable, and sociodemographic factors, medications, cognitive function, functional capacity, and mood symptoms as potential confounders. RESULTS: Apathy was observed in 23.7% of individuals, and logistic regression revealed significant associations with both pre-frailty and frailty after confounder adjustment (pre-frailty: odds ratio (OR) 1.80, 95% CI 1.22-2.64; frailty: OR 3.24, 95% CI 1.63-6.42). Participants with apathy also exhibited greater deficits in the Kihon Checklist subdomains instrumental activities of daily living (P = 0.022), physical function (P < 0.001), oral function (P < 0.001), and cognitive function (P = 0.001). CONCLUSIONS: Our findings underscore the importance of comprehensive frailty assessment and demonstrate that apathy can have pervasive deleterious effects on geriatric health.

DOI： 10.1111/psyg.12867

Scopus

PubMed

川畑孟子, 小島聡子, 窪薗琢郎, 川添晋, 池田義之, 大石充 . レンバチニブメシル酸塩による薬剤性心筋症を来した一例 . 日本心臓病学会学術集会抄録70回 C - 14 2022.9

西晴香, 安崎和博, 神田大輔, 池田義之, 大石充 . PCIにてDES留置直後の外傷性左浅腹壁動脈損傷に対してコイル塞栓を行い良好に止血し得た一例 . 日本心臓病学会学術集会抄録70回 C - 8 2022.9

横峯辰生, 楠元啓介, 大坪稔拓, 福宿愛, 請園友之, 平峯温子, 湯淺敏典, 大石充 . COVID-19罹患後症状の経過中に冠動脈慢性完全閉塞病変が判明し治療し得た一例 . 日本心臓病学会学術集会抄録70回 C - 7 2022.9

Maruta Michio, Shimokihara Suguru, Makizako Hyuma, Ikeda Yuriko, Han Gwanghee, Akasaki Yoshihiko, Hidaka Yuma, Kamasaki Taishiro, Kubozono Takuro, Ohishi Mitsuru, Tabira Takayuki . 地域在住日本人高齢者におけるアパシーと基本チェックリストにより包括的に評価されたフレイルとの関連(Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community-dwelling Japanese older adults) . Psychogeriatrics22 ( 5 ) 651 - 658 2022.9

Language：English Publisher：John Wiley & Sons Australia, Ltd

地域在住高齢者におけるアパシーとフレイルとの横断的な関連について検討した。健康診断調査(垂水調査)に参加した地域在住高齢者882名(平均74.4±6.4歳、女性62.1%)を対象とした。アパシーはGeriatric Depression Scale-3Aで評価し、フレイルは基本チェックリスト(下位尺度;日常生活関連動作、運動器機能、低栄養状態、口腔機能、閉じこもり、認知機能)で評価した。その結果、209名(23.7%)でアパシーが認められた。交絡因子調整後の多項ロジスティック回帰分析の結果、アパシーはプレフレイルおよびフレイルと有意に関連していた。アパシーを有する高齢者では有さない高齢者と比較して、基本チェックリストの日常生活関連動作、運動器機能、口腔機能、認知機能に問題を呈する割合が有意に高かった。以上から、包括的なフレイル評価の重要性が示され、アパシーは老年期の健康に広範かつ有害な影響を及ぼす可能性が示唆された。

稲津真穂人, 片岡哲郎, 川畑深怜, 福崎篤, 新地秀也, 福元大地, 福永研吾, 高崎州亜, 永富脩二, 金城玉洋, 城ヶ崎倫久, 中島均, 大石充 . 卵円孔に管状静脈血栓が嵌頓した交通外傷後の1例 . 日本心臓病学会学術集会抄録70回 C - 11 2022.9

濱元裕喜, 田島亜佳里, 内山洋太, 堀添善尚, 安田久代, 大石充 . 三尖弁置換後早期に三尖弁人工弁機能不全を来たした1例 . 日本心臓病学会学術集会抄録70回 C - 22 2022.9

牛飼純平, 桑波田聡, 毛利翔悟, 才原啓司, 楠元啓介, 亀甲真弘, 山川暢英, 加藤智之, 小林拓也, 稲場俊弥, 村田信高, 斎藤理, 水野努, 竹中俊宏, 大石充 . 心音の定量指標(Cardiac Acoustic Biomarkers)の経時的変化が心不全の悪化予測に有用と考えられた慢性心不全の一例 . 日本心臓病学会学術集会抄録70回 C - 21 2022.9

吉元一成, 市來仁志, 鎌田博之, 二宮雄一, 入來泰久, 池田義之, 宮田昌明, 大石充 . 頻回の再発に対して3回目のアブレーション施行後に重度の急性胃拡張を発症した持続性心房細動の一例 . 日本心臓病学会学術集会抄録70回 C - 2 2022.9

上山未紗, 大牟禮健太, 安崎和博, 神田大輔, 池田義之, 大石充 . 深腸骨回旋動脈損傷による広範な皮下血腫を来した一例 . 日本心臓病学会学術集会抄録70回 C - 23 2022.9

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Papers - OHISHI Mitsuru