Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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Hiroaki Kanouchi, Mikako Yamashita, Kaori Kaimoto, Akiko Kuwabara, Yukiko Kawakami, Shigeo Takenaka, Chihaya Koriyama, So Kuwahata, Toshihiro Takenaka, Yuichi Akasaki, Takuro Kubozono, Masaaki Miyata, Mitsuru Ohishi . Association of blood pressure and dietary intake of Sunomono, Japanese vinegared side dishes, in community-dwelling Japanese: A cross-sectional study. . Heliyon8 ( 5 ) e09505 2022.5Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

Objective: Vinegar has been reported to have a hypotensive effect. We aimed to investigate the relationship between the consumption of vinegar-based side dishes and blood pressure. Research methods & procedures: This cross-sectional study included 746 individuals (257 men and 489 women) aged ≥40 years from Tarumizu, Kagoshima, Japan. Nutrient intake was estimated based on the brief-type self-administered diet history questionnaire. The intake frequency of vinegar-based side dishes (Sunomono and pickles) was determined using a self-administered diet history questionnaire. Participants who did not consume vinegar-based side dishes for a month were defined as having no Sunomono or pickle eating habit. Blood pressure was categorized into four groups according to the Japanese Society of Hypertension Guidelines for the Management of Hypertension. The association between the intake of vinegar-based side dishes and blood pressure categories was analyzed using ordinal logistic regression analysis adjusted for age, body mass index, smoking history, excessive alcohol intake, living situation, energy intake, protein intake, sodium intake, potassium intake, and seaweed intake. Results: Approximately 13.6% men and 6.1% women had no Sunomono eating habits. In men, eating Sunomono, but not pickles, was significantly related to blood pressure categories (estimate, -0.702; 95% CI, -1.122 to -0.310), whereas more frequent consumption of Sunomono did not show an improvement in the blood pressure category. The relationship between eating Sunomono and blood pressure categories was not recognized in women. Conclusion: This was the first study assessing the association between consumption of vinegar-based side dishes and blood pressure categories. We highlighted the effect of Sunomono consumption on blood pressure categories in men. Consumption of Sunomono may improve blood pressure in men.

DOI： 10.1016/j.heliyon.2022.e09505

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Shidou Rumi, Kohjitani Atsushi, Miyata Masaaki, Yamashita Kaoru, Ohno Sachi, Ohishi Mitsuru, Sugimura Mitsutaka . 心エコー所見およびバイオマーカーを用いた軽度から中等度の手術後の高血圧発症リスクの推定(Estimation of the Risk of Postoperative Hypertension Following Minor to Moderate Surgery Using an Echocardiogram and Biomarkers) . International Heart Journal63 ( 3 ) 558 - 565 2022.5

Language：English Publisher：(一社)インターナショナルハートジャーナル刊行会

全身麻酔による歯科口腔外科手術を施行した患者213例を対象に、術後高血圧症の関連因子について検討した。術後1週間以内に収縮期血圧が170mmHg以上または拡張期血圧が100mmHg以上を呈した症例を術後高血圧と定義した。術後高血圧は32例で認めた。患者を術後高血圧の陽性群32例(男性19例、女性13例、平均74.6±10.6歳)と陰性群181例(男性111例、女性70例、平均70.9±11.4歳)に分類した。左室心筋重量係数は術後高血圧群(113.5±31.3)の方が陰性群(100.1±24.6)より有意に高く(P=0.0072)、E/e'も術後高血圧群の方が有意に高かった。脳性ナトリウム利尿ペプチド(BNP)、NT-proBNP、高感度心筋トロポニンT(hs-TnT)は術後高血圧群の方が有意に高く、NT-proBNPおよびhs-TnTはE/e'と正に相関した。多重ロジスティック回帰分析でNT-proBNP(OR:1.0020、P=0.0496)、hs-TnT(OR:1.0658、P=0.0472)、入院時の収縮期血圧(OR:1.0348、P=0.0026)が術後高血圧の有意な関連因子であった。

Koichi Yamamoto, Hiroshi Akasaka, Yukiko Yasunobe, Atsuya Shimizu, Kenichiro Nomoto, Kumiko Nagai, Hiroyuki Umegaki, Yuichi Akasaki, Taro Kojima, Koichi Kozaki, Masafumi Kuzuya, Mitsuru Ohishi, Masahiro Akishita, Yoichi Takami, Hiromi Rakugi . Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment. . Hypertension research : official journal of the Japanese Society of Hypertension45 ( 4 ) 612 - 619 2022.4Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

To treat older patients with hypertension, it is important to detect cognitive impairment at an early stage because of its potential influence on treatment efficacy and functional prognosis. In this study, we aimed to identify the incidence and determinants of cognitive impairment in hypertensive patients aged 65 years and above who visited our outpatient clinic and were not previously diagnosed with cognitive impairment. Among 312 patients with hypertension, we found that 35% (n = 109) and 7.7% (n = 24) had cognitive impairment and dementia, respectively, as defined by the Mini-Mental State Examination (≤27 or ≤23, respectively). Patients with cognitive impairment were older, had lower levels of education, and had lower instrumental activities of daily living (IADL) scores than those without cognitive impairment. Multiple regression analysis revealed that age and IADL were associated with cognitive impairment in patients with hypertension. Regarding the treatment of hypertension, the office and home blood pressure levels, number of antihypertensive medications prescribed, and proportion of the use of each antihypertensive drug was equivalent between patients with and without cognitive impairment. Finally, patients with unrecognized cognitive impairment showed distinct clinical characteristics, including high antihypertensive medication burden and preserved IADL, when compared to hypertensive patients in the different cohorts of definitive mild cognitive impairment of a similar age. These findings suggest that older hypertensive patients are at a high risk of masked cognitive decline, even if they are functionally independent.

DOI： 10.1038/s41440-022-00861-z

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Kazuki Shiina, Hirofumi Tomiyama, Atsushi Tanaka, Hisako Yoshida, Kazuo Eguchi, Kazuomi Kario, Toru Kato, Hiroki Teragawa, Shigeru Toyoda, Mitsuru Ohishi, Yoshihiro Fukumoto, Bonpei Takase, Tomoko Ishizu, Koichi Node . Differential effect of a xanthine oxidase inhibitor on arterial stiffness and carotid atherosclerosis: a subanalysis of the PRIZE study. . Hypertension research : official journal of the Japanese Society of Hypertension45 ( 4 ) 602 - 611 2022.4Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

Atherosclerosis and arterial stiffness are phenotypes of atherosclerotic vascular damage. Atherosclerosis originates from endothelial vascular damage and forms focal morphological lesions; arterial stiffness originates from diffuse medial-layer damage in the arterial tree. Thus, the two phenomena reflect different facets of atherosclerotic vascular damage, and they both gradually progress. We conducted a subanalysis to compare the long-term effects of febuxostat on atherosclerosis and arterial stiffness in the PRIZE study (a multicenter, prospective, randomized, open-label, blinded-endpoint clinical trial to examine the effect of febuxostat on carotid atherosclerosis). Among 514 study participants, arterial stiffness parameters (brachial-ankle pulse wave velocity or cardio-ankle vascular index) were obtained at baseline, 12 months, and 24 months in 100 subjects. Among them, 48 subjects were allocated to the control group (i.e., nonpharmacological lifestyle modification for hyperuricemia), and 52 subjects were allocated to the febuxostat treatment group. While the decrease in serum uric acid was greater in the febuxostat group than in the control group, the adjusted percentage decrease in arterial stiffness parameters at month 24 was greater in the febuxostat group than in the control group, with a mean between-group difference (febuxostat - control) of -5.099% (95% confidence interval (CI) -10.009% to -0.188%, p = 0.042). Thus, long-term treatment with febuxostat may exert beneficial effects on arterial stiffness without improving carotid atherosclerosis. A long-term study to examine the effect of febuxostat on cardiovascular outcomes related to increased arterial stiffness is warranted.

DOI： 10.1038/s41440-022-00857-9

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Yamamoto Koichi, Akasaka Hiroshi, Yasunobe Yukiko, Shimizu Atsuya, Nomoto Kenichiro, Nagai Kumiko, Umegaki Hiroyuki, Akasaki Yuichi, Kojima Taro, Kozaki Koichi, Kuzuya Masafumi, Ohishi Mitsuru, Akishita Masahiro, Takami Yoichi, Rakugi Hiromi, Cherry Study Group . 【アジアにおける高血圧管理の現在のエビデンスと展望】認知機能障害が認められない高血圧症高齢者の臨床的特徴(【Current evidence and perspectives for hypertension management in Asia】Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment) . Hypertension Research45 ( 4 ) 612 - 619 2022.4

Language：English Publisher：Nature Publishing Group

当院外来を受診した65歳以上の高血圧症患者のうち、過去に認知障害と診断されていない患者312例を対象に、認知機能障害の発生率とその決定要因について検討した。評価項目は患者背景、ミニメンタルステート検査、手段的日常生活動作(IADL)などとした。認知機能障害の高血圧患者109例(男性54例、平均79.0±6.5歳)、非認知機能障害の高血圧患者203例(男性95例、平均75.0±5.4歳)を対象とした。その結果、認知機能障害の高血圧患者は、非認知機能障害の高血圧患者と比較して、高齢で、教育水準が低く、IADLスコアが低かった。重回帰分析の結果、年齢およびIADLが高血圧患者の認知障害と関連していることが示された。両群間で診察室血圧および家庭血圧、降圧剤処方数、各降圧剤の使用割合は同程度であった。また、本試験に参加した認知機能障害の高血圧患者とORANGEレジストリに登録されたMCIを有する高血圧患者を比較した。その結果、本試験に参加した認知機能障害の高血圧患者はORANGEレジストリ患者と比較して降圧剤処方数が多く、重度の高血圧であることが示された。ORANGEレジストリ患者では本試験の患者と比較してIADL障害を有していることが示された。以上から、高血圧高齢患者は、たとえ機能的に自立していたとしても、隠れた認知機能低下リスクが高いことが示唆された。

Shiina Kazuki, Tomiyama Hirofumi, Tanaka Atsushi, Yoshida Hisako, Eguchi Kazuo, Kario Kazuomi, Kato Toru, Teragawa Hiroki, Toyoda Shigeru, Ohishi Mitsuru, Fukumoto Yoshihiro, Takase Bonpei, Ishizu Tomoko, Node Koichi, the PRIZE Study Investigators . 【アジアにおける高血圧管理の現在のエビデンスと展望】動脈壁硬化および頸動脈アテローム硬化に対するキサンチンオキシダーゼ阻害剤の効果の違い　PRIZE試験のサブ解析(【Current evidence and perspectives for hypertension management in Asia】Differential effect of a xanthine oxidase inhibitor on arterial stiffness and carotid atherosclerosis: a subanalysis of the PRIZE study) . Hypertension Research45 ( 4 ) 602 - 611 2022.4

Language：English Publisher：Nature Publishing Group

PRIZE試験は、頸動脈アテローム硬化に対するフェブキソスタット(Feb)の効果について検討した多施設共同前向き無作為化非盲検エンドポイント臨床試験である。今回、PRIZE試験のサブ解析を実施し、アテローム硬化および動脈壁硬化に対するFebの長期効果を比較した。Feb群52例(中央値66.55歳)と対照群48例(中央値71.00歳)を対象とした。評価項目は、ベースライン時、12ヵ月時、24ヵ月時の動脈壁硬化パラメータ(上腕・足首間脈波伝播速度または心臓足首血管指数)、総頸動脈中膜内膜複合体厚などとした。その結果、Feb群では対照群と比較して血清尿酸値の減少が大きかった。しかし、24ヵ月時点での動脈壁硬化パラメータの調整済み減少率は、対照群と比較してFeb群で大きかった(平均群間差、Feb-対照、p=0.042)。平均総頸動脈中膜内膜複合体厚のベースラインから24ヵ月までの変化率に両群間で差は認められなかった。以上から、Feb長期投与は頸動脈アテローム硬化を改善することなく、動脈壁硬化に有益な効果を発揮する可能性が示された。

Kawasoe M., Kawasoe S., Kubozono T., Ojima S., Kawabata T., Ikeda Y., Oketani N., Miyahara H., Tokushige K., Miyata M., Ohishi M. . Development of a risk prediction score for hypertension incidence using Japanese health checkup data . Hypertension Research45 ( 4 ) 730 - 740 2022.4Reviewed

Language：Japanese Publisher：Hypertension Research

Hypertension is a risk factor for cardiovascular disease. We developed a simple scoring method for predicting future hypertension using health checkup data. A total of 41,902 participants aged 30–69 years without baseline hypertension who underwent annual health checkups (mean age, 52.3 ± 10.2 years; male, 47.7%) were included. They were randomly assigned to derivation (n = 27,935) and validation cohorts (n = 13,967) at a ratio of 2:1. In the derivation cohort, we performed multivariable logistic regression analysis and assigned scores to each factor significantly associated with 5-year hypertension. We evaluated the predictive ability of the scores using area under the curve (AUC) analysis and then applied them to the validation cohort to assess their validity. The score including items requiring blood sampling ranged from 0 to 14 and included seven indicators (age, body mass index, blood pressure, current smoking, family history of hypertension, diabetes, and hyperuricemia). The score not including items requiring blood sampling ranged from 0 to 12 and included five indicators (the above indicators, except diabetes and hyperuricemia). The score not including items requiring blood sampling was better; blood sampling did not improve diagnostic ability. The AUC of the score not including items requiring blood sampling was 0.76, with a sensitivity and specificity of 0.82 and 0.60, respectively, for scores ≥6 points. The incidence of hypertension gradually and constantly increased (from 0.9 to 49.6%) as the score increased from 0 to ≥10. Analysis in the validation cohort yielded similar results. We developed a simple and useful clinical prediction model to predict the 5-year incidence of hypertension among a general Japanese population. The model had reasonably high predictive ability and reproducibility.

DOI： 10.1038/s41440-021-00831-x

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谷口善昭, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における骨量および筋量の低下と身体活動との関連性 . 理学療法学49 ( 2 ) 131 - 138 2022.4

Language：Japanese Publisher：(一社)日本理学療法学会連合

【目的】地域在住高齢者における骨量・筋量低下と身体活動との関連性を明らかにすることを目的とした。【方法】地域コホート研究(垂水研究2018)に参加した地域在住高齢者173名を分析対象とした。骨量低下は%YAMが70%以下とし,筋量低下は四肢骨格筋指数がサルコペニアの基準より低いものとした。身体活動量は3軸加速度計を用いて,座位行動時間延長,中高強度身体活動時間低下,歩数低下の有無に分類した。骨量・筋量をもとに正常群,骨量低下群,筋量低下群,骨量・筋量低下群の4群に分類し,基本情報および身体活動を比較した。【結果】骨量・筋量低下群は正常群と比べて中高強度身体活動時間が有意に減少していた(オッズ比3.29,p<0.05,共変量:年齢(5歳階級),性別,歩行速度低下,うつ傾向)。【結論】骨量・筋量低下を併存している高齢者は,中高強度身体活動時間が減少していることが示唆された。(著者抄録)

Kawasoe Mariko, Kawasoe Shin, Kubozono Takuro, Ojima Satoko, Kawabata Takeko, Ikeda Yoshiyuki, Oketani Naoya, Miyahara Hironori, Tokushige Koichi, Miyata Masaaki, Ohishi Mitsuru . 日本の健康診断データを用いた高血圧発症リスク予測スコアの開発(Development of a risk prediction score for hypertension incidence using Japanese health checkup data) . Hypertension Research45 ( 4 ) 730 - 740 2022.4

Language：English Publisher：Nature Publishing Group

大規模健康診断データを用いて、5年高血圧発症リスクを予測するためスコアリング法の開発を試みた。ベースライン時点で高血圧を有さなかった年次健康診断受診者41902例(男性47.7%、平均52.3±10.2歳)を対象とした。受診者をderivationコホート27935例、validationコホート13967例に無作為にわけて検討した。採血を要するリスクスコア(0～14点;年齢、BMI、血圧、現在の喫煙状況、高血圧の家族歴、糖尿病、高尿酸血症の有無)、採血不要のリスクスコア(0～12点;糖尿病および高尿酸血症を除く上記因子)を作成した。その結果、採血不要スコアのAUCは0.76であり、6点以上では感度、特異度はそれぞれ0.82、0.60であり、採血を要するスコアとほぼ同じであった。高血圧発症率はスコアが高くなるにつれて上昇していた(0～10点以上)。validationコホートでの解析でも同様の結果が得られた。以上から、本モデルの高い予測能および再現性が示された。

Language：English Publisher：Nature Publishing Group

MAIZAKO Hyuma, SHIRATSUCHI Daijo, SHIIBA Ryuhei, TANIGUCHI Yoshiaki, KUBOZONO Takuro, OHISHI Mitsuru . Correlation of sarcopenia with orthopedic disorders, history of falls, and polypharmacy among community-dwelling older adults . Journal of Physical Therapy for Prevention1 ( 0 ) 19 - 24 2022.3Reviewed

Language：Japanese Publisher：Japanese Society of physical therapy for prevention

Objective: This study aimed to examine the correlation of sarcopenia with orthopedic disorders, history of falls, and polypharmacy among community-dwelling older adults.Methods: Data from 905 older adults who participated in community-based health check-up were analyzed. Participants were asked to provide their history of orthopedic disorders, number of prescription medicines, and experience of fall during the past year. Sarcopenia was assessed based on the AWGS2019 criteria.Results: The prevalence rate of sarcopenia was 18.3 % (n = 166). Although participants with osteoporosis showed a higher prevalence rate, there were no associations of sarcopenia with osteoarthritis and spinal disease. In the logistic regression analyses, there was no significant association between orthopedic disorders and sarcopenia, whereas history of falls (odds ratio = 1.65) and polypharmacy (≥6) (odds ratio = 1.56) were significantly associated with sarcopenia.Conclusions: A higher prevalence rate of sarcopenia was observed in older adults with osteoporosis. However, there was no significant association found between sarcopenia and orthopedic disorders, including osteoporosis in the multivariate analysis, whereas history of falls and polypharmacy were determined as associated factors with sarcopenia among community-dwelling older adults.

DOI： 10.57304/jptp.1.0_19

CiNii Research

Taniguchi Yoshiaki, Nakai Yuki, Tomioka Kazutoshi, Kubozono Takuro, Takenaka Toshihiro, Ohishi Mitsuru, Makizako Hyuma . Relationship between bone mass and the frequency of stair usage in community-dwelling older adults . Japanese Journal of Community-based Comprehensive Physical Therapy1 ( 0 ) 18 - 23 2022.3

Language：Japanese Publisher：Japanese Society of Community-based Comprehensive Physical Therapy

Objective: The purpose of this study was to determine the relationship between the measured mass of the calcaneus bone and the number of stairs used by community-dwelling older adults. Methods: Data obtained from 169 older adults who participated in a community-based health-check survey (Tarumizu Study 2018) were analyzed. Bone mass was measured using the speed of sound of the calcaneal bone and the obtained values were considered to be low when the percentage of the %YAM of the SOS was ≤ 70%. The frequency of stair usage was classified into two groups: 0 and 1 or more times per day at home, and three sub-groups comprising of: 0–2, 3–7, and 8 or more times per week outside home. Results: The results of logistic regression analysis, in which the dependent variable was the presence or absence of bone loss, and the independent variable was the number of stairs used, showed no significant association with the number of stairs used at home. The number of times the stairs were used outside home was set at 0–2 times as a reference, and bone loss was significantly reduced by 8 times or more (odds ratio 0.32, 95% confidence interval 0.11 –0.97, p = 0.045, covariates: age, gender, ASMI, grip strength, walking speed). Conclusion: It was suggested that the frequent use of stairs outside the home may aid in suppressing bone loss. It could be concluded that the use of stairs in activities including going out may affect bone mass as the frequency of stair usage in the house is not relevant.

DOI： 10.57351/jjccpt.1.0_18

CiNii Research

Anzaki K, Kanda D, Ikeda Y, Takumi T, Tokushige A, Ohmure K, Sonoda T, Arikawa R, Ohishi M . Impact of Malnutrition on Prognosis and Coronary Artery Calcification in Patients with Stable Coronary Artery Disease . Current Problems in Cardiology 101185 2022.3Reviewed

Publisher：Current Problems in Cardiology

Nutritional status is an important factor affecting prognosis of cardiovascular diseases. We compared major cardiovascular and cerebrovascular events (MACCE) between the malnutrition (geriatric nutritional risk index <92) and non-malnutrition (geriatric nutritional risk index ≥92) groups in 500 stable coronary artery disease patients undergoing percutaneous coronary intervention and evaluated coronary calcification by intravascular ultrasound. Incidences of all-cause death and MACCE differed between the malnutrition and non-malnutrition groups (22% vs 5%, P < 0.001 and 24% vs 6%, P < 0.001). In multivariate Cox proportional hazards regression, malnutrition significantly correlated with all-cause death (P = 0.006) and MACCE (P = 0.010). The proportion of moderate/severe calcification differed between the malnutrition (64%) and non-malnutrition groups (33%, P < 0.001). Multivariate logistic analysis identified age (P < 0.001), malnutrition (P = 0.048), and hemodialysis (P < 0.001) as significantly related to moderate/severe calcification. Malnutrition was an independent risk factor for all-cause death and MACCE in coronary artery disease patients after percutaneous coronary intervention and was associated with moderately/severely calcified lesions.

DOI： 10.1016/j.cpcardiol.2022.101185

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Ayumi Wada, Hyuma Makizako, Yuki Nakai, Kazutoshi Tomioka, Yoshiaki Taniguchi, Nana Sato, Yuto Kiuchi, Ryoji Kiyama, Takuro Kubozono, Toshihiro Takenaka, Mitsuru Ohishi . Association between cognitive frailty and higher-level competence among community-dwelling older adults. . Archives of gerontology and geriatrics99 104589 - 104589 2022.3Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

OBJECTIVES: The purpose of this cross-sectional study was to examine the association between cognitive frailty (CF) and higher-level competence among community-dwelling older adults. METHODS: Data from 871 older adults (aged ≥ 65 years, mean age 74.3 years, 61.5% women) who had participated in a community-based health check survey (Tarumizu Study 2018-2019) were analyzed. CF was defined as comorbid physical frailty and mild cognitive impairment (MCI). We defined physical frailty as either slow walking speed or poor grip strength. MCI was defined as values below the age- and education-adjusted reference threshold in several tests. Participants were categorized into four groups: robust, physical frailty, MCI, and CF. Higher-level competence was assessed using the Japan Science and Technology Agency Index of Competence (JST-IC). The JST-IC consists of 16 items and four subscales (technology usage, information practice, life management and social engagement). The bottom 20-30% score of the JST-IC and each subscale corresponded to poor higher-level competence. RESULTS: The prevalence of CF was 14.4%. Multivariate logistic regression analysis showed that, CF was significantly associated with poor higher-level competence (odds ratio 1.92, 95% confidence interval 1.18-3.13) after adjusting for covariates. Using a similar analysis to assess the JST-IC subscales, CF was associated with limitations on technology usage (odds ratio 2.29, 95% confidence interval 1.36-3.85) and low social engagement (odds ratio 1.62, 95% confidence interval 1.00-2.61). CONCLUSIONS: This study suggests that CF is associated with poor higher-level competence, especially limitations on technology usage and low social engagement.

DOI： 10.1016/j.archger.2021.104589

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Michio Maruta, Hyuma Makizako, Yuriko Ikeda, Gwanghee Han, Suguru Shimokihara, Hironori Miyata, Atsushi Nakamura, Keiichiro Tokuda, Takuro Kubozono, Mitsuru Ohishi, Kounosuke Tomori, Shoma Akaida, Takayuki Tabira . Characteristics of meaningful activities in community-dwelling Japanese older adults with pre-frailty and frailty . Archives of Gerontology and Geriatrics99 104616 - 104616 2022.3Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

OBJECTIVES: This cross-sectional study aimed to clarify the association between physical and social frailty, cognitive impairment, and meaningful activity in older adults. METHODS: Data were obtained from 747 older adults (mean age, 74.7 ± 6.2 years; women, 63.9%) who participated in a community-based health check survey (Tarumizu Study 2018). Physical frailty, cognitive impairment, and social frailty were evaluated using the Fried phenotype model (exhibiting one or more of the criteria, including having a pre-frailty status); computerized cognitive test including memory, attention, executive functions, and processing speed (having a score below an age-education adjusted reference threshold in one or more domains); and Makizako's 5 items (exhibiting one or more of the criteria, including having a pre-frailty status), respectively. Participants selected meaningful activities from the 95 activities included in the Aid for Decision-Making in Occupation Choice, after which their satisfaction and performance were evaluated. Meaningful activities were categorized into physical activity, cognitive activity, social activity, and other daily activity. RESULTS: The physical frailty group was significantly less likely to choose physical activity over other activities (p < 0.05). The cognitive impairment group was significantly less likely to choose cognitive activity over other activities (p < 0.01). The multi-domain frailty group (including cognitive impairment) was significantly less likely to choose social activity over other activities (p < 0.05). No significant differences in satisfaction and performance were observed according to frailty status. CONCLUSIONS: Our findings indicated that physical and social frailty and cognitive impairment may affect participation in meaningful activities corresponding to these domains.

DOI： 10.1016/j.archger.2021.104616

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MAKIZAKO Hyuma, AKAIDA Shoma, TATEISHI Mana, MATSUNO Takaya, SUZUKI Shingo, HIRATSUKA Tatsuya, TAKENAKA Toshihiro, KUBOZONO Takuro, OHISHI Mitsuru . Modifiable factors related to mild cognitive impairment in community-dwelling older adults: A cross-sectional study using a propensity score-matched analysis . Japanese Journal of Geriatric Therapy1 ( 0 ) 1 - 8 2022.3

Language：Japanese Publisher：The Japan Geriatric Therapy Society

【Aim】 This study aimed to determine the modifiable risk factors related to mild cognitive impairment (MCI) and associations between combinations of those factors and MCI in community-dwelling older adults.【Methods】 This cross-sectional study included a total of 578 community-dwelling older adults (aged ≥ 65 years) who had undergone health checkups and were divided into MCI (n = 289) and non-MCI (n = 289) groups. Non-MCI participants were selected through propensity score matching to balance age and gender. The modifiable factors related with MCI were determined and categorized based on those combinations using a decision tree analysis.【Results】 Weakness (grip strength < 28 kg for men, < 18 kg for women), poor sleep quality, and social inactivity (non-participate in regional events) were determined as and categorized based on combinations of those factors. The lowest prevalence rate of MCI was in the non-weakness and non-poor sleep quality group (37.7%) and the highest was in the weakness and social inactivity group (82.0%).【Conclusions】 The combinational status that maintained muscle strength and better sleep quality could be associated with a lower risk of cognitive deficits. However, older adults with weakness and social inactivity would have a greater risk of MCI. Maintenance of muscle strength, sleep quality, and social activity may be helpful in preventing cognitive decline among community-dwelling older adults. When any of those factors decline, the other factors should be maintained for cognitive health.

DOI： 10.57270/jgts.2022_006

CiNii Research

Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, Kuwahata S, Takenaka T, Maeda M, Fujiwara S, Miyagawa K, Ikeda Y, Ohishi M. . The relationship between day-to-day variability in home blood pressure measurement and multiple organ function. . Hypertens Res45 ( 3 ) 474 - 482 2022.3Reviewed

牧迫飛雄馬, 白土大成, 椎葉竜平, 谷口善昭, 窪薗琢郎, 大石充 . 地域在住高齢者における運動器疾患、転倒歴および多剤併用とサルコペニアとの関連 . 日本予防理学療法学会雑誌1 19 - 24 2022.3

Language：Japanese Publisher：(一社)日本予防理学療法学会

【目的】地域在住高齢者における運動器疾患,転倒歴および多剤併用とサルコペニアとの関連性を調べることを目的とした。【方法】地域コホート研究に参加した高齢者905名を対象とし,運動器疾患の有無,1日の服薬数,過去1年間での転倒歴を聴取した。サルコペニアはAWGS2019の基準で判定した。【結果】全対象者のうちの166名(18.3%)がサルコペニアに該当した。骨粗鬆症を有する者ではサルコペニアの該当者が有意に多かったが,脊椎疾患および変形性関節症とサルコペニアとの関連は認められなかった。ロジスティック回帰分析の結果,運動器疾患とサルコペニアの関連は確認されず,多剤併用(6剤以上)(オッズ比1.56)および転倒歴(オッズ比1.65)がサルコペニアと有意に関連していた。【結論】骨粗鬆症を有する高齢者ではサルコペニアに該当する者の割合が高かったものの,多変量解析においてはサルコペニアと運動器疾患との関連性は認められず,多剤併用および転倒歴がサルコペニアと関連する要因として抽出された。(著者抄録)

Kubozono Takuro, Akasaki Yuichi, Kawasoe Shin, Ojima Satoko, Kawabata Takeko, Makizako Hyuma, Kuwahata So, Takenaka Toshihiro, Maeda Mayuka, Fujiwara Seisuke, Miyagawa Ken, Ikeda Yoshiyuki, Ohishi Mitsuru . 家庭血圧測定の日間変動と複数臓器の機能との関係(The relationship between day-to-day variability in home blood pressure measurement and multiple organ function) . Hypertension Research45 ( 3 ) 474 - 482 2022.3

Language：English Publisher：Nature Publishing Group

鹿児島県の地域健診受診者315名(女性201名、平均70±9歳)を対象に、血圧変動と臓器機能の関連について検討した。1ヵ月間(連日、起床後1時間以内)の家庭血圧値の変動係数(CV)四分位群間で心機能(脳性ナトリウム利尿ペプチド前駆体N端フラグメント(NT-proBNP)と高感度トロポニンT)、肝機能(Fib4 index)、腎機能(推算糸球体濾過量;eGFR)を比較した。多変量ロジスティック回帰分析の結果、収縮期血圧CV高位群ほどeGFR低値(<60mL/min/1.73m2)、Fib4 index高値(>2.67)、NT-proBNP高値(>70pg/mL[中央値])のオッズ比が高かった。高感度トロポニンT高値(>0.007ng/mL[中央値])との関連は全群で認められなかった。拡張期血圧CV高位群はNT-proBNP高値のオッズ比が高く、最高四分位群はFib4 index高値のオッズ比も高かったが、eGFR低値および高感度トロポニンT高値との関連はみられなかった。以上から、家庭血圧の日間変動は心臓、肝臓、腎臓のバイオマーカーと独立して関連していることが示された。

牧迫飛雄馬, 赤井田将真, 立石麻奈, 松野孝也, 鈴木真吾, 平塚達也, 竹中俊宏, 窪薗琢郎, 大石充 . 地域在住高齢者の軽度認知障害と関連する可変因子　傾向スコア・マッチング法を用いた横断研究 . 日本老年療法学会誌1 1 - 7 2022.3

Language：Japanese Publisher：(一社)日本老年療法学会

地域在住高齢者の軽度認知障害(Mild Cognitive Impairment:MCI)に関連する可変因子を探索し、それらの組み合わせによるMCIとの関連を傾向スコア・マッチング法を用いて検討することを目的に、地域コホート研究の参加者で年齢と性別でマッチングされた65歳以上の高齢者578名(MCI群289名[平均年齢76.4±6.4歳]、非MCI群289名[平均年齢75.9±6.5歳])を対象に、身体機能評価(握力、通常歩行速度)および質問紙による生活状況の調査を行った。決定木分析の結果、握力低下(男性28kg未満、女性18kg未満)、睡眠の質の低下、社会参加(地域の祭りや行事などへの参加)の有無の組み合わせによりグループが形成され、MCIの割合は握力低下なし+睡眠の質の低下なし群(グループI)で最も低く(37.7%)、握力低下あり+地域行事の参加なしの群(グループIV)で最も高かった(82.0%)。

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