Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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Yokomine T., Kajiya T., Takei T., Kitazono K., Ninomiya T., Inoue T., Takaoka J., Atsuchi Y., Atsuchi N., Ohishi M. . Impact of Calcified Nodules on Clinical Outcomes in Hemodialysis Patients Undergoing Percutaneous Coronary Intervention . American Journal of Cardiology245 35 - 37 2025.6Reviewed

Language：Japanese Publisher：American Journal of Cardiology

Calcified nodules (CNs) are associated with poor prognosis after percutaneous coronary intervention (PCI) and have been reported to occur more frequently in hemodialysis patients. However, their prognosis in hemodialysis patients undergoing PCI has not been fully elucidated. We aimed to investigate the prognosis of hemodialysis patients who underwent PCI for CNs using intravascular ultrasound (IVUS) and/or optical coherence tomography (OCT)/optical frequency domain imaging (OFDI). About 141 hemodialysis patients who underwent PCI between January 2020 and December 2021 were analyzed retrospectively in a single center. CNs are defined as heavily calcified plaques that protruding into lumen in a convex shape. MACE (a composite of cardiovascular death, target lesion related myocardial infarction, and target lesion revascularization) between CNs and Non-CNs at 1 year were compared. In the entire study population, the mean age was 69.3 ± 10.7 years, and 94 (77.0%) were male. At 1 year, the incidence of MACE following PCI was significantly higher in the CNs group (39.2% vs 9.9%, log-rank p <0.001), particularly for cardiovascular death (17.7% vs 4.2%, log-rank p = 0.009). After multivariate analysis adjusting for demographic characteristics, CNs remained independently associated with increased risk of MACE (adjusted hazard ratio: 4.93, 95% confidence interval 2.07 to 11.76; p <0.001). CNs were associated with a higher incidence of MACE and a higher cardiovascular death rate in hemodialysis patients who underwent PCI.

DOI： 10.1016/j.amjcard.2025.03.007

Scopus

PubMed

Kanda D, Tokushige A, Ohmure K, Fukumoto D, Shimono H, Tabata H, Ito N, Kubozono T, Ohishi M . Impact of Angiotensin-Converting Enzyme Inhibitor on Coronary Artery Calcification Evaluated by Intravascular Ultrasound: A Retrospective Cohort Study . Health Sci Rep.8 ( 6 ) e70900 2025.6Reviewed

赤﨑雄一, 大石充 . 特集肥満と循環器疾患識る3 循環器専門医の観点から . Heart View29 ( 6 ) 552 - 555 2025.6

黒田正幸, 宮田昌明, 赤崎雄一, 宇辰賢祐, 三好潤子, 切無澤美香, 前澤善朗, 大石充, 横手幸太郎 . LCAT活性の測定により診断に至ったマイルドな複合ヘテロ接合体魚眼病症例 . 日本動脈硬化学会総会プログラム・抄録集57回 239 - 239 2025.6

赤崎雄一, 大石充 . 【肥満と循環器疾患】識る　循環器専門医の観点から　肥満と高血圧 . Heart View29 ( 6 ) 552 - 555 2025.6

Language：Japanese Publisher：(株)メジカルビュー社

＜文献概要＞Point　1 肥満による幼少期や若年の高血圧は,成人に移行しやすく,循環器疾患の最大のリスクである。2 交感神経系やレニン・アンジオテンシン・アルドステロン系の活性化が,高血圧発症に関与する。3 仮面高血圧や測定誤差に注意し,家庭血圧測定や適切なカフサイズで診断する必要がある。

赤崎雄一, 徳武大輔, 新地秀也, 上坊翔太, 宮田昌明, 大石充 . 家族性高コレステロール血症を疑われていたが、シトステロール血症と診断された1例 . 日本動脈硬化学会総会プログラム・抄録集57回 240 - 240 2025.6

赤崎雄一, 大石充 . 【肥満と循環器疾患】識る循環器専門医の観点から肥満と高血圧 . Heart View29 ( 6 ) 552 - 555 2025.6

Language：Japanese Publisher：(株)メジカルビュー社

＜文献概要＞Point 1 肥満による幼少期や若年の高血圧は,成人に移行しやすく,循環器疾患の最大のリスクである。2 交感神経系やレニン・アンジオテンシン・アルドステロン系の活性化が,高血圧発症に関与する。3 仮面高血圧や測定誤差に注意し,家庭血圧測定や適切なカフサイズで診断する必要がある。

Kawasoe S, Kubozono T, Ojima S, Yamaguchi S, Higuchi K, Miyahara H, Tokushige K, Miyata M, Ohishi M . Development of risk prediction equations for 5-year diabetes incidence using Japanese health check-up data: a retrospective cohort study . BMJ Open.15 ( 5 ) e097005 2025.5Reviewed

Wada R, Miyata M, Masumitsu T, Sasaki Y, Takenouchi M, Tsumagari M, Kawasoe S, Kubozono T, Takenaka T, Ohishi M . Association Between Depressive Tendencies and Bathing or Hot Spring Bathing Habits Among Community-Dwelling Middle-Aged and Older Adults . Psychogeriatrics.25 ( 3 ) e70046 2025.5Reviewed

Inadome Naoko, Kawasoe Shin, Miyata Masaaki, Kubozono Takuro, Ojima Satoko, Mori Ryuko, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 【アジアでの高血圧管理に関する現在のエビデンスと今後の展望】日本人の縦断的健診データを用いた動脈壁硬化進展のリスク予測スコアと予測式(【Current evidence and perspectives for hypertension management in Asia】Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data) . Hypertension Research48 ( 5 ) 1690 - 1701 2025.5

Language：English Publisher：Nature Publishing Group

中高年者における5年間の動脈壁硬化の進展に関わる因子について、上腕-足首脈波伝播速度(baPWV)を指標に検討した。2005～2019年の特定健診者のうち、初回と5(範囲3～7)年後のデータが比較可能で、かつ初回baPWV<1400cm/sの男性3394名および女性2710名を対象とした。多変量解析の結果、5年後baPWV≧1400cm/sの発生と関連する因子は、男性で年齢、BMI、収縮期・拡張期血圧、心拍数、空腹時血糖、トリグリセリド、女性で年齢、収縮期・拡張期血圧、心拍数、喫煙歴であった。これらの因子を用いて、5年後baPWV≧1400cm/sの発生リスクを予測するモデルを構築した。ROC解析による識別能(ROC曲線下面積)は、予測スコアが男性(6因子)で0.68、女性(4因子)で0.71、予測式が男性(7因子)で0.71、女性(5因子)で0.77であった。

Wada Rei, Miyata Masaaki, Masumitsu Tomomi, Sasaki Yachiyo, Takenouchi Misa, Tsumagari Masatsugu, Kawasoe Shin, Kubozono Takuro, Takenaka Toshihiro, Ohishi Mitsuru . 地域在住中高年者における抑うつ傾向と入浴または温泉浴習慣の関連性(Association Between Depressive Tendencies and Bathing or Hot Spring Bathing Habits Among Community-Dwelling Middle-Aged and Older Adults) . Psychogeriatrics25 ( 3 ) psyg.70046 - psyg.70046 2025.5

Language：English Publisher：John Wiley & Sons Australia, Ltd

2021年のTarumizu研究に参加した40歳以上の地域在住中高年者542名(平均69.4±10.4歳、女性60.5%)を対象に横断研究を行い、抑うつ傾向と入浴または温泉浴習慣の関連性を評価した。質問票を用いて入浴および温泉浴の頻度を評価し、入浴習慣については週7回未満と週7回、温泉浴習慣については週1回未満と週1回以上に分類した。抑うつ傾向の評価には15項目の老年期うつ病尺度を用い、スコアが5以上の場合に抑うつ傾向とした。入浴習慣が週7回なのは487名(89.9%)、温泉浴習慣が週1回以上なのは124名(22.9%)で、抑うつ傾向は95名(17.5%)で認められた。抑うつ傾向を認めた中高年では、温泉浴習慣が週1回以上の割合が有意に低かった。年齢、性別、収入が得られる職業、外出頻度、移動問題、喫煙歴、飲酒量を調整した多変量ロジスティック回帰解析において、温泉浴習慣が週1回以上の場合は抑うつ傾向のリスクが有意に低かったが(調整オッズ比0.51)、抑うつ傾向と入浴頻度には有意な関連性は認められなかった。

Language：English Publisher：Nature Publishing Group

Language：English Publisher：John Wiley & Sons Australia, Ltd

Kario K, Ohbayashi H, Hashimoto M, Itabashi N, Kato M, Uchiyama K, Hirano K, Nakamura N, Miyamoto T, Nagashima H, Ishida H, Ebe Y, Hatta T, Fukui T, Katsuya T, Shimosawa T, Taguchi T, Tanabe A, Ohishi M . Home blood pressure-lowering effect of esaxerenone vs trichlormethiazide for uncontrolled hypertension: a prespecified subanalysis of the EXCITE-HT randomized controlled study by age subgroup . Hypertens Res.48 ( 4 ) 1586 - 1598 2025.4Reviewed

Aoki Y, Kawasoe S, Kubozono T, Yoshimoto J, Kishi M, Kanouchi H, Suzuki S, Ohishi M . Association between defecation status and the habit of eating vinegar-based dishes in community-dwelling Japanese individuals: a cross-sectional study . Sci Rep.15 ( 1 ) 10732 2025.4Reviewed

赤﨑雄一, 大石充 . 特集高血圧診療 Update 各論新しい降圧治療の立ち位置 ARNI(angiotensin receptor neprilysin inhibitor) . 腎と透析98 ( 4 ) 510 - 515 2025.4

Shimono Hirokazu, Tokushige Akihiro, Kanda Daisuke, Arikawa Ryo, Okui Hideki, Oketani Naoya, Ohishi Mitsuru . Clinical Importance of Optimal Medical Therapy on the Clinical Outcomes of Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention . Internal Medicine64 ( 21 ) 3088 - 3102 2025.4Reviewed

Language：English Publisher：The Japanese Society of Internal Medicine

Objective Optimal medical therapy (OMT) is recommended for the secondary prevention of acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). We investigated the relationship between the OMT prescription rate at hospital discharge and clinical outcomes in patients with AMI who underwent successful PCI. Methods We enrolled 294 consecutive AMI patients who underwent successful emergency PCI between January 2017 and December 2020. The patients were divided into two groups based on their medications at discharge: OMT, defined as a combination of statins, beta-blockers, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers; and non-OMT, defined as the absence of at least one of the aforementioned agents. The primary outcome measure was major adverse cardiovascular events (MACEs), defined as the composite of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and heart failure requiring hospitalization. Results According to prescription data, 186 patients (63.3%) were prescribed OMT at discharge. During a median follow-up period of 957 (591-1,308) days, 45 patients developed MACEs. Kaplan-Meier curves showed a significantly lower incidence of MACE in the OMT group than in the non-OMT group (log-rank p<0.001). In the multivariate analysis, OMT remained independently associated with a reduced risk of MACE (hazard ratio, 0.47; 95% confidence interval: 0.25-0.88; p=0.017). Conclusions Fundamental OMT at discharge was associated with a reduced risk of MACE in AMI patients after successful PCI. Therefore, OMT may be necessary to improve the clinical outcomes of patients with AMI after discharge.

DOI： 10.2169/internalmedicine.5192-24

PubMed

CiNii Research

Yokomine T, Kajiya T, Takei T, Kitazono K, Ninomiya T, Inoue T, Takaoka J, Atsuchi Y, Atsuchi N, Ohishi M. . Impact of Calcified Nodules on Clinical Outcomes in Hemodialysis Patients Undergoing Percutaneous Coronary Intervention. . Am J Cardiol.245 35 - 37 2025.4Reviewed

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