Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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濱元裕喜, 田島亜佳里, 内山洋太, 堀添善尚, 安田久代, 大石充 . 三尖弁置換後早期に三尖弁人工弁機能不全を来たした1例 . 日本心臓病学会学術集会抄録70回 C - 22 2022.9

川畑孟子, 小島聡子, 窪薗琢郎, 川添晋, 池田義之, 大石充 . レンバチニブメシル酸塩による薬剤性心筋症を来した一例 . 日本心臓病学会学術集会抄録70回 C - 14 2022.9

西晴香, 安崎和博, 神田大輔, 池田義之, 大石充 . PCIにてDES留置直後の外傷性左浅腹壁動脈損傷に対してコイル塞栓を行い良好に止血し得た一例 . 日本心臓病学会学術集会抄録70回 C - 8 2022.9

吉元一成, 市來仁志, 鎌田博之, 二宮雄一, 入來泰久, 池田義之, 宮田昌明, 大石充 . 頻回の再発に対して3回目のアブレーション施行後に重度の急性胃拡張を発症した持続性心房細動の一例 . 日本心臓病学会学術集会抄録70回 C - 2 2022.9

大石充 . 【予防医学と健康増進学】高齢者疾患のゼロ次予防 . 老年科6 ( 2 ) 85 - 90 2022.8

赤尾光優, 宮永直, 窪田佳代子, 大石充 . CPFE-severe PHに対しupfront combination therapyを行った一例 . 日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集7回・28回 137 - 137 2022.7

Sameshima Kohei, Higo Kenjuro, Hiwatari Sawako, Shioura Takuya, Torigoe Takako, Yoshimura Akino, Ohishi Mitsuru . 回復中、心尖部肥大型心筋症に似た形態変化がみられたたこつぼ心筋症の1例(A case of Takotsubo cardiomyopathy with apical hypertrophic cardiomyopathy-like morphological changes during recovery) . Journal of Rural Medicine17 ( 3 ) 171 - 175 2022.7

Language：English Publisher：(一社)日本農村医学会

症例は56歳女性で、統合失調症のため入院しており、摂食量が不安定であったため点滴を受け、心電図のモニタリングも行われていた。入院24日目に異常心電図を発見され、当心臓科へ診察依頼された。自覚症状はみられなかった。心エコー法では、たこつぼ心筋症に合致する心臓形態が観察された。患者の精神状態のため冠動脈造影法による検査は行えなかったが、その他の検査で網羅的に評価した結果から、たこつぼ心筋症と診断した。発見された心尖部血栓に対する抗凝固療法の他には治療は行わず、患者へは安静を保つよう指導した上で経過観察を続けた。入院18日目に施行した心エコー法では心尖部肥大型心筋症(APH)例に似た心臓形態が示された。この時点でも自覚症状は無く、心不全の徴候もみられなかった。肥大型心筋症例に適用するのと同様の方法にて2Dスペックルトラッキング心エコー法を実施した。その発症早期の所見では、心尖部の円周方向ストレイン(CS)は内層、中層、外層の全てで低下していた。しかし、APH様形態が観察された回復期においては、心尖部内層のCSは急速に回復していた。

Kanda Daisuke, Miyata Masaaki, Ikeda Yoshiyuki, Tokushige Akihiro, Sonoda Takeshi, Arikawa Ryo, Anzaki Kazuhiro, Kosedo Ippei, Yoshino Satoshi, Takumi Takuro, Ohishi Mitsuru . The Priority of Non-HDL-C Assessment to Predict New Lesions among Stable Angina Patients with Strong Statins . Journal of Atherosclerosis and Thrombosis29 ( 6 ) 894 - 905 2022.6

Publisher：Japan Atherosclerosis Society

Aim: In this study, we aim to examine the clinical meaning of low-density lipoprotein cholesterol (LDL-C) ＜70 mg/dL as assessed by Friedewald equation [LDL-C (F)] and Martin method [LDL-C (M)] and non-high-density lipoprotein cholesterol (HDL-C) ＜100 mg/dL on the occurrence of new lesions among Japanese patients with stable angina who underwent percutaneous coronary intervention (PCI) and were prescribed with strong statins.Methods: Among the 537 consecutive stable angina patients who had underwent PCI and had been prescribed with strong statins, the association between the occurrence of new lesions with myocardial ischemia at the 9-month follow-up coronary angiography and ≤ 2 years after PCI and baseline characteristics were assessed.Results: New lesions appeared 9 months and ≤ 2 years after PCI in 31 and 90 patients, respectively. Multivariate logistic regression analysis revealed diabetes mellitus (DM) was significantly associated with the occurrence of new lesions ≤ 2 years after PCI [odds ratio (OR) 1.71, 95 % confidence interval (CI) 1.06–2.83, p=0.031], and only non-HDL-C ≥ 100 mg/dL was associated with the occurrence of new lesions both at 9 months and ≤ 2 years after PCI [OR 1.80, 95 % CI 1.10–3.00, p=0.021 and OR 1.85, 95 % CI 1.13–3.07, p=0.016].Conclusions: Non-HDL-C ≥ 100 mg/dL was determined to be the independent risk factor for the occurrence of new lesions 9 months and ≤ 2 years after PCI among stable angina patients with strong statins. Residual risk after PCI should be considered by assessing not only DM but also non-HDL-C beyond the scope of LDL-C-lowering therapy with strong statins.

DOI： 10.5551/jat.62908

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CiNii Research

AKAIDA Shoma, NAKAI Yuki, TOMIOKA Kazutoshi, TANIGUCHI Yoshiaki, TATEISHI Mana, TABIRA Takayuki, TAKENAKA Toshihiro, KUBOZONO Takuro, OHISHI Mitsuru, MAKIZAKO Hyuma . Association between car accidents and falls among community-dwelling older drivers . Japanese Journal of Geriatric Therapy1 ( 0 ) 1 - 7 2022.6

Language：Japanese Publisher：The Japan Geriatric Therapy Society

【Aim】 This study aimed to examine the association between car accident history and fall history among community-dwelling older drivers.【Methods】 A cross-sectional analysis was conducted on 602 older drivers (mean age: 72.8 ± 5.6 years, women: 50.0%) who participated in the regional cohort study (Tarumizu Research 2018, 2019) and were driving at 65 years or older. For car accident history, we listened to their accident history for the past two years and classified it into “accident history” and “no accident history.” The fall history was classified into “with fall history” and “no fall history” based on the presence or absence of falls in the past year. In the statistical analysis, a binomial logistic regression analysis was performed with accident history as the dependent variable, fall history as the independent variable, and age and sex as the covariates.【Results】 It was found that 5.6% of the subjects had a history of car accidents, and 13.0% had a history of falls. Among those with a history of car accidents, a significantly higher percentage of people had a history of falls than among those with no history of car accidents (p = 0.003). The logistic regression analysis showed that having a history of falls was significantly associated with having a history of car accidents (odds ratio: 3.12, 95% confidence interval: 1.42–6.85, p = 0.004).【Conclusions】 The results suggested an association between a history of car accidents and a history of falls among community-dwelling older drivers.

DOI： 10.57270/jgts.2022_007

CiNii Research

Shibata Keisuke, Tokushige Akihiro, Imamura Masakazu, Ikeda Yoshiyuki, Ohishi Mitsuru . Khoranaリスクスコア評価は消化管癌患者における初回化学療法時の死亡率を予測する　後向き研究(Evaluating the Khorana risk score of gastrointestinal cancer patients during initial chemotherapy as a predictor of patient mortality: A retrospective study) . Journal of Cardiology79 ( 5-6 ) 655 - 663 2022.6

Language：English Publisher：(一社)日本心臓病学会

初回化学療法を施行した消化管癌患者260例(男性165例、女性95例)を対象に、静脈血栓塞栓症の発症リスクを評価するKhoranaリスクスコア(KRS)と死亡率の関連を後ろ向きに検討した。静脈血栓塞栓症の既往患者は除外した。患者をKRSに基づき低リスク群122例(男性62.3%、年齢中央値67歳)、中等度リスク群114例(男性64.9%、年齢中央値69歳)、高リスク群24例(男性62.5%、年齢中央値65歳)の3群に分類した。主要評価項目は総死亡および腫瘍関連静脈血栓症の発生とした。追跡期間中に腫瘍関連静脈血栓症は61例で発生した。発生率は低リスク群31例(23.3%)、中等度リスク群4例(31.1%)、高リスク群4例(17.4%)の間に有意差はなかった(P=0.4)。死亡は84例で、総死亡率は全体で37.9%であった。総死亡率は低リスク群30例(27.5%)、中等度リスク群41例(44.6%)に比べて高リスク群13例(58.2%)で有意に高かった(P=0.002)。多変量解析で交絡因子を調整した後もKRSは総死亡と有意に関連した(HR:2.83、95%CI:1.37～5.83、P=0.005)。

Kanda Daisuke, Miyata Masaaki, Ikeda Yoshiyuki, Tokushige Akihiro, Sonoda Takeshi, Arikawa Ryo, Anzaki Kazuhiro, Kosedo Ippei, Yoshino Satoshi, Takumi Takuro, Ohishi Mitsuru . ストロングスタチン服用の安定狭心症患者における新たな病変の予測にはnon-HDLコレステロールによる評価を優先すべきである(The Priority of Non-HDL-C Assessment to Predict New Lesions among Stable Angina Patients with Strong Statins) . Journal of Atherosclerosis and Thrombosis29 ( 6 ) 894 - 905 2022.6

Language：English Publisher：(一社)日本動脈硬化学会

ストロングスタチンを服用している安定狭心症患者537例(男性392例、女性145例)を対象に、non-HDLコレステロール(non-HDL-C)が経皮的冠動脈インターベンション(PCI)後の新たな冠動脈狭窄病変を予測するかどうかについて検討した。予測能をFridewald式およびMartin式で推算したLDLコレステロール(LDL-C)値と比較した。追跡期間は2年で、新たな狭窄病変(NL)は90例で検出された。患者をNL群90例(男性74%、年齢中央値66歳)と非NL群447例(男性73%、年齢中央値70歳)の2群に分類した。患者背景はNL群の方が若年で、糖尿病が有意に多かった。Fridewald(F)式およびMartin式による推算LDL-C値が70mg/dL以上、non-HDL-Cが100mg/dL以上の患者はNL群の方が多かった。単変量解析で糖尿病、F式とMartin式の推算LDL-C値が70mg/dL以上、non-HDL-Cが100mg/dL以上が新たな病変と有意に関連した。多変量解析では糖尿病、およびnon-HDL-Cが100mg/dL以上(OR:1.85、P=0.016)が新たな病変を予測する独立因子であった。

赤井田将真, 中井雄貴, 富岡一俊, 谷口善昭, 立石麻奈, 田平隆行, 竹中俊宏, 窪薗琢郎, 大石充, 牧迫飛雄馬 . 地域在住高齢者ドライバーにおける自動車事故歴と転倒歴の関係 . 日本老年療法学会誌1 1 - 6 2022.6

Language：Japanese Publisher：(一社)日本老年療法学会

地域在住高齢者ドライバーにおける自動車事故歴と転倒歴の関連性について検討した。地域コホート研究(垂水研究2018または2019)に参加した地域在住高齢者1029名のうち、調査時点で自動車運転免許を保有しており自動車運転をしている602名(女性50.0%、平均72.8±5.6歳)を対象とした。過去2年間の自動車事故経験者(事故歴あり)は34名(女性55.9%、平均72.7±4.9歳)、事故歴なしは568名(女性49.6%、平均72.9±5.7歳)であった。過去1年間の転倒経験者は78名(13.0%)であった。事故歴あり群は事故歴なし群に比べ転倒歴を有する割合が有意に高かった。事故歴とその他の変数(年齢、性別、多剤併用、運転頻度、運転距離、GDS-15、身体機能低下、MCI)の関係については群間での有意な差は認められなかった。二項ロジスティック回帰分析では、転倒歴を有することは事故歴を有することと有意な関連を認めた。

Hamamoto Yuki, Tokushige Akihiro, Yuasa Toshinori, Ikeda Yoshiyuki, Horizoe Yoshihisa, Yasuda Hisayo, Kubozono Takuro, Ohishi Mitsuru . 術前患者の深部静脈血栓症診断のための新たな検査前確率スコア(A new pre-test probability score for diagnosis of deep vein thrombosis in patients before surgery) . Journal of Cardiology79 ( 5-6 ) 664 - 670 2022.6

Language：English Publisher：(一社)日本心臓病学会

深部静脈血栓症(DVT)が疑われる外来および入院患者973例(男性490例、女性483例)を対象に、術前にDVTを予測する検査前確率スコアを作成し、その妥当性を検証した。全例で超音波検査(全下肢静脈エコー)を実施した。いずれの症例も術前のDダイマー値は1μg/mL以上であった。患者を、予測スコアを作成するための導出群651例(女性51%、平均67.6±13.9歳)と妥当性を検証するための検証群322例(女性49%、平均67.6±13.9歳)に分類した。検査前確率スコアはDダイマー値が1.5μg/mL以上に2点、60歳以上、女性、糖質コルチコイドの使用、長期の運動制限、DVTリスクの高い悪性腫瘍にそれぞれ1点を加算して、0～2点を低リスク、3～4点を中等度リスク、5点以上を高リスクとした。検査前確率スコアのROC曲線下面積(AUC)は導出群で0.72、検証群で0.70であった。導出群でDVTの診断率は低リスク群(7%)、中等度リスク群(23%)に比べて高リスク群(47%)で有意に高かった。同様に検証群もそれぞれ6%、22%、50%と高リスク群で有意に高かった(いずれもP<0.0001)。

Language：Japanese Publisher：(一社)日本老年療法学会

Shidou Rumi, Kohjitani Atsushi, Miyata Masaaki, Yamashita Kaoru, Ohno Sachi, Ohishi Mitsuru, Sugimura Mitsutaka . Estimation of the Risk of Postoperative Hypertension Following Minor to Moderate Surgery Using an Echocardiogram and Biomarkers . 63 ( 3 ) 558 - 565 2022.5Reviewed

Publisher：International Heart Journal Association

This study aimed to determine independent factors for developing postoperative hypertension using 4 biomarkers in patients receiving oral and maxillofacial surgery under general anesthesia. Brain natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity myocardial troponin T (hs-TnT), and high-sensitivity myocardial troponin I (hs-TnI) were measured and preoperative echocardiograms were examined. Episodes of systolic blood pressure (SBP) ≥ 170 mmHg or diastolic blood pressure ≥ 100 mmHg within 1 week after surgery were considered postoperative hypertension. We analyzed 213 (130 men; 83 women) patients, who were divided into a postoperative hypertension group (HT group, n = 32) and a normal group (N group, n = 181). The HT group showed a higher LVMI (113.5 versus 100.1), higher E/e' of the lateral wall (9.1 versus 7.7), and higher BNP (39.2 versus 22.9 pg/mL), NT-proBNP (400.1 versus 143.9 pg/mL), and hs-TnT (15.6 versus 10.3 ng/L) concentrations compared to the N group. NT-proBNP and hs-TnT concentrations positively associated with E/e', but BNP and hs-TnI did not. NT-proBNP (AUC = 0.64, cutoff value: 117.0 pg/mL) and hs-TnT (AUC = 0.61, cutoff value: 11.0 ng/L) concentrations were effective for discriminating E/e' ≥ 12. Multivariate logistic regression analyses showed that risk factors responsible for developing postoperative hypertension were NT-proBNP and hs-TnT using biomarkers and E/e' as independent variables, and NT-proBNP and SBP at admission using biomarkers and SBP at admission as independent variables. These findings suggest that NT-proBNP and hs-TnT concentrations, and SBP at admission, are useful to predict postoperative hypertension after minor to moderate surgery, and that left ventricular filling pressure is a primary factor associated with postoperative hypertension.

DOI： 10.1536/ihj.22-074

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Uchikado Y., Ikeda Y., Ohishi M. . Current Understanding of the Pivotal Role of Mitochondrial Dynamics in Cardiovascular Diseases and Senescence . Frontiers in Cardiovascular Medicine9 905072 2022.5

Language：Japanese Publisher：Frontiers in Cardiovascular Medicine

The heart is dependent on ATP production in mitochondria, which is closely associated with cardiovascular disease because of the oxidative stress produced by mitochondria. Mitochondria are highly dynamic organelles that constantly change their morphology to elongated (fusion) or small and spherical (fission). These mitochondrial dynamics are regulated by various small GTPases, Drp1, Fis1, Mitofusin, and Opa1. Mitochondrial fission and fusion are essential to maintain a balance between mitochondrial biogenesis and mitochondrial turnover. Recent studies have demonstrated that mitochondrial dynamics play a crucial role in the development of cardiovascular diseases and senescence. Disruptions in mitochondrial dynamics affect mitochondrial dysfunction and cardiomyocyte survival leading to cardiac ischemia/reperfusion injury, cardiomyopathy, and heart failure. Mitochondrial dynamics and reactive oxygen species production have been associated with endothelial dysfunction, which in turn causes the development of atherosclerosis, hypertension, and even pulmonary hypertension, including pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Here, we review the association between cardiovascular diseases and mitochondrial dynamics, which may represent a potential therapeutic target.

DOI： 10.3389/fcvm.2022.905072

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Hironori Miyata, Michio Maruta, Hyuma Makizako, Gwanghee Han, Yuriko Ikeda, Atsushi Nakamura, Keiichiro Tokuda, Suguru Shimokihara, Shoma Akaida, Yuma Hidaka, Yoshihiko Akasaki, Takuro Kubozono, Mitsuru Ohishi, Takayuki Tabira . Association between satisfaction with meaningful activities and social frailty in community-dwelling Japanese older adults . Archives of Gerontology and Geriatrics100 104665 - 104665 2022.5Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

OBJECTIVES: This cross-sectional study investigates the associations among satisfaction with meaningful activities, and social frailty in community-dwelling Japanese older adults. METHODS: We analyzed data from 596 older adults (mean age 74.2 ± 6.4 years, female 63.6%) who participated in the Tarumizu Study 2019, a community-based health survey. Participants selected meaningful activities from 95 activities using the Aid for Decision-Making in Occupation Choice (ADOC) tool. Satisfaction was evaluated from 1 to 5, and those who were assigned a rating of 4 or 5 were operationally classified as the high satisfaction group (n = 487), with others occupying the low satisfaction group (n = 109). Both groups were evaluated based on the ADOC, social frailty (Makizako's five items), physical function, depressive symptoms, cognitive function, and higher-level competence. RESULTS: Of the 596 participants, 18.7% showed prevalence of social frailty. The low satisfaction group had a significantly higher prevalence of social frailty (low satisfaction 28.4% vs. high satisfaction 16.4%, P = 0.004) and depressive symptoms (low satisfaction 30.3% vs. high satisfaction 17.9%, P<0.01), and poor higher-level competence (P = 0.026) than the high satisfaction group. Logistic regression analysis showed that social frailty (Odds Ratio 1.78, 95% Confidence Interval 1.068-2.990, P = 0.027) was significantly associated with satisfaction with meaningful activity after adjusting for covariates. We found no significant differences in categories of meaningful activities between the low and high satisfaction groups (P = 0.549). CONCLUSIONS: This study suggested that social frailty was associated with satisfaction with meaningful activities, regardless of the degree or category of satisfaction.

DOI： 10.1016/j.archger.2022.104665

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Yuki Hamamoto, Akihiro Tokushige, Yuasa Toshinori, Yoshiyuki Ikeda, Yoshihisa Horizoe, Hisayo Yasuda, Takuro Kubozono, Mitsuru Ohishi . A new pre-test probability score for diagnosis of deep vein thrombosis in patients before surgery. . Journal of cardiology79 ( 5 ) 664 - 670 2022.5Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Venous thromboembolism is a serious perioperative complication. We developed a new pre-test probability score for predicting deep vein thrombosis (DVT) before surgery. METHODS: Whole leg ultrasonography was performed on 973 inpatients and outpatients with suspected DVT based on a preoperative D-dimer cut-off value of ≥ 1 μg/ml. We allocated two-thirds (n = 651) of the study participants to a derivation cohort and one-third (n = 322) to a validation cohort. The pre-test probability model was developed from the derivation cohort data. RESULTS: The pre-test probability model for DVT assigned 2 points to D-dimer ≥ 1.5 μg/mL and 1 point each to age ≥ 60 years, female sex, ongoing glucocorticoid therapy, prolonged immobility, and cancer with high risk of DVT. The area under the curve of the pre-test probability score was 0.72 and 0.70 in the derivation and validation cohorts, respectively. The rates of DVT according to pre-test probability scores in the derivation and validation cohorts were 7% and 6% in the low (score = 0-2), 23% and 22% in the intermediate (score = 3-4), and 47% and 50% in the high probability group (score ≥ 5), respectively (p < 0.0001). CONCLUSIONS: The pre-test probability score (Kagoshima-DVT score) was helpful in detecting preoperative DVT in both inpatients and outpatients. We identified low probability group to reduce whole-leg ultrasonography and high probability group to detect more DVT before surgery.

DOI： 10.1016/j.jjcc.2021.11.025

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Keisuke Shibata, Akihiro Tokushige, Masakazu Imamura, Yoshiyuki Ikeda, Mitsuru Ohishi . Evaluating the Khorana risk score of gastrointestinal cancer patients during initial chemotherapy as a predictor of patient mortality: A retrospective study. . Journal of cardiology79 ( 5 ) 655 - 663 2022.5Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: The Khorana risk score (KRS) has been recommended for predicting the incidence of cancer-associated thrombosis (CAT). However, it has been reported KRS was not useful in predicting CAT, but rather in predicting death by setting high scores for the primary tumor site or a low prevalence of severe obesity. METHODS: A total of 260 consecutive patients with no history of thrombosis and who started initial chemotherapy for gastrointestinal cancer from January 2017 to December 2018 at our hospital were divided into three groups according to KRS; they were observed until December 2019 [122 patients (46.9%) in the low-risk group, 114 patients (43.8%) in the intermediate-risk group, and 24 patients (9.2%) in the high-risk group]. The incidence of CAT and all-cause death were compared among the three groups. RESULTS: The median age of the patients was 67 years; 63.5% were men. CAT was observed in 61 patients (26.1%); 84 patients (37.9%) died during the observation period. The incidence rate of CAT was similar among the three groups (log-rank p = 0.4); but all-cause death showed a significant difference among the three groups (high-risk group: 58.2%, intermediate-risk group: 44.6%, low-risk group: 27.5%, log-rank p = 0.002). In the multivariate analysis, the high-risk KRS group remained at increased risk for all-cause death (HR, 2.83; 95% CI, 1.37-5.83; p = 0.005), but not with CAT. CONCLUSIONS: The KRS at the start of chemotherapy for gastrointestinal cancer is not effective in predicting CAT, but it is effective in predicting prognosis in patients with gastrointestinal cancer.

DOI： 10.1016/j.jjcc.2021.11.024

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