Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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佐々木雄一, 大石充 . 【高齢者動脈硬化予防の新展開】動脈硬化性疾患予防のための高齢者高血圧管理 . Pharma Medica38 ( 10 ) 17 - 22 2020.10

Language：Japanese Publisher：(株)メディカルレビュー社

＜文献概要＞はじめに高血圧は,動脈硬化性疾患である脳卒中,心筋梗塞や大動脈解離のみならず,認知症,心不全や慢性腎臓病の発症に及ぼす影響は大きく,降圧療法によりリスクを低減することができる。わが国では75歳以上の後期高齢者人口が全体の10%を占めており,さらに高齢者高血圧の有病率は非常に高くなってきている。本稿では,2019年に改訂した「高血圧治療ガイドライン(JSH2019)」を踏まえ,高齢者の動脈硬化予防のための高齢者高血圧管理について概説する。

大石充 . 【新しい老年病専門医制度について:老年病専門医が持つべき能力とは】他の診療科、診療チームとの連携、コンサルテーション/高齢者に対する侵襲的診断の判断 . 老年内科2 ( 3 ) 300 - 305 2020.9

Kawasoe Shin, Kubozono Takuro, Ojima Satoko, Kawabata Takeko, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . Sex Differences in the Effects of Weight Reduction on Future Blood Pressure Elevation in a Mildly Obese Middle-Aged Population . Circulation Reports2 ( 8 ) 385 - 392 2020.8

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

Background:The effectiveness of weight loss (WL) in preventing blood pressure (BP) elevation is common knowledge; however, the effect of sex differences is not known.Methods and Results:Health checkup data from Kagoshima Kouseiren Medical Healthcare Center for middle-aged participants (40–49 years old) with mild obesity (body mass index [BMI] 25.0–29.9 kg/m2) who had examination data for 2 follow-up time-points (after 3 and 10 years) were analyzed. Propensity score (PS) matching using data from the first examination was used to match participants with a decrease in BMI ≥1.0 kg/m2at 3 years (WL group) with those with a BMI decrease <1.0 kg/m2or weight gain (non-WL group). BP values were compared after 3 and 10 years between the 2 groups, as was the prevalence of hypertension after 10 years. PS matching resulted in 232 men and 160 women in each group. Among women, systolic BP (SBP) and hypertension prevalence after 10 years were significantly lower in the WL than non-WL group (P<0.01 and P<0.05, respectively). There were no significant differences in SBP and hypertension prevalence after 10 years in men in the 2 groups.Conclusions:There were sex differences in the effectiveness of WL in preventing future BP elevation in mildly obese middle-aged participants: WL prevented future BP elevation and hypertension onset in women, but not in men.

DOI： 10.1253/circrep.cr-20-0050

PubMed

CiNii Research

Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, Ohishi M. . Sex differences in the effects of weight reduction on future blood pressure elevation in a mildly obese middle-aged population. . Circ Rep2 ( 8 ) 385 - 392 2020.8Reviewed

Shimono H., Kajiya T., Takaoka J., Atsuchi Y., Atsuchi N., Ohishi M. . Inadvertent Percutaneous Coronary Endarterectomy Assessed by Multiple Imaging Modalities . Journal of Invasive Cardiology32 ( 8 ) E221 - E222 2020.8

Higo K., Kubota K., Hiwatari Takeshita S., Iwatani N., Minayaga S., Jinguji M., Ohishi M. . The potential for early diagnosis of pulmonary arterial hypertension using lung iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake: a case report . Radiol Case Rep15 ( 8 ) 1164 - 1167 2020.8International journal

Language：Japanese

Previous reports have found evidence that the lung uptake of iodine-123-metaiodobenzylguanidine (123I-MIBG) represents pulmonary vascular endothelial function. Therefore, it was believed that the reduced lung uptake of 123I-MIBG in patients with pulmonary artery hypertension may indicate poor pulmonary vascular endothelial function in those patients. In our previous report, we analyzed the lung uptake of 123I-MIBG in patients with pulmonary hypertension, and demonstrated that it is lower in patients with pulmonary arterial hypertension (PAH) than in those with chronic thromboembolic pulmonary hypertension and controls, suggesting that reduced uptake of 123I-MIBG in patients with PAH indicates endothelial dysfunction of the pulmonary artery. In the current report, we describe a 46-year-old woman diagnosed with scleroderma whose lung uptake of 123I-MIBG was decreased on admission, but she was not diagnosed with pulmonary artery hypertension at that time because her pulmonary artery pressure during right heart catheterization was not elevated. However, she was diagnosed with borderline PAH 2 years later. The lung uptake of 123I-MIBG was reduced before a reduction in %DLCO was observed. This report suggests that the lung uptake of 123I-MIBG may be useful for the early diagnosis of pulmonary artery hypertension.

DOI： 10.1016/j.radcr.2020.05.036

Scopus

PubMed

Kawasoe Shin, Kubozono Takuro, Ojima Satoko, Kawabata Takeko, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 軽度肥満の中年者において減量が血圧上昇に及ぼす影響にみられる性差(Sex Differences in the Effects of Weight Reduction on Future Blood Pressure Elevation in a Mildly Obese Middle-Aged Population) . Circulation Reports2 ( 8 ) 385 - 392 2020.8

Language：English Publisher：(一社)日本循環器学会

軽度肥満中年者において減量による血圧上昇抑制効果に性差がみられるかどうか検討した。軽度肥満(BMI 25.0～29.9kg/m2)を呈する40～49歳の中年者を対象に、3年後と10年後の健診データを評価した。傾向スコアマッチングにより3年後にBMIが1.0kg/m2以上減少した体重減少群(WL群)392名(男性232名、女性160名)と体重非減少群(非WL群)392名(男性232名、女性160名)に分類し、3～10年後の血圧を比較し、10年後における高血圧の有病率について検討した。その結果、男性では3年後の拡張期血圧(DBP)はWL群の方が非WL群より有意に低値であり、収縮期血圧(SBP)もWL群の方が有意に低かった。10年後ではDBP、SBPともに有意な群間差は認められなかった。女性では10年後のSBPはWL群の方が非WL群より有意に低く、DBPに有意差はみられなかった。また、10年後の高血圧の発症率に関して、男性ではWL群と非WL群との間に有意差はなかったが、女性ではWL群の方が有意に低値を示していた。減量による血圧上昇抑制効果に性差が認められ、女性の方が減量の効果が大きいことが明らかになった。

Language：English Publisher：(一社)日本循環器学会

Kubota Kayoko, Miyanaga Sunao, Iwatani Noriko, Higo Kenjuro, Tokushige Akihiro, Ikeda Yoshiyuki, Ohishi Mitsuru . Geriatric Nutritional Risk Index Is Associated With Prognosis in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension . Circulation Reports2 ( 7 ) 372 - 377 2020.7

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

Background:The Geriatric Nutritional Risk Index (GNRI) is a simple tool for assessing nutritional risk that predicts prognosis in patients with heart failure. This study evaluated associations between the GNRI at first hospitalization and prognosis in patients with pulmonary artery hypertension (PAH) and those with chronic thromboembolic pulmonary hypertension (CTEPH).Methods and Results:This retrospective investigation included 104 patients with either PAH or CTEPH who were treated at Kagoshima University Hospital in Japan. Patients were divided into a high (≥92) and low (<92) GNRI groups. Body mass index and serum albumin levels were significantly lower in the low GNRI group (P<0.001). Over a median follow-up period of 24 months, the incidence of pulmonary hypertension rehospitalization was higher in the low GNRI group (P=0.04). Kaplan-Meier analysis revealed that the cumulative event-free rate was significantly lower in the low GNRI group (P=0.002). Low GNRI was significantly associated with a poorer outcome after adjusting for different sets of confounding factors, including: age and sex (P=0.004); age, sex, and PAH (P=0.043); and age, sex, and mean pulmonary artery pressure (P=0.003).Conclusions:The GNRI at first hospitalization is useful for predicting prognosis in PAH and CTEPH patients.

DOI： 10.1253/circrep.cr-20-0046

PubMed

CiNii Research

Hirase T, Makizako H, Okubo Y, Lord SR, Okita M, Nakai Y, Takenaka T, Kubozono T, Ohishi M . Falls in community-dwelling older adults with lower back or knee pain are associated with cognitive and emotional factors. . Int J Environ Res Public Health17 ( 14 ) 4960 - 4960 2020.7Reviewed

Falls in Community-Dwelling Older Adults with Lower Back or Knee Pain Are Associated with Cognitive and Emotional Factors . International journal of environmental research and public health17 ( 14 ) 2020.7

Hirase T, Makizako H, Okubo Y, Lord SR, Okita M, Nakai Y, Takenaka T, Kubozono T, Ohishi M . Falls in Community-Dwelling Older Adults with Lower Back or Knee Pain Are Associated with Cognitive and Emotional Factors. . International journal of environmental research and public health17 ( 14 ) 2020.7

Tatsuya Hirase, Hyuma Makizako, Yoshiro Okubo, Stephen R Lord, Minoru Okita, Yuki Nakai, Toshihiro Takenaka, Takuro Kubozono, Mitsuru Ohishi . Falls in Community-Dwelling Older Adults with Lower Back or Knee Pain Are Associated with Cognitive and Emotional Factors. . International journal of environmental research and public health17 ( 14 ) 4960 - 4960 2020.7Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

(1) Background: The present study aimed to examine physical, cognitive and emotional factors affecting falls in community-dwelling older adults with and without pain; (2) Methods: Data from 789 older adults who participated in a community-based health survey were analyzed. Participants completed questionnaires on the presence of pain and previous falls. Muscle weakness (handgrip strength < 26.0 kg for men and < 18.0 kg for women) and low skeletal muscle mass (appendicular skeletal muscle mass index < 7.0 kg/m2 for men and < 5.7 kg/m2 for women) were determined. Mild cognitive impairment (MCI) and depressive symptoms were assessed using the National Center for Geriatrics and Gerontology-Functional Assessment Tool and 15-item geriatric depression scale (GDS-15), respectively; (3) Results: In participants with pain, MCI and GDS-15 were associated with previous falls after adjusting for age, sex, education and medication use. In participants without pain, muscle weakness and low skeletal muscle mass were associated with previous falls when adjusting for the above covariates; (4) Conclusions: Falls in participants with pain were associated with cognitive and emotional factors, whereas falls in those without pain were associated with physical factors. Fall prevention interventions for older adults with pain may require tailored strategies to address cognitive and emotional factors.

DOI： 10.3390/ijerph17144960

PubMed

Nakai Y., Takenaka T., Kubozono T., Ohishi M., Okubo Y., Lord S.R., Okita M., Hirase T., Makizako H. . Falls in community-dwelling older adults with lower back or knee pain are associated with cognitive and emotional factors . International Journal of Environmental Research and Public Health17 ( 14 ) 1 - 8 2020.7

Language：Japanese Publisher：International Journal of Environmental Research and Public Health

(1) Background: The present study aimed to examine physical, cognitive and emotional factors affecting falls in community-dwelling older adults with and without pain; (2) Methods: Data from 789 older adults who participated in a community-based health survey were analyzed. Participants completed questionnaires on the presence of pain and previous falls. Muscle weakness (handgrip strength < 26.0 kg for men and < 18.0 kg for women) and low skeletal muscle mass (appendicular skeletal muscle mass index < 7.0 kg/m2 for men and < 5.7 kg/m2 for women) were determined. Mild cognitive impairment (MCI) and depressive symptoms were assessed using the National Center for Geriatrics and Gerontology-Functional Assessment Tool and 15-item geriatric depression scale (GDS-15), respectively; (3) Results: In participants with pain, MCI and GDS-15 were associated with previous falls after adjusting for age, sex, education and medication use. In participants without pain, muscle weakness and low skeletal muscle mass were associated with previous falls when adjusting for the above covariates; (4) Conclusions: Falls in participants with pain were associated with cognitive and emotional factors, whereas falls in those without pain were associated with physical factors. Fall prevention interventions for older adults with pain may require tailored strategies to address cognitive and emotional factors.

DOI： 10.3390/ijerph17144960

Scopus

Kubota Kayoko, Miyanaga Sunao, Iwatani Noriko, Higo Kenjuro, Tokushige Akihiro, Ikeda Yoshiyuki, Ohishi Mitsuru . Geriatric Nutritional Risk Indexは肺動脈性肺高血圧症患者および慢性血栓塞栓性肺高血圧症患者の予後と関連する(Geriatric Nutritional Risk Index Is Associated With Prognosis in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension) . Circulation Reports2 ( 7 ) 372 - 377 2020.7

Language：English Publisher：(一社)日本循環器学会

診断時のGeriatric Nutritional Risk Index(GNRI)スコアから、肺動脈性肺高血圧症(PAH)または慢性血栓塞栓性肺高血圧症(CTEPH)の患者の予後を予測できるか調査した。対象患者は104例(平均60±14歳、女性84.6%)で、71例(68.3%)がWHO機能クラスIIIまたはIVであった。追跡調査期間中(中央値24ヵ月)、16例(15.4%)が死亡した。6例(37.5%)の死因は肺高血圧症(PH)と関連しており、残り10例(62.5%)の主な死因は感染症(3例)、呼吸器疾患(4例)、がん(2例)、その他(1例)であった。PH再入院または全死因の複合転帰は、低GNRI群の22例中10例(45.5%)および高GNRI群の82例中17例(20.7%)で発生した。PH再入院の発生率は、高GNRI群の方が低GNRI群よりも高かった。カプラン・マイヤー分析では、高GNRI群は低GNRI群よりも累積イベント無発生率が有意に高かった。多変量Cox比例ハザードモデルでは、低GNRIが高GNRIよりも高い全死因死亡率またはPH再入院率と有意に関連していた。以上の結果より、栄養失調はPH患者の予後予測因子であることが示された。

徳重明央, 大石充 . 【高血圧学　下-高血圧制圧の現状と展望-】降圧治療の現状と展望　降圧薬からデバイスまで　降圧薬治療の現状　ガイドラインにおける降圧薬の推奨と日本の使用状況 . 日本臨床78 ( 増刊2 高血圧学(下) ) 93 - 102 2020.7

川添晋, 大石充 . 【高血圧学　下-高血圧制圧の現状と展望-】高血圧の診断　血圧測定・臨床検査・リスク判定　血圧変動性の臨床的意義 . 日本臨床78 ( 増刊2 高血圧学(下) ) 30 - 33 2020.7

徳重明央, 大石充 . 【高血圧学下-高血圧制圧の現状と展望-】降圧治療の現状と展望降圧薬からデバイスまで降圧薬治療の現状ガイドラインにおける降圧薬の推奨と日本の使用状況 . 日本臨床78 ( 増刊2 高血圧学(下) ) 93 - 102 2020.7

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