Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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中村幸美, 水上尚子, 湯之上真吾, 野口慶久, 湯淺敏典, 高崎州亜, 堀添善尚, 茶圓秀人, 木佐貫彰, 大石充 . 肝未分化肉腫の心臓内転移を認めた1症例 . 超音波医学43 ( 1 ) 156 - 156 2016.1

多田野祐子, 湯淺敏典, 宮下裕子, 富山えり奈, 野元裕太朗, 小瀬戸一平, 剣田昌伸, 松元仁久, 木原浩一, 大石充 . 脳梗塞発症を契機に見つかった左房内腫瘍 . 超音波医学43 ( 1 ) 164 - 165 2016.1

大石充 . 【ここに注意する高齢高血圧患者治療】高齢者における降圧薬の選択 . 日本医事新報 ( 4785 ) 18 - 22 2016.1

Language：Japanese Publisher：(株)日本医事新報社

＜Point＞▼非薬物療法は積極的に行うべきであるが、QOLに配慮して個々に方針を決定する▼降圧薬治療の第一選択薬は非高齢者と同様にCa拮抗薬、ARB、ACE阻害薬、少量の利尿薬とする。一般に常用量の1/2量から開始する。降圧効果が不十分な場合はこれらの併用を行う▼合併症を伴う場合は、個々の症例に最も適した降圧薬を選択する(著者抄録)

Tei C, Imamura T, Kinugawa K, Inoue T, Masuyama T, Inoue H, Noike H, Muramatsu T, Takeishi Y, Saku K, Harada K, Daida H, Kobayashi Y, Hagiwara N, Nagayama M, Momomura S, Yonezawa K, Ito H, Gojo S, Akaishi M, Miyata M, Ohishi M, WAON-CHF Study Investigators. . Waon therapy for managing chronic heart failure: results from a multicenter prospective randomized WAON-CHF study. . Circ J80 ( 4 ) 827 - 834 2016Reviewed

Fukunaga K, Kajiya T, Takaoka J, Arima R, Miyamura A, Atsuchi N, Atsuchi Y, Yamaguchi H, Ohishi M. . Smooth arterial healing after paclitaxel-coated balloon angioplasty for in-stent restenosis assessed by optical frequency domain imaging. . Asia Intervention2 44 - 47 2016Reviewed

Kanda D, Takumi T, Miyata M, Tokushige A, Sonoda T, Yoshino S, Saihara K, Ohishi M. . Angiotensin-converting enzyme inhibitor prevents the worsening of renal function in the late phase after percutaneous coronary intervention. . J Atheroscler Thromb23 ( 2 ) 233 - 240 2016Reviewed

Tei Chuwa, Imamura Teruhiko, Kinugawa Koichiro, Inoue Teruo, Masuyama Tohru, Inoue Hiroshi, Noike Hirofumi, Muramatsu Toshihiro, Takeishi Yasuchika, Saku Keijiro, Harada Kazumasa, Daida Hiroyuki, Kobayashi Youichi, Hagiwara Nobuhisa, Nagayama Masatoshi, Momomura Shinichi, Yonezawa Kazuya, Ito Hiroshi, Gojo Satoshi, Akaishi Makoto, Miyata Masaaki, Ohishi Mitsuru, WAON-CHF Study Investigators . Waon Therapy for Managing Chronic Heart Failure　– Results From a Multicenter Prospective Randomized WAON-CHF Study – . Circulation Journal80 ( 4 ) 827 - 834 2016

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

Background:Waon therapy improves heart failure (HF) symptoms, but further evidence in patients with advanced HF remains uncertain.Methods and Results:In 19 institutes, we prospectively enrolled hospitalized patients with advanced HF, who had plasma levels of B-type natriuretic peptide (BNP) >500 pg/ml on admission and BNP >300 pg/ml regardless of more than 1 week of medical therapy. Enrolled patients were randomized into Waon therapy or control groups. Waon therapy was performed once daily for 10 days with a far infrared-ray dry sauna maintained at 60℃ for 15 min, followed by bed rest for 30 min covered with a blanket. The primary endpoint was the ratio of BNP before and after treatment. In total, 76 Waon therapy and 73 control patients (mean age 66 years, men 61%, mean plasma BNP 777 pg/ml) were studied. The groups differed only in body mass index and the frequency of diabetes. The plasma BNP, NYHA classification, 6-min walk distance (6MWD), and cardiothoracic ratio significantly improved only in the Waon therapy group. Improvements in NYHA classification, 6MWD, and cardiothoracic ratio were significant in the Waon therapy group, although the change in plasma BNP did not reach statistical significance. No serious adverse events were observed in either group.Conclusions:Waon therapy, a holistic soothing warmth therapy, showed clinical advantages in safety and efficacy among patients with advanced HF. (Circ J 2016; 80: 827–834)

DOI： 10.1253/circj.cj-16-0051

Daisuke Kanda, Takuro Takumi, Masaaki Miyata, Akihiro Tokushige, Takeshi Sonoda, Satoshi Yoshino, Keishi Saihara, Mitsuru Ohishi . Angiotensin-Converting Enzyme Inhibitor Prevents the Worsening of Renal Function in the Late Phase after Percutaneous Coronary Intervention . JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS23 ( 2 ) 233 - 240 2016Reviewed

Takumi Takuro, Miyata Masaaki, Ohishi Mitsuru . Physiological Assessment in Peripheral Artery Disease: Going Beyond Angiography . Journal of Atherosclerosis and Thrombosis23 ( 1 ) 44 - 45 2016

Kanda Daisuke, Takumi Takuro, Miyata Masaaki, Tokushige Akihiro, Sonoda Takeshi, Yoshino Satoshi, Saihara Keishi, Ohishi Mitsuru . Angiotensin-Converting Enzyme Inhibitor Prevents the Worsening of Renal Function in the Late Phase after Percutaneous Coronary Intervention . Journal of Atherosclerosis and Thrombosis23 ( 2 ) 233 - 240 2016

Language：English Publisher：Japan Atherosclerosis Society

Aim: The amount of contrast media and renal atheroemboli are risk factors for acute kidney injury after percutaneous coronary intervention (PCI). However, the chronic kidney injury after PCI has not been fully characterized. The purpose of this study was to investigate factors affecting renal function in the late phase after PCI by measuring serum Cystatin C (CysC). Methods: In 143 consecutive patients who underwent elective PCI, CysC was evaluated at baseline and at 9 months after PCI, and the percent change in CysC (%CysC) was calculated. The association between %CysC and baseline characteristics, including medication use, was assessed. Results: Of 143 patients, 86 had worsening renal function (WRF; %CysC ≥0), and 57 did not (non-WRF; %CysC ＜0). Only the use of angiotensin-converting enzyme inhibitor (ACEI) and baseline CysC were significantly different between WRF and non-WRF patients (15 vs. 40%, p=0.001 and 1.02±0.26 vs. 1.13±0.26 mg/L, p=0.015). In univariate analysis, the use of ACEI and CysC were negatively associated with WRF [Odds ratio (OR)=0.26, 95% confidence interval (CI)=0.12–0.57, p＜0.001 and OR=0.20, 95% CI=0.05–0.73, p=0.015]. Furthermore, multivariate analysis revealed that the use of ACEI and CysC significantly correlated with WRF (OR=0.26, 95% CI=0.11–0.57, p＜0.001 and OR=0.20, 95% CI=0.05–0.74, p=0.016). The %CysC in 36 patients with ACEI was significantly lower than that in 107 patients without ACEI [median: －3.8%; interquartile range (IQR), －11.0 to 4.2%; vs. median: 3.3%; IQR －2.9 to 11.0%, p=0.001]. Conclusion: The use of ACEI was associated with lower CysC after PCI, suggesting that ACEI prevents worsening of renal function in late phase after PCI.

DOI： 10.5551/jat.33266

Scopus

PubMed

CiNii Research

Kawasoe Shin, Kubozono Takuro, Yoshifuku Shiro, Ojima Satoko, Oketani Naoya, Miyata Masaaki, Miyahara Hironori, Maenohara Shigeho, Ohishi Mitsuru . Uric Acid Level and Prevalence of Atrial Fibrillation in a Japanese General Population of 285,882 . Circulation Journal80 ( 12 ) 2453 - 2459 2016

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

Background:The association between serum uric acid (UA) levels and atrial fibrillation (AF) in the general population in Japan is not well known.Methods and Results:In total, 285,882 consecutive subjects (men, 130,897; women, 154,985; age, 58±15 years) not receiving treatment for hyperuricemia who underwent health checkups were enrolled. Subjects were stratified into deciles according to age, body mass index, estimated glomerular filtration rate, systolic blood pressure, and UA level. AF prevalence was calculated for each decile. The odds ratio that defined the decile with the lowest AF prevalence as reference was calculated in each sex. In men, the mean UA was 6.0±1.4 mg/dl; AF prevalence was 1.8% and was lowest in the decile with UA 4.4–4.9 mg/dl. Deciles with both high and low UA (5.4–5.6 mg/dl to >7.8 mg/dl and <4.3 mg/dl) were associated with significantly higher AF prevalence. In women, the mean UA was 4.5±1.1 mg/dl; AF prevalence was 0.7% and was lowest in the decile with UA 3.6–3.8 mg/dl. Deciles with highest UA (5.0–5.2 mg/dl to >5.9 mg/dl) were associated with significantly higher AF prevalence. The analysis adjusted for other clinical covariates demonstrated an independent association between UA and AF in both sexes.Conclusions:In a representative Japanese general population, UA level was significantly associated with AF, independently of other cardiovascular risk factors. (Circ J 2016; 80: 2453–2459)

DOI： 10.1253/circj.cj-16-0766

Iriki Yasuhisa, Oketani Naoya, Ohishi Mitsuru . The implantation of a loop recorder to detect the cause of pre-syncope in an 85-year-old man . Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics53 ( 4 ) 419 - 423 2016

Language：Japanese Publisher：The Japan Geriatrics Society

The patient was an-85-year-old man with hypertension and hyperlipidemia. The patient had a history of faintness on standing. He visited our hospital after experiencing chest oppression and pre-syncope in 2015. Brain magnetic resonance imaging and echocardiography did not detect any structural brain or heart disease. Ischemic heart disease was suspected based on the myocardial scintigraphy findings, but coronary angiography revealed no unusual findings. Holter electrocardiography did not reveal the reason for his symptoms. Because he had experienced 2-second sinus arrest rather than faintness or pre-syncope during the Holter monitoring (not an indication for the implantation of a pacemaker), we implanted a loop recorder to detect the cause of pre-syncope.The loop recorder required that he or his family to manually send the telemetry monitoring data, but he and his wife did not understand how to do it. After the loop recorder failed to reveal the cause of his symptoms, he was hospitalized for its extraction. When we manually checked the loop recorder data on the day of hospitalization, sinus arrest of >3 seconds was detected 271 times; the maximum sinus arrest was 4 seconds. Sinus arrest was confirmed to be cause of his symptoms. His symptoms completely disappeared after the implantation of a permanent pacemaker.Although faintness is not rare in elderly people, it can be difficult to diagnose. An implantable loop recorder was useful for diagnosing pre-syncope; however, in the present case, it was difficult for the elderly patient and his wife to perform telemetry monitoring.

DOI： 10.3143/geriatrics.53.419

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CiNii Research

Chaen Hideto, Kinchiku Shigesumi, Miyata Masaaki, Kajiya Shoko, Uenomachi Hitoshi, Yuasa Toshinori, Takasaki Kunitsugu, Ohishi Mitsuru . Validity of a Novel Method for Estimation of Low-Density Lipoprotein Cholesterol Levels in Diabetic Patients . Journal of Atherosclerosis and Thrombosis23 ( 12 ) 1355 - 1364 2016

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

Aim: Low-density lipoprotein cholesterol (LDL-C) is routinely estimated using the Friedewald equation [LDL-C(F)]. A novel method for LDL-C [LDL-C(M)] estimation recently proposed by Martin et al. was reported to be more accurate than the Friedewald formula in subjects in the United States. The validity of LDL-C(M) in different races and patients with diabetes mellitus (DM) has not been elucidated. The purpose of this study was to validate the LDL-C(M) estimates in Japanese population with type 2 DM by comparing with LDL-C(F) and directly measured LDL-C [LDL-C(D)].Methods: Both LDL-C(M) and LDL-C(F) levels were compared against LDL-C(D) measured by selective solubilization method in 1,828 Japanese patients with type 2 DM.Results: On linear regression analysis, LDL-C(M) showed a stronger correlation than that shown by LDL-C(F) (R=0.979 vs. R=0.953, respectively) with LDL-C(D). We further analyzed the effect of serum triglyceride (TG) concentrations on the accuracy of LDL-C(F) and LDL-C(M). Although LDL-C levels showed a positive correlation with TG levels, the LDL-C(F) levels tended to show a greater divergence from LDL-C(D) levels than that shown by LDL-C(M) with changes in TG levels.Conclusion: We for the first time demonstrated a more useful measurement of LDL-C levels estimated by Martin's method than that estimated by the Friedewald equation in Japanese patients with DM.

DOI： 10.5551/jat.35972

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PubMed

CiNii Research

Sachi Ohno, Masaaki Miyata, Atsushi Kohjitani, Akina Tohya, Mitsuru Ohishi, Kazuna Sugiyama . Associations between blood pressure responses to acute stress and impaired renal function and serum uric acid level . CLINICAL AND EXPERIMENTAL HYPERTENSION37 ( 8 ) 656 - 660 2015.11Reviewed

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：TAYLOR & FRANCIS INC

The study aimed to examine correlations between blood pressure (BP) responses to direct laryngoscopy and tracheal intubation and parameters of renal function, serum uric acid (SUA) level, and mean preoperative BP. Fifty-four patients (40 years) who were scheduled for oral surgery were analyzed. General anesthesia was induced by the rapid sequence method without opioid analgesics. Systolic and diastolic BP (SBP, DBP) in the operation room were measured when an electrocardiogram, a BP cuff, and a pulse oximetry probe were attached to the patients (T1) and immediately after the trachea was intubated (T2). The SBP was defined as the difference between SBP at T2 and T1. The increasing rate of SBP (SBPr) was defined as SBP/SBP at T1. SBP at T2 was associated with increasing age (R=0.44), serum creatinine (R=0.32), SUA (R=0.30), mean preoperative SBP and DBP (R=0.54 and 0.37, respectively), and reduced estimated glomerular filtration rate (eGFR) (R=-0.44). Serum creatinine and SUA were positively associated, and eGFR was negatively associated with SBP (R=0.36, 0.34, and -0.29) and SBPr (R=0.39, 0.37, and -0.29). Multivariate regression analysis revealed that age and mean preoperative SBP was independently associated with SBP at T2, and serum creatinine was independently associated with SBP and SBPr. These findings suggested that elevated serum creatinine level, as well as elevated preoperative BP level, was associated with enhanced BP responses to acute stress in middle-aged to elderly patients.

DOI： 10.3109/10641963.2015.1047939

Web of Science

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PubMed

吉野聡史, 大牟禮健太, 福元大地, 田端宏之, 立石繁宜, 大石充 . SES留置後の冠動脈内皮機能障害に対する内科的治療と左主幹部病変に対するBES留置にて胸部症状消失した1例 . 日本冠疾患学会雑誌 ( Suppl. ) 174 - 174 2015.11

池田義之, 大石充 . 【フレイルと心血管疾患:転倒・骨折との関わり】フレイルの心血管リスクについて . Progress in Medicine35 ( 11 ) 1683 - 1686 2015.11

Lee Y, Motomura G, Yamamoto T, Nakashima Y, Ohishi M, Hamai S, Iura K, Iwamoto Y . Rapidly destructive arthrosis of the hip joint in a young adult with systemic lupus erythematosus. . Rheumatology international35 ( 10 ) 1753 - 7 2015.10Reviewed

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Papers - OHISHI Mitsuru