研究者詳細 - 牧迫　飛雄馬

論文 - 牧迫　飛雄馬

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Shiratsuchi D. . Associations Between Health Literacy and Changes in Exercise Behavior During the Coronavirus Disease 2019 State of Emergency Among Middle-Aged Adults: A Cross-Sectional Online Survey . Asia-Pacific Journal of Public Health34 ( 2-3 ) 10105395211053160 - 10105395211053160 2021年10月査読国際誌

Kiuchi Y. . Associations of alpha-actinin-3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia . Experimental Gerontology154 111525 - 111525 2021年10月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Experimental Gerontology

Background: This cross-sectional study aimed to investigate the relationship of the ACTN3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia. Methods: Data from 64 older Japanese adults (mean age 74.4 ± 6.9 years, women 71.9%) with sarcopenia or pre-sarcopenia were analyzed. Sarcopenia and pre-sarcopenia were defined using the Asian Working Group for Sarcopenia. We collected oral mucosa samples to determine the ACTN3 genotype. Thigh muscle volumes were measured using magnetic resonance imaging. Physical performance was assessed using the usual and maximum gait speed, timed up and go test, and five-repetition sit-to-stand test. Muscle strength was assessed using grip strength. Result: The ACTN3 genotype proportions were 20.3% for RR, 51.6% for RX, and 28.1% for XX. Participants with the RR genotype showed greater thigh muscle volume/ht2 compared to those with the RX and XX ACTN3 genotypes (p < 0.05). The multiple linear regression analysis revealed that RX (p < 0.01) and XX (p < 0.01) ACTN3 genotypes, compared to RR, were associated with lower thigh muscle volume/ht2 and with age, sex (reference; men), weight and maximum walking speed. There was no significant difference between physical performance and muscle strength between the ACTN3 genotypes. Conclusion: The ACTN3 genotype of the X allele was associated with decreased thigh muscle volume compared to the ACTN3 genotype of RR in older adults with sarcopenia or pre-sarcopenia.

DOI： 10.1016/j.exger.2021.111525

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Makizako H. . Association between regular exercise and self-rated health and sleep quality among adults in japan during the covid-19 pandemic . International Journal of Environmental Research and Public Health18 ( 19 ) 2021年10月査読国際誌

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Regular exercise may be associated with better self-rated health and sleep status. However, this correlation among various age groups, such as young, middle-aged, and older people, as well as during the COVID-19 pandemic, has not been examined. This study examined the correlation between regular exercise and self-rated health and sleep quality among adults in Japan during the COVID-19 pandemic. Data were collected using an online survey conducted between February 26 and 27, 2021. A total of 1410 adults in Japan (age range, 20–86 years) completed the online survey. Regular exercise was divided into: (1) more than 30 min of moderate exercise a day, (2) more than 2 days per week, and (3) continuous for 1 year or longer. Self-rated health and sleep quality were assessed using the Likert scale. After adjusting for multiple confounders, regular exercise was correlated with decreased poor self-rated health and poor sleep quality in middle-aged adults; however, no significant correlation was observed among young and older adults. The promotion of regular exercise among middle-aged people during the COVID-19 pandemic may contribute to better self-rated health and sleep quality status.

DOI： 10.3390/ijerph181910515

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Makizako H, Akaida S, Shono S, Shiiba R, Taniguchi Y, Shiratsuchi D, Nakai Y . Physical Activity and Perceived Physical Fitness during the COVID-19 Epidemic: A Population of 40- to 69-Year-Olds in Japan. . International journal of environmental research and public health18 ( 9 ) 2021年4月査読国際誌

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International journal of environmental research and public health

The COVID-19 pandemic has caused an abrupt change in lifestyle for many people with restrictions, often leading to a decrease in physical activity (PA), and thus contributing to a negative perception of health status. The purpose of this study was to examine the effects of the COVID-19 epidemic on physical activity and perceived physical fitness in Japanese adults aged 40 to 69 years. Data were collected from an online survey conducted between October 19 and 28, 2020. The analytic sample consisted of 1989 Japanese adults (mean age, 50.1 ± 6.9 years; women, 38.9%) who were aged between 40 and 69 years and completed the online survey. Overall, the PA time per week decreased by 32.4% between October 2019 and April 2020. A decrease in PA time was recorded in October 2020; however, a decline of 15.5% was observed. Compared to individuals who did not perceive a decline in physical fitness, individuals who perceived declining physical fitness during the COVID-19 state of emergency demonstrated a greater decrease in PA time in April 2020 (–50.5%), and this trend continued into October 2020 (–25.0%). These findings may indicate that Japanese adults aged 40 to 69 years who perceived declining physical fitness experienced a greater decrease in physical activity.

DOI： 10.3390/ijerph18094832

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Makizako H. . Perceived declining physical and cognitive fitness during the COVID-19 state of emergency among community-dwelling Japanese old-old adults . Geriatrics and Gerontology International21 ( 4 ) 364 - 369 2021年4月査読

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Geriatrics and Gerontology International

Aim: Perceived health status, including physical and cognitive fitness, will be negatively associated with future health conditions among old-old adults. The coronavirus disease 2019 (COVID-19) pandemic has caused sudden changes in lifestyle. Thus, this study examined the associations of participation in an exercise class before the COVID-19 pandemic and the exercise habits and disruption to the rhythms of daily life during the COVID-19 state of emergency with perceived declining physical and cognitive fitness among community-dwelling old-old adults. Methods: In July 2020, we carried out a mail survey of community-dwelling old-old adults aged between 77 and 99 years in Bibai, Hokkaido, Japan, to determine their perceived declining physical and cognitive fitness during the COVID-19 state of emergency. Results: Of the 774 responders, 339 (43.8%) participants reported a decline in physical fitness, whereas 259 (33.5%) perceived declining cognitive fitness during the COVID-19 state of emergency. In a multivariate logistic regression model adjusted for potential confounders, exercise habits during the COVID-19 state of emergency were significantly associated with a lower perception of declining physical fitness. Disruption to the rhythms of daily life during the COVID-19 state of emergency was significantly associated with a higher perception of declining physical and cognitive fitness. Conclusions: Approximately half and more than one-third of community-dwelling old-old adults perceived declining physical and cognitive fitness, respectively, during the COVID-19 state of emergency. During this period, exercise habits were positively correlated with perceived health status among old-old adults, whereas disruption to the rhythms of daily life was negatively correlated. Geriatr Gerontol Int 2021; 21: 364–369.

DOI： 10.1111/ggi.14140

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Saji N. . Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study :Hearing impairment and the clock drawing task . Archives of Gerontology and Geriatrics93 104302 - 104302 2021年3月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Gerontology and Geriatrics

Background: Hearing impairment (HI) is associated with dementia. However, the cognitive screening tasks effective in older community dwellers presenting with HI are unclear. Methods: We retrospectively and cross-sectionally investigated the associations between HI and cognitive function assessed with screening tasks using data from two healthcare check-up programs for community dwellers ≥65 years old in 2018. We examined demographics, risk factors, cognitive function, hearing condition, lifestyles, and self-care levels. Cognitive function was assessed using the clock drawing task and the delayed three words recall task. Hearing condition was assessed using questionnaires on the use of hearing aids and HI during conversation situations. Multivariate analysis was used to identify independent associations between HI and cognitive assessment tasks. Results: We analyzed 1602 eligible participants (61.9% women; 74.3 ± 6.5 years old). Hearing aid users (n = 90) were older (80 vs. 73 years, respectively; p < 0.001) and less likely to draw the clock correctly (71.1% vs. 80.1% years, respectively; p = 0.044) than non-hearing aid users. Multivariate logistic regression analysis showed that HI was associated with inability to draw the clock correctly (odds ratio 1.60, 95% confidence interval 1.12–2.26; p = 0.011), independent of age, living alone, memory impairment, and impaired self-care levels. Conclusion: Hearing impairment is independently associated with cognitive decline assessed by the clock drawing task. The clock drawing task may be useful for identifying an increased risk of dementia in older subjects presenting with HI.

DOI： 10.1016/j.archger.2020.104302

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Saji N, Makizako H, Suzuki H, Nakai Y, Tabira T, Obuchi S, Kawai H, Murotani K, Katayama N, Toba K, Uchida Y, Nakashima T. . Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study . Arch Gerontol Geriatr93 2021年3月査読

Saji N, Suzuki H, Katayama N, Makizako H, Uchida Y, Nakashima T. . Sensory impairment: A preventable risk factor in older adults . Arch Gerontol Geriatr93 2021年3月査読

和田あゆみ, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 佐藤菜々, 木山良二, 田平隆行, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における社会的フレイルとうつ傾向との関連 . 鹿児島大学医学部保健学科紀要31 ( 1 ) 11 - 18 2021年3月査読

担当区分：責任著者記述言語：日本語出版者・発行元：鹿児島大学医学部保健学科

地域コホート研究(垂水研究2018)のデータを用いて、地域在住高齢者における社会的フレイルとうつ傾向との関連について横断観察研究を行った。対象は研究に対する同意が得られた65歳以上の地域在住高齢者859名であった。最終的に社会的フレイルの有無および高齢者用うつ尺度短縮版(GDS15)、その他基本属性に欠損のない812名(男性304名、女性508名、平均年齢74.8歳)を有効回答とし分析対象とした。対象者のうち社会的フレイルを有する者は112名(13.8%)であった。社会的フレイルを有する者は社会的フレイルを有しない者と比較し、高齢で、GDS15の点数は高く、歩行速度、握力が低下していた。社会的フレイルを有する者でうつ傾向のある者は37名(33.0%)で、社会的フレイルを有さない者でうつ傾向のある者90名(12.9%)と比較して有意に高い割合であった。ロジスティック回帰分析の結果からも社会的フレイルはうつ傾向と関連していることが示された。

機関リポジトリURL

Shiratsuchi D. . Association of health literacy with the implementation of exercise during the declaration of covid-19 state of emergency among Japanese community-dwelling old-old adults . International Journal of Environmental Research and Public Health18 ( 4 ) 1 - 9 2021年2月査読国際誌

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Health literacy is important for promoting and maintaining good health in old-old adults. It may influence the implementation of exercise in the coronavirus disease epidemic. The present cross-sectional study investigated the association of each dimension of health literacy with the implementation of exercise during the declaration of a state of emergency due to coronavirus disease in community-dwelling old-old adults. We collected data from 483 community-dwelling old-old adults (52.8% women) aged between 77 and 99 years who participated in a mail survey. Participants were divided into exercise or nonexercise groups based on the implementation of exercise during the declaration of a state of emergency. Health literacy was assessed using a 14-item health literacy scale. There were 327 (67.7%) participants in the exercise group and 156 (32.3%) in the nonexercise group. A significantly higher score of health literacy was observed in the exercise group than in the nonexercise group (communicative health literacy score = 14.0 ± 3.6 vs. 12.7 ± 3.8, p = 0.001). In a multivariate logistic regression model adjusted for potential confounders, high communicative health literacy scores were significantly associated with the implementation of exercise during the declaration of a state of emergency (odds ratio = 1.88, 95% confidence interval = 1.20–2.93). Approximately two-thirds of community-dwelling old-old adults implement exercise during the declaration of a state of emergency. High communicative health literacy was associated with the implementation of exercise during this period.

DOI： 10.3390/ijerph18042100

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Suzuki T. . Are Japanese Older Adults Rejuvenating? Changes in Health-Related Measures among Older Community Dwellers in the Last Decade . Rejuvenation Research24 ( 1 ) 37 - 48 2021年2月査読国際誌

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Rejuvenation Research

During the last three decades, Japan has become one of the world's top countries for longevity, and the increase in average life expectancy is accompanied by a sharp rise in older population 65 years of age and above to ∼28%. This study aimed to examine the changes in major health-related measures, including a physical constitution, physical function, and functional capacity of community-dwelling Japanese older people in the last decade. From the data of 13 longitudinal cohort studies on aging conducted in Japan with a total of 13,441 older subjects, this study analyzed the changes in six indices that are related to health and functioning of the older people; height, weight, body mass index, walking speed, grip strength, and instrumental activity of daily living, between 2007 (±2 years) and 2017 (±2 years). Comparison of data for the two periods between subjects matched for age group and gender evidently showed better health status and a slower decline in most of the health-related measures in 2017 compared to a decade ago. The results of this study indicate that the phenomenon of "rejuvenation"is occurring among the new generation of Japanese older adults, and the importance of this older population as a social resource in the super-aged society should be reacknowledged.

DOI： 10.1089/rej.2019.2291

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Kiuchi Y, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Kimura M, Kanouchi H, Takenaka T, Kubozono T, Ohishi M. . The Association between Dietary Variety and Physical Frailty in Community-Dwelling Older Adults . Healthcare9 ( 1 ) 32 2021年1月査読

Shiratsuchi D, Taniguchi Y, Akaida S, Tateishi M, Kiuchi Y, Kuratsu R, Makizako H . Influence of exercise and dietary habits on the association of alpha-actinin-3 gene polymorphisms with physical function and body composition in community-dwelling individuals aged 60 years and older. . Geriatrics & gerontology international 2024年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Geriatrics and Gerontology International

Aim: Alpha-actinin 3 (ACTN3) is associated with diminished physical function and muscle mass in older individuals. However, the effects of lifestyle on this relationship remain unclear. This study explored whether the association between ACTN3 polymorphisms and physical function and body composition varied based on exercise and dietary habits. Methods: A longitudinal analysis of 197 community-dwelling individuals aged 60 years and older (mean age 72.5 ± 5.9 years, 60.9% women) in the Tarumizu study provided data on ACTN3 gene polymorphisms, with surveys completed in 2019 and 2022 (mean follow-up 1156 ± 80.0 days). Physical performance (grip strength, walking speed) and body composition (body weight, appendicular skeletal muscle mass [ASMM], and fat mass) were assessed. Genetic polymorphisms were analyzed in oral mucosa samples and categorized into type R allele carriers and type XX alleles (homozygous for minor alleles). Median values determined exercise habits (≤4 days/week or ≥5 days/week) and dietary habits based on high-protein-food frequency scores. Results: The proportion of type XX genetic polymorphism was 26.4%. Two-way repeated-measures analysis of covariance showed a significant interaction between genetic polymorphism and time for ASMM (F = 10.552, P = 0.002) in the ≤4 days/week exercise habits group. Significant interactions were observed in grip strength (F = 7.013, P = 0.009) and ASMM (F = 5.347, P = 0.023) for the ≤11 score high-protein-intake group. Conclusions: This association may contribute to accelerated age-related changes in physical performance and body composition, particularly among individuals with type XX genetic polymorphism who have low exercise habits and a limited intake of high-protein foods. Geriatr Gerontol Int 2024; ••: ••–••.

DOI： 10.1111/ggi.15042

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Akasaki Y, Tabira T, Maruta M, Makizako H, Shimokihara S, Hidaka Y, Kamasaki T, Kukizako W, Kubozono T, Ohishi M . Subjective Memory Complaints Related to Satisfaction With Meaningful Activities Among Community-Dwelling Older Adults. . Cureus16 ( 11 ) e73433 2024年11月

立石麻奈, 赤井田将真, 谷口善昭, 木内悠人, 白土大成, 牧迫飛雄馬 . フレイル高齢者に対する個別運動と集団運動による効果の相違の検証―ランダム化比較試験― . 日本老年医学会雑誌61 ( 4 ) 447 - 455 2024年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本老年医学会

目的：フレイルの予防・改善を目的とした運動介入において個別運動または集団運動といった運動の実施形態の違いは異なった効果をもたらすことが考えられる．本研究は地域在住のフレイルおよびプレフレイル高齢者を対象に運動介入形態の違い（個別または集団）が心身機能に及ぼす影響を明らかにすることを目的とした．方法：フレイルまたはプレフレイルを有する高齢者21名（平均77.1±3.3歳，女性90.5％）を個別群11名と集団群10名にランダムに割りつけ，週1回90分の運動を12週間実施した．個別群はトレーニングマシンを使用して行う筋力トレーニングを含むマルチコンポーネント運動プログラム，集団群は椅子座位中心，自重での筋力トレーニングを含むマルチコンポーネント運動プログラムを実施した．評価項目は身体組成，身体機能，認知機能とした．介入前後の比較および，群間における変化率の比較を行った．結果：介入前後の比較において個別群でBMI（p＝0.03），体脂肪量（p＜0.01）で有意な減少が認められ，5回立ち座り（p＜0.01），歩行速度（p＝0.02）が有意に改善した．集団群では，5回立ち座り（p＜0.01），情報処理機能（p＝0.03）で有意な改善が認められた．群間における変化率の比較では5回立ち座りにおいて個別群は集団群と比較して有意な改善が認められた（p＝0.01）．結論：運動の実施形態に関わらず，身体機能の改善が示され，個別群のみでBMI，体脂肪量の減少，集団群のみで認知機能の改善がみられた．フレイルおよびプレフレイル高齢者における運動介入において運動の実施形態による効果の特性を考慮することは，個人の背景に則した運動プログラム作成の一助になりうる．

DOI： 10.3143/geriatrics.61.447

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Shiratsuchi D., Taniguchi Y., Kiuchi Y., Akaida S., Makizako H. . Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults . European Geriatric Medicine 2024年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：European Geriatric Medicine

Aim: To investigate the association between ACTN3 R577X polymorphism and appendicular skeletal muscle mass, walking speed, and muscle strength in older adults. Findings: RR homozygosity in the ACTN3 gene was associated with a lower likelihood of having low muscle mass. However, no significant association existed between ACTN3 polymorphism and walking speed or muscle strength. Message: ACTN3 R577X polymorphism may be associated with muscle mass but not physical function in terms of walking speed and muscle strength in older adults.

DOI： 10.1007/s41999-024-01080-0

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その他リンク： https://link.springer.com/article/10.1007/s41999-024-01080-0/fulltext.html

Kiuchi Y., Tsutsumimoto K., Nishimoto K., Misu Y., Ohata T., Makizako H., Shimada H. . Effect of eating alone and depression symptoms on incident disability among community-dwelling older adults . Nutrition129 112599 - 112599 2024年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrition

Objectives: The intent of the present study was to elucidate the association of eating alone and depressive symptoms with the development of disability among community-dwelling older adults, using a longitudinal study. Method: Participants included 4648 Japanese older adults (mean age 73.8 ± 5.4 years; 44.3% men) aged ≥ 65 years at the time of the examination. Eating status was divided into two categories: “Eating with others at least once a day” and “Other.” The 15-item Geriatric Depression Scale was used to measure depressive symptoms. Incident disability was certified by long-term care insurance (median duration: 36 months). Results: During a median follow-up at 36 months, 8.0% of the participants developed an incident disability. Adjusted for covariates, the participants who ate alone were associated with a higher hazard ratio of incident disability compared to those who ate with others (hazard ratio: 1.36, 95% confidence interval: 1.05–1.75). However, adjusted for the covariate depressive symptoms, eating alone was not significantly associated with incident disability. Structural equation models revealed that the indirect model confirmed eating alone habits were associated with disability via depressive symptoms. Conclusions: This study confirmed that eating alone was associated with an incident disability after adjusting for the covariates. Furthermore, the present study suggests an indirect relationship between eating alone and incident disability via depressive symptoms, the result of the structural equation model.

DOI： 10.1016/j.nut.2024.112599

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Makizako H, Akaida S, Tateishi M, Shiratsuchi D, Kiyama R, Kubozono T, Takenaka T, Ohishi M . A Three-Year Longitudinal Follow-Up Study: Does Mild Cognitive Impairment Accelerate Age-Related Changes in Physical Function and Body Composition? . Cureus16 ( 9 ) e68605 2024年9月

Ishigaki T, Misu S, Miyashita T, Matsumoto D, Kamiya M, Okamae A, Ogawa T, Ihira H, Taniguchi Y, Ohnuma T, Chibana T, Morikawa N, Ikezoe T, Makizako H . Effects of Walking-Only Intervention on Physical Function, Fall-Related Outcomes, and Health-Related Quality of Life in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. . Journal of aging and physical activity 1 - 13 2024年8月

鈴木隆雄, 鄭丞媛, 西田裕紀子, 大塚礼, 島田裕之, 牧迫飛雄馬, 金憲経, 大渕修一, 河合恒, 藤原佳典, 阿部巧, 小島成実, 平野浩彦, 増井幸恵, 稲垣宏樹, 吉田祐子, 飯島勝矢, 吉村典子, 山田実, 渡辺修一郎, 近藤克則, 村木功, 岩佐一 . 地域在宅高齢者における高次生活機能について　ILSA-JにおけるJST版活動能力指標の分析から . 応用老年学18 ( 1 ) 107 - 116 2024年8月

記述言語：日本語出版者・発行元：(一社)日本応用老年学会

日本は急速な超高齢社会を迎え,平均寿命の著しい伸びとともに,高齢者の生活機能も大きく変容し,健康水準の高い活力ある高齢者が増加している.本研究では,我が国の地域在宅高齢者を対象とした老化に関する多数のコホート研究の統合研究(「長寿コホートの統合的研究;Integrated Longitudinal Study on Aging in Japan:ILSA-J」)で収集された高次生活機能評価指標であるJST版活動能力指標(JST-IC)を用いて,現代の地域在宅高齢者における生活活動能力の現状を報告した.JST-ICでは総合スコアおよび4項目の下位尺度(新機器利用,情報収集,生活マネジメント,社会参加)について性別および年齢階級別の平均値と標準偏差を算出した.その結果,男女間では情報収集以外の全ての項目で性差が認められ,年齢階級間では男女ともに全ての項目で有意差が認められ,加齢に伴いスコアは低下していた.本研究では,高齢者の高次生活機能の一端を明らかにし,今後の利活用に資する資料とした.(著者抄録)

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