研究者詳細 - 牧迫　飛雄馬

論文 - 牧迫　飛雄馬

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Shiratsuchi D. . Associations Between Health Literacy and Changes in Exercise Behavior During the Coronavirus Disease 2019 State of Emergency Among Middle-Aged Adults: A Cross-Sectional Online Survey . Asia-Pacific Journal of Public Health34 ( 2-3 ) 10105395211053160 - 10105395211053160 2021年10月査読国際誌

Kiuchi Y. . Associations of alpha-actinin-3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia . Experimental Gerontology154 111525 - 111525 2021年10月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Experimental Gerontology

Background: This cross-sectional study aimed to investigate the relationship of the ACTN3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia. Methods: Data from 64 older Japanese adults (mean age 74.4 ± 6.9 years, women 71.9%) with sarcopenia or pre-sarcopenia were analyzed. Sarcopenia and pre-sarcopenia were defined using the Asian Working Group for Sarcopenia. We collected oral mucosa samples to determine the ACTN3 genotype. Thigh muscle volumes were measured using magnetic resonance imaging. Physical performance was assessed using the usual and maximum gait speed, timed up and go test, and five-repetition sit-to-stand test. Muscle strength was assessed using grip strength. Result: The ACTN3 genotype proportions were 20.3% for RR, 51.6% for RX, and 28.1% for XX. Participants with the RR genotype showed greater thigh muscle volume/ht2 compared to those with the RX and XX ACTN3 genotypes (p < 0.05). The multiple linear regression analysis revealed that RX (p < 0.01) and XX (p < 0.01) ACTN3 genotypes, compared to RR, were associated with lower thigh muscle volume/ht2 and with age, sex (reference; men), weight and maximum walking speed. There was no significant difference between physical performance and muscle strength between the ACTN3 genotypes. Conclusion: The ACTN3 genotype of the X allele was associated with decreased thigh muscle volume compared to the ACTN3 genotype of RR in older adults with sarcopenia or pre-sarcopenia.

DOI： 10.1016/j.exger.2021.111525

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Makizako H. . Association between regular exercise and self-rated health and sleep quality among adults in japan during the covid-19 pandemic . International Journal of Environmental Research and Public Health18 ( 19 ) 2021年10月査読国際誌

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Regular exercise may be associated with better self-rated health and sleep status. However, this correlation among various age groups, such as young, middle-aged, and older people, as well as during the COVID-19 pandemic, has not been examined. This study examined the correlation between regular exercise and self-rated health and sleep quality among adults in Japan during the COVID-19 pandemic. Data were collected using an online survey conducted between February 26 and 27, 2021. A total of 1410 adults in Japan (age range, 20–86 years) completed the online survey. Regular exercise was divided into: (1) more than 30 min of moderate exercise a day, (2) more than 2 days per week, and (3) continuous for 1 year or longer. Self-rated health and sleep quality were assessed using the Likert scale. After adjusting for multiple confounders, regular exercise was correlated with decreased poor self-rated health and poor sleep quality in middle-aged adults; however, no significant correlation was observed among young and older adults. The promotion of regular exercise among middle-aged people during the COVID-19 pandemic may contribute to better self-rated health and sleep quality status.

DOI： 10.3390/ijerph181910515

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Makizako H, Akaida S, Shono S, Shiiba R, Taniguchi Y, Shiratsuchi D, Nakai Y . Physical Activity and Perceived Physical Fitness during the COVID-19 Epidemic: A Population of 40- to 69-Year-Olds in Japan. . International journal of environmental research and public health18 ( 9 ) 2021年4月査読国際誌

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International journal of environmental research and public health

The COVID-19 pandemic has caused an abrupt change in lifestyle for many people with restrictions, often leading to a decrease in physical activity (PA), and thus contributing to a negative perception of health status. The purpose of this study was to examine the effects of the COVID-19 epidemic on physical activity and perceived physical fitness in Japanese adults aged 40 to 69 years. Data were collected from an online survey conducted between October 19 and 28, 2020. The analytic sample consisted of 1989 Japanese adults (mean age, 50.1 ± 6.9 years; women, 38.9%) who were aged between 40 and 69 years and completed the online survey. Overall, the PA time per week decreased by 32.4% between October 2019 and April 2020. A decrease in PA time was recorded in October 2020; however, a decline of 15.5% was observed. Compared to individuals who did not perceive a decline in physical fitness, individuals who perceived declining physical fitness during the COVID-19 state of emergency demonstrated a greater decrease in PA time in April 2020 (–50.5%), and this trend continued into October 2020 (–25.0%). These findings may indicate that Japanese adults aged 40 to 69 years who perceived declining physical fitness experienced a greater decrease in physical activity.

DOI： 10.3390/ijerph18094832

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Makizako H. . Perceived declining physical and cognitive fitness during the COVID-19 state of emergency among community-dwelling Japanese old-old adults . Geriatrics and Gerontology International21 ( 4 ) 364 - 369 2021年4月査読

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Geriatrics and Gerontology International

Aim: Perceived health status, including physical and cognitive fitness, will be negatively associated with future health conditions among old-old adults. The coronavirus disease 2019 (COVID-19) pandemic has caused sudden changes in lifestyle. Thus, this study examined the associations of participation in an exercise class before the COVID-19 pandemic and the exercise habits and disruption to the rhythms of daily life during the COVID-19 state of emergency with perceived declining physical and cognitive fitness among community-dwelling old-old adults. Methods: In July 2020, we carried out a mail survey of community-dwelling old-old adults aged between 77 and 99 years in Bibai, Hokkaido, Japan, to determine their perceived declining physical and cognitive fitness during the COVID-19 state of emergency. Results: Of the 774 responders, 339 (43.8%) participants reported a decline in physical fitness, whereas 259 (33.5%) perceived declining cognitive fitness during the COVID-19 state of emergency. In a multivariate logistic regression model adjusted for potential confounders, exercise habits during the COVID-19 state of emergency were significantly associated with a lower perception of declining physical fitness. Disruption to the rhythms of daily life during the COVID-19 state of emergency was significantly associated with a higher perception of declining physical and cognitive fitness. Conclusions: Approximately half and more than one-third of community-dwelling old-old adults perceived declining physical and cognitive fitness, respectively, during the COVID-19 state of emergency. During this period, exercise habits were positively correlated with perceived health status among old-old adults, whereas disruption to the rhythms of daily life was negatively correlated. Geriatr Gerontol Int 2021; 21: 364–369.

DOI： 10.1111/ggi.14140

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Saji N. . Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study :Hearing impairment and the clock drawing task . Archives of Gerontology and Geriatrics93 104302 - 104302 2021年3月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Gerontology and Geriatrics

Background: Hearing impairment (HI) is associated with dementia. However, the cognitive screening tasks effective in older community dwellers presenting with HI are unclear. Methods: We retrospectively and cross-sectionally investigated the associations between HI and cognitive function assessed with screening tasks using data from two healthcare check-up programs for community dwellers ≥65 years old in 2018. We examined demographics, risk factors, cognitive function, hearing condition, lifestyles, and self-care levels. Cognitive function was assessed using the clock drawing task and the delayed three words recall task. Hearing condition was assessed using questionnaires on the use of hearing aids and HI during conversation situations. Multivariate analysis was used to identify independent associations between HI and cognitive assessment tasks. Results: We analyzed 1602 eligible participants (61.9% women; 74.3 ± 6.5 years old). Hearing aid users (n = 90) were older (80 vs. 73 years, respectively; p < 0.001) and less likely to draw the clock correctly (71.1% vs. 80.1% years, respectively; p = 0.044) than non-hearing aid users. Multivariate logistic regression analysis showed that HI was associated with inability to draw the clock correctly (odds ratio 1.60, 95% confidence interval 1.12–2.26; p = 0.011), independent of age, living alone, memory impairment, and impaired self-care levels. Conclusion: Hearing impairment is independently associated with cognitive decline assessed by the clock drawing task. The clock drawing task may be useful for identifying an increased risk of dementia in older subjects presenting with HI.

DOI： 10.1016/j.archger.2020.104302

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Saji N, Makizako H, Suzuki H, Nakai Y, Tabira T, Obuchi S, Kawai H, Murotani K, Katayama N, Toba K, Uchida Y, Nakashima T. . Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study . Arch Gerontol Geriatr93 2021年3月査読

Saji N, Suzuki H, Katayama N, Makizako H, Uchida Y, Nakashima T. . Sensory impairment: A preventable risk factor in older adults . Arch Gerontol Geriatr93 2021年3月査読

和田あゆみ, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 佐藤菜々, 木山良二, 田平隆行, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における社会的フレイルとうつ傾向との関連 . 鹿児島大学医学部保健学科紀要31 ( 1 ) 11 - 18 2021年3月査読

担当区分：責任著者記述言語：日本語出版者・発行元：鹿児島大学医学部保健学科

地域コホート研究(垂水研究2018)のデータを用いて、地域在住高齢者における社会的フレイルとうつ傾向との関連について横断観察研究を行った。対象は研究に対する同意が得られた65歳以上の地域在住高齢者859名であった。最終的に社会的フレイルの有無および高齢者用うつ尺度短縮版(GDS15)、その他基本属性に欠損のない812名(男性304名、女性508名、平均年齢74.8歳)を有効回答とし分析対象とした。対象者のうち社会的フレイルを有する者は112名(13.8%)であった。社会的フレイルを有する者は社会的フレイルを有しない者と比較し、高齢で、GDS15の点数は高く、歩行速度、握力が低下していた。社会的フレイルを有する者でうつ傾向のある者は37名(33.0%)で、社会的フレイルを有さない者でうつ傾向のある者90名(12.9%)と比較して有意に高い割合であった。ロジスティック回帰分析の結果からも社会的フレイルはうつ傾向と関連していることが示された。

機関リポジトリURL

Shiratsuchi D. . Association of health literacy with the implementation of exercise during the declaration of covid-19 state of emergency among Japanese community-dwelling old-old adults . International Journal of Environmental Research and Public Health18 ( 4 ) 1 - 9 2021年2月査読国際誌

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Health literacy is important for promoting and maintaining good health in old-old adults. It may influence the implementation of exercise in the coronavirus disease epidemic. The present cross-sectional study investigated the association of each dimension of health literacy with the implementation of exercise during the declaration of a state of emergency due to coronavirus disease in community-dwelling old-old adults. We collected data from 483 community-dwelling old-old adults (52.8% women) aged between 77 and 99 years who participated in a mail survey. Participants were divided into exercise or nonexercise groups based on the implementation of exercise during the declaration of a state of emergency. Health literacy was assessed using a 14-item health literacy scale. There were 327 (67.7%) participants in the exercise group and 156 (32.3%) in the nonexercise group. A significantly higher score of health literacy was observed in the exercise group than in the nonexercise group (communicative health literacy score = 14.0 ± 3.6 vs. 12.7 ± 3.8, p = 0.001). In a multivariate logistic regression model adjusted for potential confounders, high communicative health literacy scores were significantly associated with the implementation of exercise during the declaration of a state of emergency (odds ratio = 1.88, 95% confidence interval = 1.20–2.93). Approximately two-thirds of community-dwelling old-old adults implement exercise during the declaration of a state of emergency. High communicative health literacy was associated with the implementation of exercise during this period.

DOI： 10.3390/ijerph18042100

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Suzuki T. . Are Japanese Older Adults Rejuvenating? Changes in Health-Related Measures among Older Community Dwellers in the Last Decade . Rejuvenation Research24 ( 1 ) 37 - 48 2021年2月査読国際誌

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Rejuvenation Research

During the last three decades, Japan has become one of the world's top countries for longevity, and the increase in average life expectancy is accompanied by a sharp rise in older population 65 years of age and above to ∼28%. This study aimed to examine the changes in major health-related measures, including a physical constitution, physical function, and functional capacity of community-dwelling Japanese older people in the last decade. From the data of 13 longitudinal cohort studies on aging conducted in Japan with a total of 13,441 older subjects, this study analyzed the changes in six indices that are related to health and functioning of the older people; height, weight, body mass index, walking speed, grip strength, and instrumental activity of daily living, between 2007 (±2 years) and 2017 (±2 years). Comparison of data for the two periods between subjects matched for age group and gender evidently showed better health status and a slower decline in most of the health-related measures in 2017 compared to a decade ago. The results of this study indicate that the phenomenon of "rejuvenation"is occurring among the new generation of Japanese older adults, and the importance of this older population as a social resource in the super-aged society should be reacknowledged.

DOI： 10.1089/rej.2019.2291

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Kiuchi Y, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Kimura M, Kanouchi H, Takenaka T, Kubozono T, Ohishi M. . The Association between Dietary Variety and Physical Frailty in Community-Dwelling Older Adults . Healthcare9 ( 1 ) 32 2021年1月査読

中原伶奈, 田平隆行, 下木原俊, 赤﨑義彦, 日高雄磨, 久木崎航, 釜崎大志郎, 松永修歩, 久村悠祐, 丸田道雄, 韓侊熙, 牧迫飛雄馬, 菅原英輝, 寺薗英之, 窪薗琢郎, 大石充 . 主観的記憶障害を有する地域在住高齢者の服薬管理の特徴 . 日本老年療法学会誌4 ( 0 ) n/a 2025年7月

記述言語：日本語出版者・発行元：一般社団法人日本老年療法学会

【目的】認知症の前臨床期である主観的記憶障害（SMC）段階からの複雑なIADL評価は重要であるが，SMC段階での服薬管理状況を詳しく調べた報告は希少である。本研究では，SMCを有する地域在住高齢者の服薬管理の具体的な特徴を明らかにすることを目的とした。【方法】本研究は，横断観察研究である。2019年度における地域コホート研究に参加した65歳以上の高齢者690名のうち，除外基準に該当する者を除外した573名を解析対象とした。対象者をSMCの有無で2群に分け，服薬状況調査項目との関連について2群間比較および共変量で調整した二項ロジスティック回帰分析を行った。【結果】対象者のうち，健常群が206名，SMC群が367名であり，共変量調整した二項ロジスティック回帰分析の結果，「残薬あり」（OR: 1.62, 95％ CI: 1.01–2.59, p＝0.04）と「抑うつ症状」（OR: 1.48, 95％ CI: 1.20–1.69, p＜0.001）はSMCと有意に関連した。【結論】地域在住高齢者において，SMCの段階から残薬の有無を把握し，服薬管理の早期支援を行うことは，認知機能低下が進行した際に服薬管理の介護負担を軽減し，残薬問題を解消する一助になる可能性がある。

DOI： 10.57270/jgts.2024_013_oa

CiNii Research

Hidaka Y, Shimokihara S, Akasaki Y, Maruta M, Han G, Kamasaki T, Kumura Y, Kukizaki W, Nakahara R, Makizako H, Kubozono T, Ohishi M, Tabira T . Longitudinal Relationship Between Grave Visitation and Depressive Symptoms Among Community-Dwelling Older Adults. . Clinical gerontologist 1 - 12 2025年7月

記述言語：英語出版者・発行元：Clinical Gerontologist

Objectives: Participating in religious activities benefits older adults’ mental health; however, the effects of grave visitation, a significant religious practice in Japan, on older adults’ mental health remain unclear. Therefore, this study examined the relationship between grave visitation frequency and depressive symptoms. Methods: A prospective cohort study of 273 community-dwelling older adults in Japan was conducted with baseline (2018) and follow-up (2022) assessments. Participants were categorized by visitation frequency: more or less than once a week. Changes in visitation frequency were classified as continued high, decreased, continued low, or increased. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Multivariable linear regressions were used to examine the association between visitation and depressive symptoms. Results: Lower visitation at baseline was associated with worse GDS-15 scores in the follow-up. Those with decreased or continued low visitation had significantly worse depressive symptoms. After adjusting for baseline GDS-15 scores and covariates, the decreased group had significantly worse depressive symptoms than the continued high group. Conclusions: The findings indicate that changes in grave visitation frequency are significantly associated with depressive symptoms. Clinical Implications: Supporting older adults’ access to grave visitation through transportation or community programs may help maintain their well-being and emotional health.

DOI： 10.1080/07317115.2025.2538105

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Takaoka R, Nishi K, Nakamura M, Yoshinaga H, Noma Y, Hayashi Y, Yuda S, Mishima Y, Ishikawa M, Yanagita Y, Yamashiro K, Kume K, Matsuda Y, Kanno T, Makizako H, Takenaka T, Kubozono T, Ohishi M, Okui T . Association between malnutrition and low tongue pressure in community-dwelling older people: a population-based cohort study. . Scientific reports15 ( 1 ) 25420 2025年7月

記述言語：英語出版者・発行元：Scientific Reports

The aim of this study was to analyze the data from a cohort study of community-dwelling older people to clarify the impact of low tongue pressure on the onset of malnutrition. The analysis was divided into a baseline and a longitudinal analysis. The baseline analysis included 765 people (median age: 74 years; 276 men and 489 women), and the longitudinal analysis included 100 people (median age: 72 years; 33 men and 67 women). The baseline analysis showed that tongue pressure and the diagnosis of low tongue pressure using a cut-off of 30 kPa were associated with the risk of malnutrition (tongue pressure: odds ratio [OR] = 0.972, 95% confidence interval [95% CI] = 0.953–0.992, p = 0.006; the diagnosis of low tongue pressure: OR = 1.555, 95% CI = 1.050–2.302, p = 0.027). In the longitudinal analysis, tongue pressure and the diagnosis of low tongue pressure at baseline were associated with the onset of the risk of malnutrition after 4 years (tongue pressure: OR = 0.952, 95% CI = 0.907–0.998, p = 0.041; the diagnosis of low tongue pressure: OR = 2.698, 95% CI = 1.148–6.341; p = 0.023). In community-dwelling older people, low tongue pressure could increase the risk of future malnutrition.

DOI： 10.1038/s41598-025-11229-x

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牧迫飛雄馬 . おさえておきたい転倒･転落予防の基本知識と現場での応用 7.転倒･転落の主な原因と対策:⑥ 環境 . J. of Clinical Rehabilitation34 ( 4 ) 421 - 426 2025年4月

牧迫飛雄馬 . 特集科学的介護科学的介護を推進するための理学療法士の役割と期待 . 理学療法ジャーナル59 ( 3 ) 322 - 327 2025年3月

Mishima Y., Nakamura M., Matsuda Y., Nishi K., Takaoka R., Kanno T., Takenaka T., Tabira T., Makizako H., Kubozono T., Ohishi M., Sugiura T., Okui T. . Association Between Cognitive Impairment and Poor Oral Function in Community-Dwelling Older People: A Cross-Sectional Study . Healthcare (Switzerland)13 ( 6 ) 2025年3月国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Healthcare (Switzerland)

Background/Objectives: The population of Japan has a high life expectancy, but there is room for improvement in terms of the country’s healthy life expectancy. The long period of care dependency among Japan’s elderly is also a major economic health challenge. Dementia is a major factor in the need for care, and its prevention is a crucial and urgent challenge. There are recent reports of a possible association between changes in oral function and cognitive impairment, but the details of this association remain unclear. To clarify the relationship between poor oral function and cognitive impairment, we conducted an exploratory investigation using a cognitive function assessment (Mini-Cog) administered in a large-scale study and its relevance to oral function. Methods: The study population was 678 community-dwelling individuals aged ≥65 years living in Tarumizu city, Japan, in 2019. Cognitive function was assessed using the Mini-Cog test, and the oral survey was a modification of the content of the Oral Hypofunction Examination as defined by the Japanese Society of Gerodontology. Results: The participants’ median age was 73 years. The oral function results revealed median scores below the oral hypofunction criterion for occlusal force, tongue pressure, oral diadochokinesis, and swallowing function. The results of a binomial logistic regression analysis indicated that tongue–lip motor function was independently associated with oral function in relation to cognitive impairment. Conclusions: The oral function associated with cognitive impairment in this study was tongue–lip motor function. Aiming to improve this function may prevent the exacerbation of cognitive impairment.

DOI： 10.3390/healthcare13060589

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牧芳昭, 森田秋子, 山田将成, 加藤涼平, 牧迫飛雄馬 . 回復期リハビリテーション病棟入院患者における行動観察評価による認知機能障害と転倒との関連性 . 日本転倒予防学会誌11 31 - 38 2025年3月

記述言語：日本語出版者・発行元：(一社)日本転倒予防学会

【目的】本研究の目的は,回復期リハビリテーション病棟の入院患者に対して,行動観察から評価される認知関連行動アセスメント(以下CBA)の総合点から判定した認知機能障害の重症度と転倒の関連性を検討することであった。【方法】本研究は後ろ向きコホート研究であり,対象は2019年4月から2021年3月までの期間に当院回復期リハビリテーション病棟に入院した患者とした。認知機能障害の評価はCBAを使用し,転倒の有無は電子カルテ内の転倒・転落事故報告書の記録から調査した。入院時のCBAと入院早期の転倒との関連性を検証するため,入院1ヵ月以内の転倒を集計対象とし,入院1ヵ月以内で転倒を認めた者を転倒群,認めなかった者を非転倒群とした。転倒と非転倒の2群とCBA重症度とのクロス集計から,どの組み合わせが期待値から大きく乖離しているかを確認するために残差分析を行い,調整済み残差を算出した。そして,入院後1ヵ月以内の転倒の有無を従属変数とし,CBA重症度を独立変数とした2項ロジスティック回帰分析を行った。【結果】本研究の解析対象は879名であり,年齢の中央値は76(四分位範囲:65-83)歳であった。転倒群(68名)は非転倒群(811名)よりもCBA重症度が最重度～中等度の者の割合が多かった。また,転倒群におけるCBA重症度の内訳では,最重度4名(5.9%),重度24名(35.3%),中等度24名(35.3%),軽度11名(16.2%),良好5名(7.4%)であった。残差分析の結果,転倒群ではCBA重度(p<0.01)の者が有意に多く,非転倒群ではCBA軽度(p<0.01)の者が有意に多かった。入院後1ヵ月以内の転倒の有無を従属変数としたロジスティック回帰分析は,70歳以上などの転倒に関連する因子を共変量として調整しても,転倒とCBA重度の有無との関連性は有意であった(オッズ比1.92;95%CI,1.00-3.68;p<0.05)。【結論】回復期リハビリテーション病棟の入院患者における入院患者のCBA重症度は,入院1ヵ月以内の転倒発生と有意に関連していた。(著者抄録)

白土大成, 牧迫飛雄馬, 赤井田将真, 立石麻奈, 谷口善昭, 竹中俊宏, 窪薗琢郎, 大石充 . 高齢者におけるメタボリックシンドロームおよび身体機能低下と軽度認知障害との関連：垂水研究による横断分析 . 日本循環器病予防学会誌60 ( 1 ) 36 - 43 2025年2月

記述言語：日本語出版者・発行元：一般社団法人日本循環器病予防学会

【目的】地域在住高齢者を対象にメタボリックシンドローム (MetS; Metabolic Syndrome) および身体機能低下の併存と軽度認知機能障害 (MCI; Mild Cognitive Impairment) の関連を検討することを目的とした。【方法】垂水研究2019に参加した65歳以上の地域在住高齢者554名 (平均年齢73.7±6.2歳、女性63.4％) のデータを横断的に分析した。MetSは国際糖尿病連合の基準を用いて判定した。身体機能は握力 (男性＜28 kg、女性＜18 kg) および通常歩行速度 (＜1.0 m／秒) で評価し、いずれか、または両方がカットオフ値未満であれば、身体機能低下ありと判定した。MetSおよび身体機能低下の有無から、健常群、MetS単独群 (MetS群)、身体機能低下単独群 (身体機能低下群)、MetSおよび身体機能低下併存群 (併存群) の4群に分類した。認知機能は、National Center for Geriatrics and Gerontology Functional Assessment Tool (NCGG-FAT) により記憶力、注意機能、遂行機能、情報処理速度を評価し、いずれかの領域で年齢と教育歴を考慮した参照値より 1.5SD以上の低下を認めた者をMCIの該当と判定した。MCIの有無を従属変数、MetSおよび身体機能低下の有無で定義された4群を独立変数とし、年齢、性別、教育歴、服薬数を共変量としたロジスティック回帰分析を実施した。【結果】健常群が191名 (34.5％)、MetS群が218名 (39.4％)、身体機能低下群が62名 (11.2％)、併存群が83名 (15.0％) であった。ロジスティック回帰分析の結果、健常群と比較し、身体機能低下群 (オッズ比：2.39、95％信頼区間：1.17-4.87)、併存群 (オッズ比：2.41、95％信頼区間：1.21-4.79) のそれぞれがMCIと有意な関連を認めた。一方、MetS単独群では健常群と比較したMCIと有意な関連を認めなかった。【結論】地域在住高齢者において身体機能低下を有すること、およびMetSと身体機能低下が併存していることはMCIを有することと関連することが示唆された。

DOI： 10.11381/jjcdp.60.1_36

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