研究者詳細 - 牧迫　飛雄馬

論文 - 牧迫　飛雄馬

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Shiratsuchi D. . Associations Between Health Literacy and Changes in Exercise Behavior During the Coronavirus Disease 2019 State of Emergency Among Middle-Aged Adults: A Cross-Sectional Online Survey . Asia-Pacific Journal of Public Health34 ( 2-3 ) 10105395211053160 - 10105395211053160 2021年10月査読国際誌

Kiuchi Y. . Associations of alpha-actinin-3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia . Experimental Gerontology154 111525 - 111525 2021年10月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Experimental Gerontology

Background: This cross-sectional study aimed to investigate the relationship of the ACTN3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia. Methods: Data from 64 older Japanese adults (mean age 74.4 ± 6.9 years, women 71.9%) with sarcopenia or pre-sarcopenia were analyzed. Sarcopenia and pre-sarcopenia were defined using the Asian Working Group for Sarcopenia. We collected oral mucosa samples to determine the ACTN3 genotype. Thigh muscle volumes were measured using magnetic resonance imaging. Physical performance was assessed using the usual and maximum gait speed, timed up and go test, and five-repetition sit-to-stand test. Muscle strength was assessed using grip strength. Result: The ACTN3 genotype proportions were 20.3% for RR, 51.6% for RX, and 28.1% for XX. Participants with the RR genotype showed greater thigh muscle volume/ht2 compared to those with the RX and XX ACTN3 genotypes (p < 0.05). The multiple linear regression analysis revealed that RX (p < 0.01) and XX (p < 0.01) ACTN3 genotypes, compared to RR, were associated with lower thigh muscle volume/ht2 and with age, sex (reference; men), weight and maximum walking speed. There was no significant difference between physical performance and muscle strength between the ACTN3 genotypes. Conclusion: The ACTN3 genotype of the X allele was associated with decreased thigh muscle volume compared to the ACTN3 genotype of RR in older adults with sarcopenia or pre-sarcopenia.

DOI： 10.1016/j.exger.2021.111525

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Makizako H. . Association between regular exercise and self-rated health and sleep quality among adults in japan during the covid-19 pandemic . International Journal of Environmental Research and Public Health18 ( 19 ) 2021年10月査読国際誌

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Regular exercise may be associated with better self-rated health and sleep status. However, this correlation among various age groups, such as young, middle-aged, and older people, as well as during the COVID-19 pandemic, has not been examined. This study examined the correlation between regular exercise and self-rated health and sleep quality among adults in Japan during the COVID-19 pandemic. Data were collected using an online survey conducted between February 26 and 27, 2021. A total of 1410 adults in Japan (age range, 20–86 years) completed the online survey. Regular exercise was divided into: (1) more than 30 min of moderate exercise a day, (2) more than 2 days per week, and (3) continuous for 1 year or longer. Self-rated health and sleep quality were assessed using the Likert scale. After adjusting for multiple confounders, regular exercise was correlated with decreased poor self-rated health and poor sleep quality in middle-aged adults; however, no significant correlation was observed among young and older adults. The promotion of regular exercise among middle-aged people during the COVID-19 pandemic may contribute to better self-rated health and sleep quality status.

DOI： 10.3390/ijerph181910515

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Makizako H, Akaida S, Shono S, Shiiba R, Taniguchi Y, Shiratsuchi D, Nakai Y . Physical Activity and Perceived Physical Fitness during the COVID-19 Epidemic: A Population of 40- to 69-Year-Olds in Japan. . International journal of environmental research and public health18 ( 9 ) 2021年4月査読国際誌

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International journal of environmental research and public health

The COVID-19 pandemic has caused an abrupt change in lifestyle for many people with restrictions, often leading to a decrease in physical activity (PA), and thus contributing to a negative perception of health status. The purpose of this study was to examine the effects of the COVID-19 epidemic on physical activity and perceived physical fitness in Japanese adults aged 40 to 69 years. Data were collected from an online survey conducted between October 19 and 28, 2020. The analytic sample consisted of 1989 Japanese adults (mean age, 50.1 ± 6.9 years; women, 38.9%) who were aged between 40 and 69 years and completed the online survey. Overall, the PA time per week decreased by 32.4% between October 2019 and April 2020. A decrease in PA time was recorded in October 2020; however, a decline of 15.5% was observed. Compared to individuals who did not perceive a decline in physical fitness, individuals who perceived declining physical fitness during the COVID-19 state of emergency demonstrated a greater decrease in PA time in April 2020 (–50.5%), and this trend continued into October 2020 (–25.0%). These findings may indicate that Japanese adults aged 40 to 69 years who perceived declining physical fitness experienced a greater decrease in physical activity.

DOI： 10.3390/ijerph18094832

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Makizako H. . Perceived declining physical and cognitive fitness during the COVID-19 state of emergency among community-dwelling Japanese old-old adults . Geriatrics and Gerontology International21 ( 4 ) 364 - 369 2021年4月査読

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Geriatrics and Gerontology International

Aim: Perceived health status, including physical and cognitive fitness, will be negatively associated with future health conditions among old-old adults. The coronavirus disease 2019 (COVID-19) pandemic has caused sudden changes in lifestyle. Thus, this study examined the associations of participation in an exercise class before the COVID-19 pandemic and the exercise habits and disruption to the rhythms of daily life during the COVID-19 state of emergency with perceived declining physical and cognitive fitness among community-dwelling old-old adults. Methods: In July 2020, we carried out a mail survey of community-dwelling old-old adults aged between 77 and 99 years in Bibai, Hokkaido, Japan, to determine their perceived declining physical and cognitive fitness during the COVID-19 state of emergency. Results: Of the 774 responders, 339 (43.8%) participants reported a decline in physical fitness, whereas 259 (33.5%) perceived declining cognitive fitness during the COVID-19 state of emergency. In a multivariate logistic regression model adjusted for potential confounders, exercise habits during the COVID-19 state of emergency were significantly associated with a lower perception of declining physical fitness. Disruption to the rhythms of daily life during the COVID-19 state of emergency was significantly associated with a higher perception of declining physical and cognitive fitness. Conclusions: Approximately half and more than one-third of community-dwelling old-old adults perceived declining physical and cognitive fitness, respectively, during the COVID-19 state of emergency. During this period, exercise habits were positively correlated with perceived health status among old-old adults, whereas disruption to the rhythms of daily life was negatively correlated. Geriatr Gerontol Int 2021; 21: 364–369.

DOI： 10.1111/ggi.14140

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Saji N. . Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study :Hearing impairment and the clock drawing task . Archives of Gerontology and Geriatrics93 104302 - 104302 2021年3月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Gerontology and Geriatrics

Background: Hearing impairment (HI) is associated with dementia. However, the cognitive screening tasks effective in older community dwellers presenting with HI are unclear. Methods: We retrospectively and cross-sectionally investigated the associations between HI and cognitive function assessed with screening tasks using data from two healthcare check-up programs for community dwellers ≥65 years old in 2018. We examined demographics, risk factors, cognitive function, hearing condition, lifestyles, and self-care levels. Cognitive function was assessed using the clock drawing task and the delayed three words recall task. Hearing condition was assessed using questionnaires on the use of hearing aids and HI during conversation situations. Multivariate analysis was used to identify independent associations between HI and cognitive assessment tasks. Results: We analyzed 1602 eligible participants (61.9% women; 74.3 ± 6.5 years old). Hearing aid users (n = 90) were older (80 vs. 73 years, respectively; p < 0.001) and less likely to draw the clock correctly (71.1% vs. 80.1% years, respectively; p = 0.044) than non-hearing aid users. Multivariate logistic regression analysis showed that HI was associated with inability to draw the clock correctly (odds ratio 1.60, 95% confidence interval 1.12–2.26; p = 0.011), independent of age, living alone, memory impairment, and impaired self-care levels. Conclusion: Hearing impairment is independently associated with cognitive decline assessed by the clock drawing task. The clock drawing task may be useful for identifying an increased risk of dementia in older subjects presenting with HI.

DOI： 10.1016/j.archger.2020.104302

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Saji N, Makizako H, Suzuki H, Nakai Y, Tabira T, Obuchi S, Kawai H, Murotani K, Katayama N, Toba K, Uchida Y, Nakashima T. . Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study . Arch Gerontol Geriatr93 2021年3月査読

Saji N, Suzuki H, Katayama N, Makizako H, Uchida Y, Nakashima T. . Sensory impairment: A preventable risk factor in older adults . Arch Gerontol Geriatr93 2021年3月査読

和田あゆみ, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 佐藤菜々, 木山良二, 田平隆行, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における社会的フレイルとうつ傾向との関連 . 鹿児島大学医学部保健学科紀要31 ( 1 ) 11 - 18 2021年3月査読

担当区分：責任著者記述言語：日本語出版者・発行元：鹿児島大学医学部保健学科

地域コホート研究(垂水研究2018)のデータを用いて、地域在住高齢者における社会的フレイルとうつ傾向との関連について横断観察研究を行った。対象は研究に対する同意が得られた65歳以上の地域在住高齢者859名であった。最終的に社会的フレイルの有無および高齢者用うつ尺度短縮版(GDS15)、その他基本属性に欠損のない812名(男性304名、女性508名、平均年齢74.8歳)を有効回答とし分析対象とした。対象者のうち社会的フレイルを有する者は112名(13.8%)であった。社会的フレイルを有する者は社会的フレイルを有しない者と比較し、高齢で、GDS15の点数は高く、歩行速度、握力が低下していた。社会的フレイルを有する者でうつ傾向のある者は37名(33.0%)で、社会的フレイルを有さない者でうつ傾向のある者90名(12.9%)と比較して有意に高い割合であった。ロジスティック回帰分析の結果からも社会的フレイルはうつ傾向と関連していることが示された。

機関リポジトリURL

Shiratsuchi D. . Association of health literacy with the implementation of exercise during the declaration of covid-19 state of emergency among Japanese community-dwelling old-old adults . International Journal of Environmental Research and Public Health18 ( 4 ) 1 - 9 2021年2月査読国際誌

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Health literacy is important for promoting and maintaining good health in old-old adults. It may influence the implementation of exercise in the coronavirus disease epidemic. The present cross-sectional study investigated the association of each dimension of health literacy with the implementation of exercise during the declaration of a state of emergency due to coronavirus disease in community-dwelling old-old adults. We collected data from 483 community-dwelling old-old adults (52.8% women) aged between 77 and 99 years who participated in a mail survey. Participants were divided into exercise or nonexercise groups based on the implementation of exercise during the declaration of a state of emergency. Health literacy was assessed using a 14-item health literacy scale. There were 327 (67.7%) participants in the exercise group and 156 (32.3%) in the nonexercise group. A significantly higher score of health literacy was observed in the exercise group than in the nonexercise group (communicative health literacy score = 14.0 ± 3.6 vs. 12.7 ± 3.8, p = 0.001). In a multivariate logistic regression model adjusted for potential confounders, high communicative health literacy scores were significantly associated with the implementation of exercise during the declaration of a state of emergency (odds ratio = 1.88, 95% confidence interval = 1.20–2.93). Approximately two-thirds of community-dwelling old-old adults implement exercise during the declaration of a state of emergency. High communicative health literacy was associated with the implementation of exercise during this period.

DOI： 10.3390/ijerph18042100

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Suzuki T. . Are Japanese Older Adults Rejuvenating? Changes in Health-Related Measures among Older Community Dwellers in the Last Decade . Rejuvenation Research24 ( 1 ) 37 - 48 2021年2月査読国際誌

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Rejuvenation Research

During the last three decades, Japan has become one of the world's top countries for longevity, and the increase in average life expectancy is accompanied by a sharp rise in older population 65 years of age and above to ∼28%. This study aimed to examine the changes in major health-related measures, including a physical constitution, physical function, and functional capacity of community-dwelling Japanese older people in the last decade. From the data of 13 longitudinal cohort studies on aging conducted in Japan with a total of 13,441 older subjects, this study analyzed the changes in six indices that are related to health and functioning of the older people; height, weight, body mass index, walking speed, grip strength, and instrumental activity of daily living, between 2007 (±2 years) and 2017 (±2 years). Comparison of data for the two periods between subjects matched for age group and gender evidently showed better health status and a slower decline in most of the health-related measures in 2017 compared to a decade ago. The results of this study indicate that the phenomenon of "rejuvenation"is occurring among the new generation of Japanese older adults, and the importance of this older population as a social resource in the super-aged society should be reacknowledged.

DOI： 10.1089/rej.2019.2291

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Kiuchi Y, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Kimura M, Kanouchi H, Takenaka T, Kubozono T, Ohishi M. . The Association between Dietary Variety and Physical Frailty in Community-Dwelling Older Adults . Healthcare9 ( 1 ) 32 2021年1月査読

Shiratsuchi D., Makizako H., Tabira K., Miyake Y., Kubozono T., Ohishi M. . Comparative associations of height- and body mass index-adjusted muscle mass with sarcopenia under the Asian Working Group for Sarcopenia 2025 consensus . Archives of Gerontology and Geriatrics143 106153 - 106153 2026年4月

Tabira K, Shiratsuchi D, Miyake Y, Makizako H . Low Body Mass Index Increases Frailty Risk in Old-Old Adults: Findings From a 3-Year Longitudinal Study. . Geriatrics & gerontology international26 ( 4 ) e70474 2026年4月

田平健人, 牧迫飛雄馬 . 特集デジタルリハ 2.0─AI･ウェアラブル･デジタルツインが創る個別化治療ウェアラブルデバイスによる運動機能のモニタリング . J. of Clinical Rehabilitation35 ( 3 ) 253 - 258 2026年3月

Otsuka R., Zhang S., Nishita Y., Tange C., Tateishi M., Makizako H., Kinoshita K., Mizokami F., Kabayama M., Kamide K., Satake S., Arai H. . Heatmap of 10-year disability risk according to the frailty–intrinsic capacity (FR-IC) index in older Japanese adults . Archives of Gerontology and Geriatrics142 106119 - 106119 2026年3月国際誌

Shimokihara S., Tabira T., Maruta M., Makizako H., Han G., Kamasaki T., Akasaki Y., Hidaka Y., Kumura Y., Kukizaki W., Kubozono T., Ohishi M. . Longitudinal associations between satisfaction with meaningful activities and domains of frailty in community-dwelling older adults: A 2-year prospective cohort study . British Journal of Occupational Therapy 2026年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：British Journal of Occupational Therapy

Introduction: Frailty in older adults is a multidimensional condition that affects healthy life expectancy. Engagement in meaningful activities (MA) is thought to support healthy aging, but the specific relationship between satisfaction with MA and frailty remains underexplored. This study investigated the longitudinal association between satisfaction with MA and frailty (physical, social, and cognitive domains) in community-dwelling older adults. Method: A total of 231 community-dwelling older adults who completed a 2-year follow-up were analyzed. Frailty in each domain was assessed at baseline and at 1- and 2-years. Participants’ MA and satisfaction were obtained through face-to-face interviews. Mixed-effects logistic regression models were used to examine the longitudinal associations between satisfaction with MA and frailty status trajectories. Results: At follow-up, changes in physical frailty status were observed in most participants. Robust status was commonly maintained in the social and cognitive frailty domain. Participants’ MA primarily involved leisure, sports, and domestic activities. Mixed-effects logistic regression analysis showed that satisfaction with MA was significantly associated with physical frailty, even after adjusting for potential covariates (odds ratio 0.68; 95% confidence interval 0.45, 0.99, p = 0.045). However, this association was not significant for social or cognitive frailty. Conclusion: Satisfaction with MA was longitudinally associated with physical frailty, but not with social or cognitive frailty.

DOI： 10.1177/03080226261417513

Web of Science

Scopus

Ohta M., Kaimoto K., Makizako H., Aburada S., Imamura K., Manabe H., Takenaka T., Kubozono T., Ohishi M., Kuwabara A., Kanouchi H. . Association Between Serum Pyridoxal 5′-Phosphate and Frailty Risk in Community-Dwelling Older Japanese Adults . Geriatrics and Gerontology International26 ( 2 ) e70412 2026年2月

記述言語：日本語出版者・発行元：Geriatrics and Gerontology International

Background: Pyridoxal 5′-phosphate (PLP) is the coenzyme form of vitamin B<inf>6</inf>. PLP is essential for amino acid metabolism, protein turnover, and neurotransmitter synthesis. Plasma or serum PLP concentration is used as an indicator of vitamin B<inf>6</inf> status. A deficiency in PLP may be a risk factor for frailty. While previous cross-sectional studies have associated low plasma or serum PLP levels with frailty, this association has not yet been examined in older Japanese adults. Methods: We analyzed data from 419 community-dwelling individuals aged ≥ 65 years in Tarumizu City, Kagoshima, Japan. Participants with relevant medical histories, missing data, or extreme values were excluded. Frailty was assessed using J-CHS criteria. Serum PLP concentrations were divided into quartiles (Q1–Q4). Logistic regression was used to estimate the Odds ratios (ORs) for pre-frailty/frailty after adjusting for demographic, lifestyle, and clinical factors. Results: Pre-frailty/frailty prevalence was 62%, 40%, 57%, and 57% in Q1–Q4, respectively. The proportion of pre-frailty/frailty was the lowest in Q2. Compared to Q2, adjusted ORs were 1.94 (95% CI: 1.06–3.59; p = 0.033) in Q1, 1.68 (95% CI: 0.93–3.07; p = 0.089) in Q3, and 1.86 (95% CI: 1.01–3.47; p = 0.047) in Q4. Conclusion: The relationship between PLP levels and pre-frailty/frailty was found to be non-linear. The lowest prevalence was observed in Q2, whereas both low and high PLP levels were associated with increased ORs of pre-frailty/frailty. Further prospective studies are needed to clarify the causal relationship in older Japanese adults.

DOI： 10.1111/ggi.70412

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Shimokihara Suguru, Tabira Takayuki, Maruta Michio, Makizako Hyuma, Han Gwanghee, Kamasaki Taishiro, Akasaki Yoshihiko, Hidaka Yuma, Kumura Yusuke, Kukizaki Wataru, Kubozono Takuro, Ohishi Mitsuru . Associations Between the Diverse Aspects of Psychological Frailty and Health-Related Outcomes in Community-Dwelling Older Adults: A Cross-Sectional Study(タイトル和訳中) . Psychogeriatrics26 ( 1 ) psyg.70115 - psyg.70115 2026年1月

Akasaki Y., Shimokihara S., Hidaka Y., Maruta M., Han G., Kamasaki T., Kumura Y., Kukizaki W., Nakahara R., Makizako H., Kubozono T., Ohishi M., Tabira T. . Satisfaction with Meaningful Activities and Sleep in Community-Dwelling Older Adults: Cross-Sectional Study . Clinical Gerontologist 1 - 15 2025年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Gerontologist

Objectives: To examine whether satisfaction with meaningful activities (MA) is associated with self-rated sleep quality and sleep duration among community-dwelling older adults. Methods: Data were drawn from 833 individuals aged ≥65 years who participated in a health survey between 2018 and 2019 in Japan. Sleep quality (good, moderate, or poor) and duration (< 6, 6–8, or ≥8 h) were assessed through a questionnaire. Participants selected the MA they considered most meaningful from a list of 95 activities in the Aid for Decision-Making in Occupation Choice, and their satisfaction with these MA were measured. Results: Ordinal logistic regression analysis, with sleep quality or duration as the dependent variable and satisfaction with MA as the independent variable, showed that higher satisfaction with MA was significantly associated with lower odds of poor sleep quality (OR: 0.84, 95% CI: 0.72–0.97, p =.03), but not with sleep duration. However, the association was not significant in sensitivity analyses that reversed the model. Conclusions: Satisfaction with MA may be associated with better sleep quality in older adults. Clinical Implications: Evaluating and enhancing satisfaction with MA may help identify older adults at risk of poor sleep quality, indicating that MA may be useful in supporting sleep.

DOI： 10.1080/07317115.2025.2597956

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