研究者詳細 - 牧迫　飛雄馬

論文 - 牧迫　飛雄馬

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生野佐紀, 赤井田将真, 椎葉竜平, 白土大成, 谷口善昭, 木内悠人, 立石麻奈, 中井雄貴, 牧迫飛雄馬 . COVID-19の流行に伴う緊急事態宣言中の生活習慣の変化と主観的幸福感との関係 . Journal of Epidemiology32 ( Suppl.1 ) 114 - 114 2022年1月

Nakai Y. . Association of Sleep Quality Status With Worsening Low Back or Knee Pain During The COVID-19 State of Emergency Among Old-Old Adults . Pain Management Nursing23 ( 4 ) 473 - 477 2022年国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Pain Management Nursing

Background: Poor sleep quality has a negative effect on pain among older adults. During the coronavirus disease 2019 (COVID-19) state of emergency, lifestyle changes can cause psychologic stressors and lead to poor sleep quality. Aim: This study examined whether sleep quality status was associated with low back or knee pain changes during the COVID-19 state of emergency among community-dwelling Japanese old-old adults. Design: Cross-sectional investigation. Methods: In July 2020, during the COVID-19 epidemic, we conducted a postal survey for old-old adults aged ≥77 years and collected data on 597 participants. For those who had low back or knee pain at the time of the survey (in July), characteristics such as low back pain, knee pain, changes in pain status, and sleep quality status during the COVID-19 state of emergency (in March) were assessed. Results: Data from 597 participants showed the prevalence of low back pain (50.6%) and knee pain (40.7%) in July. Of those with low back or knee pain, 374 had pain changes during the state of emergency, with 12.3% worsening. Of these, 23.9% had poor sleep quality in March compared to non-change (p = .008). In a multivariate logistic regression model adjusted for potential confounders, poor sleep quality was significantly associated with pain worsening (odds ratio 2.80, 95% confidence interval 1.26-6.22). Conclusions: During the COVID-19 state of emergency, poor sleep quality was associated with worsening low back or knee pain. This may indicate the need to pay attention to poor sleep quality to prevent the exacerbation of pain among old-old adults.

DOI： 10.1016/j.pmn.2022.01.001

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谷口善昭, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における骨量および筋量の低下と身体活動との関連性 . 理学療法学49 ( 2 ) 131 - 138 2022年査読

記述言語：日本語出版者・発行元：一般社団法人日本理学療法学会連合

【目的】地域在住高齢者における骨量・筋量低下と身体活動との関連性を明らかにすることを目的とした。【方法】地域コホート研究（垂水研究2018）に参加した地域在住高齢者173 名を分析対象とした。骨量低下は％YAM が70% 以下とし，筋量低下は四肢骨格筋指数がサルコペニアの基準より低いものとした。身体活動量は3 軸加速度計を用いて，座位行動時間延長，中高強度身体活動時間低下，歩数低下の有無に分類した。骨量・筋量をもとに正常群，骨量低下群，筋量低下群，骨量・筋量低下群の4 群に分類し，基本情報および身体活動を比較した。【結果】骨量・筋量低下群は正常群と比べて中高強度身体活動時間が有意に減少していた（オッズ比3.29，p < 0.05，共変量：年齢（5 歳階級），性別，歩行速度低下，うつ傾向）。【結論】骨量・筋量低下を併存している高齢者は，中高強度身体活動時間が減少していることが示唆された。

DOI： 10.15063/rigaku.12150

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J-GLOBAL

その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03978/

Masumitsu T, Kubozono T, Miyata M, Makizako H, Tabira T, Takenaka T, Kawasoe S, Tokushige A, Niwa S, Ohishi M . Association of Sleep Duration and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults. . Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓadvpub ( 0 ) 1864 - 1871 2022年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本動脈硬化学会

Aim: This study aims to investigate the association of the Cardio-Ankle Vascular Index (CAVI) with self-reported sleep duration and sleep quality in community-dwelling older adults aged ≥ 65 years. Methods: The Tarumizu Study was a cohort of community-based health checkups conducted in the Tarumizu City, Japan, in 2018 and 2019. In total, 997 participants aged ≥ 65 years (median age, 74 years) were examined. We obtained the average sleep duration and sleep quality using self-reported questionnaires and classified them into three separate groups according to sleep duration (＜6 h, 6–8 h, and ≥ 8 h) and sleep quality (good, medium, and poor). The arterial stiffness was measured using the CAVI. Results: As per our findings, the CAVI was significantly higher in the ≥ 8 h sleep group (CAVI=9.6±1.3) than in the ＜6 h (CAVI=9.1±1.1) or 6–8 h (CAVI=9.1±1.2) groups (p＜0.001). After adjustment for age, sex, systolic blood pressure, current smoking status, body mass index, frequency of exercise, educational background, frailty, sleep medication, sleep quality, and nap duration, multivariable regression analysis demonstrated that the CAVI was significantly higher in the ≥ 8 h group than in the 6–8 h group (p=0.016). In contrast, multivariable regression analysis showed that there was no significant association between sleep quality and CAVI. Conclusions: A significant association was noted between long sleep duration (≥ 8 h) and elevated CAVI in community-dwelling older adults aged ≥ 65 years. We, therefore, suggest that long sleep duration, not sleep quality, is correlated with arterial stiffness in older adults.

DOI： 10.5551/jat.63594

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Shiratsuchi D., Makizako H., Nakai Y., Bae S., Lee S., Kim H., Matsuzaki-Kihara Y., Miyano I., Ota H., Shimada H. . Associations of fall history and fear of falling with multidimensional cognitive function in independent community-dwelling older adults: findings from ORANGE study . Aging Clinical and Experimental Research34 ( 12 ) 2985 - 2992 2022年国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Aging Clinical and Experimental Research

Background: Falls and fear of falling (FoF) inhibit healthy longevity and have been suggested to be associated with cognitive function. However, the domains of cognitive function that are associated with them remain controversial. It is speculated that clarifying this will help in the assessment of health status and interventions in the community. Aim: To analyse the associations between fall history and FoF and multidimensional cognitive function in independent community-dwelling older adults. Methods: The data from 9759 (73.3 ± 5.4 years, 59.9% women) older individuals enrolled in the cross-sectional ORANGE study were analysed. Simple questions were used to assess fall history in the past year and current FoF. Assessments of multidimensional cognitive function were performed using the National Center for Geriatrics and Gerontology-Functional Assessment Tool (NCGG-FAT) to evaluate memory, attention, executive function, and processing speed. The independent associations of fall history and FoF with multidimensional cognitive function were assessed using multivariate linear regressions adjusted for potential confounding variables. Results: A total of 18.3% and 35.4% of participants presented with fall history and FoF, respectively. Fall history (p = 0.008) and FoF (p = 0.002) were significantly associated with memory. FoF, but not fall history was associated with attention (p = 0.004), executive function (p < 0.01), and processing speed (p < 0.01). Conclusion: In independent community-dwelling older adults, fall history was associated only with the memory domain; in contrast, fear of falling was associated with multidimensional cognitive function. This study provides weak evidence suggesting the need to assess falls and FoF in all situations involving independent community-dwelling older adults.

DOI： 10.1007/s40520-022-02235-4

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Nishi K. . Relationship between oral hypofunction, and protein intake: A cross-sectional study in local community-dwelling adults . Nutrients13 ( 12 ) 2021年12月国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrients

Few studies have investigated the relationship between nutritional status and comprehensive assessment of oral hypofunction, especially protein intake-related sarcopenia. Thus, we explored these relationships in a large-scale cross-sectional cohort study using the seven-item evaluation for oral hypofunction and Diet History Questionnaire for nutritional assessment. We used the data from 1004 individuals who participated in the 2019 health survey of the residents of Tarumizu City, Kagoshima Prefecture, Japan for analysis. We found that individuals with oral hypofunction were significantly older with a lower skeletal muscle index. Although there were few foods that had a sig-nificant difference between the groups with and without oral hypofunction, the consumption of beans and meats was significantly lower in women and men in the oral hypofunction group, respectively. According to the lower limit of the tentative dietary goal defined in Japan, comprehensive evaluation of oral hypofunction was significantly and independently associated with protein intake in both men and women (odds ratio, 1.70; 95% confidence interval, 1.21–2.35). In conclusion, we found that oral hypofunction was associated with targeted protein intake for sarcopenia and frailty prevention in middle-aged and older community-dwelling adults. Comprehensive evaluation of oral function with intervention in cases of hypofunction could inform clinicians to better prevent sarcopenia.

DOI： 10.3390/nu13124377

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Nakamura A. . Meaningful activities and psychosomatic functions in japanese older adults after driving cessation . International Journal of Environmental Research and Public Health18 ( 24 ) 2021年12月査読国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

The purpose of this cross-sectional study was to analyse the differences in meaningful activities and psychosomatic function depending on the driving status of community-dwelling older adults. Data from 594 older adults were obtained, including activities meaningful to individuals and psychosomatic functions, such as grip strength, depression, cognitive function, and ability of activity. Participants were divided into active driving (n = 549) and after driving cessation (n = 45) groups. In addition, the active driving group was operationally divided into three groups: high-frequency group (n = 387), medium group (n = 119), and infrequent group (n = 42). In the after driving cessation group, grip strength, and Japan Science and Technology Agency Index of Competence scores were significantly lower. Furthermore, the proportion of apathy and physical and social frailty was significantly higher in the after driving cessation group. Regarding meaningful activity, domestic life scores in the after driving cessation group were significantly higher than those of the active driving group. Decreased driving frequency in the active driving group was associated with weak muscle strength, lack of interest, and low activity. This study demonstrated that meaningful activity differed based on the driving status. Hence, we should support the activities of older adults who are considering driving cessation.

DOI： 10.3390/ijerph182413270

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Wada A, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Sato N, Kiuchi Y, Kiyama R, Kubozono T, Takenaka T, Ohishi M . Association between cognitive frailty and higher-level competence among community-dwelling older adults. . Archives of gerontology and geriatrics99 104589 - 104589 2021年11月国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Archives of Gerontology and Geriatrics

Objectives: The purpose of this cross-sectional study was to examine the association between cognitive frailty (CF) and higher-level competence among community-dwelling older adults. Methods: Data from 871 older adults (aged ≥ 65 years, mean age 74.3 years, 61.5% women) who had participated in a community-based health check survey (Tarumizu Study 2018-2019) were analyzed. CF was defined as comorbid physical frailty and mild cognitive impairment (MCI). We defined physical frailty as either slow walking speed or poor grip strength. MCI was defined as values below the age- and education-adjusted reference threshold in several tests. Participants were categorized into four groups: robust, physical frailty, MCI, and CF. Higher-level competence was assessed using the Japan Science and Technology Agency Index of Competence (JST-IC). The JST-IC consists of 16 items and four subscales (technology usage, information practice, life management and social engagement). The bottom 20–30% score of the JST-IC and each subscale corresponded to poor higher-level competence. Results: The prevalence of CF was 14.4%. Multivariate logistic regression analysis showed that, CF was significantly associated with poor higher-level competence (odds ratio 1.92, 95% confidence interval 1.18–3.13) after adjusting for covariates. Using a similar analysis to assess the JST-IC subscales, CF was associated with limitations on technology usage (odds ratio 2.29, 95% confidence interval 1.36–3.85) and low social engagement (odds ratio 1.62, 95% confidence interval 1.00–2.61). Conclusions: This study suggests that CF is associated with poor higher-level competence, especially limitations on technology usage and low social engagement.

DOI： 10.1016/j.archger.2021.104589

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Miyazaki T. . The relationship between leg extension angle at late stance and knee flexion angle at swing phase during gait in community-dwelling older adults . International Journal of Environmental Research and Public Health18 ( 22 ) 2021年11月国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

e, s Abstract: This study aimed to clarify the relationship between leg extension angle and knee flexion angle during gait in older adults. The subjects of this cross-sectional study were 588 community-dwelling older adults (74.6 ± 6.1 y). Segment angles and acceleration were measured using five inertial measurement units during comfortable gait, and bilateral knee and hip joint angles, and leg extension angle, reflecting whole lower limb extension at late stance, were calculated. Propulsion force was estimated using the increase in velocity calculated from anterior acceleration of the sacrum during late stance. Correlation analysis showed that leg extension angle was associated with knee flexion angle at swing phase and hip extension angle and increase in velocity at late stance (r = 0.444–508, p < 0.001). Multiple regression analysis showed that knee flexion angle at mid-swing was more affected by leg extension angle (β = 0.296, p < 0.001) than by gait speed (β = 0.219, p < 0.001) and maximum hip extension angle (β = −0.150, p < 0.001). These findings indicate that leg extension angle may be a meaningful parameter for improving gait function in older adults due to the association with knee kinematics during swing as well as propulsion force at late stance.

DOI： 10.3390/ijerph182211925

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Miyazaki T. . Relationships between gait regularity and cognitive function, including cognitive domains and mild cognitive impairment, in community-dwelling older people . Healthcare (Switzerland)9 ( 11 ) 2021年11月国際誌

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Healthcare (Switzerland)

The aim of this cross-sectional study was to examine the correlations between gait regularity, cognitive functions including cognitive domains, and the mild cognitive impairment (MCI) in community-dwelling older people. This study included 463 older adults (63.4% women, mean age: 74.1), and their step and stride regularity along the three-axis components was estimated from trunk acceleration, which was measured by inertial measurement units during a comfortable gait. Four aspects of cognitive function were assessed using a tablet computer: attention, executive function, processing speed, and memory, and participants were classified into those with or without MCI. The vertical component of stride and step regularity was associated with attention and executive function (r = −0.176–−0.109, p ≤ 0.019), and processing speed (r = 0.152, p < 0.001), after it was adjusted for age and gait speed. The low vertical component of step regularity was related to the MCI after it was adjusted for covariates (OR 0.019; p = 0.016). The results revealed that cognitive function could affect gait regularity, and the vertical component of gait regularity, as measured by a wearable sensor, could play an important role in investigating cognitive decline in older people.

DOI： 10.3390/healthcare9111571

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白土大成, 椎葉竜平, 牧迫飛雄馬 . 【疾患別にみたサルコペニアに対する理学療法の考え方と実際】運動器疾患患者のサルコペニアに対する理学療法の考え方と実際 . 理学療法38 ( 11 ) 988 - 995 2021年11月

記述言語：日本語出版者・発行元：(株)メディカルプレス

1.運動器疾患を有する患者ではサルコペニアの併存が懸念され、運動器疾患に起因もしくは併存する骨格筋量の減少および筋力の低下に対するアプローチを検討することが求められる。2.運動器疾患患者では、骨量減少を伴うオステオサルコペニアによる脆弱性骨折のリスク増大に対する対策を考慮する必要がある。3.高齢の運動器疾患患者の身体機能評価においては、疾患そのものに関する評価のみならずサルコペニアに関する評価を実施し、サルコペニアの予防・改善を含めた活動や社会参加のための包括的な介入方針を検討することが求められる。(著者抄録)

Hirase T, Okita M, Nakai Y, Akaida S, Shono S, Makizako H . Pain and physical activity changes during the COVID-19 state of emergency among Japanese adults aged 40 years or older: A cross-sectional study. . Medicine100 ( 41 ) e27533 - e27533 2021年10月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Medicine

ABSTRACT: Understanding the relationship between pain and physical activity (PA) levels is beneficial for maintaining good health status. However, the impact of pain on changes in PA during the coronavirus disease 2019 (COVID-19) pandemic is unknown. The purpose of this study was to examine whether PA levels pre-, during, and post-COVID-19 state of emergency differ between Japanese adults who had pain after the COVID-19 state of emergency and those who did not.Data were collected from a cross-sectional online survey conducted between October 19 and 28, 2020. The analytic sample consisted of 1967 Japanese adults aged ≥40 years who completed the online survey. Participants completed questionnaires on the presence of pain and duration of PA, defined as the total PA time per week based on activity frequency and time. Participants were asked to report their PA at 3 time points: October 2019 (before the COVID-19 pandemic), April 2020 (during the COVID-19 state of emergency), and October 2020 (after the COVID-19 state of emergency).Among participants aged ≥60 years who reported pain in October 2020, the total PA time was significantly lower than participants who did not report having pain. Furthermore, the total PA time in April 2020 was significantly lower than that in October 2019; however, no significant difference in total PA time was observed between April and October 2020. Among participants aged 40 to 59 years, no significant differences were observed in total PA times at the 3 time points between those with and without pain. In addition, the total PA time in October 2020 significantly increased compared to that in April 2020, although it significantly decreased in April 2020 compared to October 2019.This study suggests that older adults with pain have lower PA levels after the COVID-19 state of emergency.

DOI： 10.1097/MD.0000000000027533

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赤井田将真, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 立石麻奈, 田平隆行, 竹中俊宏, 窪薗琢郎, 大石充 . 地域在住高齢者における自動車事故歴と転倒歴との関連 . 日本老年医学会雑誌58 ( 4 ) 663 - 663 2021年10月

立石麻奈, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 赤井田将真, 和田あゆみ, 佐藤菜々, 窪薗琢郎, 大石充 . 転倒歴を有さない地域在住高齢女性における転倒恐怖感と身体活動量との関連 . 日本老年医学会雑誌58 ( 4 ) 663 - 663 2021年10月

牧迫飛雄馬, 窪薗琢郎, 大石充 . 【日本における高齢者コホート研究の成果と現状】垂水研究 . 老年内科4 ( 4 ) 405 - 409 2021年10月

Jujo K. . Impact of social frailty in hospitalized elderly patients with heart failure: A fragile-hf registry subanalysis . Journal of the American Heart Association10 ( 17 ) e019954 2021年9月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of the American Heart Association

BACKGROUND: Frailty is conceptualized as an accumulation of deficits in multiple areas and is strongly associated with the prognosis of heart failure (HF). However, the social domain of frailty is less well investigated. We prospectively evaluated the clinical characteristics and prognostic impact of social frailty (SF) in elderly patients with HF. METHODS AND RESULTS: FRAGILE-HF (prevalence and prognostic value of physical and social frailty in geriatric patients hospitalized for heart failure) is a multicenter, prospective cohort study focusing on patients hospitalized for HF and aged ≥65 years. We defined SF by Makizako’s 5 items, which have been validated as associated with future disability. The primary end point was a composite of all-cause death and rehospitalization because of HF. The impact of SF on all-cause mortality alone was also evaluated. Among 1240 enrolled patients, 825 (66.5%) had SF. During the 1-year observation period after discharge, the rates of the combined end point and all-cause mortality were significantly higher in patients with SF than in those without SF (Log-rank test: both P < 0.05). SF remained as significantly associated with both the combined end point (hazard ratio, 1.30; 95% CI, 1.02–1.66; P = 0.038) and all-cause mortality (hazard ratio, 1.53; 95% CI, 1.01–2.30; P = 0.044), even after adjusting for key clinical risk factors. Furthermore, SF showed significant incremental prognostic value over known risk factors for both the combined end point (net-reclassification improvement: 0.189, 95% CI, 0.063–0.316, P = 0.003) and all-cause mortality (net-reclassification improvement: 0.234, 95% CI, 0.073–0.395, P = 0.004). CONCLUSIONS: Among hospitalized geriatric patients with HF, two thirds have SF. Evaluating SF provides additive prognostic information in elderly patients with HF. REGISTRATION: URL: https://upload.umin.ac.jp/. Unique identifier: UMIN000023929.

DOI： 10.1161/JAHA.120.019954

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牧迫飛雄馬 . 書評 -太田　進,藤田玲美,大古拓史(著)-｢動画でわかる運動器理学療法臨床実習スキル｣ . 理学療法ジャーナル55 ( 7 ) 778 - 778 2021年7月

牧迫飛雄馬, 赤井田将真 . 【認知症-最近の動向】認知機能低下に対する運動療法の効果 . カレントテラピー39 ( 7 ) 656 - 661 2021年7月

記述言語：日本語出版者・発行元：(株)ライフメディコム

身体活動の不足は、認知症の発症や認知機能の低下に強く関連するため、身体活動を向上させて活動的なライフスタイルを確立することは、認知機能の低下を抑制するために重要な要因である。定期的な運動習慣を有する高齢者では、将来の認知症発症のリスクが軽減され、運動介入による認知機能低下の抑制に対する効果が期待される。特に、有酸素運動を中心とした身体活動の向上は、認知症の発症の予防や遅延に効果が期待されている。認知機能の維持・改善に対するより効果的な運動療法においては、運動による身体活動の促進のみではなく、知的な刺激が伴う活動を付加することが推奨される。高齢期における認知機能の低下を抑制するためには、一時的な運動療法にとどまらず、習慣化できるようにいかに支援するかも重要なポイントとなる。(著者抄録)

谷口善昭, 牧迫飛雄馬, 富岡一俊, 中井雄貴, 佐藤菜々, 和田あゆみ, 木山良二, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係 . 日本サルコペニア・フレイル学会誌5 ( 1 ) 96 - 103 2021年6月

記述言語：日本語出版者・発行元：一般社団法人日本サルコペニア・フレイル学会

［目　的］ 地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係を明らかにする。 ［方　法］ 地域での健康チェックに参加した高齢女性265名を分析対象とした。骨粗鬆症の有無，身体・認知・社会的フレイルを評価し，身体・社会的フレイルに関しては，プレフレイルとフレイルを合わせてプレフレイル以上とした。骨粗鬆症を従属変数とし，身体的プレフレイル以上，認知的フレイル，社会的プレフレイル以上を独立変数としたロジスティック回帰分析を行い，さらに前期・後期高齢女性に分けてオッズ比を算出した。 ［結　果］ 年齢，内服数，教育歴，BMI，関節リウマチの有無，呼吸器疾患の有無で傾向スコアを算出し，傾向スコアで調整したロジスティック回帰分析の結果，後期高齢女性において骨粗鬆症と社会的プレフレイル以上が関連していた（オッズ比3.14，95％ CI1.25-7.93，p＝0.02）。 ［結　論］ 地域在住後期高齢女性において，社会的フレイルは骨粗鬆症のリスクを高める可能性がある。

DOI： 10.69303/jjasf.5.1_96

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