Faculty Profiles - MAKIZAKO Hyuma

Papers - MAKIZAKO Hyuma

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Shoma Akaida, Takayuki Tabira, Yuki Nakai, Michio Maruta, Yoshiaki Taniguchi, Kazutoshi Tomioka, Nana Sato, Ayumi Wada, Hyuma Makizako . Are satisfaction and performance of meaningful activities associated with frailty in older adults? . Archives of gerontology and geriatrics105 104845 - 104845 2022.10International journal

SHIRATSUCHI Daijo, MAKIZAKO Hyuma, AKAIDA Shoma, SHONO Saki, SHIIBA Ryuhei, TANIGUCHI Yoshiaki, TOMIOKA Kazutoshi, SATO Nana, WADA Ayumi, KIUCHI Yuto, TATEISHI Mana, NAKAI Yuki . Association of Changes in Low Back Pain in Workers and Presenteeism Following an Epidemic of Novel Coronavirus Infection . Physical Therapy Japan49 ( 5 ) 339 - 347 2022.10

Language：Japanese Publisher：Japanese Society of Physical Therapy

Objective: To determine the association between changes in low back pain and in presenteeism in workers before and after the epidemic of the new coronavirus (COVID-19), and to further examine the association by assessing changes in working patterns.Methods: A cross-sectional analysis was conducted on 1865 workers (mean age 49.6±6.6 years) who participated in an online survey. We investigated changes in low back pain and presenteeism associated with the COVID-19 epidemic and examined the relationship between worsening low back pain and presenteeism.Results: Worsening of low back pain was significantly associated with the occurrence of presenteeism in the group without pre-epidemic presenteeism (odds ratio: 4.26, p<0.01) and worsening of presenteeism in the group with pre-epidemic presenteeism (odds ratio: 1.80, p=0.01).Conclusion: The worsening of low back pain following the COVID-19 epidemic was associated with presenteeism, and this association was particularly strong in a group of people who were continuously engaged in office work.

DOI： 10.15063/rigaku.12259

CiNii Research

Yoshiaki Taniguchi, Hyuma Makizako, Yuki Nakai, Yuto Kiuchi, Shoma Akaida, Mana Tateishi, Toshihiko Takenaka, Takuro Kubozono, Mitsuru Ohishi . Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults. . Journal of clinical medicine11 ( 20 ) 2022.10International journal

Language：Japanese Publishing type：Research paper (scientific journal)

Bone and muscle mass loss are known to occur simultaneously. The alpha-actinin three (ACTN3) genotype has been shown to potentially affect bone and muscle mass. In this study, we investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged ≥ 60 years. This study was a cross-sectional analysis of data from 295 participants who participated in a community health checkup. The ACTN3 genotypes were classified as RR, RX, or XX types. Bone mass loss was defined as a calcaneal speed of sound T-score of <-1.32 and <-1.37, and muscle mass loss was defined as an appendicular skeletal muscle index of <7.0 kg/m2 and <5.7 kg/m2 in men and women, respectively. The percentages of XX, RX, and RR in the combined bone and muscle mass loss group were 33.8%, 30.8%, and 16.7%, respectively, with a significantly higher trend for XX. Multinomial logistic regression analysis showed that XX had an odds ratio of 3.00 (95% confidence interval 1.05-8.54) of being in the combined bone and muscle mass loss group compared to the RR group (covariates: age, sex, grip strength, and medications). The ACTN3 genotype of XX is associated with a higher rate of comorbid bone and muscle mass loss. Therefore, ACTN3 genotyping should be considered for preventing combined bone and muscle mass loss.

DOI： 10.3390/jcm11206172

Scopus

PubMed

Yuto Kiuchi, Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo, Satoshi Kurita, Kazuhei Nishimoto, Hyuma Makizako, Hiroyuki Shimada . Association between dietary diversity and sarcopenia in community-dwelling older adults . Nutrition106 111896 - 111896 2022.10International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier {BV}

OBJECTIVES: The aim of this study was to examine whether dietary diversity is associated with sarcopenia in community-dwelling older Japanese adults. METHODS: We used a cross-sectional large cohort data set from the National Center for Geriatrics and Gerontology-Study of Geriatric Syndromes. Data from 9080 older adults (mean age 74 ± 5.6 y; 44.4% were men) were included in this cross-sectional study. Sarcopenia was assessed using muscle mass, muscle strength, and physical performance represented by gait speed. We assessed 1-wk consumption frequency of food types, including meat, fish/shellfish, eggs, milk, soybean products, green and yellow vegetables, potatoes, fruits, seaweeds, fats, and oil. Consumption frequency was allotted to each category for the following responses: eat almost every day, eat 3 or 4 /wkd, eat 1 or 2 d/wk, and hardly ever eat. Poor dietary diversity was defined as those who responded hardly ever eat for any of the 10 foods. RESULTS: This study revealed that 2647 participants (29.2%) had poor dietary diversity. Poor dietary diversity was associated with confirmed sarcopenia (odds ratio [OR], 1.46; 95% confidence interval [CI], 1.08-1.96) and severe sarcopenia (OR, 1.58; 95% CI, 1.08-2.39). Furthermore, poor dietary diversity of low-protein foods was significantly associated with sarcopenia (OR, 1.57; 95% CI, 1.13-2.20) as well as poor dietary diversity of high-protein foods (OR, 1.47; 95% CI, 1.12-1.92). CONCLUSIONS: This cross-sectional study revealed that poor dietary diversity was associated with sarcopenia among older adults. Ingestion of low-protein foods and high-protein foods is infrequently associated with sarcopenia and ingestion of high-protein foods.

DOI： 10.1016/j.nut.2022.111896

Scopus

PubMed

白土大成, 牧迫飛雄馬, 赤井田将真, 生野佐紀, 椎葉竜平, 谷口善昭, 富岡一俊, 佐藤菜々, 和田あゆみ, 木内悠人, 立石麻奈, 中井雄貴 . 新型コロナウイルス感染症の流行に伴う就労者の腰痛変化とプレゼンティーズムとの関連 . 理学療法学49 ( 5 ) 339 - 347 2022.10

Language：Japanese Publisher：(一社)日本理学療法学会連合

【目的】新型コロナウイルス感染症(以下,COVID-19)の流行前後における就労者の腰痛変化とプレゼンティーズムとの関連を検討し,さらに勤務形態の変化との関連性を明らかにする。【方法】WEB調査で回答のあった就労者1865名(平均年齢49.6±6.6歳)を横断的に解析した。COVID-19流行に伴う腰痛およびプレゼンティーズムの変化を調査し,腰痛悪化とプレゼンティーズムとの関連性を検討した。【結果】腰痛悪化は,流行前プレゼンティーズムなし群におけるプレゼンティーズム発生(オッズ比:4.26,p<0.01),流行前プレゼンティーズムあり群におけるプレゼンティーズム悪化(オッズ比:1.80,p=0.01)と有意に関連していた。【結論】COVID-19の流行に伴う腰痛悪化はプレゼンティーズムと関連することが示唆され,特にその関連性は継続してオフィスワークに従事している集団において強い傾向を認めた。(著者抄録)

牧迫飛雄馬 . 認知症・フレイルからみた糖尿病合併症の重症化予防の重要性 . 日本糖尿病理学療法学雑誌2 ( Supplement ) 6 - 6 2022.9

Language：Japanese Publisher：一般社団法人日本糖尿病理学療法学会

糖尿病，高血圧，肥満，喫煙などの生活習慣に関わる要因は，認知症の重大な危険因子とされている．とくに，糖尿病は認知症および認知機能障害の発生リスクを増大させるだけでなく，認知機能が低下している中高齢者では将来の糖尿病発症リスクを増大させることが報告されており，双方からの予防対策が重要である．さらに，糖尿病に至らずとも，HbA1c が5.7～6.4％程度の前糖尿病に該当する者でも認知症の発症リスクが高く，さらには脳萎縮の進行が懸念されている．また，糖尿病を合併するフレイル高齢者では，要介護の発生リスクが増大することが報告されており，糖尿病の診断基準に該当しなくとも，前糖尿病の段階からフレイルや身体機能の低下を惹起するリスクが高いことが示唆されている．このように，糖尿病の診断に至らずとも，その前段階である前糖尿病においても，認知症およびフレイルの発生リスクは高く，より早期からの血糖コントロールおよび重症化の予防が重要であろう．認知症の発症者では，発症の10～12 年程前から身体活動量は低下してくることが指摘されており，継続した身体活動の促進に取り組むことが望ましい．とくに，65 歳以上の高齢者では，座位時間を身体活動（強度は問わない）に置き換えることや，1 週間で150～300 分以上の中強度の有酸素運動，もしくは75～150 分の高強度の有酸素運動に取り組むことが推奨されている．有酸素運動を中心とした身体活動の向上によって，認知症の発症の予防や遅延に効果が期待されている．認知機能の維持・改善に対するより効果的な運動療法としては，運動による身体活動の促進のみではなく，知的な刺激が伴う活動を付加することが推奨される．とりわけ，認知機能の低下が疑われる状態においては，運動のみによる介入では認知機能の改善には限界があると言わざるを得ず，知的な刺激の伴う活動を加えることで認知機能が維持・改善することが期待されている．フレイルに対しては，筋力トレーニングを中心として，有酸素運動，柔軟運動，バランス運動を含めた多面的な運動が推奨されている．血糖コントロールの改善を目指すうえでは，具体的な運動方法の提示とともに，いかに継続できるかの支援も重要であろう．

DOI： 10.51106/ptdm.2.supplement_6

CiNii Research

J-GLOBAL

Yukiko Nishita, Hyuma Makizako, Seungwon Jeong, Rei Otsuka, Hunkyung Kim, Shuichi Obuchi, Yoshinori Fujiwara, Yuki Ohara, Shuichi Awata, Minoru Yamada, Katsuya Iijima, Hiroyuki Shimada, Takao Suzuki . Temporal trends in cognitive function among community-dwelling older adults in Japan: Findings from the ILSA-J integrated cohort study. . Archives of gerontology and geriatrics102 104718 - 104718 2022.9International journal

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: As the population ages, it is important to consider whether older adults tend to have healthier lives. This study examined temporal trends in cognitive function among community-dwelling Japanese older adults. METHODS: The data source for this study was Integrated Longitudinal Studies on Aging in Japan (ILSA-J). We collected representative values for the Mini-Mental State Examination (MMSE) score obtained in 2010 and 2017; mean, standard deviation, and prevalence of ≤23 as cognitive impairment and ≥28 as intact cognitive function. Six cohorts (n=8,575) in 2010 and seven cohorts (n=6,089) in 2017 were included (age range 65-89). One-group meta-analyses were conducted to calculate pooled means of MMSE scores, the pooled prevalence of MMSE scores ≤23 and ≥28, and 95% confidence intervals (CIs). RESULTS: The mean MMSE score was higher in 2017 than in 2010 for all age groups in both men and women. The prevalence of MMSE ≤23 was lower in 2017 than in 2010 for all age groups for men and was lower in 2017 than in 2010 for all age groups other than for women aged 75-79 years. The prevalence of MMSE ≥28 was higher in 2017 than in 2010 for all age groups in both men and women. In addition, the pooled means of years of education was lower in 2010 than in 2017, which might be an explanatory factor. CONCLUSIONS: This study suggests that the cognitive function of community-dwelling Japanese older adults has improved in recent years. Future studies need to identify factors associated with the improvement.

DOI： 10.1016/j.archger.2022.104718

Scopus

PubMed

Maruta Michio, Shimokihara Suguru, Makizako Hyuma, Ikeda Yuriko, Han Gwanghee, Akasaki Yoshihiko, Hidaka Yuma, Kamasaki Taishiro, Kubozono Takuro, Ohishi Mitsuru, Tabira Takayuki . Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community-dwelling Japanese older adults(和訳中) . Psychogeriatrics22 ( 5 ) 651 - 658 2022.9

Language：English Publisher：John Wiley & Sons Australia, Ltd

地域在住高齢者におけるアパシーとフレイルとの横断的な関連について検討した。健康診断調査(垂水調査)に参加した地域在住高齢者882名(平均74.4±6.4歳、女性62.1%)を対象とした。アパシーはGeriatric Depression Scale-3Aで評価し、フレイルは基本チェックリスト(下位尺度;日常生活関連動作、運動器機能、低栄養状態、口腔機能、閉じこもり、認知機能)で評価した。その結果、209名(23.7%)でアパシーが認められた。交絡因子調整後の多項ロジスティック回帰分析の結果、アパシーはプレフレイルおよびフレイルと有意に関連していた。アパシーを有する高齢者では有さない高齢者と比較して、基本チェックリストの日常生活関連動作、運動器機能、口腔機能、認知機能に問題を呈する割合が有意に高かった。以上から、包括的なフレイル評価の重要性が示され、アパシーは老年期の健康に広範かつ有害な影響を及ぼす可能性が示唆された。

田平隆行, 池田由里子, 益満智美, 大重匡, 牧迫飛雄馬 . Relationship between hobbies and their satisfaction and subjective cognitive complains in older adults . 日本作業療法学会抄録集(CD-ROM)56回 OJ - 5 2022.9

牧迫飛雄馬, 赤井田将真, 立石麻奈, 谷口善昭, 白土大成 . 60歳以上の中高齢者におけるフレイルと転倒恐怖感との関連 . 日本転倒予防学会誌9 ( 2 ) 138 - 138 2022.9

牧迫飛雄馬, 立石麻奈 . 【ポストコロナ時代に向けた高齢者の孤立対策～予防から支援まで～】地域高齢者の孤立予防のための運動を介した社会活動の促進 . Geriatric Medicine60 ( 8 ) 707 - 710 2022.8

Language：Japanese Publisher：(株)ライフ・サイエンス

■新型コロナウイルス感染症の流行に伴い、日常での諸々の活動は制限を余儀なくされ、特に高齢者においては孤立や孤独のリスクが増大することが懸念される。高齢期における習慣的な運動は、心身機能や生活の質(QOL)の向上に有用となることが示されており、さらには運動行動を介して社会活動を促進することも期待され、孤立予防のための手段の1つともなり得る。コロナ禍における孤立や孤独の回避に対する対策が必要であると考えられた事例から、孤立予防のための運動を介した社会活動の促進のあり方について再考が必要であろう。(著者抄録)

J-GLOBAL

Language：Japanese Publisher：(株)ライフ・サイエンス

牧迫飛雄馬 . 【予防医学と健康増進学】運動習慣で健康増進と疾病予防は達成できるか . 老年科6 ( 2 ) 98 - 104 2022.8

益満智美, 宮田昌明, 丹羽さよ子, 牧迫飛雄馬, 田平隆行, 窪薗拓郎, 川添晋, 徳重明央, 大石充 . 地域在住高齢者における睡眠時間と血管硬化度との検討 . 日本動脈硬化学会総会プログラム・抄録集54回 262 - 262 2022.7

Michio Maruta, Suguru Shimokihara, Hyuma Makizako, Yuriko Ikeda, Gwanghee Han, Yoshihiko Akasaki, Yuma Hidaka, Taishiro Kamasaki, Takuro Kubozono, Mitsuru Ohishi, Takayuki Tabira . Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community‐dwelling Japanese older adults . Psychogeriatrics22 ( 5 ) 651 - 658 2022.6International journal

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Wiley

BACKGROUND: Frailty is a multidimensional condition characterised by reduced physical and psychological resilience. Older adults also frequently demonstrate apathy, suggesting that it shares similar neuro-physiological pathways with frailty. This cross-sectional study aimed to investigate the association between apathy and frailty as defined by a comprehensive assessment. METHODS: We analyzed 882 older adults (mean age: 74.4 ± 6.4 years; 62.1% female) who participated in a community-based health check survey (Tarumizu Study). Apathy was measured by the Geriatric Depression Scale-3A, a three-item subset of the Geriatric Depression Scale-15, and frailty by the Kihon Checklist of physical, psychological, functional, and social status. Associations were examined by multinomial logistic regression with frailty status (robust, pre-frailty, frailty) as the dependent variable, apathy as the independent variable, and sociodemographic factors, medications, cognitive function, functional capacity, and mood symptoms as potential confounders. RESULTS: Apathy was observed in 23.7% of individuals, and logistic regression revealed significant associations with both pre-frailty and frailty after confounder adjustment (pre-frailty: odds ratio (OR) 1.80, 95% CI 1.22-2.64; frailty: OR 3.24, 95% CI 1.63-6.42). Participants with apathy also exhibited greater deficits in the Kihon Checklist subdomains instrumental activities of daily living (P = 0.022), physical function (P < 0.001), oral function (P < 0.001), and cognitive function (P = 0.001). CONCLUSIONS: Our findings underscore the importance of comprehensive frailty assessment and demonstrate that apathy can have pervasive deleterious effects on geriatric health.

DOI： 10.1111/psyg.12867

Scopus

PubMed

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/psyg.12867

AKAIDA Shoma, NAKAI Yuki, TOMIOKA Kazutoshi, TANIGUCHI Yoshiaki, TATEISHI Mana, TABIRA Takayuki, TAKENAKA Toshihiro, KUBOZONO Takuro, OHISHI Mitsuru, MAKIZAKO Hyuma . Association between car accidents and falls among community-dwelling older drivers . Japanese Journal of Geriatric Therapy1 ( 0 ) 1 - 6 2022.6Reviewed

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Geriatric Therapy Society

【Aim】 This study aimed to examine the association between car accident history and fall history among community-dwelling older drivers.【Methods】 A cross-sectional analysis was conducted on 602 older drivers (mean age: 72.8 ± 5.6 years, women: 50.0%) who participated in the regional cohort study (Tarumizu Research 2018, 2019) and were driving at 65 years or older. For car accident history, we listened to their accident history for the past two years and classified it into “accident history” and “no accident history.” The fall history was classified into “with fall history” and “no fall history” based on the presence or absence of falls in the past year. In the statistical analysis, a binomial logistic regression analysis was performed with accident history as the dependent variable, fall history as the independent variable, and age and sex as the covariates.【Results】 It was found that 5.6% of the subjects had a history of car accidents, and 13.0% had a history of falls. Among those with a history of car accidents, a significantly higher percentage of people had a history of falls than among those with no history of car accidents (p = 0.003). The logistic regression analysis showed that having a history of falls was significantly associated with having a history of car accidents (odds ratio: 3.12, 95% confidence interval: 1.42–6.85, p = 0.004).【Conclusions】 The results suggested an association between a history of car accidents and a history of falls among community-dwelling older drivers.

DOI： 10.57270/jgts.2022_007

CiNii Research

J-GLOBAL

赤井田将真, 中井雄貴, 富岡一俊, 谷口善昭, 立石麻奈, 田平隆行, 竹中俊宏, 窪薗琢郎, 大石充, 牧迫飛雄馬 . 地域在住高齢者ドライバーにおける自動車事故歴と転倒歴の関係 . 日本老年療法学会誌1 1 - 6 2022.6

Language：Japanese Publisher：(一社)日本老年療法学会

地域在住高齢者ドライバーにおける自動車事故歴と転倒歴の関連性について検討した。地域コホート研究(垂水研究2018または2019)に参加した地域在住高齢者1029名のうち、調査時点で自動車運転免許を保有しており自動車運転をしている602名(女性50.0%、平均72.8±5.6歳)を対象とした。過去2年間の自動車事故経験者(事故歴あり)は34名(女性55.9%、平均72.7±4.9歳)、事故歴なしは568名(女性49.6%、平均72.9±5.7歳)であった。過去1年間の転倒経験者は78名(13.0%)であった。事故歴あり群は事故歴なし群に比べ転倒歴を有する割合が有意に高かった。事故歴とその他の変数(年齢、性別、多剤併用、運転頻度、運転距離、GDS-15、身体機能低下、MCI)の関係については群間での有意な差は認められなかった。二項ロジスティック回帰分析では、転倒歴を有することは事故歴を有することと有意な関連を認めた。

Language：Japanese Publisher：(一社)日本老年療法学会

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Papers - MAKIZAKO Hyuma