Faculty Profiles - MAKIZAKO Hyuma

Papers - MAKIZAKO Hyuma

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Daijo Shiratsuchi, Hyuma Makizako, Shoma Akaida, Saki Shono, Ryuhei Shiiba, Yoshiaki Taniguchi, Kazutoshi Tomioka, Nana Sato, Ayumi Wada, Yuto Kiuchi, Mana Tateishi, Yuki Nakai . Associations Between Health Literacy and Changes in Exercise Behavior During the Coronavirus Disease 2019 State of Emergency Among Middle-Aged Adults: A Cross-Sectional Online Survey. . Asia-Pacific journal of public health34 ( 2-3 ) 10105395211053160 - 10105395211053160 2021.10Reviewed International journal

Yuto Kiuchi, Hyuma Makizako, Yuki Nakai, Yoshiaki Taniguchi, Kazutoshi Tomioka, Nana Sato, Ayumi Wada, Takehiko Doi, Ryoji Kiyama, Toshihiro Takenaka . Associations of alpha-actinin-3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia. . Experimental gerontology154 111525 - 111525 2021.10Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: This cross-sectional study aimed to investigate the relationship of the ACTN3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia. METHODS: Data from 64 older Japanese adults (mean age 74.4 ± 6.9 years, women 71.9%) with sarcopenia or pre-sarcopenia were analyzed. Sarcopenia and pre-sarcopenia were defined using the Asian Working Group for Sarcopenia. We collected oral mucosa samples to determine the ACTN3 genotype. Thigh muscle volumes were measured using magnetic resonance imaging. Physical performance was assessed using the usual and maximum gait speed, timed up and go test, and five-repetition sit-to-stand test. Muscle strength was assessed using grip strength. RESULT: The ACTN3 genotype proportions were 20.3% for RR, 51.6% for RX, and 28.1% for XX. Participants with the RR genotype showed greater thigh muscle volume/ht2 compared to those with the RX and XX ACTN3 genotypes (p < 0.05). The multiple linear regression analysis revealed that RX (p < 0.01) and XX (p < 0.01) ACTN3 genotypes, compared to RR, were associated with lower thigh muscle volume/ht2 and with age, sex (reference; men), weight and maximum walking speed. There was no significant difference between physical performance and muscle strength between the ACTN3 genotypes. CONCLUSION: The ACTN3 genotype of the X allele was associated with decreased thigh muscle volume compared to the ACTN3 genotype of RR in older adults with sarcopenia or pre-sarcopenia.

DOI： 10.1016/j.exger.2021.111525

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Hyuma Makizako, Ryoji Kiyama, Daisaku Nishimoto, Ikuko Nishio, Tomomi Masumitsu, Yuriko Ikeda, Misako Hisamatsu, Sachiko Shimizu, Masami Mizuno, Mikiyo Wakamatsu, Naomi Inoue, Takayuki Tabira, Tadasu Ohshige, Ayako Yamashita, Satoshi Nagano, Ku-Ohl Project Team . Association between Regular Exercise and Self-Rated Health and Sleep Quality among Adults in Japan during the COVID-19 Pandemic. . International journal of environmental research and public health18 ( 19 ) 2021.10Reviewed International journal

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Regular exercise may be associated with better self-rated health and sleep status. However, this correlation among various age groups, such as young, middle-aged, and older people, as well as during the COVID-19 pandemic, has not been examined. This study examined the correlation between regular exercise and self-rated health and sleep quality among adults in Japan during the COVID-19 pandemic. Data were collected using an online survey conducted between February 26 and 27, 2021. A total of 1410 adults in Japan (age range, 20-86 years) completed the online survey. Regular exercise was divided into: (1) more than 30 min of moderate exercise a day, (2) more than 2 days per week, and (3) continuous for 1 year or longer. Self-rated health and sleep quality were assessed using the Likert scale. After adjusting for multiple confounders, regular exercise was correlated with decreased poor self-rated health and poor sleep quality in middle-aged adults; however, no significant correlation was observed among young and older adults. The promotion of regular exercise among middle-aged people during the COVID-19 pandemic may contribute to better self-rated health and sleep quality status.

DOI： 10.3390/ijerph181910515

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Hyuma Makizako, Shoma Akaida, Saki Shono, Ryuhei Shiiba, Yoshiaki Taniguchi, Daijo Shiratsuchi, Yuki Nakai . Physical Activity and Perceived Physical Fitness during the COVID-19 Epidemic: A Population of 40- to 69-Year-Olds in Japan. . International journal of environmental research and public health18 ( 9 ) 2021.4Reviewed International journal

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

The COVID-19 pandemic has caused an abrupt change in lifestyle for many people with restrictions, often leading to a decrease in physical activity (PA), and thus contributing to a negative perception of health status. The purpose of this study was to examine the effects of the COVID-19 epidemic on physical activity and perceived physical fitness in Japanese adults aged 40 to 69 years. Data were collected from an online survey conducted between October 19 and 28, 2020. The analytic sample consisted of 1989 Japanese adults (mean age, 50.1 ± 6.9 years; women, 38.9%) who were aged between 40 and 69 years and completed the online survey. Overall, the PA time per week decreased by 32.4% between October 2019 and April 2020. A decrease in PA time was recorded in October 2020; however, a decline of 15.5% was observed. Compared to individuals who did not perceive a decline in physical fitness, individuals who perceived declining physical fitness during the COVID-19 state of emergency demonstrated a greater decrease in PA time in April 2020 (-50.5%), and this trend continued into October 2020 (-25.0%). These findings may indicate that Japanese adults aged 40 to 69 years who perceived declining physical fitness experienced a greater decrease in physical activity.

DOI： 10.3390/ijerph18094832

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Hyuma Makizako, Yuki Nakai, Daijo Shiratsuchi, Tomomi Akanuma, Kaori Yokoyama, Yuriko Matsuzaki-Kihara, Hiroto Yoshida . Perceived declining physical and cognitive fitness during the COVID-19 state of emergency among community-dwelling Japanese old-old adults. . Geriatrics & gerontology international21 ( 4 ) 364 - 369 2021.4Reviewed

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

AIM: Perceived health status, including physical and cognitive fitness, will be negatively associated with future health conditions among old-old adults. The coronavirus disease 2019 (COVID-19) pandemic has caused sudden changes in lifestyle. Thus, this study examined the associations of participation in an exercise class before the COVID-19 pandemic and the exercise habits and disruption to the rhythms of daily life during the COVID-19 state of emergency with perceived declining physical and cognitive fitness among community-dwelling old-old adults. METHODS: In July 2020, we carried out a mail survey of community-dwelling old-old adults aged between 77 and 99 years in Bibai, Hokkaido, Japan, to determine their perceived declining physical and cognitive fitness during the COVID-19 state of emergency. RESULTS: Of the 774 responders, 339 (43.8%) participants reported a decline in physical fitness, whereas 259 (33.5%) perceived declining cognitive fitness during the COVID-19 state of emergency. In a multivariate logistic regression model adjusted for potential confounders, exercise habits during the COVID-19 state of emergency were significantly associated with a lower perception of declining physical fitness. Disruption to the rhythms of daily life during the COVID-19 state of emergency was significantly associated with a higher perception of declining physical and cognitive fitness. CONCLUSIONS: Approximately half and more than one-third of community-dwelling old-old adults perceived declining physical and cognitive fitness, respectively, during the COVID-19 state of emergency. During this period, exercise habits were positively correlated with perceived health status among old-old adults, whereas disruption to the rhythms of daily life was negatively correlated. Geriatr Gerontol Int 2021; ••: ••-••.

DOI： 10.1111/ggi.14140

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Naoki Saji, Hyuma Makizako, Hiroyuki Suzuki, Yuki Nakai, Takayuki Tabira, Shuichi Obuchi, Hisashi Kawai, Kenta Murotani, Naomi Katayama, Kenji Toba, Yasue Uchida, Tsutomu Nakashima . Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study. . Archives of gerontology and geriatrics93 104302 - 104302 2021.3Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Hearing impairment (HI) is associated with dementia. However, the cognitive screening tasks effective in older community dwellers presenting with HI are unclear. METHODS: We retrospectively and cross-sectionally investigated the associations between HI and cognitive function assessed with screening tasks using data from two healthcare check-up programs for community dwellers ≥65 years old in 2018. We examined demographics, risk factors, cognitive function, hearing condition, lifestyles, and self-care levels. Cognitive function was assessed using the clock drawing task and the delayed three words recall task. Hearing condition was assessed using questionnaires on the use of hearing aids and HI during conversation situations. Multivariate analysis was used to identify independent associations between HI and cognitive assessment tasks. RESULTS: We analyzed 1602 eligible participants (61.9% women; 74.3 ± 6.5 years old). Hearing aid users (n = 90) were older (80 vs. 73 years, respectively; p < 0.001) and less likely to draw the clock correctly (71.1% vs. 80.1% years, respectively; p = 0.044) than non-hearing aid users. Multivariate logistic regression analysis showed that HI was associated with inability to draw the clock correctly (odds ratio 1.60, 95% confidence interval 1.12-2.26; p = 0.011), independent of age, living alone, memory impairment, and impaired self-care levels. CONCLUSION: Hearing impairment is independently associated with cognitive decline assessed by the clock drawing task. The clock drawing task may be useful for identifying an increased risk of dementia in older subjects presenting with HI.

DOI： 10.1016/j.archger.2020.104302

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Saji N, Makizako H, Suzuki H, Nakai Y, Tabira T, Obuchi S, Kawai H, Murotani K, Katayama N, Toba K, Uchida Y, Nakashima T. . Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study . Arch Gerontol Geriatr93 2021.3Reviewed

Saji N, Suzuki H, Katayama N, Makizako H, Uchida Y, Nakashima T. . Sensory impairment: A preventable risk factor in older adults . Arch Gerontol Geriatr93 2021.3Reviewed

和田あゆみ, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 佐藤菜々, 木山良二, 田平隆行, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における社会的フレイルとうつ傾向との関連 . 鹿児島大学医学部保健学科紀要31 ( 1 ) 11 - 18 2021.3Reviewed

Authorship：Corresponding author Language：Japanese Publisher：鹿児島大学医学部保健学科

地域コホート研究(垂水研究2018)のデータを用いて、地域在住高齢者における社会的フレイルとうつ傾向との関連について横断観察研究を行った。対象は研究に対する同意が得られた65歳以上の地域在住高齢者859名であった。最終的に社会的フレイルの有無および高齢者用うつ尺度短縮版(GDS15)、その他基本属性に欠損のない812名(男性304名、女性508名、平均年齢74.8歳)を有効回答とし分析対象とした。対象者のうち社会的フレイルを有する者は112名(13.8%)であった。社会的フレイルを有する者は社会的フレイルを有しない者と比較し、高齢で、GDS15の点数は高く、歩行速度、握力が低下していた。社会的フレイルを有する者でうつ傾向のある者は37名(33.0%)で、社会的フレイルを有さない者でうつ傾向のある者90名(12.9%)と比較して有意に高い割合であった。ロジスティック回帰分析の結果からも社会的フレイルはうつ傾向と関連していることが示された。

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Daijo Shiratsuchi, Hyuma Makizako, Yuki Nakai, Yoshiaki Taniguchi, Tomomi Akanuma, Kaori Yokoyama, Yuriko Matsuzaki-Kihara, Hiroto Yoshida . Association of Health Literacy with the Implementation of Exercise during the Declaration of COVID-19 State of Emergency among Japanese Community-Dwelling Old-Old Adults. . International journal of environmental research and public health18 ( 4 ) 1 - 9 2021.2Reviewed International journal

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Health literacy is important for promoting and maintaining good health in old-old adults. It may influence the implementation of exercise in the coronavirus disease epidemic. The present cross-sectional study investigated the association of each dimension of health literacy with the implementation of exercise during the declaration of a state of emergency due to coronavirus disease in community-dwelling old-old adults. We collected data from 483 community-dwelling old-old adults (52.8% women) aged between 77 and 99 years who participated in a mail survey. Participants were divided into exercise or nonexercise groups based on the implementation of exercise during the declaration of a state of emergency. Health literacy was assessed using a 14-item health literacy scale. There were 327 (67.7%) participants in the exercise group and 156 (32.3%) in the nonexercise group. A significantly higher score of health literacy was observed in the exercise group than in the nonexercise group (communicative health literacy score = 14.0 ± 3.6 vs. 12.7 ± 3.8, p = 0.001). In a multivariate logistic regression model adjusted for potential confounders, high communicative health literacy scores were significantly associated with the implementation of exercise during the declaration of a state of emergency (odds ratio = 1.88, 95% confidence interval = 1.20-2.93). Approximately two-thirds of community-dwelling old-old adults implement exercise during the declaration of a state of emergency. High communicative health literacy was associated with the implementation of exercise during this period.

DOI： 10.3390/ijerph18042100

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Takao Suzuki, Yukiko Nishita, Seungwon Jeong, Hiroyuki Shimada, Rei Otsuka, Katsunori Kondo, Hunkyung Kim, Yoshinori Fujiwara, Shuichi Awata, Akihiko Kitamura, Shuichi Obuchi, Katsuya Iijima, Noriko Yoshimura, Shuichiro Watanabe, Minoru Yamada, Kenji Toba, Hyuma Makizako . Are Japanese older adults rejuvenating? Changes in health-related measures among older community dwellers in the last decade. . Rejuvenation research24 ( 1 ) 37 - 48 2021.2Reviewed International journal

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

During the last three decades, Japan has become one of the world's top countries for longevity, and the increase in average life expectancy is accompanied by a sharp rise in older population aged 65 years and above to approximately 28%. This study aimed to examine the changes in major health-related measures including physical constitution, physical function, and functional capacity of community-dwelling Japanese older people in the last decade. From the data of 13 longitudinal cohort studies on aging conducted in Japan with a total of 13,441 older subjects, the present study analyzed the changes in six indices that are related to health and functioning of the older people; height, weight, BMI, walking speed, grip strength, and instrumental ADL, between 2007 (± 2 years) and 2017 (± 2 years). Comparison of data for the two periods between subjects matched for age group and gender evidently showed better health status and a slower decline in most of the health-related measures in 2017 compared to a decade ago. The results of the present study indicate that the phenomenon of "rejuvenation" is occurring among the new generation of Japanese older adults, and the importance of this older population as a social resource in the super-aged society should be re-acknowledged.

DOI： 10.1089/rej.2019.2291

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Kiuchi Y, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Kimura M, Kanouchi H, Takenaka T, Kubozono T, Ohishi M. . The Association between Dietary Variety and Physical Frailty in Community-Dwelling Older Adults . Healthcare9 ( 1 ) 32 2021.1Reviewed

Makizako H., Shiratsuchi D., Miyake Y., Tabira K., Tateishi M., Akaida S., Nishi H., Fukumori M., Baba Y., Kobayashi M., Takihara T. . Effects of catechin-enriched green tea combined with exercise on physical performance and muscle mass in community-dwelling older adults: A cluster-randomized, placebo-controlled trial . Archives of Gerontology and Geriatrics147 106260 2026.8

Language：Japanese Publisher：Archives of Gerontology and Geriatrics

Background: Catechin could improve physical performance through enhanced muscle recovery and mitochondria function. Clinical evidence regarding the effect of catechin supplementation on muscle strength and physical performance in older adults remains scarce. Objectives: This community-based randomized controlled trial investigated the effects of catechin-enriched green tea combined with exercise on physical performance and muscle mass in community-dwelling older adults. Methods: Seventy-eight adults aged ≥60 years who perceived themselves as experiencing weakness or slowness were randomly assigned to either an intervention group (exercise plus catechin-enriched green tea, n = 45) or a control group (exercise plus placebo, n = 33). All participants attended regular community self-management group exercise classes and a supplementary 60 min exercise session once per month. The intervention group consumed catechin-enriched green tea, providing 613 mg of catechin per day for 24 weeks. Results: Fifty-one of the 78 randomized participants completed the trial with high adherence (≥60%). In the intent-to-treat analysis, there were no statistically significant differences in physical performance tests or muscle mass between the groups at pre- and post-intervention assessments by the linear mixed-effects models. The percentage change in knee extension strength over 24 weeks differed significantly between the intervention and control groups (P = 0.016). Catechin-enriched green tea intake was associated with changes in Titin N-terminal fragment. Conclusions: The combination of catechin-enriched green tea and exercise had a beneficial effect on lower limb muscle strength in community-dwelling older adults who perceived a decline in physical performance.

DOI： 10.1016/j.archger.2026.106260

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Araki Y., Kawasoe S., Kubozono T., Yoshimoto J., Kishi M., Suzuki S., Makizako H., Ohishi M. . Habitual natto consumption is inversely associated with mild cognitive impairment and depressive symptoms in older Japanese adults: A cross-sectional study . Nutrition Research150 174 - 183 2026.6

Language：Japanese Publisher：Nutrition Research

The association of the consumption of natto, a traditional Japanese fermented food, with mild cognitive impairment (MCI) and depressive symptoms remains poorly understood. We hypothesized that natto consumption may be negatively associated with MCI and depressive symptoms among older Japanese adults. We analyzed 616 individuals aged 65 years and older in the logistic regression model. We adjusted for age, sex, living alone, educational level, medication history, physical frailty, dietary diversity, tofu/atsuage (fried tofu) consumption habits, and miso soup consumption habits. The logistic regression analysis showed that natto consumption habits were negatively associated with MCI, even after adjustment (odds ratio [OR]: 0.63; p = .025). Natto consumption habits were also negatively associated with depressive symptoms (OR: 0.63; p = .037). Our findings indicate that natto consumption may be a simple and sustainable approach for maintaining cognitive function and mental health.

DOI： 10.1016/j.nutres.2026.04.009

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Daijo Shiratsuchi, Hyuma Makizako, Kento Tabira, Yuto Miyake, Takuro Kubozono, Mitsuru Ohishi . Comparative associations of height- and body mass index-adjusted muscle mass with sarcopenia under the Asian Working Group for Sarcopenia 2025 consensus . Archives of Gerontology and Geriatrics143 106153 - 106153 2026.4

Tabira K, Shiratsuchi D, Miyake Y, Makizako H . Low Body Mass Index Increases Frailty Risk in Old-Old Adults: Findings From a 3-Year Longitudinal Study. . Geriatrics & gerontology international26 ( 4 ) e70474 2026.4

Language：English Publisher：Geriatrics and Gerontology International

Objectives: Frailty risk increases with age. It is important to understand how body mass index (BMI) relates to changes in frailty risk among adults aged 75 years and older (old–old adults). We examined the longitudinal association between baseline BMI and changes in frailty risk over 3 years. Methods: This 3-year retrospective cohort study included 515 old–old adults (median age 79.3 years; 45.0% male) who participated in the Latter-Stage Older Persons Health Checkup in Amami City, Japan. Participants were categorized into three BMI groups: < 21.5, 21.5–24.9, and ≥ 25.0 kg/m2. Frailty risk was assessed using the Old–Old Questionnaire for Medical Checkups, a validated tool for assessing multidimensional frailty. Thirteen items were analyzed, excluding smoking and social support domains, to better examine the association between BMI and frailty risk. Higher scores indicate a greater frailty risk. We used linear mixed-effects models to analyze the associations between BMI categories at baseline and changes in frailty risk. Results: The BMI < 21.5 kg/m2 group participants reported a greater annual increase in frailty risk compared with those in the BMI 21.5–24.9 kg/m2 group (β = 0.17, Standard error = 0.07, p = 0.014). The BMI ≥ 25.0 kg/m2 group participants reported no significant change in frailty risk compared with those in the BMI 21.5–24.9 kg/m2 group (β = −0.01, Standard error = 0.06, p = 0.821). Conclusion: Old–old adults with a BMI of ≤ 21.5 kg/m2 experienced a more pronounced increase in frailty risk over the 3-year follow-up period.

DOI： 10.1111/ggi.70474

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Satake S., Osuka Y., Kozaki K., Makizako H., Shiratsuchi D., Akaida S., Tateishi M., Inoue T., Maeda K., Yamamoto K., Rakugi H., Akishita M., Arai H. . HQ6: Do Interventions or Assessments Using Digital Health Services Improve Sarcopenia Among Older Adults With Sarcopenia?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty . Geriatrics and Gerontology International26 ( S1 ) 63 - 67 2026.4

Maeda K., Iijima K., Makizako H., Shiratsuchi D., Akaida S., Tateishi M., Inoue T., Yamamoto K., Rakugi H., Akishita M., Arai H. . HQ4: Do Interventions and Assessments That Use Digital Health Services Prevent Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty . Geriatrics and Gerontology International26 ( S1 ) 44 - 50 2026.4

田平健人, 牧迫飛雄馬 . 特集デジタルリハ 2.0─AI･ウェアラブル･デジタルツインが創る個別化治療ウェアラブルデバイスによる運動機能のモニタリング . J. of Clinical Rehabilitation35 ( 3 ) 253 - 258 2026.3

Rei Otsuka, Shu Zhang, Yukiko Nishita, Chikako Tange, Mana Tateishi, Hyuma Makizako, Kaori Kinoshita, Fumihiro Mizokami, Mai Kabayama, Kei Kamide, Shosuke Satake, Hidenori Arai . Heatmap of 10-year disability risk according to the frailty-intrinsic capacity (FR-IC) index in older Japanese adults. . Archives of gerontology and geriatrics142 106119 - 106119 2026.3International journal

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Papers - MAKIZAKO Hyuma