Faculty Profiles - MAKIZAKO Hyuma

Papers - MAKIZAKO Hyuma

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牧迫飛雄馬, 窪薗琢郎, 大石充 . 【日本における高齢者コホート研究の成果と現状】垂水研究 . 老年内科4 ( 4 ) 405 - 409 2021.10

Kentaro Jujo, Nobuyuki Kagiyama, Kazuya Saito, Kentaro Kamiya, Hiroshi Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Hiroshi Wada, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Shuhei Yamamoto, Naoki Aizawa, Ryusuke Yonezawa, Kazuhiro Oka, Hyuma Makizako, Shin-Ichi Momomura, Yuya Matsue . Impact of Social Frailty in Hospitalized Elderly Patients With Heart Failure: A FRAGILE-HF Registry Subanalysis. . Journal of the American Heart Association10 ( 17 ) e019954 2021.9Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Background Frailty is conceptualized as an accumulation of deficits in multiple areas and is strongly associated with the prognosis of heart failure (HF). However, the social domain of frailty is less well investigated. We prospectively evaluated the clinical characteristics and prognostic impact of social frailty (SF) in elderly patients with HF. Methods and Results FRAGILE-HF (prevalence and prognostic value of physical and social frailty in geriatric patients hospitalized for heart failure) is a multicenter, prospective cohort study focusing on patients hospitalized for HF and aged ≥65 years. We defined SF by Makizako's 5 items, which have been validated as associated with future disability. The primary end point was a composite of all-cause death and rehospitalization because of HF. The impact of SF on all-cause mortality alone was also evaluated. Among 1240 enrolled patients, 825 (66.5%) had SF. During the 1-year observation period after discharge, the rates of the combined end point and all-cause mortality were significantly higher in patients with SF than in those without SF (Log-rank test: both P < 0.05). SF remained as significantly associated with both the combined end point (hazard ratio, 1.30; 95% CI, 1.02-1.66; P = 0.038) and all-cause mortality (hazard ratio, 1.53; 95% CI, 1.01-2.30; P = 0.044), even after adjusting for key clinical risk factors. Furthermore, SF showed significant incremental prognostic value over known risk factors for both the combined end point (net-reclassification improvement: 0.189, 95% CI, 0.063-0.316, P = 0.003) and all-cause mortality (net-reclassification improvement: 0.234, 95% CI, 0.073-0.395, P = 0.004). Conclusions Among hospitalized geriatric patients with HF, two thirds have SF. Evaluating SF provides additive prognostic information in elderly patients with HF. Registration URL: https://upload.umin.ac.jp/. Unique identifier: UMIN000023929.

DOI： 10.1161/JAHA.120.019954

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PubMed

牧迫飛雄馬 . 書評 -太田　進,藤田玲美,大古拓史(著)-｢動画でわかる運動器理学療法臨床実習スキル｣ . 理学療法ジャーナル55 ( 7 ) 778 - 778 2021.7

牧迫飛雄馬, 赤井田将真 . 【認知症-最近の動向】認知機能低下に対する運動療法の効果 . カレントテラピー39 ( 7 ) 656 - 661 2021.7

Language：Japanese Publisher：(株)ライフメディコム

身体活動の不足は、認知症の発症や認知機能の低下に強く関連するため、身体活動を向上させて活動的なライフスタイルを確立することは、認知機能の低下を抑制するために重要な要因である。定期的な運動習慣を有する高齢者では、将来の認知症発症のリスクが軽減され、運動介入による認知機能低下の抑制に対する効果が期待される。特に、有酸素運動を中心とした身体活動の向上は、認知症の発症の予防や遅延に効果が期待されている。認知機能の維持・改善に対するより効果的な運動療法においては、運動による身体活動の促進のみではなく、知的な刺激が伴う活動を付加することが推奨される。高齢期における認知機能の低下を抑制するためには、一時的な運動療法にとどまらず、習慣化できるようにいかに支援するかも重要なポイントとなる。(著者抄録)

谷口善昭, 牧迫飛雄馬, 富岡一俊, 中井雄貴, 佐藤菜々, 和田あゆみ, 木山良二, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係 . 日本サルコペニア・フレイル学会誌5 ( 1 ) 96 - 103 2021.6

Language：Japanese Publisher：一般社団法人日本サルコペニア・フレイル学会

［目　的］ 地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係を明らかにする。 ［方　法］ 地域での健康チェックに参加した高齢女性265名を分析対象とした。骨粗鬆症の有無，身体・認知・社会的フレイルを評価し，身体・社会的フレイルに関しては，プレフレイルとフレイルを合わせてプレフレイル以上とした。骨粗鬆症を従属変数とし，身体的プレフレイル以上，認知的フレイル，社会的プレフレイル以上を独立変数としたロジスティック回帰分析を行い，さらに前期・後期高齢女性に分けてオッズ比を算出した。 ［結　果］ 年齢，内服数，教育歴，BMI，関節リウマチの有無，呼吸器疾患の有無で傾向スコアを算出し，傾向スコアで調整したロジスティック回帰分析の結果，後期高齢女性において骨粗鬆症と社会的プレフレイル以上が関連していた（オッズ比3.14，95％ CI1.25-7.93，p＝0.02）。 ［結　論］ 地域在住後期高齢女性において，社会的フレイルは骨粗鬆症のリスクを高める可能性がある。

DOI： 10.69303/jjasf.5.1_96

CiNii Research

Keitaro Makino, Sangyoon Lee, Seongryu Bae, Ippei Chiba, Kenji Harada, Osamu Katayama, Yohei Shinkai, Hyuma Makizako, Hiroyuki Shimada . Prospective Associations of Physical Frailty With Future Falls and Fear of Falling: A 48-Month Cohort Study. . Physical therapy101 ( 6 ) 2021.6Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The present study aimed to examine the prospective associations of physical frailty with future falls and fear of falling (FOF) among community-dwelling older adults. METHODS: A prospective cohort study with a 48-month follow-up was conducted in a Japanese community. Participants were 2469 community-dwelling older adults aged 65 years or older who completed baseline and follow-up assessments at intervals of 48 ± 2 months. Primary outcomes were recent falls (defined as at least one fall within the past year) and FOF (determined by response to "Are you afraid of falling?") at follow-up survey. Physical frailty, operationalized by the frailty phenotype (slowness, weakness, exhaustion, weight loss, and low activity) based on the criteria of the Japanese version of the Cardiovascular Health Study (J-CHS), was also assessed as a predictor of future falls and FOF. RESULTS: Multivariable logistic regression showed that prefrailty or frailty increase the risk of not only future falls (odds ratio [OR]: 1.57; 95% CI = 1.20-2.05) but also FOF (OR: 1.33; 95%CI = 1.05-1.69). In addition, the relationship between baseline frailty status and future falls remained significant after adjusting for baseline FOF (OR: 1.55; 95% CI = 1.19-2.02), and the relationship between baseline frailty status and future FOF also remained significant after adjusting for baseline falls (OR: 1.32; 95% CI = 1.04-1.68). CONCLUSIONS: Frailty status may predict future falls and FOF among community-dwelling older adults. Strategies to prevent frailty may be beneficial to prevent not only future falls but also future FOF in a community setting. IMPACT: Falls and FOF have a close relationship but a different clinical meaning. Older adults with physical frailty may require monitoring as high risk not only for falls but also for FOF.

DOI： 10.1093/ptj/pzab059

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PubMed

西田裕紀子, 牧迫飛雄馬, 鄭丞媛, 大塚礼, 藤原佳典, 北村明彦, 鈴木宏幸, 渡辺修一郎, 近藤克則, 島田裕之, 鈴木隆雄 . 地域在住高齢者の認知機能の時代的推移長寿コホートの総合的研究(ILSA-J)より . 老年社会科学43 ( 2 ) 163 - 163 2021.6

谷口善昭, 牧迫飛雄馬, 富岡一俊, 中井雄貴, 佐藤菜々, 和田あゆみ, 木山良二, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係 . 日本サルコペニア・フレイル学会雑誌5 ( 1 ) 96 - 103 2021.6

Language：Japanese Publisher：(一社)日本サルコペニア・フレイル学会

[目的]地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係を明らかにする。[方法]地域での健康チェックに参加した高齢女性265名を分析対象とした。骨粗鬆症の有無、身体・認知・社会的フレイルを評価し、身体・社会的フレイルに関しては、プレフレイルとフレイルを合わせてプレフレイル以上とした。骨粗鬆症を従属変数とし、身体的プレフレイル以上、認知的フレイル、社会的プレフレイル以上を独立変数としたロジスティック回帰分析を行い、さらに前期・後期高齢女性に分けてオッズ比を算出した。[結果]年齢、内服数、教育歴、BMI、関節リウマチの有無、呼吸器疾患の有無で傾向スコアを算出し、傾向スコアで調整したロジスティック回帰分析の結果、後期高齢女性において骨粗鬆症と社会的プレフレイル以上が関連していた(オッズ比3.14、95%CI1.25-7.93、p=0.02)。[結論]地域在住後期高齢女性において、社会的フレイルは骨粗鬆症のリスクを高める可能性がある。(著者抄録)

佐藤菜々, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 和田あゆみ, 木山良二, 堤本広大, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における社会参加とサルコペニアとの関連 . 日本サルコペニア・フレイル学会雑誌5 ( 1 ) 73 - 80 2021.6

Language：Japanese Publisher：(一社)日本サルコペニア・フレイル学会

[目的]地域在住高齢者における社会参加とサルコペニアとの関連を明らかにすることを目的とした。[方法]地域コホート研究(垂水研究2018)に参加した65歳以上の地域在住高齢者859名のうち、脳卒中等の既往歴のない751名を分析対象とした。Asian Working Group for Sarcopenia2019に基づいてサルコペニアの有無、またJST版活動能力指標の社会参加に関する4項目より社会参加の状況を評価した。[結果]サルコペニアを有する者では、社会参加得点が有意に低値であった(p<0.001)。従属変数をサルコペニアの有無、独立変数を社会参加得点としたロジスティック回帰分析の結果、社会参加とサルコペニアに有意な関連を認めた(オッズ比0.83、95%信頼区間0.71-0.97)(共変量:年齢、性別、教育歴、服薬数、転倒歴、運動習慣、うつ傾向、認知機能)。[結論]地域在住高齢者の社会参加状況はサルコペニアと関連することが示唆された。(著者抄録)

丸田道雄, 牧迫飛雄馬, 池田由里子, 韓こう煕, 中村篤, 宮田浩紀, 下木原俊, 大勝巌, 大勝秀樹, 田平隆行 . 地域在住高齢者が重要とする活動の満足度と抑うつ症状の関連 . 日本作業療法研究学会雑誌24 ( 1 ) 62 - 63 2021.5

赤井田将真, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 和田あゆみ, 佐藤菜々, 丸田道雄, 田平隆行 . 地域在住高齢者における意味のある活動の満足度とフレイルの関係 . 日本作業療法研究学会雑誌24 ( 1 ) 76 - 76 2021.5

Maya Nakamura, Tomofumi Hamada, Akihiko Tanaka, Keitaro Nishi, Kenichi Kume, Yuichi Goto, Mahiro Beppu, Hiroshi Hijioka, Yutaro Higashi, Hiroaki Tabata, Kazuki Mori, Yumiko Mishima, Yoshinori Uchino, Kouta Yamashiro, Yoshiaki Matsumura, Hyuma Makizako, Takuro Kubozono, Takayuki Tabira, Toshihiro Takenaka, Mitsuru Ohishi, Tsuyoshi Sugiura . Association of Oral Hypofunction with Frailty, Sarcopenia, and Mild Cognitive Impairment: A Cross-Sectional Study of Community-Dwelling Japanese Older Adults. . Journal of clinical medicine10 ( 8 ) 2021.4Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Oral hypofunction is a new concept that addresses the oral function of older adults. Few studies have investigated the relationship between oral hypofunction and general health conditions such as frailty, sarcopenia, and mild cognitive impairment. This paper explores these relationships in a large-scale, cross-sectional cohort study. The relationships of oral hypofunction with frailty, sarcopenia, and mild cognitive impairment were examined using data from 832 individuals who participated in the 2018 health survey of the residents of Tarumizu City, Kagoshima Prefecture, Japan. Individuals with frailty, sarcopenia, and mild cognitive impairment had significantly higher rates of oral hypofunction. Frailty was independently associated with deterioration of the swallowing function (odds ratio 2.56; 95% confidence interval, 1.26-5.20), and mild cognitive impairment was independently associated with reduced occlusal force (odds ratio 1.48; 95% confidence interval, 1.05-2.08) and decreased tongue pressure (odds ratio 1.77; 95% confidence interval, 1.28-2.43). There was no independent association found between sarcopenia and oral function. In conclusion, early intervention for related factors such as deterioration of the swallowing function in frailty, reduced occlusal force, and decreased tongue pressure in mild cognitive impairment could lead to the prevention of general hypofunction in older adults.

DOI： 10.3390/jcm10081626

Scopus

PubMed

牧迫飛雄馬 . 特集整形外科疾患の運動療法-最近の進歩サルコペニアに対する運動療法 . 整形･災害外科64 ( 4 ) 457 - 464 2021.4

Yu Kume, Tomoko Takahashi, Yuki Itakura, Sangyoon Lee, Hyuma Makizako, Tsuyosi Ono, Hiroyuki Shimada, Hidetaka Ota . Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study . Gerontology67 ( 2 ) 184 - 193 2021.4Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Introduction: A prevalence of frailty is gradually increasing with the progress of aging in Japan, and critical challenges regarding early diagnosis and prevention of frailty were necessary in community. Although previous studies have well documented the characteristics of physical disability, there is limited information on frail state differences among older adults in Japanese rural areas. The aim of our cross-sectional observational study was to clarify the association of frail status in northern Japanese community-dwellers aged 65 or more. Methods: 345 participants were recruited from 2018 to 2020, and after getting informed consent from each participant, assessments and outcomes were evaluated according to the ORANGE protocol. We applied the frailty index of Gerontology-the Study of Geriatric Syndromes (NCGG-SGS) to classify frailty status by collecting data of demographics and psychosocial status using the Kihon checklist (KCL) and cognitive domains used by the National Center for Geriatrics and Gerontology-Functional Assessment Tool (NCGG-FAT). Results: Our subjects included 313 older adults divided into 138 robust, 163 prefrail, and 12 frail. For statistical analysis, we found that the frail group had a lower educational duration, worsened KCL items, lower cognitive functions, and a tendency toward depression compared to the other groups. Moreover, physical frailty and cognitive decline were related, and polypharmacy and a lack of joy in daily life were explanatory variables of frail status. Conclusions: We suggest that KCL is important for frail discrimination, and in order to prevent physical frailty, our community should take care of not only exercise and nutrition but also cognitive functioning and depressive tendencies. In particular, polypharmacy and the presence of fun in your life are possible to be related to frailty.

DOI： 10.1159/000511986

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PubMed

Takuro Kubozono, Yuichi Akasaki, Shin Kawasoe, Satoko Ojima, Takeko Kawabata, Hyuma Makizako, So Kuwahata, Toshihiro Takenaka, Mayuka Maeda, Mayu Ohno, Mika Kijimuta, Seisuke Fujiwara, Ken Miyagawa, Mitsuru Ohishi . The relationship between home blood pressure measurement and room temperature in a Japanese general population. . Hypertension research : official journal of the Japanese Society of Hypertension44 ( 4 ) 454 - 463 2021.4Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Blood pressure (BP) is influenced by various factors, and it is known that temperature and BP have a negative relationship. However, few reports have examined the relationship between BP and temperature throughout the day in the same participant over time. Therefore, this study aimed to investigate the relationship between BP and temperature in the morning and evening in the same participants during a time period of ~1 year. In total, 401 participants, who participated in a community-based health checkup survey in Tarumizu, Japan, were enrolled. Five participants were excluded due to missing data. All participants measured their BP and the room temperature at home using a blood pressure monitor (HEM-9700T, OMRON Healthcare, Kyoto, Japan). The mean systolic BP (SBP) and diastolic BP (DBP) in the morning were significantly higher than the mean of the measurements taken in the evening (SBP: morning vs. evening 128 ± 15 mmHg vs. 122 ± 14 mmHg, P < 0.0001; DBP: morning vs. evening 77 ± 10 mmHg vs. 72 ± 8 mmHg, P < 0.0001). Using a linear mixed model with participants as a random effect, SBP and DBP were significantly associated with temperature in both the morning and evening. In the morning, in almost every month except July, a significant association between SBP and temperature was observed. However, there was a significant relationship between evening BP and temperature in all months. In conclusion, BP was significantly related to temperature in both the morning and evening during the year-long study. Furthermore, BP and temperature were significantly associated in all months except morning measurements in July.

DOI： 10.1038/s41440-020-00564-3

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PubMed

Kobozono Takuro, Akasaki Yuichi, Kawasoe Shin, Ojima Satoko, Kawabata Takeko, Makizako Hyuma, Kuwahata So, Takenaka Toshihiro, Maeda Mayuka, Ohno Mayu, Kijimuta Mika, Fujiwara Seisuke, Miyagawa Ken, Ohishi Mitsuru . The relationship between home blood pressure measurement and room temperature in a Japanese general population(和訳中) . Hypertension Research44 ( 4 ) 454 - 463 2021.4

Language：English Publisher：Nature Publishing Group

朝夕に自宅で測定した血圧と、同時に記録した室温との関係性を調査した。地域健康診断を受診した参加者395名(男性136名、女性259名、平均71±8歳)を被験者とし、血圧モニターを使用して自宅で血圧と室温を測定した。平均収縮期血圧(SBP)と拡張期血圧(DBP)は、それぞれ139±18mmHgと80±11mmHgで、191名が降圧薬を使用していた。朝のSBPとDBPは、夕方の平均測定値の平均よりも有意に高かった。変量効果としての家庭血圧と室温との関連を検討した線形混合モデルでは、SBPとDBPは朝夕両方の気温と有意に関連していた。7月以外の月の朝においてSBPと気温の間に有意な関連が観察されたが、夕方の血圧と気温の間には全ての月で有意な関連がみられた。血圧は、1年間の研究期間中、朝夕の両方で気温と有意に関連していた。また気温は7月の朝の血圧測定値を除き、全ての月で血圧に有意に影響していた。

Makizako Hyuma, Nakai Yuki, Shiratsuchi Daijo, Akanuma Tomomi, Yokoyama Kaori, Matsuzaki-Kihara Yuriko, Yoshida Hiroto . COVID-19緊急事態宣言下での日本人後期高齢者における体力低下および認知機能低下の認識(Perceived declining physical and cognitive fitness during the COVID-19 state of emergency among community-dwelling Japanese old-old adults) . Geriatrics & Gerontology International21 ( 4 ) 364 - 369 2021.4

Language：English Publisher：John Wiley & Sons Australia, Ltd

2020年7月に北海道美唄市在住の地域在住後期高齢者1112名を対象として、COVID-19緊急事態宣言下での体力・認知機能低下の認識に関する質問紙調査を郵送法により実施した。調査項目は、年齢、性別、居住形態、病歴、ポリファーマシー、高齢者うつ尺度、体力低下や認知機能低下の認識の有無、緊急事態宣言前の運動教室への参加状況、緊急事態宣言下での運動習慣(週に2回以上、30分以上)や日常生活リズムの乱れの有無などとした。774名(女性433名、平均83.3±4.4歳)を解析対象とした。その結果、COVID-19緊急事態下で体力低下を認識していたのは339名(43.8%)、認知機能低下を認識していたのは259名(33.5%)であった。潜在的交絡因子を調整した多変量ロジスティック回帰モデルの結果、COVID-19緊急事態宣言下での運動習慣は体力低下の認識の低さと有意に関連していた。また、COVID-19緊急事態宣言下での日常生活リズムの乱れは、体力低下および認知機能低下の認識が高いことと有意に関連していた。

牧迫飛雄馬 . 【整形外科疾患の運動療法-最近の進歩】サルコペニアに対する運動療法　最新の知見 . 整形・災害外科64 ( 4 ) 457 - 464 2021.4

Language：Japanese Publisher：金原出版(株)

＜文献概要＞サルコペニアは,高齢期にみられる骨格筋量の減少と筋力もしくは身体機能(歩行速度など)の低下により定義される。サルコペニアは,2016年に国際疾病分類(ICD-10)においてM62.84のコードを取得しており,サルコペニアの治療やリハビリテーション,予防の重要性がさらに高まると考えられる。サルコペニアの定義や分類が整理されつつあるが,サルコペニアの判定方法については臨床的な活用可能性も考慮され,改訂がなされている。現状においては,サルコペニアの予防・改善のためには運動と栄養改善による介入戦略が有効であろうと考えられる。特に,運動療法に関しては,筋力トレーニングを中心とした多面的な運動プログラムが推奨される。しかし,サルコペニアに対する運動介入のエビデンスは十分なレベルではないため,さらにエビデンスが蓄積されていくことが望まれる。

Osamu Iritani, Tazuo Okuno, Takaki Miwa, Hyuma Makizako, Fumino Okutani, Tetsuo Kashibayashi, Kumiko Suzuki, Hideo Hara, Eri Mori, Shusaku Omoto, Hirokazu Suzuki, Minori Shibata, Hiroaki Adachi, Kenji Kondo, Yumi Umeda-Kameyama, Kumie Kodera, Shigeto Morimoto . Olfactory-cognitive index distinguishes involvement of frontal lobe shrinkage, as in sarcopenia from shrinkage of medial temporal areas, and global brain, as in Kihon Checklist frailty/dependence, in older adults with progression of normal cognition to Alzheimer's disease . GERIATRICS & GERONTOLOGY INTERNATIONAL21 ( 3 ) 291 - 298 2021.3Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

Aim: Olfactory impairment as a prodromal symptom, as well as sarcopenia, frailty and dependence as geriatric syndromes, is often associated with cognitive decline in older adults with progression of Alzheimer's disease. The present study aimed to evaluate the associations of olfactory and cognitive decline with these geriatric syndromes, and with structural changes of the brain in older adults.Methods: The participants were 135 older adults (47 men and 88 women, mean age 79.5 years), consisting of 64 with normal cognition, 23 with mild cognitive impairment and 48 with Alzheimer's disease. Olfactory function was evaluated by the Open Essence odor identification test. Shrinkage of the regional brain was determined by magnetic resonance imaging.Results: Logistic regression analysis with Open Essence, Mini-Mental State Examination, age and sex as covariates showed higher olfactory-cognitive index (|coefficient for Open Essence (a) / coefficient for Mini-Mental State Examination (b)|) in participants with sarcopenia (Asia Working Group for Sarcopenia), and lower values of (|a/b|) in participants with Barthel Index dependence, Kihon Checklist frailty, Lawton Index dependence and support/care-need certification as objective variables. Logistic regression analysis adjusted by age and sex also showed significant shrinkage of the frontal lobe in participants with AWGS sarcopenia, especially in women, and shrinkage of the medial temporal areas and global brain in participants with Kihon Checklist frailty/dependence.Conclusions: Olfactory-cognitive index (|a/b|) might be a useful tool to distinguish involvement of frontal lobe shrinkage, as in sarcopenia from shrinkage of the medial temporal areas, and global brain, as in frailty/dependence, in older adults with progression of normal cognition to Alzheimer's disease.

DOI： 10.1111/ggi.14128

Web of Science

Scopus

PubMed

Iritani Osamu, Okuno Tazuo, Miwa Takaki, Makizako Hyuma, Okutani Fumino, Kashibayashi Tetsuo, Suzuki Kumiko, Hara Hideo, Mori Eri, Omoto Shusaku, Suzuki Hirokazu, Shibata Minori, Adachi Hiroaki, Kondo Kenji, Umeda-Kameyama Yumi, Kodera Kumie, Morimoto Shigeto . Olfactory-cognitive index distinguishes involvement of frontal lobe shrinkage, as in sarcopenia from shrinkage of medial temporal areas, and global brain, as in Kihon Checklist frailty/dependence, in older adults with progression of normal cognition to Alzheimer's disease(和訳中) . Geriatrics & Gerontology International21 ( 3 ) 291 - 298 2021.3

Language：English Publisher：John Wiley & Sons Australia, Ltd

高齢者135名(男性47名、女性88名、平均79.5歳)を対象として、嗅覚や認知機能低下、老年症候群、脳の構造変化との関連を評価した。認知機能正常64名、MCI 23名、アルツハイマー病48名であった。評価項目は年齢、性別、Open Essenceによる嗅覚機能、ミニメンタルステート検査、AWGSによるサルコペニア、補正四肢筋量、握力、歩行速度、Barthel ADL、基本チェックリストによるフレイル、LawtonのIADLスケール、要介護・要支援認定、脳MRI所見などとした。嗅覚認知指数(|a/b|)をロジスティック回帰式(老年症候群の発生=a[OE]+b[MMSE]+c[年齢]+d[性別]+e)より算出した。ロジスティック回帰分析の結果、サルコペニア患者では嗅覚認知指数が高く、フレイル、Barthel ADLおよびIADLにおける非自立者、要介護・要支援認定者では嗅覚認知指数が低かった。また、サルコペニア患者のうち特に女性では前頭葉の有意な萎縮が認められ、フレイル/非自立者では側頭葉内側部および全脳の萎縮がみられた。

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