Faculty Profiles - MAKIZAKO Hyuma

Papers - MAKIZAKO Hyuma

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Yoshiaki Taniguchi, Hyuma Makizako, Ryoji Kiyama, Kazutoshi Tomioka, Yuki Nakai, Takuro Kubozono, Toshihiro Takenaka, Mitsuru Ohishi . The Association between Osteoporosis and Grip Strength and Skeletal Muscle Mass in Community-Dwelling Older Women. . International journal of environmental research and public health16 ( 7 ) 2019.4Reviewed International journal

Language：English

This cross-sectional study investigated the association between osteoporosis, grip strength, and skeletal muscle mass in community-dwelling older women. Data obtained from 265 older women who participated in a community-based health check survey (Tarumizu Study) were analyzed. Face-to-face interviews with participants revealed their history of osteoporosis. Appendicular skeletal muscle mass was assessed through bioelectrical impedance analysis, and appendicular skeletal muscle index was calculated. Dominant grip strength was also assessed. Loss of skeletal muscle mass (appendicular skeletal muscle mass < 5.7 kg/m²) and muscle weakness (grip strength < 18 kg) were determined based on criteria for sarcopenia put forth by the Asian Working Group for Sarcopenia. The prevalence rates of osteoporosis, muscle weakness, and loss of skeletal muscle mass were 27.2%, 28.7%, and 50.2%, respectively. Loss of skeletal muscle mass was more prevalent in participants with osteoporosis than in those without (65.3% vs. 44.6%, p < 0.01). The association between osteoporosis and muscle strength was not significant (30.6% vs. 28.0%, p = 0.68). After covariate adjustment, loss of skeletal muscle mass was found to be independently associated with osteoporosis (odds ratio 2.56, 95% confidence interval 1.33⁻4.91). In sum, osteoporosis was found to be associated with loss of skeletal muscle mass, but not with muscle weakness in community-dwelling older women.

DOI： 10.3390/ijerph16071228

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PubMed

Lee Sungchul, Lee Sangyoon, Bae Seongryu, Harada Kazuhiro, Jung Songee, Makizako Hyuma, Shimada Hiroyuki . Impact of sedentary time on chronic kidney disease and disability incidence in community-dwelling Japanese older adults: A 4-year prospective cohort study . Journal of Aging and Physical Activity27 ( 2 ) 184 - 190 2019.4Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

This study examined the association between the estimated glomerular filtration rate (eGFR) and disability incidence according to sedentary time in community-dwelling Japanese older adults. This prospective cohort study sampled 5,104 community-dwelling older adults (≥65 years) enrolled in a health promotion study in a general population. The participants (n = 4,457; ≥65 years) were monitored for inclusion in the long-term care insurance system for 4 years. This study used blood samples to assess eGFR. Cox proportional regression analysis was used to determine predictors of disability. In total, 461 participants (10.3%) became newly certified as needing long-term care insurance services. Cox regression models were adjusted for multiple confounders: eGFR < 45 ml/min/1.73 m2 (hazard ratio = 1.741, 95% confidence interval [1.193-2.539]) and eGFR < 45 ml/min/1.73 m2 with high sedentary time (≥8 hr) (hazard ratio = 4.367, 95% confidence interval [2.021-9.438]) remained significantly associated with disability incidence. Our findings suggest that in the case of chronic kidney disease, the disability incidence rate may be affected by sedentary time.

DOI： 10.1123/japa.2017-0326

PubMed

Shimada H, Doi T, Lee S, Makizako H. . Reversible predictors of reversion from mild cognitive impairment to normal cognition: a 4-year longitudinal study. . Alzheimers Res Ther11 ( 1 ) 24 2019.3Reviewed

Hiroyuki Shimada, Takehiko Doi, Sangyoon Lee, Hyuma Makizako . Reversible predictors of reversion from mild cognitive impairment to normal cognition: a 4-year longitudinal study. . Alzheimer's research & therapy11 ( 1 ) 24 - 24 2019.3Reviewed International journal

Language：English

BACKGROUND: Although previous studies have revealed many factors related to mild cognitive impairment (MCI) reversion, information about reversible factors related MCI reversion is limited, impeding the development of intervention strategies. The aim of the present study was to examine whether reversible factors such as lifestyle activities are associated with MCI reversion in elderly individuals using the National Center for Geriatrics and Gerontology-Study of Geriatric Syndromes database. A total of 396 community-living older adults (age ≥ 65 years) participated in the study. They were classified as reverters or non-reverters from mild cognitive impairment to normal cognition. We assessed lifestyle activities, potential confounding factors of cognitive decline, and reversion of mild cognitive impairment. RESULTS: In a completed data set of 396 participants, 202 participants (51.0%) reverted from MCI to normal cognition. The reversion rate in participants for whom we imputed data was 34.3%. In the imputed group, a logistic regression model showed that the odds ratios (ORs) for reversion were significantly higher in participants who drove a car (OR 1.50, 95% confidence interval (CI) 1.41-1.60), used a map to travel to unfamiliar places (OR 1.12, 95% CI 1.06-1.18), read books or newspapers (OR 1.54, 95% CI 1.37-1.73), took cultural classes (OR 1.10, 95% CI 1.04-1.15), attended meetings in the community (OR 1.22, 95% CI 1.16-1.28), participated in hobbies or sports activities (OR 1.09, 95% CI 1.03-1.16), and engaged in fieldwork or gardening (OR 1.14, 95% CI 1.08-1.21). The imputed sample showed that non-reverters were more likely to discontinue fieldwork or gardening (11.0% vs. 6.1%) than reverters during the follow-up period. CONCLUSIONS: Specific lifestyle activities may play important roles in MCI reversion in older adults. The longitudinal data indicate that it is reasonable to recommend that individuals continue to engage in fieldwork or gardening to increase their chance of recovery from MCI.

DOI： 10.1186/s13195-019-0480-5

Scopus

PubMed

丸田道雄, 田平隆行, 牧迫飛雄馬, 韓こう煕, 吉満孝二, 中村篤, 窪薗琢郎, 大石充 . 地域在住独居高齢者における心の理論課題成績と社会参加との関連 . 老年精神医学雑誌30 ( 2 ) 177 - 184 2019.2

Language：Japanese Publisher：(株)ワールドプランニング

本研究は、独居高齢者に焦点をあてて、心の理論と社会参加の関連について検討した。鹿児島県垂水市における垂水研究2017に参加した地域在住高齢者のうち独居者102人を対象とした。調査項目は、心の理論、年齢、性別、認知機能、抑うつ状態、社会参加、外出頻度、毎日の他者との会話の有無とした。心の理論の一次的信念課題はサリーとアン課題とし、同課題に「アンが宝物を移す様子を窓からサリーが見ている」という内容を加え「アンは、戻ってきたサリーがどこを探すと思うか」と質問し、二次的信念課題とした。一次的・二次的信念課題それぞれで、正解と不正解の2群に分けて単変量解析を行い、有意差を認めた項目を独立変数、正解・不正解を従属変数としたロジスティック回帰分析を行った。その結果、二次的信念課題において、社会参加が関連因子として抽出された。独居高齢者において、心の理論を保つために社会参加を支援することの重要性が示唆された。(著者抄録)

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J02464&link_issn=&doc_id=20190305030008&doc_link_id=%2Faj2rsizd%2F2019%2F003002%2F009%2F0177-0184%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faj2rsizd%2F2019%2F003002%2F009%2F0177-0184%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Hideaki Ishii, H. Makizako, T. Doi, K. Tsutsumimoto, H. Shimada . Associations of Skeletal Muscle Mass, Lower-Extremity Functioning, and Cognitive Impairment in Community-Dwelling Older People in Japan . The journal of nutrition, health & aging23 ( 1 ) 35 - 41 2019.1

Makizako H, Kubozono T, Kiyama R, Takenaka T, Kuwahata S, Tabira T, Kanoya T, Horinouchi K, Shimada H, Ohishi M . Associations of social frailty with loss of muscle mass and muscle weakness among community-dwelling older adults. . Geriatrics & gerontology international19 ( 1 ) 76 - 80 2019.1Invited Reviewed

Ishii H, Makizako H, Doi T, Tsytynuniti K, Shimada H. . Associations of skeletal muscle mass, lower-extremity functioning, and cognitive impairment in community-dwelling older people in Japan . J Nutr Health Aging23 ( 1 ) 35 - 41 2019Reviewed

丸田道雄，田平隆行，牧迫飛雄馬，韓侊熙，吉満孝二，中村篤，窪園琢郎，大石充 . 地域在住独居高齢者における心の理論課題成績と社会参加との関連． . 老年精神医学雑誌30 ( 2 ) 177 - 184 2019Reviewed

木村美佳，守安愛，牧迫飛雄馬，伊平井平光，古名丈人 . 介護予防を目的とした郵便による食習慣介入の効果：積雪・寒冷・過疎地域在住高齢者における検討． . 日本公衛誌66 ( 11 ) 681 - 689 2019Reviewed

Hiroyuki Shimada, Ryo Hotta, Hyuma Makizako, Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo, Keitaro Makino . Effects of Driving Skill Training on Safe Driving in Older Adults with Mild Cognitive Impairment. . Gerontology65 ( 1 ) 90 - 97 2019Reviewed International journal

Language：English

BACKGROUND: Driving cessation is strongly associated with adverse health outcomes in the older adults. Although there were numerous documentations of driving rehabilitation in disabled adults, the effects of interventions on safe driving were not clear in older adults with cognitive impairment who had low driving skills. OBJECTIVE: This randomized controlled trial was designed to determine whether a safe driving skill program consisting of classroom and on-road training could enhance driving performance of older drivers with cognitive impairment in Japan. METHODS: A total of 160 community-living older drivers participated in the randomized controlled trial with blinded endpoint assessment. Participants randomized to intervention underwent 10 1-h classroom sessions and 10 1-h on-road sessions focused on common problem areas of older drivers. Controls received 1 classroom education. On-road driving performance was assessed by certified driving school instructors in a driving school. The participants carried out dynamic vision and cognitive performance tests. RESULTS: One hundred and forty-six (intervention group, n = 71) subjects completed the 3-month follow-up. Mean adherence to classroom-based vision training and driving simulator training and on-road training programs, including the 71 participants, was 99.0 ± 6.4 and 99.0 ± 7.2%, respectively. Regarding the safe driving skill score, there were group × time interactions (p < 0.01) indicating benefits of the intervention over time. Although there were no significant group × time interactions in cognitive tests, dynamic vision showed group × time interactions (p < 0.01). CONCLUSION: The driving skill program significantly improved safe driving performance in older adults with cognitive impairment who were at a potentially high risk of a car accident.

DOI： 10.1159/000487759

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PubMed

Hyuma Makizako, Yuki Nakai, Kazutoshi Tomioka, Yoshiaki Taniguchi . Prevalence of sarcopenia defined using the Asia Working Group for Sarcopenia criteria in Japanese community-dwelling older adults: A systematic review and meta-analysis. . Physical therapy research22 ( 2 ) 53 - 57 2019Reviewed

Language：English

The aim of this systematic review and meta-analyses was to calculate the pooled prevalence of sarcopenia based on the Asia Working Group for Sarcopenia (AWGS) criteria among Japanese community-dwelling older adults. Data from 8 studies were used to determine the prevalence of sarcopenia in the overall population and in men; data from 9 studies were used to determine that of women. The pooled prevalence rates of sarcopenia using random-effects models were 9.9% (95% confidence interval [CI], 6.2%-15.4%) overall; 9.8% (95% CI, 6.2%-15.2%) among men; and 10.1% (95% CI, 6.4%-15.5%) among women. These findings would be useful to inform community-based strategies and advanced research addressing sarcopenia prevention.

DOI： 10.1298/ptr.R0005

PubMed

CiNii Research

田平隆行, 牧迫飛雄馬, 吉満孝二, 丸田道雄, 池田由里子, 中村篤, 下木原俊, 徳田圭一郎, 竹中俊宏, 窪薗琢郎, 大石充 . 地域在住高齢者における墓参り行動と心身機能、生活機能との関連 . 日本作業療法研究学会雑誌21 ( 2 ) 63 - 63 2018.12

Doi T, Makizako H, Tsutsumimoto K, Nakakubo S, Kim MJ, Kurita S, Hotta R, Shimada H. . Transitional status and modifiable risk of frailty in Japanese older adults: A prospective cohort study. . Geriatrics & Gerontology International18 ( 11 ) 1562 - 1566 2018.11Reviewed

Takehiko Doi, Hyuma Makizako, Kota Tsutsumimoto, Sho Nakakubo, Min-Ji Kim, Satoshi Kurita, Ryo Hotta, Hiroyuki Shimada . Transitional status and modifiable risk of frailty in Japanese older adults: A prospective cohort study. . Geriatrics & gerontology international18 ( 11 ) 1562 - 1566 2018.11Reviewed

Language：English

AIM: The purpose of the present study was to identify risk factors for physical frailty and to understand the transitional status of frailty. METHODS: The participants were 4676 older adults in the National Center for Geriatrics and Gerontology - Study of Geriatric Syndromes. Physical frailty status was classified as robust, pre-frail and frail at baseline and 4-year follow up (mean follow up 47.9 ± 1.8 months). Data for demographic variables, medical conditions, fall, depressive symptoms and cognitive function were also collected. Multiple imputation was used to reduce selection bias and loss of information. RESULTS: Progression occurred from a robust to frail status in 52 participants (2.6%) and from pre-frailty to frailty in 281 participants (12.0%). Mortality increased with frailty status at baseline: robust 46 (2.3%), pre-frail 112 (4.8%) and frail 54 (15.6%). In logistic regression analysis, age (OR 1.10, 95% CI 1.06-1.13), sex (men; OR 0.67, 95% CI 0.46-0.95), body mass index (OR 1.06, 95% CI 1.01-1.12]), fall (OR 1.92, 95% CI 1.31-2.81), Geriatric Depression Scale (OR 1.15, 95% CI 1.08-1.22), Mini-Mental State Examination (OR 0.87, 95% CI 0.82-0.93) and education (OR 0.91, 95% CI 0.85-0.98), were related with new incident frailty. Among participants in the pre-frail class at baseline, exhaustion (OR 3.24, 95% CI 1.97-5.34), physical inactivity (OR 3.09, 95% CI 1.94-4.93), lower muscle strength (OR 3.77, 95% CI 2.35-6.03) and lower mobility (OR 2.54, 95% CI 1.57-4.10) were related to progression to frailty (all P < 0.05). CONCLUSIONS: The results of the present prospective study provide key information on the transitional status of frailty and the risk factors for progression to frailty. A further study is required to determine the pathophysiological changes that underlie the transition to frailty. Geriatr Gerontol Int 2018; 18: 1562-1566.

DOI： 10.1111/ggi.13525

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PubMed

Kota Tsutsumimoto, Takehiko Doi, Hyuma Makizako, Ryo Hotta, Sho Nakakubo, Keitaro Makino, Takao Suzuki, Hiroyuki Shimada . Aging-related anorexia and its association with disability and frailty. . Journal of cachexia, sarcopenia and muscle9 ( 5 ) 834 - 843 2018.10Reviewed International journal

Language：English

BACKGROUND: Anorexia of ageing may be a precursor to various geriatric syndromes. We elucidated whether anorexia of ageing had a significant impact on incident disability and investigated whether anorexia of ageing had a direct association with future disability or an indirect association with disability via frailty. METHODS: This study employed an observational, longitudinal, cohort design in a community setting. Participants were 4393 older adults (75.9 ± 4.3 years). Anorexia of ageing was assessed by a simplified nutritional appetite questionnaire. Frailty was operationalized as slowness, weakness, exhaustion, low physical activity, and weight loss. Participants who had none of these characteristics were considered robust, those with one or two characteristics were considered pre-frail, and those with three or more characteristics were considered frail. We examined sociodemographic variables (age, sex, and education), medical history (medication and chronic disease history), lifestyle factors (smoking and drinking habits and living arrangement), body mass index, blood nutrition data, depressive symptoms, physical functioning, and cognitive functioning. RESULTS: The prevalence of anorexia of ageing was 10.7% (n = 468). The proportion of physical frailty, pre-frailty, and robustness were 8.4, 52.0, and 39.6%, respectively, in the without anorexia of ageing group, and 20.3, 57.7, and 22.0%, respectively, in the anorexia of ageing group (P < 0.001). During a 2-year follow-up, the prevalence proportion of disability was 5.6% in the without anorexia of ageing group and 10.7% in the anorexia of ageing group (P < 0.001). Adjusted for covariates (except for frailty status), the participants with anorexia of ageing had an independently associated higher risk of incident disability compared with those without anorexia of ageing (hazard ratio: 1.43, 95% confidence interval: 1.04-1.95, P = 0.03). However, adjusted for covariates (including frailty status), anorexia of ageing was not significantly associated with incident disability (P = 0.09). Structural equation models revealed that anorexia of ageing had no direct effect on disability; however, anorexia of ageing was associated with frailty. CONCLUSIONS: Older adults with anorexia of ageing had a higher proportion of frailty and a higher prevalence proportion of disability compared with those without anorexia of ageing. Although anorexia of ageing may not have a direct effect on incident disability, the structural equation model suggests an indirect relationship between anorexia of ageing and incident disability via frailty status.

DOI： 10.1002/jcsm.12330

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PubMed

Sho Nakakubo, Takehiko Doi, Hyuma Makizako, Kota Tsutsumimoto, Ryo Hotta, Satoshi Kurita, Minji Kim, Takao Suzuki, Hiroyuki Shimada . Association of walk ratio during normal gait speed and fall in community-dwelling elderly people. . Gait & posture66 151 - 154 2018.10Reviewed International journal

Language：English

BACKGROUND: Walk ratio (WR), calculated by dividing step length by cadence, can be used to represent the gait characteristics of human beings to maintain their gait speed. RESEARCH QUESTION: The aim of this study was to examine whether WR could distinguish fallers from community-dwelling elderly people. METHODS: We recruited 9205 elderly people (mean age: 73.7 ± 5.6 years, 4218 men and 4987 women) from the National Center for Geriatrics and Gerontology - Study of Geriatric Syndromes. Fall history was assessed by face-to-face interview, and "fallers" were defined as people who had fallen at least once within the past year. WR was calculated as corrected step length divided by corrected cadence, and we divided the subjects into three groups according to the tertile of WR (T1, T2, and T3). We also stratified the participants by gait speed (<1.0 or ≥1.0 m/s). RESULTS: With reference to the T3 group, the T1 group had a higher odds ratio (OR) of falling in the past year [OR: 1.24, 95% confidence interval (CI): 1.09-1.41], even after adjusting for other covariates. After stratification by gait speed, the same multivariate analyses were conducted. In the participants who walked at 1.0 m/s or faster, the T1 group had a higher OR [1.27, 95% confidence interval (CI): 1.10-1.48], while there was no significant association with fall rate among those who walked slower than 1.0 m/s. SIGNIFICANCE: This study revealed that the smallest WR was independently associated with falling in the past year among community-dwelling elderly people, especially elderly people with no deterioration of gait speed. These results suggest that intervention regarding gait pattern, especially WR, would help to prevent falls.

DOI： 10.1016/j.gaitpost.2018.08.030

Web of Science

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PubMed

Hiroyuki Shimada, Hyuma Makizako, Sangyoon Lee, Takehiko Doi, SungChul Lee . Lifestyle activities and the risk of dementia in older Japanese adults. . Geriatrics & gerontology international18 ( 10 ) 1491 - 1496 2018.10Reviewed

Language：English

AIM: The prevalence of dementia is rising due to increases in the aging population and chronic health conditions. The present study examined whether lifestyle activities, including instrumental activities of daily living and social roles, were associated with dementia incidence in Japanese community-dwelling older adults. METHODS: This longitudinal study involved 4564 participants (age ≥65 years) who were classified by age and sex. Lifestyle activities, risk factors for dementia and incidence of new dementia were recorded. RESULTS: After an average of 42.6 months, 219 participants (4.8%) experienced a new onset of dementia. Survival analyses using the Cox proportional hazards regression model showed that the probability of dementia was significantly lower in participants who engaged in daily conversation (hazard ratio [HR] 0.56, 95% confidence interval [CI] 0.35-0.89, P = 0.015), driving a car (HR 0.63, 95% CI 0.45-0.88, P = 0.007), shopping (HR 0.57, 95% CI 0.34-0.96, P = 0.033) and field work or gardening (HR 0.71, 95% CI 0.54-0.94, P = 0.016). CONCLUSIONS: We concluded that specific lifestyle activities might play an important role in preventing dementia in older adults. The activities that prevent dementia might differ depending on sex and age. Geriatr Gerontol Int 2018; 18: 1491-1496.

DOI： 10.1111/ggi.13504

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PubMed

Takehiko Doi, Hyuma Makizako, Kota Tsutsumimoto, Ryo Hotta, Sho Nakakubo, Keitaro Makino, Takao Suzuki, Hiroyuki Shimada . Combined effects of mild cognitive impairment and slow gait on risk of dementia. . Experimental gerontology110 146 - 150 2018.9Reviewed International journal

Language：English

BACKGROUND: Mild cognitive impairment (MCI) is a high risk of conversion to dementia and gait dysfunction is also a risk for dementia. The goal of the study was to examine if co-occurrence of MCI and slow gait (SG) increases the risk of dementia. METHODS: A prospective study was conducted in 3937 older adults who did not have dementia at baseline. Participants were classified into groups based on status of MCI and SG: without MCI and SG (control), without MCI and with SG (SG), without SG and with MCI in a single domain (sMCI) or multiple domains (mMCI), sMCI and SG (sMCI + SG), and mMCI and SG (mMCI + SG). Incident dementia was followed monthly. Cox proportional hazards regression models were used to calculate the hazard ratio for incident dementia in each group. RESULTS: During a mean follow-up period of 43 months, 182 subjects had incident dementia. MCI was a risk factor for dementia and SG increased the risk, even after adjusting for covariates (SG: HR = 1.31 (0.81-2.14), 95% CI = 0.276, sMCI: HR = 1.87, 95% CI = 1.21-2.88, p = .005; mMCI: HR = 3.36, 95% CI = 1.98-5.71, p < .001; sMCI + SG: HR = 3.33, 95% CI = 1.92-5.77, p < .001; mMCI + SG: HR = 5.02, 95% CI = 2.75-9.14, p < .001). CONCLUSIONS: Co-occurrence of MCI and SG has a high risk of dementia compared to that of each condition alone. Evaluation of both gait and cognition is useful in risk assessment of dementia.

DOI： 10.1016/j.exger.2018.06.002

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PubMed

丸田道雄, 韓こう煕, 吉満孝二, 牧迫飛雄馬, 田平隆行 . 地域在住独居高齢者における心の理論課題成績と社会参加との関連 . 日本作業療法学会抄録集52回 OJ - 1 2018.9

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Papers - MAKIZAKO Hyuma