Faculty Profiles - MAKIZAKO Hyuma

Papers - MAKIZAKO Hyuma

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三宅悠斗, 白土大成, 田平健人, 牧迫飛雄馬 . 地域在住高齢者における起立動作時の床反力と1年後の転倒および転倒恐怖感との関連 . 日本転倒予防学会誌12 79 - 88 2026.3

Suguru Shimokihara, Takayuki Tabira, Michio Maruta, Hyuma Makizako, Gwanghee Han, Taishiro Kamasaki, Yoshihiko Akasaki, Yuma Hidaka, Yusuke Kumura, Wataru Kukizaki, Takuro Kubozono, Mitsuru Ohishi . Longitudinal associations between satisfaction with meaningful activities and domains of frailty in community-dwelling older adults: A 2-year prospective cohort study . BRITISH JOURNAL OF OCCUPATIONAL THERAPY 2026.2

Ohta M., Kaimoto K., Makizako H., Aburada S., Imamura K., Manabe H., Takenaka T., Kubozono T., Ohishi M., Kuwabara A., Kanouchi H. . Association Between Serum Pyridoxal 5′-Phosphate and Frailty Risk in Community-Dwelling Older Japanese Adults . Geriatrics and Gerontology International26 ( 2 ) e70412 2026.2

Language：Japanese Publisher：Geriatrics and Gerontology International

Background: Pyridoxal 5′-phosphate (PLP) is the coenzyme form of vitamin B<inf>6</inf>. PLP is essential for amino acid metabolism, protein turnover, and neurotransmitter synthesis. Plasma or serum PLP concentration is used as an indicator of vitamin B<inf>6</inf> status. A deficiency in PLP may be a risk factor for frailty. While previous cross-sectional studies have associated low plasma or serum PLP levels with frailty, this association has not yet been examined in older Japanese adults. Methods: We analyzed data from 419 community-dwelling individuals aged ≥ 65 years in Tarumizu City, Kagoshima, Japan. Participants with relevant medical histories, missing data, or extreme values were excluded. Frailty was assessed using J-CHS criteria. Serum PLP concentrations were divided into quartiles (Q1–Q4). Logistic regression was used to estimate the Odds ratios (ORs) for pre-frailty/frailty after adjusting for demographic, lifestyle, and clinical factors. Results: Pre-frailty/frailty prevalence was 62%, 40%, 57%, and 57% in Q1–Q4, respectively. The proportion of pre-frailty/frailty was the lowest in Q2. Compared to Q2, adjusted ORs were 1.94 (95% CI: 1.06–3.59; p = 0.033) in Q1, 1.68 (95% CI: 0.93–3.07; p = 0.089) in Q3, and 1.86 (95% CI: 1.01–3.47; p = 0.047) in Q4. Conclusion: The relationship between PLP levels and pre-frailty/frailty was found to be non-linear. The lowest prevalence was observed in Q2, whereas both low and high PLP levels were associated with increased ORs of pre-frailty/frailty. Further prospective studies are needed to clarify the causal relationship in older Japanese adults.

DOI： 10.1111/ggi.70412

Scopus

PubMed

Shimokihara Suguru, Tabira Takayuki, Maruta Michio, Makizako Hyuma, Han Gwanghee, Kamasaki Taishiro, Akasaki Yoshihiko, Hidaka Yuma, Kumura Yusuke, Kukizaki Wataru, Kubozono Takuro, Ohishi Mitsuru . Associations Between the Diverse Aspects of Psychological Frailty and Health-Related Outcomes in Community-Dwelling Older Adults: A Cross-Sectional Study(タイトル和訳中) . Psychogeriatrics26 ( 1 ) psyg.70115 - psyg.70115 2026.1

Yoshihiko Akasaki, Suguru Shimokihara, Yuma Hidaka, Michio Maruta, Gwanghee Han, Taishiro Kamasaki, Yusuke Kumura, Wataru Kukizaki, Rena Nakahara, Hyuma Makizako, Takuro Kubozono, Mitsuru Ohishi, Takayuki Tabira . Satisfaction with Meaningful Activities and Sleep in Community-Dwelling Older Adults: Cross-Sectional Study . Clinical Gerontologist 1 - 15 2025.12

牧迫飛雄馬 . 特集によせて . 日本サルコペニア・フレイル学会誌9 ( 3 ) 351 - 351 2025.11

牧迫飛雄馬 . 編集後記 . 日本サルコペニア・フレイル学会誌9 ( 3 ) 428 - 428 2025.11

Suguru Shimokihara, Takayuki Tabira, Michio Maruta, Hyuma Makizako, Gwanghee Han, Taishiro Kamasaki, Yoshihiko Akasaki, Yuma Hidaka, Yusuke Kumura, Wataru Kukizaki, Takuro Kubozono, Mitsuru Ohishi . Associations Between the Diverse Aspects of Psychological Frailty and Health‐Related Outcomes in Community‐Dwelling Older Adults: A Cross‐Sectional Study . Psychogeriatrics26 ( 1 ) e70115 2025.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Wiley

ABSTRACT

Background

Psychological frailty (PsF), encompassing cognitive and emotional vulnerabilities, remains understudied despite its potential impact on health outcomes in older adults. This cross‐sectional study aimed to explore the characteristics of diverse aspects of PsF, including cognitive frailty (CF), lower cognitive function, and affective frailty (AF), and to examine their associations with health‐related outcomes in community‐dwelling older adults.

Methods

Data were analysed from 420 community‐dwelling older adults participating in the Tarumizu Study in Japan, excluding those exhibiting physical or social frailty. Participants were categorised into Robust, Lower cognitive function, CF, AF, and Multi‐domain PsF groups. AF was assessed using five items from the Geriatric Depression Scale, focusing on emotional vulnerability. Health outcomes included self‐rated health, subjective memory complaints (SMC), and functional ability of daily living. Associations were analysed using adjusted multiple regression models controlling for covariates.

Results

PsF was present in 39.5% of the cohort (lower cognitive function: 18.1%, CF: 7.6%, AF: 11.0%, Multi‐domain PsF: 2.9%). In the adjusted models, only AF showed a significant positive association with SMC (adjusted risk ratio = 1.62, 95% CI: 1.06–2.42, p = 0.023). No significant associations were found between any PsF domain and subjective health or daily functional ability in the adjusted models.

Conclusions

AF, characterised by emotional vulnerability, was uniquely associated with SMC, suggesting emotional factors may play a more central role than cognitive decline in shaping perceptions of memory problems. These findings highlight the heterogeneous nature of PsF and underscore the need for nuanced assessments to inform targeted prevention and intervention strategies.

DOI： 10.1111/psyg.70115

Scopus

PubMed

Daijo Shiratsuchi, Yuto Miyake, Ryota Kuratsu, Hiroki Nishi, Manami Fukumori, Shoko Atae, Ryoji Kiyama, Rieko Kosakamoto, Hiromi Tanaka, Hyuma Makizako . Is psychological engagement more important than participation? Volunteer activity and subjective cognitive function in older adults . Aging Clinical and Experimental Research37 ( 1 ) 332 2025.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

While previous studies have shown inconsistent associations between volunteer participation and cognitive health in later life, less attention has been paid to qualitative aspects of engagement. This study examined whether psychological engagement in volunteer activities is associated with subjective cognitive function in community-dwelling older adults.

Method

This cross-sectional study included 431 community-dwelling older adults (mean age: 78.2 ± 5.7 years; 90.0% female) from self-management exercise class. Volunteer activity status was assessed using a self-reported participation questionnaire. Psychological engagement (Volunteer Engagement; VE) was evaluated using a three-item version of the Utrecht Work Engagement Scale adapted for volunteer settings. Based on VE scores, the participants were categorized into three groups: non-volunteers, low-engagement volunteers, and high-engagement volunteers. Subjective cognitive function was assessed using three self-reported items addressing memory complaints and disorientation, derived from the Kihon Checklist. Logistic regression analyses were conducted to examine the associations between (1) volunteer activity status and (2) VE scores with low cognitive function, adjusting for relevant covariates.

Results

Of 431 participants, 60.1% reported volunteering. There was no significant association between being a volunteer and low cognitive function. In contrast, high-engagement volunteers had significantly lower odds of low cognitive function than non-volunteers (OR = 0.51, 95% CI: 0.27–0.97). No significant differences were observed between low-engagement volunteers and non-volunteers.

Conclusions

These findings suggest that psychological engagement in volunteer activities rather than mere participation may be more closely related to the subjective cognitive health of older adults. Highlighting this engagement may help inform policies and programs for promoting cognitive health.

DOI： 10.1007/s40520-025-03245-8

Scopus

PubMed

Other Link： https://link.springer.com/article/10.1007/s40520-025-03245-8/fulltext.html

牧迫飛雄馬 . 特集医療関係者が知っておきたいロコモ･サルコペニア･フレイルフレイルの評価･判定法 . 関節外科　基礎と臨床44 ( 11 ) 1121 - 1129 2025.11

牧迫飛雄馬 . 【医療関係者が知っておきたいロコモ・サルコペニア・フレイル】フレイルの評価・判定法 . 関節外科44 ( 11 ) 1121 - 1129 2025.11

Language：Japanese Publisher：(株)メジカルビュー社

＜文献概要＞フレイルの評価および判定においては,表現型モデルと欠損累積モデルによるフレイルの捉え方を整理したうえで,具体的な評価指標を活用することが必要である。身体的なフレイルは,改訂日本語版CHS基準による評価・判定が浸透しつつある。フレイルには多様な要因が関連するため,多様な視点による評価やフレイルの包括的な評価が可能な指標の適用など,評価の目的や評価結果に基づく対策や支援を考慮した活用が望まれる。

Yoshihiko Akasaki, Suguru Shimokihara, Yuma Hidaka, Michio Maruta, Gwanghee Han, Taishiro Kamasaki, Yusuke Kumura, Wataru Kukizaki, Rena Nakahara, Hyuma Makizako, Takuro Kubozono, Mitsuru Ohishi, Takayuki Tabira . Changes in satisfaction with meaningful activities and subsequent subjective memory complaints: a two-wave longitudinal analysis of Japanese older adults . Aging & Mental Health30 ( 3 ) 1 - 12 2025.10

Preface to the special issue on "Cardiopulmonary Function and Exercise Load" . Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics62 ( 4 ) 363 - 363 2025.10

Yuma Hidaka, Takayuki Tabira, Michio Maruta, Hyuma Makizako, Gwanghee Han, Suguru Shimokihara, Yoshihiko Akasaki, Taishiro Kamasaki, Wataru Kukizaki, Rena Nakahara, Takuro Kubozono, Mitsuru Ohishi . Satisfaction with grave visitation and depressive symptoms among community-dwelling older Japanese adults . Mental Health, Religion & Culture28 ( 1 ) 1 - 15 2025.10

牧迫飛雄馬 . 【リハビリテーション栄養のポピュレーションアプローチ】デジタルデバイスによるアプローチ . リハビリテーション栄養9 ( 2 ) 178 - 183 2025.10

Language：Japanese Publisher：(一社)日本リハビリテーション栄養学会

デジタル技術は著しい速度で進歩しており,サルコペニアの評価指標となる身体機能や骨格筋量に対するデジタルデバイスを用いた運動介入によるランダム化比較対照試験の効果も報告されつつある.とりわけ,フレイルやサルコペニアに対する予防・改善の方策は,積極的な身体活動のほか,食生活の改善,社会活動の促進など多岐にわたり,多面的な支援におけるデジタルデバイス活用によるエビデンスの蓄積が望まれる.一方,個人情報の取り扱い,ユーザーとなる高齢者のデバイス利用スキルの習熟など,高齢者に対するデジタルデバイスによるアプローチでは検討すべき課題も少なくはない.効果的な健康寿命の延伸対策を促進するためには,デジタルデバイスを活用したアプローチのさらなる展開が期待される.(著者抄録)

Daijo Shiratsuchi, Hyuma Makizako, Shoma Akaida, Yuto Miyake, Ryoji Kiyama, Takayuki Tabira, Mana Tateishi, Rei Otsuka, Toshihiro Takenaka, Takuro Kubozono, Mitsuru Ohishi . Combinations of intrinsic capacity and frailty and their associations with self-rated health in community-dwelling older adults . Aging Clinical and Experimental Research37 ( 1 ) 275 2025.9

吉村芳弘, 牧迫飛雄馬 . 第12回日本サルコペニア・フレイル学会大会長より . 日本サルコペニア・フレイル学会誌9 ( 1 ) 109 - 109 2025.8

牧迫飛雄馬 . 特集認知症に対するリハビリテーション医療コグニサイズ . J. of Clinical Rehabilitation34 ( 9 ) 910 - 916 2025.8

牧迫飛雄馬 . 【認知症に対するリハビリテーション医療】コグニサイズ . Journal of Clinical Rehabilitation34 ( 9 ) 910 - 916 2025.8

Language：Japanese Publisher：医歯薬出版(株)

＜文献概要＞内容のポイントQ&A　Q1 コグニサイズとは何か?コグニサイズとは,cognition(=認知)とexercise(=運動)を掛け合わせた造語であり,国立長寿医療研究センターで開発された認知機能低下の抑制を目指した運動プログラムである.脳機能の賦活を目的とした運動と知的な刺激の伴う活動を組み合わせた方法の1つとして,コグニサイズが推奨される.Q2 コグニサイズの対象は?主観的に認知機能低下の自覚がある,もしくは軽度認知障害といった認知機能に軽度の問題を有する高齢者において,コグニサイズによる認知機能の維持・改善に効果が期待される.認知機能に問題のない健常高齢者においても認知機能低下の予防に推奨されるが,認知症の診断のある中等度以上の認知機能障害を有する場合は,混乱を招く恐れがあるため,注意を要する.Q3 コグニサイズの効果は?軽度認知障害を有する地域在住高齢者を対象として,コグニサイズを含めた多面的運動プログラムでの介入によって,全体的な認知機能や言語流暢性,記憶機能に対する改善もしくは維持の効果が確認されている.さらに,脳萎縮に対する進行抑制効果が認められている.また,集団で行うことで,コグニサイズをきっかけとした他者との交流機会を引き出す環境にも有用となる.Q4 地域で新たに行うためにはどうすればよいか?コグニサイズには,個人で実施できる内容と集団で実施する内容が想定されている.個人でできるコグニサイズは,パンフレットや動画サイト等を参考にして,自宅での家事の合間や普段行う運動の追加メニューとして行うことが取り入れやすいかもしれない.また,集団で行うコグニサイズは,地域での運動教室やサロン活動でレクリエーションの1つとして,参加者同士で楽しみながら始めてみることが推奨される.

NAKAHARA Rena, TABIRA Takayuki, SHIMOKIHARA Suguru, AKASAKI Yoshihiko, HIDAKA Yuma, KUKIZAKI Wataru, KAMASAKI Taishiro, MATSUNAGA Shuto, KUMURA Yusuke, MARUTA Michio, HAN Gwanghee, MAKIZAKO Hyuma, SUGAWARA Hideki, TERAZONO Hideyuki, KUBOZONO Takuro, OHISHI Mitsuru . Characteristics of medication management in community-dwelling older adults with subjective memory complaints . Japanese Journal of Geriatric Therapy4 ( 0 ) n/a 2025.7

Language：Japanese Publisher：The Japan Geriatric Therapy Society

<p>【Aim】 The purpose of this study was to clarify the characteristics of medication management among community-dwelling older adults with subjective memory complaints (SMC) and to examine the association between SMC and medication management. 【Methods】 A total of 690 aged 65 years or older in the community cohort study in 2019 participated. Of these, 573 who met the inclusion criteria were analyzed. Participants were divided into two groups according to the presence or absence of SMC, and associations with medication management items were analyzed using Fisher's exact test for categorical variables and the unpaired <i>t</i>-test for continuous variables. In addition, binomial logistic regression analysis was conducted with SMC as the dependent variable and medication management items as the independent variables, adjusted for demographic variables. 【Results】 Among the community-dwelling older adults in this study, 206 were in the healthy group and 367 were in the SMC group. Covariate-adjusted binomial logistic regression analysis showed that "having residual medication" (OR: 1.62, 95% CI: 1.01 to 2.59, p = 0.04) and "depressive symptoms" (OR: 1.48, 95% CI: 1.20 to 1.69, p < 0.001) were significantly associated with SMC. 【Conclusion】 The characteristics of medication management among community-dwelling older adults with SMC were significantly associated with "residual medication". Understanding the presence or absence of residual medications from the SMC stage and taking measures to address the factors that led to residual medications may help reduce the burden of caregivers in managing medications.</p>

DOI： 10.57270/jgts.2024_013_oa

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