Faculty Profiles - MAKIZAKO Hyuma

Papers - MAKIZAKO Hyuma

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Makizako H, Shimada H, Hotta R, Doi T, Tsutsumimoto K, Nakakubo S, Makino K . Associations of traffic near-miss incident with attention and executive function among Japanese older drivers. . Gerontology64 ( 5 ) 495 - 502 2018Reviewed

Makizako H, Tsutsumimoto K, Shimada H, Arai H . Social frailty among community-dwelling older adults: Recommended assessments and implications. . Ann Geriatr Med Res22 ( 1 ) 3 - 8 2018Reviewed

Hyuma Makizako . Combined effect of self-reported hearing problems and social activities on incident disability in Japanese older adults: A population-based longitudinal study. . Maturitas115 51 - 55 2018Reviewed

Shimada H, Makizako H, Tsutsumimoto K, Doi T, Lee S, Suzuki T . Cognitive Frailty and Incidence of Dementia in Older Persons. . J Prev Alzheimers Dis5 ( 1 ) 42 - 48 2018Reviewed

Shimada H, Makizako H, Park H, Doi T, Lee S. . Validity of the National Center for Geriatrics and Gerontology-Functional Assessment Tool and Mini-Mental State Examination for detecting the incidence of dementia in older Japanese adults . Geriatr Gerontol Int17 ( 12 ) 2383 - 2388 2017.12Reviewed

Hyuma Makizako, Hiroyuki Shimada, Takehiko Doi, Kota Tsutumimoto, Daisuke Yoshida, Takao Suzuki . Effects of a community disability prevention program for frail older adults at 48-month follow up. . Geriatrics & gerontology international17 ( 12 ) 2347 - 2353 2017.12Reviewed

Language：English

AIM: The present prospective study was carried out to determine whether participation in community-based intervention studies exerted a positive impact on disability prevention in older adults with physical frailty. METHODS: A total of 514 community-dwelling older adults (aged ≥65 years) with physical frailty who had undergone baseline assessment and participated in community-based intervention studies (participants) or did not (non-participants) were included in the present study. Non-participants were selected through propensity score matching, to balance potential covariates at baseline. Disability incidence was followed up at 48 months as a main outcome. Demographic data (age, sex and medical history), global cognitive function, grip strength, walking speed, and blood test results including serum albumin and brain-derived neurotrophic factor at baseline were included as covariates. RESULTS: Disability incidence rates differed significantly between participants (11.3%) and non-participants (19.8%) of community-based intervention studies during the 48-month follow-up period (P = 0.007). Participation in community-based intervention studies (hazard ratio 0.55, 95% confidence interval 0.35-0.88) was significantly associated with the incidence of disability in older adults with physical frailty. CONCLUSIONS: Participation in community-based intervention studies could reduce the incidence of disability in older adults with physical frailty. Thus, strategies designed to increase the number of participants in community-based intervention programs should be considered in community-based approaches for the prevention of disability in older adults with physical frailty. Geriatr Gerontol Int 2017; 17: 2347-2353.

DOI： 10.1111/ggi.13072

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Keitaro Makino, Hyuma Makizako, Takehiko Doi, Kota Tsutsumimoto, Ryo Hotta, Sho Nakakubo, Takao Suzuki, Hiroyuki Shimada . Fear of falling and gait parameters in older adults with and without fall history. . Geriatrics & gerontology international17 ( 12 ) 2455 - 2459 2017.12Reviewed

Language：English

AIM: Fear of falling (FOF) is associated with spatial and temporal gait parameters in older adults. FOF is prevalent among older adults, both those with and without fall history. It is still unclear whether the relationships between FOF and gait parameters are affected by fall history. The aim of the present study was to compare gait parameters by the presence of FOF and fall history. METHODS: A total of 3575 older adults (mean age 71.7 years, 49.7% female) met the inclusion criteria for the present study. We assessed the presence of fall history and FOF by face-to-face interview, and gait parameters (gait speed, stride length, step rate, double support time and variation of stride length) at a comfortable speed using a computerized electronic walkway. RESULTS: Prevalences of fall history and FOF were as follows: non-fallers without FOF 52.6% (n = 1881); fallers without FOF 6.3% (n = 227); non-fallers with FOF 34.4% (n = 1229); and fallers with FOF 6.7% (n = 238). Analysis of covariance showed significant differences among the four groups in all gait variables even after adjusting for age, sex and number of medications used. It should be noted that non-fallers with FOF showed significantly slower gait speed, shorter stride length and longer double support time than did non-fallers without FOF (P < 0.001). CONCLUSIONS: The present results suggest that spatial and temporal gait parameters are influenced by FOF, even in the absence of fall history. The assessment of FOF might be helpful for better understanding of age-related changes in gait control. Geriatr Gerontol Int 2017; 17: 2455-2459.

DOI： 10.1111/ggi.13102

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Hiroyuki Shimada, Hyuma Makizako, Hyuntae Park, Takehiko Doi, Sangyoon Lee . Validity of the National Center for Geriatrics and Gerontology-Functional Assessment Tool and Mini-Mental State Examination for detecting the incidence of dementia in older Japanese adults. . Geriatrics & gerontology international17 ( 12 ) 2383 - 2388 2017.12Reviewed

Language：English

AIM: Numerous neuropsychological tests are implemented in the clinical setting. However, a readily available cognitive test is required to detect the risk of dementia in the community setting. METHODS: A total of 4151 persons aged ≥65 years participated in the present prospective cohort study. We assessed cognitive performance using the Mini-Mental State Examination and the National Center for Geriatrics and Gerontology-Functional Assessment Tool. The National Center for Geriatrics and Gerontology-Functional Assessment Tool includes tests of story and word list memory, attention and executive function, processing speed, and visuospatial skill to screen for cognitive impairment. All measurements were transformed to Z-scores to compare among the cognitive tests. The incidence of dementia was determined using data collected by the Japanese Health Insurance System over 36 months. RESULTS: After an average of 43 months, 180 (4.3%) participants were diagnosed with dementia. Survival analyses showed that the probability of dementia was significantly associated with all cognitive tests, except for visuospatial skill. The processing speed test showed the highest hazard ratios for the incidence of dementia (Z-score: hazard ratio 0.61, 95% confidence interval 0.50-0.75, P < 0.01). In subgroup analysis, there were no significant relationships between cognitive tests and the incidence of dementia in participants without global cognitive impairment. CONCLUSIONS: We conclude that the National Center for Geriatrics and Gerontology-Functional Assessment Tool, as well as the Mini-Mental State Examination, play an important role in detecting the risk of dementia in the community setting. Further analysis is required to identify the risk of dementia in older people without global cognitive impairment. Geriatr Gerontol Int 2017; 17: 2383-2388.

DOI： 10.1111/ggi.13079

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菱川法和, 牧迫飛雄馬, 森田秋子 . 回復期脳卒中患者に対する認知関連行動アセスメントの評価者間信頼性の検討 . 愛知県理学療法学会誌29 ( 2 ) 69 - 75 2017.12

Language：Japanese Publisher：(NPO)愛知県理学療法学会

【目的】回復期脳卒中患者に対する認知関連行動アセスメント(以下、CBA)の評価者間信頼性を検討した。【方法】理学療法士6名と日常業務でCBAを用いた評価を実施しており十分な臨床経験を有する言語聴覚士を評価者とし、脳卒中患者21名のCBAにおける6領域の重症度を5段階で評価させた。評価者間信頼性の検討は、理学療法士6名の評価結果と理学療法士を臨床経験年数で分けた2群の評価結果を言語聴覚士の評価結果を外的基準に比較して、領域別得点は重み付きκ係数、合計点は級内相関係数(2,1)を算出した。さらに、合計点はBland-Altman分析により系統誤差を確認した後、標準誤差を算出した。【結果】評価者間信頼性は重み付きκ係数が0.62〜0.92、級内相関係数(2,1)が0.86〜0.91と高かった。系統誤差の存在はなく、標準誤差は2〜3点であった。【結論】CBAの評価者間信頼性は高く、今後は多様な職種や環境での連携においても臨床応用が期待できると考えた。(著者抄録)

Seongryu Bae, Hiroyuki Shimada, Hyuntae Park, Sangyoon Lee, Hyuma Makizako, Takehiko Doi, Daisuke Yoshida, Kota Tsutsumimoto, Yuya Anan, Takao Suzuki . Association between body composition parameters and risk of mild cognitive impairment in older Japanese adults. . Geriatrics & gerontology international17 ( 11 ) 2053 - 2059 2017.11Reviewed

Language：English

AIM: The aim of the present study was to investigate the association between various body composition parameters and the risk of mild cognitive impairment (MCI) in older Japanese adults, as well as potential sex-related differences in the risk of MCI. METHODS: Participants underwent cognitive tests, and were divided into 840 participants with MCI (mean age 71.9 ± 5.5 years) and 1740 without MCI (mean age 71.3 ± 5.2 years). Body composition parameters were measured using a bioelectrical impedance analyzer. Multiple logistic regression analysis was then carried out to examine the associations between body composition parameters and risk of MCI. RESULTS: After adjusting for confounding factors, those in the lowest quartile for fat-free mass had a higher risk of MCI than those in the highest quartile (men: odds ratio [OR] 1.96, 95% confidence interval CI 1.24-3.10; women: OR 1.49, 95% CI 1.01-2.19). Loss of muscle mass in the upper (OR 2.17, 95% CI 1.40-3.37) and lower (OR 1.99, 95% CI 1.25-3.15) limbs was associated with a higher MCI risk in men. However, only loss of muscle mass in the lower limbs was associated with a higher MCI risk (OR 1.61, 95% CI 1.06-2.44) in women. No associations were found between obesity measures and MCI. CONCLUSIONS: We found that loss of fat-free mass was associated with MCI in older adults, regardless of sex. We also found that appendicular muscle mass was more closely associated with MCI in men than in women. These results suggest that the association between appendicular muscle mass and MCI might have different underlying mechanisms based on sex. Geriatr Gerontol Int 2017; 17: 2053-2059.

DOI： 10.1111/ggi.13018

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Bae S, Shimada H, Lee S, Makizako H, Lee S, Harada K, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, Park P, Suzuki T . The relationships between components of metabolic syndrome and mild cognitive impairment subtypes: A cross-sectional of Japanese older adults . J Alzheimers Dis 2017.10Reviewed

Shimada H, Makizako H, Doi T, Lee S, Lee S . Conversion and reversion rates in Japanese older people with mild cognitive impairment . J Am Med Dir Assoc 2017.9Reviewed

Hiroyuki Shimada, Hyuma Makizako, Takehiko Doi, SungChul Lee, Sangyoon Lee . Conversion and Reversion Rates in Japanese Older People With Mild Cognitive Impairment. . Journal of the American Medical Directors Association18 ( 9 ) 808.e1 - 808.e6 2017.9Reviewed International journal

Language：English

OBJECTIVES: Approximately 25% of individuals who are diagnosed with amnestic mild cognitive impairment (aMCI) revert to normal cognition (NC) rather than progressing to Alzheimer disease (AD). However, the prevalence of progression and reversion among older people in Asia remains unclear. DESIGN: A prospective cohort study. SETTING: A community in Japan. PARTICIPANTS: A total of 4153 individuals without dementia aged ≥65 years were classified as having NC, aMCI single domain (aMCIs), non-aMCI single domain (naMCIs), aMCI multiple domain (aMCIm), non-aMCI multiple domain (naMCIm), or global cognitive impairment (GCI). MEASUREMENTS: The National Center for Geriatrics and Gerontology-Functional Assessment Tool and the Mini-Mental State Examination were used to conduct cognitive screening. The participants completed baseline (August 2011 to June 2012) and follow-up (August 2015 to June 2016) assessments. We followed up monthly for newly incident AD, as recorded by the Japanese National Health Insurance and Later-Stage Medical Care systems. Multiple imputation was used to adjust for selection bias and loss of information. RESULTS: At 4-year follow-up, the reversion rates to NC in aMCIs, naMCIs, aMCIm, naMCIm, and GCI were 38.7%, 57.0%, 25.7%, 20.9%, and 43.7%, respectively. Of the participants with NC, aMCIs, naMCIs, aMCIm, naMCIm, and GCI at baseline, 4.7%, 4.5%, 13.1%, 20.6%, 21.6%, and 14.3%, respectively, were subsequently diagnosed with AD. We found significant associations between incident AD and naMCIs [hazard ratio (HR) compared to NC: 2.18, 95% confidence interval (CI): 1.45-3.26], and between AD and aMCIm (HR: 4.39, 95% CI: 2.06-9.39) and between AD and naMCIm (HR: 3.60, 95% CI: 2.13-6.08). However, the association between incident AD and aMCIs and between AD and GCI did not reach significance. CONCLUSION: Reversion to NC from MCI and GCI was frequent, and individuals with aMCIs and GCI did not show higher risk of incident AD than those with NC. Older adults with multiple cognitive impairments may be potential targets for preventing dementia.

DOI： 10.1016/j.jamda.2017.05.017

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Makizako H, Shimada H, Doi T, Tsutsumimoto K, Lee S, Lee S, Harada K, Hotta R, Nakakubo S, Bae S, Harada K, Yoshida D, Uemura K, Anan Y, Park H, Suzuki T . Age-dependent changes in physical performance and body composition in community-dwelling Japanese older adults . J Cachexia Sarcopenia Muscle 2017.8Reviewed

Hyuma Makizako, Hiroyuki Shimada, Takehiko Doi, Kota Tsutsumimoto, Sangyoon Lee, Sung Chul Lee, Kazuhiro Harada, Ryo Hotta, Sho Nakakubo, Seongryu Bae, Kenji Harada, Daisuke Yoshida, Kazuki Uemura, Yuya Anan, Hyuntae Park, Takao Suzuki . Age-dependent changes in physical performance and body composition in community-dwelling Japanese older adults. . Journal of cachexia, sarcopenia and muscle8 ( 4 ) 607 - 614 2017.8Reviewed International journal

Language：English

BACKGROUND: The aim of this study was to describe the age-dependent changes in the parameters of physical performance and body composition in Japanese older adults who are independently dwelling in the community. We also examined whether the age-dependent changes differ among physical performance and body composition parameters. METHODS: Cross-sectional data from 10 092 community-dwelling older adults (mean age 73.6 years; 5296 women) were analyzed. The measures of physical performance included hand-grip strength, the five-times-sit-to-stand test, and walking speed. Body composition parameters (body weight, fat mass, and appendicular skeletal muscle mass) were measured with a bioelectrical impedance analyser. Correlations between age and the physical performance and body composition parameters were tested. The T-scores of physical performance and body composition measurements were calculated and presented according to 5-year age groups to examine the differences in age-dependent changes in physical performance and body composition parameters. RESULTS: All physical performance measures significantly decreased with aging. The cumulative mean T-scores according to age group showed different age-dependent changes between body mass index (BMI) and appendicular skeletal muscle mass index (ASMI) (cumulative mean T-score change of BMI and ASMI of -5.7 to -2.9 and -12.7 to -12.1, respectively). The slope declines in age-associated changes were greater in grip strength (β = -0.77, 95% confidence interval = -0.82 to -0.76) for men and in walking speed (β = -0.95, 95% confidence interval = -0.99 to -0.90) for women. CONCLUSIONS: The patterns of age-dependent decreases in physical performance measures differed among parameters and between sexes. There is a possibility of a difference in the age-related slope patterns among parameters; decreases in grip strength in men and walking speed in women may be more prominent with advancing age. Furthermore, the decrease in ASMI with age is more striking than that of BMI.

DOI： 10.1002/jcsm.12197

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Doi T, Shimada H, Makizako H, Tsutsumimoto K, Verghese J, Suzuki T . Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability . J Alzheimers Dis 2017.7Reviewed

Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H . Association of Social Frailty with Both Cognitive and Physical Deficits among Older People . J Am Med Dir Assoc 2017.7Reviewed

Kota Tsutsumimoto, Takehiko Doi, Hyuma Makizako, Ryo Hotta, Sho Nakakubo, Keitaro Makino, Takao Suzuki, Hiroyuki Shimada . Association of Social Frailty With Both Cognitive and Physical Deficits Among Older People. . Journal of the American Medical Directors Association18 ( 7 ) 603 - 607 2017.7Reviewed International journal

Language：English

OBJECTIVES: Our objective was to investigate the association between social frailty and cognitive and physical function among older adults. DESIGN: This was a cross-sectional study. SETTING: We examined community-dwelling adults in Japan. PARTICIPANTS: Participants comprised 4425 older Japanese people from the National Center for Geriatrics and Gerontology-Study of Geriatric Syndromes. MEASUREMENTS: Social frailty was defined by using responses to 5 questions (going out less frequently, rarely visiting friends, feeling unhelpful to friends or family, living alone, and not talking with someone every day). Participants showing none of these components were considered nonfrail; those showing 1 component were considered prefrail; and those showing 2 or more components were considered frail. To screen for cognitive deficits, we assessed memory, attention, executive function, and processing speed. Having 2 or more tests with age-adjusted scores of at least 1.5 standard deviations below the reference threshold was sufficient to be characterized as cognitively deficient. To screen for physical function deficits, we assessed walking speed (<1.0 m/s cut-off) and grip strength (<26 kg for men; <18 kg for women cut-off). Scoring below the cut-off point on 1 or more tests was sufficient to be characterized as physically deficient. RESULTS: The prevalence of social frailty was the following: nonfrailty, 64.1% (N = 2835); social prefrailty, 24.8% (N = 1097); social frailty, 11.1% (N = 493; P for trend < .001). All cognitive function tests (word list memory, Trail Making Test parts A and B, and the symbol digit-substitution task) significantly varied between social frailty groups; physical function (gait speed and grip strength) also varied between social frailty groups (all Ps for trend <.001). Referred to social nonfrailty, social frailty was independently associated with each cognitive deficit (odds ratio = 1.61, 95% confidence interval 1.13-2.30) and deficits in physical function (odds ratio = 1.99, 95% confidence interval 1.57-2.52) after adjusting for covariates. CONCLUSIONS: This study revealed that social frailty is associated with both cognitive and physical function among Japanese older adults. And social frailty status was also negatively associated with physical function. Further studies are needed to elucidate if a casual association exists between social frailty and cognitive and physical function.

DOI： 10.1016/j.jamda.2017.02.004

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Shimada H, Ishii K, Makizako H, Ishiwata K, Oda K, Suzukawa M . Effects of exercise on brain activity during walking in older adults: a randomized controlled trial . J Neuroeng Rehabil 2017.5Reviewed

Hiroyuki Shimada, Kenji Ishii, Hyuma Makizako, Kiichi Ishiwata, Keiichi Oda, Megumi Suzukawa . Effects of exercise on brain activity during walking in older adults: a randomized controlled trial . JOURNAL OF NEUROENGINEERING AND REHABILITATION14 ( 1 ) 50 2017.5Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：BIOMED CENTRAL LTD

Background: Physical activity may preserve neuronal plasticity, increase synapse formation, and cause the release of hormonal factors that promote neurogenesis and neuronal function. Previous studies have reported enhanced neurocognitive function following exercise training. However, the specific cortical regions activated during exercise training remain largely undefined. In this study, we quantitatively and objectively evaluated the effects of exercise on brain activity during walking in healthy older adults.
Methods: A total of 24 elderly women (75-83 years old) were randomly allocated to either an intervention group or a control group. Those in the intervention group attended 3 months of biweekly 90-min sessions focused on aerobic exercise, strength training, and physical therapy. We monitored changes in regional cerebral glucose metabolism during walking in both groups using positron emission tomography (PET) and [F-18] fluorodeoxyglucose (FDG).
Results: All subjects completed the 3-month experiment and the adherence to the exercise program was 100%. Compared with the control group, the intervention group showed a significantly greater step length in the right foot after 3 months of physical activity. The FDG-PET assessment revealed a significant post-intervention increase in regional glucose metabolism in the left posterior entorhinal cortex, left superior temporal gyrus, and right superior temporopolar area in the intervention group. Interestingly, the control group showed a relative increase in regional glucose metabolism in the left premotor and supplemental motor areas, left and right somatosensory association cortex, and right primary visual cortex after the 3-month period. We found no significant differences in FDG uptake between the intervention and control groups before vs. after the intervention.
Conclusion: Exercise training increased activity in specific brain regions, such as the precuneus and entorhinal cortices, which play an important role in episodic and spatial memory. Further investigation is required to confirm whether alterations in glucose metabolism within these regions during walking directly promote physical and cognitive performance.

DOI： 10.1186/s12984-017-0263-9

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Papers - MAKIZAKO Hyuma