Faculty Profiles - MAKIZAKO Hyuma

Papers - MAKIZAKO Hyuma

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Yuma Hidaka, Suguru Shimokihara, Yoshihiko Akasaki, Michio Maruta, Gwanghee Han, Taishiro Kamasaki, Yusuke Kumura, Wataru Kukizaki, Rena Nakahara, Hyuma Makizako, Takuro Kubozono, Mitsuru Ohishi, Takayuki Tabira . Longitudinal Relationship Between Grave Visitation and Depressive Symptoms Among Community-Dwelling Older Adults. . Clinical gerontologist49 ( 2 ) 1 - 12 2025.7International journal

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: Participating in religious activities benefits older adults' mental health; however, the effects of grave visitation, a significant religious practice in Japan, on older adults' mental health remain unclear. Therefore, this study examined the relationship between grave visitation frequency and depressive symptoms. METHODS: A prospective cohort study of 273 community-dwelling older adults in Japan was conducted with baseline (2018) and follow-up (2022) assessments. Participants were categorized by visitation frequency: more or less than once a week. Changes in visitation frequency were classified as continued high, decreased, continued low, or increased. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Multivariable linear regressions were used to examine the association between visitation and depressive symptoms. RESULTS: Lower visitation at baseline was associated with worse GDS-15 scores in the follow-up. Those with decreased or continued low visitation had significantly worse depressive symptoms. After adjusting for baseline GDS-15 scores and covariates, the decreased group had significantly worse depressive symptoms than the continued high group. CONCLUSIONS: The findings indicate that changes in grave visitation frequency are significantly associated with depressive symptoms. CLINICAL IMPLICATIONS: Supporting older adults' access to grave visitation through transportation or community programs may help maintain their well-being and emotional health.

DOI： 10.1080/07317115.2025.2538105

Scopus

PubMed

Ryota Takaoka, Keitaro Nishi, Maya Nakamura, Haruka Yoshinaga, Yusaku Noma, Yodai Hayashi, Sayaka Yuda, Yumiko Mishima, Momoko Ishikawa, Yusei Yanagita, Kouta Yamashiro, Kenichi Kume, Yuhei Matsuda, Takahiro Kanno, Hyuma Makizako, Toshihiro Takenaka, Takuro Kubozono, Mitsuru Ohishi, Tatsuo Okui . Association between malnutrition and low tongue pressure in community-dwelling older people: a population-based cohort study. . Scientific reports15 ( 1 ) 25420 - 25420 2025.7International journal

Language：English Publishing type：Research paper (scientific journal)

The aim of this study was to analyze the data from a cohort study of community-dwelling older people to clarify the impact of low tongue pressure on the onset of malnutrition. The analysis was divided into a baseline and a longitudinal analysis. The baseline analysis included 765 people (median age: 74 years; 276 men and 489 women), and the longitudinal analysis included 100 people (median age: 72 years; 33 men and 67 women). The baseline analysis showed that tongue pressure and the diagnosis of low tongue pressure using a cut-off of 30 kPa were associated with the risk of malnutrition (tongue pressure: odds ratio [OR] = 0.972, 95% confidence interval [95% CI] = 0.953-0.992, p = 0.006; the diagnosis of low tongue pressure: OR = 1.555, 95% CI = 1.050-2.302, p = 0.027). In the longitudinal analysis, tongue pressure and the diagnosis of low tongue pressure at baseline were associated with the onset of the risk of malnutrition after 4 years (tongue pressure: OR = 0.952, 95% CI = 0.907-0.998, p = 0.041; the diagnosis of low tongue pressure: OR = 2.698, 95% CI = 1.148-6.341; p = 0.023). In community-dwelling older people, low tongue pressure could increase the risk of future malnutrition.

DOI： 10.1038/s41598-025-11229-x

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PubMed

中原伶奈, 田平隆行, 下木原俊, 赤崎義彦, 日高雄磨, 久木崎航, 釜崎大志郎, 松永修歩, 久村悠祐, 丸田道雄, 韓こう煕, 牧迫飛雄馬, 菅原英輝, 寺薗英之, 窪薗琢郎, 大石充 . 主観的記憶障害を有する地域在住高齢者の服薬管理の特徴　高齢化率40%を超える地域における横断的研究 . 日本老年療法学会誌4 jgts.2024_013_OA - jgts.2024_013_OA 2025.7

Language：Japanese Publisher：(一社)日本老年療法学会

【目的】認知症の前臨床期である主観的記憶障害(SMC)段階からの複雑なIADL評価は重要であるが,SMC段階での服薬管理状況を詳しく調べた報告は希少である。本研究では,SMCを有する地域在住高齢者の服薬管理の具体的な特徴を明らかにすることを目的とした。【方法】本研究は,横断観察研究である。2019年度における地域コホート研究に参加した65歳以上の高齢者690名のうち,除外基準に該当する者を除外した573名を解析対象とした。対象者をSMCの有無で2群に分け,服薬状況調査項目との関連について2群間比較および共変量で調整した二項ロジスティック回帰分析を行った。【結果】対象者のうち,健常群が206名,SMC群が367名であり,共変量調整した二項ロジスティック回帰分析の結果,「残薬あり」(OR:1.62,95%CI:1.01-2.59,p=0.04)と「抑うつ症状」(OR:1.48,95%CI:1.20-1.69,p<0.001)はSMCと有意に関連した。【結論】地域在住高齢者において,SMCの段階から残薬の有無を把握し,服薬管理の早期支援を行うことは,認知機能低下が進行した際に服薬管理の介護負担を軽減し,残薬問題を解消する一助になる可能性がある。(著者抄録)

牧迫飛雄馬, 白土大成, 三宅悠斗, 赤井田将真, 立石麻奈, 窪薗琢郎, 竹中俊宏, 大塚礼, 大石充 . 内在的能力は身体的フレイルの悪化および改善要因となり得るか? 5年間の前向き研究 . 日本老年医学会雑誌62 ( Suppl. ) 44 - 44 2025.5

立石麻奈, 西田裕紀子, 久保田彩, 小坂井留美, 丹下智香子, 下方浩史, 安藤富士子, 牧迫飛雄馬, 大塚礼 . 地域住民における中学・高校での運動歴と中高年期の大腿骨頸部骨密度の縦断変化 . 日本老年医学会雑誌62 ( Suppl. ) 212 - 212 2025.5

牧迫飛雄馬 . おさえておきたい転倒･転落予防の基本知識と現場での応用 7.転倒･転落の主な原因と対策:⑥ 環境 . J. of Clinical Rehabilitation34 ( 4 ) 421 - 426 2025.4

牧迫飛雄馬 . 特集科学的介護科学的介護を推進するための理学療法士の役割と期待 . 理学療法ジャーナル59 ( 3 ) 322 - 327 2025.3

Yumiko Mishima, Maya Nakamura, Yuhei Matsuda, Keitaro Nishi, Ryota Takaoka, Takahiro Kanno, Toshihiro Takenaka, Takayuki Tabira, Hyuma Makizako, Takuro Kubozono, Mitsuru Ohishi, Tsuyoshi Sugiura, Tatsuo Okui, On Behalf Of The Collaborative Group . Association Between Cognitive Impairment and Poor Oral Function in Community-Dwelling Older People: A Cross-Sectional Study. . Healthcare (Basel, Switzerland)13 ( 6 ) 2025.3International journal

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND/OBJECTIVES: The population of Japan has a high life expectancy, but there is room for improvement in terms of the country's healthy life expectancy. The long period of care dependency among Japan's elderly is also a major economic health challenge. Dementia is a major factor in the need for care, and its prevention is a crucial and urgent challenge. There are recent reports of a possible association between changes in oral function and cognitive impairment, but the details of this association remain unclear. To clarify the relationship between poor oral function and cognitive impairment, we conducted an exploratory investigation using a cognitive function assessment (Mini-Cog) administered in a large-scale study and its relevance to oral function. METHODS: The study population was 678 community-dwelling individuals aged ≥65 years living in Tarumizu city, Japan, in 2019. Cognitive function was assessed using the Mini-Cog test, and the oral survey was a modification of the content of the Oral Hypofunction Examination as defined by the Japanese Society of Gerodontology. RESULTS: The participants' median age was 73 years. The oral function results revealed median scores below the oral hypofunction criterion for occlusal force, tongue pressure, oral diadochokinesis, and swallowing function. The results of a binomial logistic regression analysis indicated that tongue-lip motor function was independently associated with oral function in relation to cognitive impairment. CONCLUSIONS: The oral function associated with cognitive impairment in this study was tongue-lip motor function. Aiming to improve this function may prevent the exacerbation of cognitive impairment.

DOI： 10.3390/healthcare13060589

Scopus

PubMed

牧芳昭, 森田秋子, 山田将成, 加藤涼平, 牧迫飛雄馬 . 回復期リハビリテーション病棟入院患者における行動観察評価による認知機能障害と転倒との関連性 . 日本転倒予防学会誌11 31 - 38 2025.3

Language：Japanese Publisher：(一社)日本転倒予防学会

【目的】本研究の目的は,回復期リハビリテーション病棟の入院患者に対して,行動観察から評価される認知関連行動アセスメント(以下CBA)の総合点から判定した認知機能障害の重症度と転倒の関連性を検討することであった。【方法】本研究は後ろ向きコホート研究であり,対象は2019年4月から2021年3月までの期間に当院回復期リハビリテーション病棟に入院した患者とした。認知機能障害の評価はCBAを使用し,転倒の有無は電子カルテ内の転倒・転落事故報告書の記録から調査した。入院時のCBAと入院早期の転倒との関連性を検証するため,入院1ヵ月以内の転倒を集計対象とし,入院1ヵ月以内で転倒を認めた者を転倒群,認めなかった者を非転倒群とした。転倒と非転倒の2群とCBA重症度とのクロス集計から,どの組み合わせが期待値から大きく乖離しているかを確認するために残差分析を行い,調整済み残差を算出した。そして,入院後1ヵ月以内の転倒の有無を従属変数とし,CBA重症度を独立変数とした2項ロジスティック回帰分析を行った。【結果】本研究の解析対象は879名であり,年齢の中央値は76(四分位範囲:65-83)歳であった。転倒群(68名)は非転倒群(811名)よりもCBA重症度が最重度～中等度の者の割合が多かった。また,転倒群におけるCBA重症度の内訳では,最重度4名(5.9%),重度24名(35.3%),中等度24名(35.3%),軽度11名(16.2%),良好5名(7.4%)であった。残差分析の結果,転倒群ではCBA重度(p<0.01)の者が有意に多く,非転倒群ではCBA軽度(p<0.01)の者が有意に多かった。入院後1ヵ月以内の転倒の有無を従属変数としたロジスティック回帰分析は,70歳以上などの転倒に関連する因子を共変量として調整しても,転倒とCBA重度の有無との関連性は有意であった(オッズ比1.92;95%CI,1.00-3.68;p<0.05)。【結論】回復期リハビリテーション病棟の入院患者における入院患者のCBA重症度は,入院1ヵ月以内の転倒発生と有意に関連していた。(著者抄録)

牧迫飛雄馬 . 【科学的介護】科学的介護を推進するための理学療法士の役割と期待 . 理学療法ジャーナル59 ( 3 ) 322 - 327 2025.3

Shiratsuchi Daijo, Makizako Hyuma, Akaida Shoma, Tateishi Mana, Taniguchi Yoshiaki, Takenaka Toshihiro, Kubozono Takuro, Ohishi Mitsuru . Association of metabolic syndrome and low physical function with mild cognitive impairment in community-dwelling older adults: a cross-sectional analysis from the Tarumizu Study . Japanese Journal of Cardiovascular Disease Prevention60 ( 1 ) 36 - 43 2025.2

Language：Japanese Publisher：The Japanese Society of Cardiovascular Disease Prevention

Objectives: To clarify the association between metabolic syndrome (MetS; Metabolic Syndrome), comorbid physical decline, and mild cognitive impairment (MCI) in community-dwelling older adults.Methods: A cross-sectional analysis of 554 community-dwelling older adults aged 65 years or older (mean age 73.7±6.2 years, 63.4% women) was conducted using data from the Tarumizu Study 2019. MetS was determined using the criteria of the International Diabetes Federation, and physical function decline was judged as applicable if either or both grip strength (<28 kg for men and <18 kg for women) and usual walking speed (<1.0 m/sec) were below the cutoff values. Based on the presence or absence of MetS and physical decline, patients were operationally classified into four groups: robust group, MetS alone group (MetS group), physical decline alone group (physical decline group), and MetS and physical decline coexisting group (coexisting group). MCI was assessed by the National Center for Geriatrics and Gerontology Functional Assessment Tool (NCGG-FAT) for memory, attention, executive function, and processing speed. Participants were considered to have MCI if they scored 1.5 SD or more below the norm, which takes into account age and education, on any of the tests. Logistic regression analysis was performed with MCI as the dependent variable and the four groups defined by the presence of MetS and physical decline as independent variables, with age, sex, educational history, and number of medications as covariates.Results: Participants characteristics were 191 (34.5%) in the robust group, 218 (39.4%) in the MetS group, 62 (11.2%) in the physical decline group, and 83 (15.0%) in the coexisting group. Logistic regression analysis showed that, compared with the robust group, the physical decline group (odds ratio: 2.39, 95% confidence interval: 1.17-4.87) and the coexisting group (odds ratio: 2.41, 95% confidence interval: 1.21-4.79) each had a significant association with MCI. On the other hand, the MetS group showed no significant association with MCI compared with the robust group.Conclusion: The presence of physical functional decline and the coexistence of MetS and physical decline are associated with MCI among community-dwelling older persons.

DOI： 10.11381/jjcdp.60.1_36

CiNii Research

J-GLOBAL

MAKI Yoshiaki, MORITA Akiko, YAMADA Masanari, KATO Ryohei, MAKIZAKO Hyuma . Association between Cognitive Dysfunction and Falls by Behavioral Observation Assessment in Hospitalized Patients in the Recovery Phase Rehabilitation Wards . JapaneseJournal of Fall Prevention11 ( 1 ) 31 - 38 2025.2

Language：Japanese Publisher：The Japanese Society for Fall Prevention

【Objective】This study aimed to investigate whether the severity of cognitive impairment, as determined from the total score of Cognitive-related Behavioral Assessment（CBA）, which is based on behavioral observations, is associated with falls in patients admitted to rehabilitation wards.【Methods】This retrospective cohort study included patients admitted to the recovery unit between April 2019 and March 2021. CBA was used to assess cognitive impairment, and falls were investigated using the records of the Falls and Falls Incident Report Form in the electronic medical record. To test the association between CBA on admission and falls early in hospitalization, falls within one month of admission were included in the tally, and those with falls within one month of admission were included in the fall group, while those without falls were included in the non-fall group. From the cross-tabulation of the two groups of falls and non-falls and CBA severity, a residual analysis was performed to identify the combination that deviated significantly from the expected values, and the adjusted residuals were calculated. Logistic regression analysis was performed with the presence of falls within one month of admission as the dependent variable and CBA severity as the independent variable.【Results】This study included 879 patients, with a median age of 76 years（interquartile range：65-83）years. The fall group（68 patients）had a higher proportion of patients with the most severe to moderate CBA severity than the non-fall group（811 patients）. CBA severity in the fall group was as follows：most severe, 4（5.9 ％）；severe, 24（35.3 ％）；moderate, 24（35.3 ％）；mild, 11（16.2 ％）；and normal, 5（7.4 ％）. Residual analysis showed that significantly more patients in the fall group had severe CBA（p ＜0.01）and significantly more patients in the non-fall group had mild CBA（p ＜0.01）. Logistic regression analysis using the presence or absence of falls within one month of admission as the dependent variable showed that the association between falls and CBA severity was significant（odds ratio 1.92；95 ％ CI, 1.00-3.68；p ＜0.05）, even after adjustment for factors related to falls, such as age 70 years or older, as covariates.【Conclusions】 Severe CBA severity was significantly associated with the risk of early falls in hospitalized patients in recovery units.

DOI： 10.11335/tentouyobou.11.1_31

CiNii Research

白土大成, 牧迫飛雄馬, 赤井田将真, 立石麻奈, 谷口善昭, 竹中俊宏, 窪薗琢郎, 大石充 . 高齢者におけるメタボリックシンドロームおよび身体機能低下と軽度認知障害との関連　垂水研究による横断分析 . 日本循環器病予防学会誌60 ( 1 ) 36 - 43 2025.2

Language：Japanese Publisher：(一社)日本循環器病予防学会

【目的】地域在住高齢者を対象にメタボリックシンドローム(MetS;Metabolic Syndrome)および身体機能低下の併存と軽度認知機能障害(MCI;Mild Cognitive Impairment)の関連を検討することを目的とした。【方法】垂水研究2019に参加した65歳以上の地域在住高齢者554名(平均年齢73.7±6.2歳、女性63.4%)のデータを横断的に分析した。MetSは国際糖尿病連合の基準を用いて判定した。身体機能は握力(男性<28kg、女性<18kg)および通常歩行速度(<1.0m/秒)で評価し、いずれか、または両方がカットオフ値未満であれば、身体機能低下ありと判定した。MetSおよび身体機能低下の有無から,健常群、MetS単独群(Mets群)、身体機能低下単独群(身体機能低下群)、MetSおよび身体機能低下併存群(併存群)の4群に分類した。認知機能は、National Center for Geriatrics and Gerontology Functional Assessment Tool(NCGG-FAT)により記憶力、注意機能、遂行機能、情報処理速度を評価し、いずれかの領域で年齢と教育歴を考慮した参照値より1.5SD以上の低下を認めた者をMCIの該当と判定した。MCIの有無を従属変数、MetSおよび身体機能低下の有無で定義された4群を独立変数とし、年齢、性別、教育歴、服薬数を共変量としたロジスティック回帰分析を実施した。【結果】健常群が191名(34.5%)、MetS群が218名(39.4%)、身体機能低下群が62名(11.2%)、併存群が83名(15.0%)であった。ロジスティック回帰分析の結果、健常群と比較し、身体機能低下群(オッズ比:2.39、95%信頼区間:1.17-4.87)、併存群(オッズ比:2.41、95%信頼区間:1.21-4.79)のそれぞれがMCIと有意な関連を認めた。一方、MetS単独群では健常群と比較したMCIと有意な関連を認めなかった。【結論】地域在住高齢者において身体機能低下を有すること、およびMetSと身体機能低下が併存していることはMCIを有することと関連することが示唆された。(著者抄録)

Yuto Kiuchi, Kota Tsutsumimoto, Kazuhei Nishimoto, Yuka Misu, Shinnosuke Nosaka, Tomoka Ohata, Hyuma Makizako, Hiroyuki Shimada . Association of trajectories of physical frailty status and incident disability in community-dwelling older adults: A longitudinal study. . Geriatrics & gerontology international25 ( 2 ) 220 - 225 2025.1

Language：English Publishing type：Research paper (scientific journal)

AIM: Frailty is a mediator between robustness and functional disability. This study examined the association between remission of frailty and incident disability. METHODS: The present study analyzed longitudinal data from 2601 community-dwelling older adults who were aged ≥65 years (mean age 70.8 ± 4.5 years, 1307 women [50.2%]) using the Cardiovascular Health Study criteria. Next, examining changes in status from wave 1 (2011) to wave 2 (2015), participants were categorized into a frailty group (those who remained or became frail), a remission of frailty group (those who were frail and became robust) and a robust group (those who remained robust). Cox proportional hazard modeling was used to determine the change of frailty status from wave 1 to wave 2, as well as incident disability at wave 2 (median duration 35 months). RESULTS: Of those participants who started in the frailty or prefrailty groups at wave 1, 15.8% had an improved frailty status at the 47-month follow up. After adjusting for covariates at baseline, the Cox proportional hazard regression models showed that the hazard ratio of disability among participants who remained robust was significantly less than for those who were in the frailty group (hazard ratio 0.515; 95% confidence interval 0.333-0.796). CONCLUSION: Our data confirm that among those whose frailty status improved, the risk of disability was lower than for those who remained frail. Geriatr Gerontol Int 2025; ••: ••-••.

DOI： 10.1111/ggi.15063

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PubMed

Makizako Hyuma . Cognitive Function and Falls . The Japanese Journal of Rehabilitation Medicine62 ( 1 ) 39 - 44 2025.1

Hyuma Makizako, Daijo Shiratsuchi, Shoma Akaida, Mana Tateishi, Keisuke Maeda, Katsuya Iijima, Hiroyuki Shimada, Tatsuro Inoue, Minoru Yamada, Ryo Momosaki, Hidetaka Wakabayashi, Koichi Yamamoto, Hidenori Arai . Effects of digital-based interventions on the outcomes of the eligibility criteria for sarcopenia in healthy older adults: a systematic review and meta-analysis . Ageing Research Reviews104 102663 - 102663 2025.1International journal

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

BACKGROUND: While the digital-based interventions targeting older adults to prevent age-related health problems such as sarcopenia have grown rapidly in recent years, there are no meta-analyses indicating synthesized pooled estimates. OBJECTIVE: To examine the effects of digital-based interventions on sarcopenia-related measures, including physical performance and muscle mass, in healthy community-dwelling older adults. METHODS: Systematic searches were performed on MEDLINE, Web of Science, and Cochrane Library for eligible studies published up to 31 March 2023. The mean difference with a 95 % confidence interval was calculated. Methodological quality was assessed using Cochrane RoB 2.0. The GRADE criteria were used to assess evidence certainty. RESULTS: Thirteen randomized controlled trials with 742 participants were included in the meta-analysis. Handgrip strength, usual walking speed, five times sit-to-stand performance, and 30-second chair stand test showed significant enhancements with the digital-based interventions. However, there were no significant effects of digital-based interventions in appendicular muscle mass. The overall evidence certainty was low. CONCLUSIONS: Although digital-based interventions for healthy older adults are effective in improving physical functions, evidence certainty is low. Additional randomized controlled trials are thus required to further validate the findings.

DOI： 10.1016/j.arr.2025.102663

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PubMed

Otsuka R., Nishita Y., Makizako H., Kinoshita K., Tange C., Tateishi M., Zhang S., Kubota S., Fujikawa K., Ando F., Shimokata H., Mizokami F., Ogayu T., Kabayama M., Kamide K., Satake S., Arai H. . A frailty-intrinsic capacity index to predict disability in community-dwelling older Japanese adults . Journal of Aging Research and Lifestyle14 100042 2025.1

Language：Japanese Publisher：Journal of Aging Research and Lifestyle

Purpose: We constructed and validated a frailty-intrinsic capacity (FR-IC) index for predicting disability in community-dwelling older Japanese adults. Methods: This longitudinal cohort study included 1179 participants aged ≥60 years (mean age: 71.3 ± 7.4 years, 51 % men). A multidisciplinary geriatric team constructed a 35-item FR-IC index (score range: 0: robust to 1: severe frailty, accumulation model) comprising 15 domains incorporating the intrinsic capacity concept (IC-Vision, IC-Hearing, IC-Locomotor capacity, IC-Cognition, IC-Vitality, and IC-Psychological capacity) based on questionnaires widely used in Japan. To test predictive validity, age- and sex-adjusted Cox proportional hazard models estimated hazard ratios (HRs) for incident disability (care need levels ≥1) by FR-IC index quartiles using the cohort study's existing data. Results: The mean FR-IC index score (32 items, three missing) was 0.08±0.05 (range: 0.00–0.31). During a mean follow-up of 9.0 ± 2.8 years, 284 (24 %) adults developed a disability. Compared with the lowest quartile, the adjusted HRs for developing an incident disability in the second to fourth quartiles were 2.32 (95 % confidence interval: 1.15–5.33), 3.18 (1.64–7.15), and 4.15 (2.14–9.32), respectively. The area under the curve of the FR-IC index for incident disability was 0.86. Among healthy participants, defined as robust by the baseline phenotypic physical frailty assessment (n = 437), sex- and age-adjusted HRs for incident support care through the second to third tertiles were 1.72 (0.79–4.30) and 2.51(1.17–6.22), respectively (trend P = 0.028). Conclusions: The novel FR-IC index can predict future disability among community-dwelling older Japanese adults. Integrating IC into frailty assessments provides a more comprehensive measure of aging.

DOI： 10.1016/j.jarlif.2025.100042

Scopus

PubMed

牧迫飛雄馬 . 【リハビリテーション医療における転倒予防】認知機能と転倒 . The Japanese Journal of Rehabilitation Medicine62 ( 1 ) 39 - 44 2025.1

Language：Japanese Publisher：(公社)日本リハビリテーション医学会

高齢期での転倒発生には,筋力低下や歩行障害,バランス障害などのほか,認知障害が独立した危険因子となる.軽度認知障害を有する高齢者では転倒リスクが増大し,身体機能の低下が併存するとさらに転倒リスクが顕著となる.そのため,転倒を予防する戦略として運動介入による効果が期待されるが,確立された転倒予防の方法が存在する状況ではない.個々の転倒リスクを考慮したうえでリハビリテーション専門職による管理や指導の下での運動介入に加えて,多職種で連携した生活環境も考慮した包括的な支援が必要となる.また,二重課題下での運動を適切に注意配分しながら遂行するようなプログラムは転倒予防の効果も期待される.(著者抄録)

Hiroyuki Shimada, Takehiko Doi, Kota Tsutsumimoto, Keitaro Makino, Kenji Harada, Kouki Tomida, Masanori Morikawa, Hyuma Makizako . A New Computer-Based Cognitive Measure for Early Detection of Dementia Risk (Japan Cognitive Function Test): Validation Study. . Journal of medical Internet research27 e59015 2025International journal

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: The emergence of disease-modifying treatment options for Alzheimer disease is creating a paradigm shift in strategies to identify patients with mild symptoms in primary care settings. Systematic reviews on digital cognitive tests reported that most showed diagnostic performance comparable with that of paper-and-pencil tests for mild cognitive impairment and dementia. However, most studies have small sample sizes, with fewer than 100 individuals, and are based on case-control or cross-sectional designs. OBJECTIVE: This study aimed to examine the predictive validity of the Japanese Cognitive Function Test (J-Cog), a new computerized cognitive battery test, for dementia development. METHODS: We randomly assigned 2520 older adults (average age 72.7, SD 6.7 years) to derivation and validation groups to determine and validate cutoff points for the onset of dementia. The Mini-Mental State Examination (MMSE) was used for comparison purposes. The J-Cog consists of 12 tasks that assess orientation, designation, attention and calculation, mental rotation, verbal fluency, sentence completion, working memory, logical reasoning, attention, common knowledge, word memory recall, and episodic memory recall. The onset of dementia was monitored for 60 months. In the derivation group, receiver operating characteristic curves were plotted to determine the MMSE and J-Cog cutoff points that best discriminated between the groups with and without dementia. In the validation group, Cox proportional regression models were developed to predict the associations of the group classified using the cutoff points of the J-Cog or MMSE with dementia incidence. Harrell C-statistic was estimated to summarize how well a predicted risk score described an observed sequence of events. The Akaike information criterion was calculated for relative goodness of fit, where lower absolute values indicate a better model fit. RESULTS: Significant hazard ratios (HRs) for dementia incidence were found using the MMSE cutoff between 23 and 24 point (HR 1.93, 95% CI 1.13-3.27) and the J-Cog cutoff between 43 and 44 points (HR 2.42, 95% CI 1.50-3.93). In the total validation group, the C-statistic was above 0.8 for all cutoff points. Akaike information criterion with MMSE cutoff between 23 and 24 points as a reference showed a poor fit for MMSE cutoff between 28 and 29 points, and a good fit for the J-Cog cutoff between 43 and 44 points. CONCLUSIONS: The J-Cog has higher accuracy in predicting the development of dementia than the MMSE and has advantages for use in the community as a test of cognitive function, which can be administered by nonprofessionals.

DOI： 10.2196/59015

Scopus

PubMed

Masato Nishiwaki, Seiya Takada, Shotaro Otsuka, Hyuma Makizako, Harutoshi Sakakima, Naoto Shiomi, Satomi Ooba, Naoyuki Matsumoto, Kiyoshi Kikuchi . Effects of agricultural or gardening physical activity on cardiovascular disease and dementia-related markers via arterial stiffness, cognitive function, and cerebral white matter status: results from cross-sectional and interventional studies. . Frontiers in public health13 1509528 - 1509528 2025International journal

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Agricultural or gardening physical activity (AGPA) offers potential as a simple strategy to improve cardiovascular disease and dementia-related markers; however, the actual preventive effects remain unclear. Our objective was to investigate AGPA regarding related markers of cardiovascular disease and dementia using cross-sectional and interventional approaches. METHODS AND RESULTS: In Study 1, community-based older individuals were assessed, and 30 individuals who performed AGPA (AG group) and 30 1:1 age-, sex-, and objective activity-matched controls were cross-sectionally compared (mean age, 75 ± 6 y). Arterial stiffness (pulse wave velocity) was lower and hand-finger dexterity (pegboard test) was higher in the AG vs. control groups. The interventional results of Study 2 (secondary analysis of a randomized controlled trial) confirmed that consistent AGPA might regress white matter hyperintensities in older individuals. CONCLUSION: Our findings suggest that consistent AGPA perse may improve cardiovascular disease and dementia-related markers in older healthy individuals via arterial stiffness, cognitive function, and cerebral white matter status. This information could have major implications for integrated strategies for lifelong health. SECONDARY ANALYSIS OF CLINICAL TRIALS STUDY 2: Study for Decreasing Depressive Symptoms and Increasing Memory Performance in the older adults (Trial registration number UMIN000018547, Date of registration 2015/08/07), URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000021462.

DOI： 10.3389/fpubh.2025.1509528

Scopus

PubMed

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