Faculty Profiles - akihide Tanimoto

Papers - akihide Tanimoto

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窪田恵美, 北薗育美, 岩切かおり, 切田ゆかり, 田崎貴嗣, 東美智代, 簗詰伸太郎, 小林裕明, 谷本昭英 . 液状化検体細胞診で診断した子宮頸部明細胞癌の1例 . 日本臨床細胞学会雑誌62 ( 6 ) 287 - 292 2023.11Reviewed

Language：Japanese Publisher：(公社)日本臨床細胞学会

背景:子宮頸部原発明細胞癌はまれであり,液状化検体細胞診(liquid-based cytology:LBC)の細胞像の報告はほとんどない.われわれは,LBC標本で診断しえた子宮頸部明細胞癌の1例を経験したので,塗抹標本所見との異同および他の腺癌との鑑別点について検討し報告する.症例:70歳代,女性.約1年前より持続する性器出血があり,子宮頸部のポリープ状腫瘍を指摘された.擦過細胞診および組織診で明細胞癌と診断された.LBC標本では,異型細胞が重積性のある集塊状や孤立性に認められ,腺腔構造や乳頭状構造およびhobnail状の核の突出も認めた.異型細胞の核は軽度の腫大を示す類円形を呈しており,大型で明瞭な核小体を認め,細胞質は豊富で,淡く微細顆粒状を呈していた.結論:LBC標木においても,塗抹標本と同様に明細胞癌の特徴とされる,大型で明瞭な核小体および豊富な細胞質を有する異型細胞を認め,LBC標本で明細胞癌の診断を行う際にも重要な細胞所見である.(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01209&link_issn=&doc_id=20231208230002&doc_link_id=%2Few5saibo%2F2023%2F006206%2F003%2F0287-0292%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Few5saibo%2F2023%2F006206%2F003%2F0287-0292%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Riho Yumisashi, Ryosuke Saito, Shinichi Togami, Yusuke Kobayashi, Ikumi Kitazono, Akihide Tanimoto, Hiroaki Kobayashi . Molecular biological analysis revealed a case of synchronous endometrial and ovarian cancer with different histological grade as metastatic ovarian cancer from endometrial cancer: Case report and review of literature. . The journal of obstetrics and gynaecology research49 ( 11 ) 2766 - 2770 2023.8Reviewed International journal

Language：English

The diagnosis of synchronous endometrial and ovarian cancer or metastatic cancer of the same histological type is difficult. In this study, molecular biology analysis was performed to determine ovarian metastasis from endometrial cancer. A 38-year-old woman had pathological evidence of endometrial cancer (endometrioid carcinoma, grade 1) and ovarian cancer (endometrioid carcinoma, grade 3); a disseminated nodule in the serosa uteri was also diagnosed as endometrioid carcinoma (grade 3). Customized panel sequencing revealed a common mutation pattern in ovarian cancer and disseminated nodules. Furthermore, endometrial cancer showed the same mutation patterns for FGFR3 and PTEN as ovarian cancer and disseminated nodules. All tumors were microsatellite instability high. Clinicopathological and molecular biology analyses suggested that the patient had ovarian metastasis from endometrial cancer. The patient underwent adjuvant chemotherapy with paclitaxel and carboplatin, with no recurrence. Molecular biology techniques may enable appropriate treatment based on clinically accurate diagnosis.

DOI： 10.1111/jog.15773

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Mari Kirishima, Toshiaki Akahane, Tomoko Takajo, Nayuta Higa, Hajime Yonezawa, Hiroyuki Uchida, Kiyohisa Kamimura, Ryosuke Hanaya, Koji Yoshimoto, Michiyo Higashi, Takashi Yoshiura, Akihide Tanimoto . A case of glioblastoma harboring non-amplified epidermal growth factor receptor variant III: Critical molecular detection using RNA-based panel analysis. . Pathology, research and practice248 154712 - 154712 2023.7Reviewed International journal

Language：English

Amplification of the epidermal growth factor receptor gene (EGFR) and its variants are the most commonly detected pathogenic gene alterations in glioblastoma. Herein, we report a case of molecularly defined glioblastoma harboring an EGFR variant III (EGFRvIII) without EGFR amplification. The initial histological diagnosis was isocitrate dehydrogenase (IDH)-wildtype low-grade glioma, due to an absence of anaplasia, necrosis, and microvascular proliferation, and a low Ki-67 labeling index. DNA-based next-generation sequencing (NGS) panel analysis revealed a TERTp promoter mutation but no EGFR mutation or amplification, supporting the diagnosis of "molecular glioblastoma." However, RNA-based NGS panel analysis revealed mRNA expression of EGFRvIII. Therefore, the final integrative diagnosis was glioblastoma with non-amplified EGFRvIII. Our report suggests that non-amplified EGFRvIII might be an early molecular event in glioblastoma tumorigenesis. In addition to the usual DNA-based analysis, RNA-based analysis is required to identify exon-skipping EGFR variants without EGFR amplification.

DOI： 10.1016/j.prp.2023.154712

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Tatsuhiko Furukawa, Kentaro Mimami, Toshiyuki Nagata, Masatasu Yamamoto, Masami Sato, Akihide Tanimoto . Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development. . International journal of molecular sciences24 ( 14 ) 2023.7Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of BHLHE41/DEC2 on differentiation have been examined using Bhlhe41/Dec2 knockout mice and/or in vitro differentiation models, and research has been conducted using genetic analysis of tumor cells, in vitro analysis of cancer cell lines, and immunohistochemical studies of the clinical samples. We summarize some of these studies, detail several problems, and consider possible reasons for contradictory results and the needs for further research.

DOI： 10.3390/ijms241411731

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古家淳行, 亀澤雅, 窪田恵美, 岩切かおり, 霧島茉莉, 田崎貴嗣, 北薗育美, 東美智代, 谷本昭英 . 右臀部に発生した類上皮肉腫の一例 . 日本臨床細胞学会九州連合会雑誌54 83 - 86 2023.7Reviewed

Language：Japanese Publisher：日本臨床細胞学会-九州連合会

背景類上皮肉腫は形態および免疫組織学的に上皮様を呈する腫瘍細胞が胞巣形成性に増殖する稀な悪性軟部腫瘍で,しばしばラブドイド細胞が出現する.今回,右臀部に発生した類上皮肉腫を経験したので報告する.症例 30代,女性.右臀部の筋肉内腫瘤および右鼠径部腫瘤を認めた.穿刺吸引細胞診では血性背景に上皮様結合を有した異型細胞が集塊状に出現していた.異型細胞の結合性は緩く,豊富な細胞質を有し,核は偏在傾向を示し,核縁は菲薄で平滑で,クロマチンは細顆粒状で均等に分布していた.癌の転移や肉腫が疑われたが,組織型の推定は困難であった.摘出された腫瘍は,組織学的に好酸性胞体の上皮様腫瘍細胞が線維性間質内に索状やシートに増殖し,腫瘍中心に壊死を伴っていた.免疫組織化学的に腫瘍細胞は,cytokeratin(AE1/AE3,CAM5.2),Vimentin,CD34陽性を示し,INI-1の欠失を認めた.細胞所見,免疫組織化学を含む組織所見より類上皮肉腫と診断した.結語類上皮肉腫の細胞像では,豊富な細胞質を有する上皮様結合を示す異型細胞を認めるが,結合性は緩いこと,肉腫を示唆する菲薄で平滑な核縁であることに着目することが重要であると考えられた.(著者抄録)

Ikumi Kitazono, Toshiaki Akahane, Seiya Yokoyama, Yusuke Kobayashi, Shinichi Togami, Shintaro Yanazume, Takashi Tasaki, Hirotsugu Noguchi, Kazuhiro Tabata, Hiroaki Kobayashi, Akihide Tanimoto . "Surface epithelial slackening" pattern in endometrioid carcinoma: A morphological feature for differentiating the POLE mutation-subtype from the no specific molecular profile subtype. . Pathology, research and practice247 154563 - 154563 2023.5Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Endometrial cancers are classified into mismatch repair (MMR) deficient- (MMRd), p53 mutation- (p53mut), DNA polymerase epsilon (POLE) mutation (POLEmut), and no specific molecular profile (NSMP) subtypes according to The Cancer Genome Atlas (TCGA). The distinction between POLEmut and NSMP subtypes is made on the basis of molecular analysis because the specific histological and immunohistochemical features of these two subtypes are still unknown. In this study, we analyzed histological features by scoring the presence of a mucinous pool, giant cells, clear cells, keratinization, neutrophilic abscess, and surface proliferating pattern in 82 cases of endometrial cancers in which an integrative diagnosis was confirmed by immunohistochemistry and genomic profiles showing POLE mutations, tumor mutation burden, and microsatellite instability. In contrast to the hierarchical branching of micropapillary proliferation observed in serous carcinoma, POLEmut-subtype endometrioid carcinomas often showed a surface epithelial slackening (SES) pattern in the tumor cells facing the uterine surface. The POLEmut subtype exhibited higher scores for clear cells and SES patterns than the other three subtypes. The scores for giant cells, clear cells, and the SES pattern were significantly higher in the POLEmut subtype than in the NSMP subtype, suggesting that these morphometric parameters are useful for differentiating POLEmut- and NSMP-subtype endometrioid carcinomas, although genomic profiling is still necessary for a definite molecular diagnosis.

DOI： 10.1016/j.prp.2023.154563

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Akahane T, Isochi-Yamaguchi T, Hashiba-Ohnuki N, Bandoh N, Aimono E, Kato Y, Nishihara H, Kamada H, Tanimoto A . Cancer gene analysis of liquid-based cytology specimens using next-generation sequencing: A technical report of bimodal DNA- and RNA-based panel application. . Diagnostic cytopathology 2023.5Reviewed

Hamada T, Higashi M, Yokoyama S, Akahane T, Hisaoka M, Noguchi H, Furukawa T, Tanimoto A . MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer. . BMC cancer23 ( 1 ) 424 2023.5Reviewed

Shintaro Yanazume, Kaori Iwakiri, Yusuke Kobayashi, Ikumi Kitazono, Toshiaki Akahane, Mika Mizuno, Shinichi Togami, Akihide Tanimoto, Hiroaki Kobayashi . Cytopathological features associated with POLE mutation in endometrial cancer. . Cytopathology : official journal of the British Society for Clinical Cytology34 ( 3 ) 211 - 218 2023.5Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: For patients with endometrial cancer, the POLE (polymerase epsilon) mutation (POLEmut)-subtype, one of four molecular-analysis-based categories in the Cancer Genome Atlas (TCGA), has the best prognosis. The following histological characteristics are typically observed in endometroid carcinoma cases with the POLEmut-subtype: (1) the presence of tumour giant cells, (2) numerous tumour-infiltrating lymphocytes (TILs) and/or peri-tumoral lymphocytes, and (3) a high grade. However, in the context of cytology, the morphological characteristics of this subtype remain unknown. METHODS: DNA extracted from formalin-fixed paraffin-embedded (FFPE) tissues was subjected to next-generation sequencing analysis and categorised according to the TCGA classifications. Genomic mutation, tumour mutation burden (TMB), and microsatellite instability were also assessed. Cytological specimens of resected uteri obtained using the Papanicolaou method were histologically separated into three types. RESULTS: Seven out of 112 patients (6%) with endometrial cancer were diagnosed with the POLEmut-subtype between January 2019 and August 2021. Tumour giant cells were observed in three cases (43%) on histology and cytology. TIL and/or peritumoral lymphocytes with inflammatory cells were detected in five cases (71%) on histology and three cases (43%) on cytology. Cases in which these three characteristics were observed on both cytology and histology may have belonged to the POLEmut-subtype. There were no cases in which these characteristics were absent on histology but present on cytology. TMB tended to be higher in cases when the three characteristics were observed in both cytological and histological findings. CONCLUSIONS: Preoperative endometrial cytology highlighted the characteristics of the POLEmut-subtype in the histological analysis of resected uterine specimens and has the potential to play an important role in treatment decisions.

DOI： 10.1111/cyt.13215

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赤羽俊章, 坂本一平, 比嘉那優大, 霧島茉莉, 牧野隆太郎, 米澤大, 内田裕之, 吉本幸司, 花谷亮典, 谷本昭英 . がんゲノム診断とバイオインフォマティクス神経膠腫の統合分子病理診断のための自動レポーティングシステムの構築とバイオインフォマティクスの重要性 . Brain Tumor Pathology40 ( Suppl. ) 067 - 067 2023.5Reviewed

比嘉那優大, 赤羽俊章, 横山勢也, 米澤大, 内田裕之, 霧島茉莉, 山本淳考, 吉本幸司, 谷本昭英, 花谷亮典 . IDH wildtype-TERTp wildtype glioblastomaにおけるPTENの予後への影響 . Brain Tumor Pathology40 ( Suppl. ) 098 - 098 2023.5Reviewed

牧野隆太郎, 比嘉那優大, 赤羽俊章, 米澤大, 内田裕之, 霧島茉莉, 山本淳考, 吉本幸司, 谷本昭英, 花谷亮典 . がんゲノム診断日本人膠芽腫患者におけるチロシンキナーゼ受容体変異と臨床像 . Brain Tumor Pathology40 ( Suppl. ) 061 - 061 2023.5Reviewed

Hirofumi Yoshino, Seiya Yokoyama, Motoki Tamai, Shunsuke Okamura, Sayaka Iizasa, Takashi Sakaguchi, Yoichi Osako, Satoru Inoguchi, Ryosuke Matsushita, Yasutoshi Yamada, Masayuki Nakagawa, Shuichi Tatarano, Akihide Tanimoto, Hideki Enokida . Characterization and treatment of gemcitabine- and cisplatin-resistant bladder cancer cells with a pan-RAS inhibitor. . FEBS open bio13 ( 6 ) 1056 - 1066 2023.4Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Combination chemotherapy with gemcitabine and cisplatin (GC) is recommended as the primary treatment for advanced bladder cancer (BC). However, the benefits of this approach are limited owing to the acquisition of drug resistance. Here, we found report that gemcitabine-resistant and cisplatin-resistant BCs do not exhibit cross-resistance, and that these BCs exhibit different mRNA patterns, as revealed using RNA sequence analysis. To overcome drug resistance, we used the newly developed pan-RAS inhibitor Compound 3144. Compound 3144 inhibited cell viability through suppression of RAS-dependent signaling in gemcitabine- and cisplatin-resistant BCs. RNA sequencing revealed that several genes and pathways, particularly those related to the cell cycle, were significantly downregulated in Compound 3144-treated BCs. These findings provide insights into potential therapeutic strategies for treating BC.

DOI： 10.1002/2211-5463.13616

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Hiromichi Iwaya, Akihide Tanimoto, Koshiro Toyodome, Issei Kojima, Makoto Hinokuchi, Shiroh Tanoue, Shinichi Hashimoto, Machiko Kawahira, Shiho Arima, Shuji Kanmura, Toshiaki Akahane, Michiyo Higashi, Shinsuke Suzuki, Shinichi Ueno, Takao Ohtsuka, Akio Ido . Next-Generation Sequencing Analysis of Pancreatic Cancer Using Residual Liquid Cytology Specimens from Endoscopic Ultrasound-Guided Fine-Needle Biopsy: A Prospective Comparative Study with Tissue Specimens. . Diagnostics (Basel, Switzerland)13 ( 6 ) 2023.3Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

This study evaluated the feasibility and clinical utility of liquid-based cytology (LBC) specimens via endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) for next-generation sequencing (NGS) of pancreatic cancer (PC). We prospectively evaluated the performance of DNA extraction and NGS using EUS-FNB samples obtained from PC. Thirty-three consecutive patients with PC who underwent EUS-FNB at our hospital were enrolled. DNA samples were obtained from 96.8% of the patients. When stratified with a variant allele frequency (VAF) > 10% tumor burden, the NGS success rate was 76.7% (n = 23) in formalin-fixed paraffin-embedded (FFPE), 83.3% (n = 25) in LBC, and 76.7% (n = 23) in frozen samples. The overall NGS success rate was 86.7% (n = 26) using FFPE, LBC, or frozen samples. The detection rates for the main mutated genes were as follows: 86.7% for KRAS, 73.3% for TP53, 66.7% for CDKN2A, 36.7% for SMAD4, and 16.7% for ARID1A. LBC had the highest median value of VAF (23.5%) for KRAS and TP53. PC mutation analysis using NGS was successfully performed using LBC compared with FFPE and frozen samples. This approach provides an alternative and affordable source of molecular testing materials.

DOI： 10.3390/diagnostics13061078

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Shinichi Togami, Akihide Tanimoto, Shintaro Yanazume, Hideki Tokunaga, Tomoyuki Nagai, Mika Watanabe, Hideaki Yahata, Kazuo Asanoma, Hidetaka Yamamoto, Tomohito Tanaka, Masahide Ohmichi, Takashi Yamada, Yukiharu Todo, Ryutaro Yamada, Hidenori Kato, Wataru Yamagami, Kenta Masuda, Miho Kawaida, Hitoshi Niikura, Takuya Moriya, Hiroaki Kobayashi . Evaluation of the one-step nucleic acid amplification assay for detecting lymph node metastasis in patients with cervical and endometrial cancer: A multicenter prospective study. . Gynecologic oncology170 70 - 76 2023.3Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: This multicenter study aimed to evaluate the accuracy of the one-step nucleic acid amplification (OSNA) assay in diagnosing lymph node metastasis (LNM) in patients with cervical and endometrial cancers. METHODS: Surgically removed LNs from patients with cervical and endometrial cancer were sectioned at 2-mm intervals along the short axis direction and alternately examined using the OSNA assay and conventional histopathological examination. Ultrastaging (200-μm LN sections) was performed for metastatic LNs using hematoxylin and eosin staining and immunostaining with an anti-CK19 antibody in cases where the OSNA assay and histopathological examination (performed using 2-mm LN sections) results showed discordance. RESULTS: A total of 437 LNs from 133 patients were included; 61 patients (14%) showed metastasis by histopathological examination, with a concordance rate of 0.979 (95% confidence interval [CI]: 0.961-0.991) with the OSNA assay. The sensitivity and specificity of the OSNA assay were 0.918 (95% CI: 0.819-0.973) and 0.989 (95% CI: 0.973-0.997), respectively. Discordance between the two methods was observed in nine LNs (2.1%), and allocation bias of metastatic foci was identified as the major cause of discordance. CONCLUSIONS: The OSNA assay showed equally accurate detection of LN metastasis as the histopathological examination. We suggest that the OSNA assay may be a useful tool for the rapid intraoperative diagnosis of LN metastasis in patients with cervical and endometrial cancers.

DOI： 10.1016/j.ygyno.2022.12.016

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Yuto Hozaka, Hideyuki Oi, Souichi Satake, Yoshinori Uchino, Yuichi Goto, Tetsuya Idichi, Kiyonori Tanoue, Yoichi Yamasaki, Yota Kawasaki, Yuko Mataki, Hiroshi Kurahara, Akihiro Nakajo, Michiyo Higashi, Akihide Tanimoto, Tsuyoshi Sugiura, Takao Ohtsuka . Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas? . Surgery173 ( 2 ) 503 - 510 2023.2Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Microbiota have been reported to influence the development of various gastrointestinal neoplasms through the mechanism of sustained inflammation; however, few data are available regarding their influence on intraductal papillary mucinous neoplasms. The aim of this study was to assess the association between specific microbiota and the clinicopathologic characteristics of intraductal papillary mucinous neoplasms of the pancreas. METHODS: DNA was extracted from formalin-fixed, paraffin-embedded samples of 30 patients who underwent pancreatectomy for intraductal papillary mucinous neoplasm, and polymerase chain reaction was used to create sequence libraries using the primer set for the V3 and V4 region of 16S recombinant DNA. Filtered sequence reads were then processed into operational taxonomic units with a 97% identity threshold and the relative abundance of bacteria compared between the 2 groups using operational taxonomic units. RESULTS: There was a trend toward fewer Firmicutes and more Proteobacteria and Fusobacteria in the relative abundance of main duct operational taxonomic units than in branch duct operational taxonomic units. The relative abundances of Bacteroidetes (P < .01) and Fusobacteria (P = .04) were significantly higher in invasive intraductal papillary mucinous neoplasms than in noninvasive intraductal papillary mucinous neoplasms. The relative abundance of the intestinal type was significantly lower in Firmicutes than the relative abundance of the nonintestinal type (P = .04). Notably, main duct operational taxonomic units with the intestinal subtype were affected by increased proportions of Proteobacteria and Fusobacteria, and Fusobacteria were abundant in the intestinal type of invasive main duct operational taxonomic units. CONCLUSION: Intratumoral microbiota may be involved in the progression of operational taxonomic units.

DOI： 10.1016/j.surg.2022.10.003

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Takumi Koji, Nagano Hiroaki, Myogasako Tsuyoshi, Nakano Tsubasa, Fukukura Yoshihiko, Ueda Kazuhiro, Tabata Kazuhiro, Tanimoto Akihide, Yoshiura Takashi . Feasibility of iodine concentration and extracellular volume fraction measurement derived from the equilibrium phase dual-energy CT for differentiating thymic epithelial tumors(タイトル和訳中) . Japanese Journal of Radiology41 ( 1 ) 45 - 53 2023.1Reviewed

Language：English Publisher：(公社)日本医学放射線学会

2017年1月～2020年12月にかけ、当院で治療前に平衡相デュアルエネルギーCT(DECT)を受けた胸腺上皮性腫瘍(TET)の治療継続患者33例(男性11例、女性22例、年齢34～89歳)を対象に、ヨウ素濃度(IC)と細胞外容積(ECV)分画測定がTET診断に実現可能か後向きに調査した。なお、TET病理診断の内訳は低リスク胸腺腫が11例(Aが0例、ABが4例、B1が7例)、高リスク胸腺腫が11例(B2が6例、B3が5例)、胸腺癌が11例であった。平衡相でICを測定し、胸腺病変と大動脈ICからECV分画を求めTETサブタイプ間でICとECV分画を比較した。次に、ROC曲線解析によりICとECV分画の胸腺癌に対する診断能を評価した結果、平衡相のICとECV分画ではTET群間で異なったが、胸腺癌に対する平衡相ICとECV分画では胸腺腫に比べ有意に高く、胸腺癌を診断するための平衡相ICとECV分画の最適なカットオフ値が、各々1.5mg/mLおよび26.8%であることが確認された。以上の結果から、DECTを用いたICとECV分画測定がTET診断に有用で、平衡相高ICと高ECV分画から胸腺癌が推察されることが明らかにされた。

田崎貴嗣, 霧島茉莉, 北薗育美, 田畑和宏, 東美智代, 安村拓人, 豊川建二, 谷本昭英 . 胸部大動脈瘤を呈した巨細胞性動脈炎の1例 . 診断病理40 ( 1 ) 91 - 95 2023.1Reviewed

Language：Japanese Publisher：(一社)日本病理学会

症例は80代女性。リウマチ性多発筋痛症の治療中に胸部大動脈瘤を指摘され,人工血管置換術が行われた。大動脈では内膜に軽度の粥状硬化を認めた。中膜ではリンパ球や形質細胞,少数の多核巨細胞の浸潤,内膜側優位の弾性線維の配列の乱れと消失を認めたが,外膜の線維化や炎症細胞浸潤は軽度であり,巨細胞性動脈炎と診断した。大動脈瘤において巨細胞性動脈炎と病理診断される症例では,側頭動脈炎の既往がなく臨床症状に乏しいことがあり,大動脈瘤を注意深く検索することで,巨細胞性動脈炎の可能性を見落とさないことが重要である。(著者抄録)

Koji Takumi, Hiroaki Nagano, Tsuyoshi Myogasako, Tsubasa Nakano, Yoshihiko Fukukura, Kazuhiro Ueda, Kazuhiro Tabata, Akihide Tanimoto, Takashi Yoshiura . Feasibility of iodine concentration and extracellular volume fraction measurement derived from the equilibrium phase dual-energy CT for differentiating thymic epithelial tumors. . Japanese journal of radiology41 ( 1 ) 45 - 53 2023.1Reviewed

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To assess the diagnostic feasibility of iodine concentration (IC) and extracellular volume (ECV) fraction measurement using the equilibrium phase dual-energy CT (DECT) for the evaluation of thymic epithelial tumors (TETs). MATERIALS AND METHODS: This study included 33 TETs (11 low-risk thymomas, 11 high-risk thymomas, and 11 thymic carcinomas) that were assessed by pretreatment DECT. IC was measured during the equilibrium phases and ECV fraction was calculated using IC of the thymic lesion and the aorta. IC and ECV fraction were compared among TET subtypes using the Kruskal-Wallis H test and Mann-Whitney U test. Receiver-operating characteristic (ROC) curve analysis was performed to evaluate the ability of IC and ECV fraction to diagnose thymic carcinoma. RESULTS: IC during the equilibrium phase and ECV fraction differed among the three TET groups (both p < 0.001). IC during the equilibrium phase and ECV fraction was significantly higher in thymic carcinomas than in thymomas (1.9 mg/mL vs. 1.2 mg/mL, p < 0.001; 38.2% vs. 25.9%, p < 0.001; respectively). The optimal cutoff values of IC during the equilibrium phase and of ECV fraction to diagnose thymic carcinoma were 1.5 mg/mL (AUC, 0.955; sensitivity, 100%; specificity, 90.9%) and 26.8% (AUC, 0.888; sensitivity, 100%; specificity, 72.7%), respectively. CONCLUSION: IC and ECV fraction measurement using DECT are helpful in diagnosing TETs. High IC during the equilibrium phase and high ECV fraction are suggestive of thymic carcinoma.

DOI： 10.1007/s11604-022-01331-9

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KUBOTA Emi, KITAZONO Ikumi, IWAKIRI Kaori, KIRITA Yukari, TASAKI Takashi, HIGASHI Michiyo, YANAZUME Shintaro, KOBAYASHI Hiroaki, TANIMOTO Akihide . A case of clear cell cancer of the cervix diagnosed by liquid-based cytology . The Journal of the Japanese Society of Clinical Cytology62 ( 6 ) 287 - 292 2023

Language：Japanese Publisher：The Japanese Society of Clinical Cytology

Background : Few studies have investigated the usefulness of liquid-based cytology (LBC) specimens in patients with primary clear cell carcinoma of the cervix, a rare neoplasm. Herein, we report the case of a patient who was diagnosed as having primary clear cell carcinoma of the cervix based on LBC, and discuss the differences between LBC and smear cytology, and useful findings for differentiation from other adenocarcinomas.Case : The patient was a 70-year-old woman. LBC examination revealed both isolated tumor cells and tumor cells in clusters ; glandular, papillary, and hobnail-like formations were also observed. On LBC, tumor cells with abundant and fine granular cytoplasm, enlarged round nuclei, and large and prominent nucleoli were observed.Conclusion : These findings could be helpful in the diagnosis of cervical cell carcinoma using LBC.

DOI： 10.5795/jjscc.62.287

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