Faculty Profiles - akihide Tanimoto

Papers - akihide Tanimoto

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Kitazono Ikumi, Murakami Miki, Takeda Aya, Noguchi Hirotsugu, Tasaki Takashi, Kirishima Mari, Higashi Michiyo, Ueda Kazuhiro, Tanimoto Akihide . Pulmonary pleomorphic carcinoma: A rare case showing arterial carcinomatosis mimicking pulmonary artery intimal sarcoma(タイトル和訳中) . Pathology International75 ( 2 ) 114 - 120 2025.2Reviewed

Yanazume Shintaro, Kobayashi Yusuke, Kirita Yukari, Kitazono Ikumi, Nagata Chikako, Kozai Ayumi, Tanimoto Akihide, Kobayashi Hiroaki . A potential inflammatory biomarker for advanced endometrial cancer treated with lenvatinib plus pembrolizumab(タイトル和訳中) . The Journal of Obstetrics and Gynaecology Research51 ( 1 ) jog.16182 - jog.16182 2025.1Reviewed

Tasaki Takashi, Baba Naoko, Noguchi Hiroyuki, Murakami Miki, Kitazono Ikumi, Higashi Michiyo, Tanimoto Akihide . A skin biopsy case of Mpox virous infection . Japanese Journal of Diagnostic Pathology42 ( 2 ) 146 - 149 2025Reviewed

Language：Japanese Publisher：The Japanese Society of Pathology

We report a case of Mpox virus infection in 30s-year-old man.　He had sexual contact with a multiple sex partner one month ago.　He had a fever and skin rash （erythema, papules or pseudopustules） on his chest, forearms, palms, and penis.　Microscopic examination of the skin biopsied specimen from his chest revealed epidermal necrosis with shadow cells, balloon cell degeneration, and exocytosis of neutrophils.　Eosinophilic inclusion bodies were observed in keratinocytes.　A final diagnosis of Mpox virus infection was confirmed by PCR.　As the histopathological features are not specific for Mpox virus infection, it is necessary to interactively diagnose in combination with patient’s history and clinical findings.

DOI： 10.69281/jspjjdp.2024_11_0048

CiNii Research

Tasaki Takashi, Noguchi Hiroyuki, Murakami Miki, Kitazono Ikumi, Higashi Michiyo, Tanimoto Akihide . A case of pleomorphic adenoma with tyrosine rich crystalloids . Japanese Journal of Diagnostic Pathology42 ( 3 ) 200 - 203 2025Reviewed

Language：Japanese Publisher：The Japanese Society of Pathology

Pleomorphic adenoma is the most common salivary gland tumor.　Tyrosine-rich crystalloids （TRCs） are rarely seen in the chondromyxoid stromal component of this tumor.　We report a case of pleomorphic adenoma with TRCs in 70s-year-old woman.　The tumor was 65 mm in diameter and located in the right parotid gland.　Microscopic examination revealed numerous floret-like TRCs in abundant myxoid stroma and myoepithelial nests.　TRCs were more clearly observed by Giemsa stain.　TRCs are most frequently seen in pleomorphic adenoma, however, they are also known to be seen in other salivary gland tumors, including malignant tumors, and non-neoplastic tissues.　TRCs should not be a diagnostic clue for pleomorphic adenoma.

DOI： 10.69281/jspjjdp.2025_01_0003

CiNii Research

Nozomi Furuzono, Shinichi Togami, Ikumi Kitazono, Takuro Nishikawa, Akihide Tanimoto, Hiroaki Kobayashi . Malignant peripheral nerve sheath tumor of the cervix in an adolescent with neurofibromatosis type 1: A case report and review of literature. . The journal of obstetrics and gynaecology research50 ( 12 ) 2372 - 2376 2024.12Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Malignant peripheral nerve sheath tumors (MPNSTs) of the cervix are rare, particularly in patients with neurofibromatosis type 1 (NF1). This report describes a cervical MPNST in an 18-year-old patient with no history of sexual activity, abnormal vaginal discharge, and prolonged menstruation. She had more than six café-au-lait spots on her body since birth and was diagnosed with NF1 at 2 years of age. Positron emission tomography-computed tomography revealed a large pelvic mass and lung and bone metastases. Biopsy confirmed MPNST. Immunohistochemical staining showed diffuse positivity for CD10, approximately 30% positivity for cyclin D1, partial positivity for α-SMA, desmin, and MyoD1, and negativity for myogenin, S-100, and SOX-10. A cancer gene panel identified several genetic abnormalities, but none were actionable mutations. Despite systemic chemotherapy, the tumor progressed rapidly, and the patient died 8 weeks post-admission. Early diagnosis of MPNST is crucial. In patients with NF1, even mild symptoms can indicate MPNST.

DOI： 10.1111/jog.16139

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Furuzono Nozomi, Togami Shinichi, Kitazono Ikumi, Nishikawa Takuro, Tanimoto Akihide, Kobayashi Hiroaki . Malignant peripheral nerve sheath tumor of the cervix in an adolescent with neurofibromatosis type 1: A case report and review of literature(タイトル和訳中) . The Journal of Obstetrics and Gynaecology Research50 ( 12 ) 2372 - 2376 2024.12Reviewed

Nonaka Yuto, Yanagi Masakazu, Sakagami Yuri, Ohnou Nobuhito, Tanimoto Akihide, Ueda Kazuhiro . A Case of Intravascular Large B-cell Lymphoma That Was Overlooked due to Nonspecific Symptoms During Combination Immunotherapy for Left Upper Lobe Lung Adenocarcinoma . Haigan64 ( 6 ) 872 - 877 2024.10

Language：Japanese Publisher：The Japan Lung Cancer Society

Background. Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal large B-cell lymphoma characterized by selective lymphoma cell growth in the lumina of vessels, mainly capillaries. We report a case of IVLBCL that was overlooked due to nonspecific symptoms during combination immune checkpoint inhibitor (ICI) therapy for lung cancer. Case. The patient was a 68-year-old man who was on maintenance therapy (pembrolizumab+PEM) for left upper lobe lung adenocarcinoma (cT2a (PL1) N0M1c (bone marrow, spleen) stage IVB). The patient was admitted to hospital with complaints of general fatigue and dyspnea and was treated for immune-related adverse events (irAE) because of pancytopenia and hypothyroidism. However, the symptoms did not improve. Multiple bone marrow punctures were performed to investigate the possibility of malignant lymphoma or recurrent bone marrow metastasis; however, no malignant cells were found. The patient was diagnosed with IVLBCL based on a random skin biopsy. Conclusion. IVLBCL is a malignant lymphoma that occurs without lymph node enlargement, and which has limited specific findings. Aggressive additional tests are important to distinguish IVLBCL from irAE during the administration of ICI therapy.

DOI： 10.2482/haigan.64.872

CiNii Research

野中裕斗, 柳正和, 坂上友梨, 大納伸人, 谷本昭英, 上田和弘 . 左上葉肺腺癌に対する複合免疫療法中に非特異的所見のため鑑別困難であった血管内大細胞型B細胞リンパ腫の1例 . 肺癌64 ( 6 ) 872 - 877 2024.10Reviewed

Language：Japanese Publisher：(NPO)日本肺癌学会

背景.血管内大細胞型B細胞リンパ腫(intravascular large B-cell lymphoma:IVLBCL)は血管,主に毛細血管内腔でリンパ腫細胞が増殖する節外性大細胞型B細胞リンパ腫の稀なタイプである.今回肺癌に対する免疫チェックポイント阻害薬(immune checkpoint inhibitor:ICI)併用薬物療法中に,鑑別困難であったIVLBCLの1例を経験したので報告する.症例.68歳男性.左上葉肺腺癌(cT2a(PL1)N0M1c(骨髄,脾臓)stage IVB)に対する維持療法中に全身倦怠感・呼吸困難感を認め,入院した.甲状腺機能低下などを認めたため,免疫関連副作用(immune-related adverse events:irAE)として加療するも改善しなかった.悪性リンパ腫や骨髄転移の再発を考慮し複数回骨髄穿刺を行うも悪性細胞は認めず,ランダム皮膚生検でIVLBCLの診断を得た.結論.IVLBCLはリンパ節腫大を認めない,特異的所見が乏しい悪性リンパ腫である.ICI投与中にはirAEとの鑑別に挙げ,積極的な検査の追加が重要である.(著者抄録)

Nayuta Higa, Toshiaki Akahane, Mari Kirishima, Hajime Yonezawa, Ryutaro Makino, Hiroyuki Uchida, Seiya Yokoyama, Tomoko Takajo, Ryosuke Otsuji, Yutaka Fujioka, Yuhei Sangatsuda, Daisuke Kuga, Hitoshi Yamahata, Nobuhiro Hata, Nobutaka Horie, Masamichi Kurosaki, Junkoh Yamamoto, Koji Yoshimoto, Akihide Tanimoto, Ryosuke Hanaya . All-in-one bimodal DNA and RNA next-generation sequencing panel for integrative diagnosis of glioma. . Pathology, research and practice263 155598 - 155598 2024.9Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Previously, we constructed a DNA-based next-generation sequencing (NGS) panel for an integrated diagnosis of gliomas according to the 2021 World Health Organization classification system. The aim of the current study was to evaluate the feasibility of a modified panel to include fusion gene detection via RNA-based analysis. Using this bimodal DNA/RNA panel, we analyzed 210 cases of gliomas and others to identify fusion genes in addition to gene alterations, including TERT promoter (TERTp) mutation and 1p/19q co-deletion, in formalin-fixed paraffin-embedded tissues. Of the 210 patients, fusion genes were detected in tumors of 35 patients. Eighteen of 112 glioblastomas (GBs) harbored fusion genes, including EGFR and FGFR3 fusions. In IDH-mutant astrocytoma, 6 of 30 cases showed fusion genes such as MET and NTRK2 fusions. Eleven molecular GBs and 20 not-elsewhere-classified cases harbored no gene fusions. Other 11 tumors including ependymoma, pilocytic astrocytoma, diffuse hemispheric glioma, infant-type hemispheric glioma, and solitary fibrous tumors exhibited diagnostic fusion genes. Overall, our results suggest that the all-in-one bimodal DNA/RNA panel is reliable for detecting diagnostic gene alterations in accordance with the latest WHO classification. The integrative pathological and molecular strategy could be valuable in confirmation of diagnosis and selection of treatment options for brain tumors.

DOI： 10.1016/j.prp.2024.155598

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Mitsuho Hirahara, Masatoyo Nakajo, Ikumi Kitazano, Megumi Jinguji, Atsushi Tani, Koji Takumi, Kiyohisa Kamimura, Akihide Tanimoto, Takashi Yoshiura . Usefulness of the Primary Tumor Standardized Uptake Value of Iodine-123 Metaiodobenzylguanidine for Predicting Metastatic Potential in Pheochromocytoma and Paraganglioma. . Molecular imaging and biology26 ( 6 ) 1005 - 1015 2024.9Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To examine the usefulness of semi-quantitative analysis using the standardized uptake value (SUV) of iodine-123 metaiodobenzylguanidine ([123I]-MIBG) for predicting metastatic potential in patients with pheochromocytoma (PHEO) and paraganglioma (PGL). PROCEDURES: This study included 18 PHEO and 2 PGL patients. [123I]-MIBG visibility and SUV-related parameters (SUVmax, SUVmean, tumor volume of [123I]-MIBG uptake [TV_MIBG], and total lesion [123I]-MIBG uptake) were compared with the pathological grading obtained using the Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and the Grading System for Adrenal Pheochromocytoma and Paraganglioma (GAPP), which are used to predict metastatic potential. The PASS scores were categorized as < 4 and ≥ 4. Based on the GAPP scores, PHEOs/PGLs were categorized as follows: well, moderately, and poorly differentiated tumors. The Mann-Whitney U test or Spearman's rank correlation was used to assess differences or associations between two quantitative variables. RESULTS: All PHEOs/PGLs were visualized on [123I]-MIBG scintigraphy. There were 16 PASS < 4 and 4 PASS ≥ 4 tumors. Moreover, 11 and 9 tumors were well and moderately differentiated, respectively. The uptake scores and SUV-related parameters significantly differed between tumors with a PASS score of < 4 and those with a PASS score of ≥ 4 (each, p > 0.05). Moderately differentiated tumors had significantly higher uptake scores and SUV-related parameters except TV_MIBG than well-differentiated tumors (each, p < 0.05). The GAPP score was positively correlated with the uptake scores and SUV-related parameters (each, p < 0.05) except TV_MIBG. CONCLUSIONS: The primary tumor [123I]-MIBG uptake assessed using SUV-related parameters can be an imaging tool for predicting metastatic potential in patients with PHEO/PGL.

DOI： 10.1007/s11307-024-01952-8

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Yuki Tanaka, Manabu Natsumeda, Masayuki Ohashi, Rie Saito, Nayuta Higa, Toshiaki Akahane, Hideki Hashidate, Junko Ito, Satoshi Fujii, Atsushi Sasaki, Akihide Tanimoto, Ryosuke Hanaya, Kei Watanabe, Makoto Oishi, Hiroyuki Kawashima, Akiyoshi Kakita . Primary spinal cord gliomas: Pathologic features associated with prognosis. . Journal of neuropathology and experimental neurology83 ( 12 ) 1010 - 1019 2024.7Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Primary spinal cord gliomas are rare and are associated with high mortality. Unlike brain tumors, the clinicopathological features of spinal cord gliomas are not well defined. We analyzed clinical, histopathology, and immunohistochemical features and overall survival (OS) of 25 patients with primary spinal cord gliomas treated between 1994 and 2023 at 4 institutions. IDH1 R132H, H3K27M, and p53 were assessed by immunohistochemistry (IHC). Four (16%), 5 (20%), 2 (8%), and 13 (52%) patients were diagnosed as having grades 1, 2, 3, and 4 gliomas according to the World Health Organization (WHO) 2021 classification, respectively. One case (4%), with a circumscribed diffuse midline glioma, H3K27-altered, had a rare molecular profile and could not be graded. IHC demonstrated H3K27M positivity, indicative of H3F3A K27M or HIST1H3B K27M mutation, in 9 (36%) patients. H3K27me3-loss was evident in 13 (52%) patients. In one patient with a grade 1 tumor that showed negative staining for H3K27M and H3K27me3 loss, numbers of EZHIP-positive cells were increased, suggesting diffuse midline glioma, H3K27-altered (WHO grade 4). H3K27me3 loss, frequency of p53 positive cells (≥10%), MIB-1 index (≥10%), and high histopathological grades significantly correlated with poor OS. These results indicate the pathological and immunohistochemical characteristics of primary spinal cord gliomas that impact prognosis.

DOI： 10.1093/jnen/nlae084

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寺原航, 田崎貴嗣, 霧島茉莉, 北薗育美, 村上未樹, 田畑和宏, 東美智代, 野元祐輔, 白濱浩, 谷本昭英 . 第2期梅毒疹の2症例 . 診断病理41 ( 3 ) 281 - 285 2024.7Reviewed

Language：Japanese Publisher：(一社)日本病理学会

症例1は30代男性,頭痛と全身に1cm大の紅斑や丘疹を認めた。症例2は30代女性,後頸部や両手掌,外陰に2cm大までの鱗屑を伴う紅斑や丘疹を認めた。皮膚生検ではいずれも過角化,不全角化と表皮内の好中球浸潤,基底層の空胞変性,真皮浅層から深層におよぶリンパ球,形質細胞や好中球の浸潤を認めた。免疫組織化学的にT.pallidumの菌体を認め,第2期梅毒と診断した。単一の炎症性皮膚疾患のカテゴリーに入れ難い,多彩な組織像を呈する皮疹には,第2期梅毒を鑑別することが重要である。(著者抄録)

寺原航, 田崎貴嗣, 霧島茉莉, 北薗育美, 村上未樹, 田畑和宏, 東美智代, 谷本昭英 . Low grade non-intestinal-type sinonasal adenocarcinomaの1例 . 診断病理41 ( 3 ) 255 - 259 2024.7Reviewed

Language：Japanese Publisher：(一社)日本病理学会

症例は30代男性。左鼻腔を充満し鼻中隔に基部を持つ有茎性病変を認めた。組織学的には,異型に乏しい類円形核を有する腫瘍細胞がback-to-back構造を示す小型の腺管を形成して密に増殖しており,間質の介在はわずかであった。腫瘍細胞はCK7,S-100,SOX10にびまん性に陽性,CDX2が部分的に陽性,DOG-1は管腔内側を縁取る陽性像を認め,low grade non-intestinal-type sinonasal adenocarcinomaと診断した。本腫瘍は鼻腔・副鼻腔に発生する稀な腫瘍であり,腺房細胞癌,漿粘液腺過誤腫などが鑑別となるが,いずれも鼻腔内でポリープ状を呈するため,組織学的検索により鑑別することが重要である。(著者抄録)

霧島茉莉, 村上未樹, 野口紘嗣, 田崎貴嗣, 北薗育美, 田畑和宏, 東美智代, 谷本昭英 . 上縦隔進展と左胸腔への突出を伴う脊髄血管芽腫の1例 . 診断病理41 ( 3 ) 267 - 273 2024.7Reviewed

Language：Japanese Publisher：(一社)日本病理学会

血管芽腫は腫瘍性間質細胞と豊富な血管からなる腫瘍である。縦隔進展を伴う稀な脊髄血管芽腫を経験したので報告する。70代女性で,胸髄から上縦隔へ進展し,左胸腔へ突出するダンベル型腫瘤を認めた。組織学的には淡明な細胞質を有する腫瘍細胞のシート状配列と豊富な血管網を認め,免疫組織化学的に腫瘍細胞はα-inhibinとS100蛋白に陽性であった。稀ではあるが縦隔や胸腔に及ぶ脊髄腫瘍の鑑別に血管芽腫を挙げることは重要であり,脊髄血管芽腫ではvon Hippel-Lindau病の精査と経過観察が必要である。(著者抄録)

中島真由美, 秋山大成, 高浪浩太, 徳村祐太, 槌田紋子, 南新洋美, 中村敬夫, 東美智代, 谷本昭英 . 神経内分泌腫瘍との鑑別が困難であった肺原発悪性黒色腫の1例 . 日本臨床細胞学会九州連合会雑誌55 37 - 40 2024.7Reviewed

Language：Japanese Publisher：日本臨床細胞学会-九州連合会

背景肺の悪性黒色腫のほとんどは他臓器からの転移であり,肺原発の症例は極めて稀である.今回,神経内分泌腫瘍との鑑別に苦慮した肺原発悪性黒色腫の一例を経験したので報告する.症例 80代,男性.右肺上葉の充実性結節に対して気管支鏡検査が施行された.気管支洗浄細胞診では,粗顆粒状の核クロマチンを有する裸核状の小型異型細胞集塊を認めた.核小体は目立たず,索状やロゼット様の配列と思われる部分を認め,神経内分泌腫瘍が示唆された.異型細胞の内外に褐色色素を散見し,核内封入体を有する異型細胞も認められた.気管支生検では,大小不同の目立つ類円形核と広い胞体を有した腫瘍細胞を認めた.免疫組織化学では,HMB-45およびMelan A陽性であり悪性黒色腫と診断した.全身検索の結果,原発巣を示唆する部位は他に認められず,肺原発の悪性黒色腫と考えられた.結語メラニン顆粒などの色素顆粒を鑑別し,顆粒含有細胞の形態を注意深く観察することで,特徴的な細胞所見に乏しい症例においても,悪性黒色腫を鑑別診断に挙げることが可能であると考えられた.(著者抄録)

Ikumi Kitazono, Toshiaki Akahane, Hiromi Sasaki, Yasuyo Ohi, Yoshiaki Shinden, Tomoko Takajo, Takashi Tasaki, Michiyo Higashi, Hirotsugu Noguchi, Masanori Hisaoka, Akihide Tanimoto . Malignant phyllodes tumor with EGFR variant III mutation: A rare case report with immunohistochemical and genomic studies. . Pathology, research and practice259 155389 - 155389 2024.7Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

A female in her 60's presented with a left-sided breast mass. A core needle biopsy specimen showed diffuse proliferation of a round cell tumor, which was positive for vimentin, NKX2.2, BCOR, and focal CD99 on immunohistochemistry (IHC). No fusion genes of the Ewing family sarcomas were detected. With a tentative diagnosis of primary breast sarcoma (PBS), total mastectomy was performed after chemotherapy. The resected tissues showed proliferation of round or spindle-shaped tumor cells with a high nuclear-to-cytoplasmic ratio, exhibiting solid and fascicular arrangements but no epithelial component or organoid pattern. While IHC indicated no particular histological diagnosis, genomic examination revealed gene alterations in MED12 p.G44D, MLL2 (KMT2D) p.T1496fs*27, and EGFR variant III (vIII). Moreover, a retrospective IHC study showed overexpression of EGFRvIII. A malignant phyllodes tumor (PT) with extensive sarcomatous overgrowth was indicated as an integrative diagnosis. This is a rare case of a malignant PT harboring EGFRvIII. The present case provides an importance of accurate diagnosis and genomic analysis of rare breast tumors, as malignant PT and PBS are different in its treatment strategy and prognosis.

DOI： 10.1016/j.prp.2024.155389

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Lynne Takada, Takafumi Kawano, Keisuke Yano, Yumiko Iwamoto, Masato Ogata, Chihiro Kedoin, Masakazu Murakami, Koshiro Sugita, Shun Onishi, Mitsuru Muto, Mari Kirishima, Akihide Tanimoto, Satoshi Ieiri . Ovarian endometrioma: a report of a pediatric case diagnosed prior to menstruation. . Surgical case reports10 ( 1 ) 152 - 152 2024.6Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Ovarian endometriomas (OEs) are rarely found in the pediatric population, especially before menstruation. We report a 6-year-old girl who was postoperatively diagnosed with OE before menstruation. CASE PRESENTATION: A 6-year-old girl presented to a local pediatrician with abdominal pain and vomiting. Abdominal ultrasonography revealed a multilocular cystic lesion to the left of the bladder. Magnetic resonance imaging (MRI) revealed similar findings, with the contents of the cyst showing a low signal on T1-weighted imaging and a high signal on T2-weighted imaging. The patient was referred to our institution for further examination. Enhanced computed tomography (CT) showed a multilocular cystic lesion sized 56 × 44 × 30 mm with partial calcification. The left ovarian vein was dilated, suggesting the origin of the tumor to be the left ovary. Extirpation of the lesion was performed under laparoscopic assistance. Pathological findings indicated an ovarian endometrioma. To our knowledge, this is the youngest report of an OE diagnosed in a patient prior to menstruation. CONCLUSIONS: OEs in children before menstruation are extremely rare; thus, the long-term prognosis is yet to be determined.

DOI： 10.1186/s40792-024-01951-5

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Takada Lynne, Kawano Takafumi, Yano Keisuke, Iwamoto Yumiko, Ogata Masato, Kedoin Chihiro, Murakami Masakazu, Sugita Koshiro, Onishi Shun, Muto Mitsuru, Kirishima Mari, Tanimoto Akihide, Ieiri Satoshi . Ovarian endometrioma: a report of a pediatric case diagnosed prior to menstruation(タイトル和訳中) . Surgical Case Reports10 s40792 - 024 2024.6Reviewed

Hideyuki Oi, Yuto Hozaka, Toshiaki Akahane, Kosuke Fukuda, Tetsuya Idichi, Kiyonori Tanoue, Yoichi Yamasaki, Yota Kawasaki, Yuko Mataki, Hiroshi Kurahara, Michiyo Higashi, Akihide Tanimoto, Takao Ohtsuka . Genetic assessment of IPMN for predicting concomitant pancreatic ductal adenocarcinoma. . Pancreas53 ( 10 ) e790 - e795 2024.5Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Krüppel-like transcription factor 4(KLF4) mutations are more frequently observed in low-grade lesions than in high-grade lesions of intraductal papillary mucinous neoplasms (IPMN) of the pancreas. However, the role of KLF4 mutations in IPMNs with concomitant pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study clarified the rate and effect of KLF4 mutations in IPMN with concomitant PDAC. METHODS: DNA was extracted from 65 formalin-fixed and paraffin-embedded samples from 52 patients including 13 IPMN with concomitant PDAC and 39 IPMN alone. A comprehensive screening was performed using next-generation sequencing (NGS) for the 5 IPMNs with concomitant PDAC and 5 IPMNs alone, followed by targeted sequencing for KLF4, GNAS, and KRAS mutations. RESULTS: In NGS screening, KRAS mutations were observed in all samples except for one, GNAS mutation in two IPMNs with concomitant PDAC, and a KLF4 mutation in one IPMN with concomitant PDAC. Targeted sequence detected KLF4 mutations in 11 of the 52 IPMNs. Concomitant PDAC developed only in the non-intestinal, non-invasive, and branch duct IPMN cases, and KLF4 mutations were more frequent in this IPMN type than in the other type (36% vs. 10%, p = 0.04). For this IPMN type with KLF4 mutation, PDAC-prediction sensitivity, specificity, and accuracy were 63%, 82%, and 79%, respectively. CONCLUSION: For selected IPMNs with non-intestinal, non-invasive, and branch duct, genetic assessment might be a helpful tool for predicting the possible development of concomitant PDAC, although a prospective validation study using a larger study population is needed.

DOI： 10.1097/MPA.0000000000002373

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大西俊平, 山崎文之, Jeet Amatya Vishwa, 米澤潮, 比嘉那優大, 赤羽俊章, 谷本昭英, 武島幸男, 花谷亮典, 堀江信貴 . Astrocytoma,IDH-mutant with primitive neuronal componentの一例 . Brain Tumor Pathology41 ( Suppl. ) 146 - 146 2024.5Reviewed

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Papers - akihide Tanimoto