Faculty Profiles - akihide Tanimoto

Papers - akihide Tanimoto

Division display 221 - 240 of about 561 ／ All the affair displays >>

Yoshihisa Umekita, Yasuyo Ohi, Orie Iwaya, Masakazu Souda, Yasuaki Sagara, Shugo Tamada, Daisuke Yotsumoto, Akihide Tanimoto . Maspin mRNA expression in sentinel lymph nodes predicts non-SLN metastasis in breast cancer patients with SLN metastasis. . Histopathology73 ( 6 ) 916 - 922 2018.12Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

AIMS: Maspin is known to be a tumour suppressor protein, but its prognostic significance in breast cancer patients is controversial. There is no report focusing on maspin expression in metastatic carcinoma of sentinel lymph nodes (SLNs); we thus investigated maspin mRNA expression in SLNs using the remaining specimens after the one-step nucleic acid amplification (OSNA) assay. METHODS AND RESULTS: Ninety-three breast cancer patients with SLNs metastasis detected by the OSNA assay were enrolled. All patients experienced additional axillary lymph nodes (LNs) dissection and all dissected LNs were examined histopathologically. Maspin mRNA expression in SLNs was detected in 49.5% (46 of 93) and was correlated significantly with the presence of non-SLN metastasis (P < 0.0001) and ≥4 LN metastases (P = 0.029). In a multivariate logistic analysis, maspin mRNA expression in SLNs (P = 0.0015) had the most significant effect on predicting non-SLN metastasis, followed by pathological tumour size (P = 0.0039) and lymphovascular invasion (P = 0.009). The status of maspin mRNA expression in SLNs was correlated significantly with that of maspin protein expression in the primary carcinoma (P < 0.0001). CONCLUSIONS: This is the first study, to our knowledge, demonstrating that maspin mRNA expression in SLNs is an independent predictor of non-SLN metastasis and the presence of ≥4 LN metastases in breast cancer patients with SLN metastasis. The investigation of maspin mRNA expression in SLNs using the remaining specimens after the OSNA assay may be useful for predicting the further progression of metastatic carcinoma in breast cancer patients with SLNs metastasis.

DOI： 10.1111/his.13718

PubMed

researchmap

Shun Onishi, Tatsuru Kaji, Seiro Machigashira, Waka Yamada, Ryuta Masuya, Kazuhiko Nakame, Masato Kawano, Keisuke Yano, Koji Yamada, Takafumi Kawano, Motoi Mukai, Takako Yoshioka, Akihide Tanimoto, Satoshi Ieiri . The effect of intravenous lipid emulsions and mucosal adaptation following massive bowel resection. . Journal of pediatric surgery53 ( 12 ) 2444 - 2448 2018.12

AIMS AND OBJECTIVES: Fish oil (FO) lipid emulsion and a new lipid emulsion (SMOF) are important treatments for intestinal failure-associated liver disease. We evaluated the efficacy of FO and SMOF lipid emulsion on intestinal mucosal adaptation using a total parenteral nutrition (TPN)-supported rat model of short bowel syndrome. MATERIAL & METHODS: Sprague-Dawley rats underwent jugular vein catheterization and 90% small bowel resection and were divided into three groups: TPN with soy bean oil lipid emulsion (SO group), FO lipid emulsion (FO group), or SMOF (SMOF group). On day 13, the rats were euthanized, and the small intestine was harvested. The microscopic morphology and crypt cell proliferation rate (CCPR) were then evaluated. RESULTS: The villus height of the ileum in the SMOF group was significantly higher than in the SO group. The crypt depth of the intestine in the SMOF group was significantly lower than in the SO group. The CCPRs of the intestine in the FO and SMOF groups were both higher than in the SO group. CONCLUSIONS: Lipid emulsion affected the bowel morphology, such as the mucosa as well as the intestinal smooth muscle. Further studies are needed to clarify the mechanisms.

DOI： 10.1016/j.jpedsurg.2018.08.019

PubMed

researchmap

桝屋隆太, 連利博, 川野正人, 矢野圭輔, 山田耕嗣, 山田和歌, 町頭成郎, 川野孝文, 中目和彦, 向井基, 加治建, 谷本昭英, 家入里志 . 胆道閉鎖症肝生検検体における門脈低形成所見の検討 . 日本小児外科学会雑誌54 ( 7 ) 1408 - 1409 2018.12

Yuki Nomoto, Yuko Kijima, Yoshiaki Shinden, Munetugu Hirata, Yuka Eguchi, Heiji Yoshinaka, Ikumi Kitazono, Tsubasa Hiraki, Akihide Tanimoto, Shoji Natsugoe . Two cases of radiation-associated angiosarcoma of the breast. . Surgical case reports4 ( 1 ) 132 - 132 2018.11Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The incidence of radiation-associated angiosarcoma (RAA) of the breast has been increasing, and its prognosis is reportedly poor. It is important to remove tumor tissues completely to prevent recurrence. CASE PRESENTATION: We report two cases of patients with RAA of the breast. Both patients had a nodule in their remaining breast a few years after undergoing breast-conserving surgery and radiation therapy for breast cancer. The nodules were diagnosed as angiosarcoma by skin biopsy and open biopsy, respectively. To determine the extent of lesion spread, mapping biopsy was performed before surgery. Both patients underwent mastectomy, extensive skin resection, and split skin grafting. Pathological findings showed that their tumors could be completely resected. After surgery, chemotherapy was performed. CONCLUSION: In our cases, no local or distant recurrence has been detected in either patient for over 4 years. We identified the range of tumor invasion by preoperative mapping biopsy and completely resected all tumor tissue.

DOI： 10.1186/s40792-018-0539-8

PubMed

researchmap

有馬大智, 佐々木裕美, 嶋田博文, 永野聡, 天辰愛弓, 瀬戸口啓夫, 後藤優子, 平木翼, 谷本昭英, 小宮節郎 . 背部に発生した紡錘形細胞脂肪腫の1例 . 整形外科と災害外科67 ( 4 ) 857 - 860 2018.9

Publisher：西日本整形・災害外科学会

【はじめに】紡錘形細胞脂肪腫spindle cell lipomaは脂肪腫の特殊型で、中年男性の後頸部、肩、背部に好発する稀な腫瘍である。【症例】70歳男性、背部皮下に弾性軟、約8cm大の腫瘤を認めた。MRI上T2強調画像にて著明な高信号を主体とし、漸増性の増強効果を呈し内部に微小な脂肪成分を認め、分葉状の形態を呈していた。粘液型脂肪肉腫との鑑別が必要と考え、生検術を施行。肉眼的に粘液性の成分と一部線維性の組織を採取した。病理所見では粘液腫様の間質内に存在する短紡錘形の腫瘍細胞はCD34陽性、ロープ状膠原線維の存在やMDM2陰性から紡錘形細胞脂肪腫と診断し、辺縁切除術を施行した。【まとめ】紡錘形細胞脂肪腫は術前診断が難しく、他の脂肪系腫瘍である粘液型脂肪肉腫や異型脂肪腫様腫瘍との鑑別が重要である。画像所見や病理所見、臨床所見について文献的考察を加え報告する。(著者抄録)

Language：Japanese Publisher：西日本整形・災害外科学会

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00766&link_issn=&doc_id=20181017080058&doc_link_id=130007507272&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007507272&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Jing Zhang, Xin Guo, Taiji Hamada, Seiya Yokoyama, Yuka Nakamura, Jianbo Zheng, Nozomu Kurose, Yasuhito Ishigaki, Hidetaka Uramoto, Akihide Tanimoto, Sohsuke Yamada . Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury. . International journal of molecular sciences19 ( 9 ) 2018.8Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Accumulating evidence indicates that oxidative stress plays a critical role in initiating the progression of inflammatory and fibrotic liver diseases, including cholestatic hepatitis. Peroxiredoxin 4 (PRDX4) is a secretory antioxidase that protects against oxidative damage by scavenging reactive oxygen species (ROS) in both the intracellular compartments and extracellular space. In this study, we examined the in vivo net effects of PRDX4 overexpression in a murine model of cholestasis. To induce cholestatic liver injury, we subjected C57BL/6J wild-type (WT) or human PRDX4 (hPRDX4) transgenic (Tg) mice to sham or bile duct ligation (BDL) surgery for seven days. Our results showed that the liver necrosis area was significantly suppressed in Tg BDL mice with a reduction in the severity of liver injuries. Furthermore, PRDX4 overexpression markedly reduced local and systemic oxidative stress generated by BDL. In addition, suppression of inflammatory cell infiltration, reduced proliferation of hepatocytes and intrahepatic bile ducts, and less fibrosis were also found in the liver of Tg BDL mice, along with a reduced mortality rate after BDL surgery. Interestingly, the composition of the hepatic bile acids (BAs) was more beneficial for Tg BDL mice than for WT BDL mice, suggesting that PRDX4 overexpression may affect BA metabolism during cholestasis. These features indicate that PRDX4 plays an important role in protecting against liver injury following BDL and might be a promising therapeutic modality for cholestatic diseases.

DOI： 10.3390/ijms19092509

PubMed

researchmap

Shun Onishi, Tatsuru Kaji, Waka Yamada, Kazuhiko Nakame, Seiro Machigashira, Masato Kawano, Keisuke Yano, Toshio Harumatsu, Koji Yamada, Ryuta Masuya, Takafumi Kawano, Motoi Mukai, Taiji Hamada, Masakazu Souda, Takako Yoshioka, Akihide Tanimoto, Satoshi Ieiri . Ghrelin stimulates intestinal adaptation following massive small bowel resection in parenterally fed rats. . Peptides106 59 - 67 2018.8Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1), has several pleiotropic effects. We investigated whether ghrelin induces intestinal adaptation in parenterally fed rats with SBS. METHODS: Sprague-Dawley rats underwent venous catheterization and were divided into 3 groups: those receiving 90% small bowel resection while leaving the proximal jejunum and distal ileum (90% SBR) with TPN (SBS/TPN group), those receiving 90% SBR with TPN + ghrelin (SBS/TPN/ghrelin group), and those receiving sham operation and fed chow (sham group). Ghrelin was administered intravenously at 10 μg/kg/day. On Day 13, the rats were euthanized and the small intestine harvested, and the histology and crypt cell proliferation rates (CCPR), apoptosis, and nutrient transporter protein levels were analyzed and the plasma hormones were measured. RESULTS: The villus height and crypt depth of the ileum in the SBS/TPN/ghrelin group were significantly higher than in the SBS/TPN group. The CCPR of the jejunum and the ileum significantly increased by the administration of ghrelin; however, the apoptosis rates did not significantly differ between the SBS/TPN and SBS/TPN/ghrelin groups. Significant differences did not exist in the plasma IGF-1 and nutrient transporter protein levels among three groups. CONCLUSIONS: The intravenous administration of ghrelin stimulated the morphological intestinal adaptation of the ileum to a greater degree than the jejunum due to the direct effect of ghrelin.

DOI： 10.1016/j.peptides.2018.06.009

PubMed

researchmap

宮本陽子, 川口博明, 谷本昭英 . 雄ラット乳腺の発達とホルモン・レセプターの関連性(Relationship between morphological development and sex hormone receptor expression of mammary glands with age in male rats) . Experimental Animals67 ( 3 ) 361 - 371 2018.7

Language：English Publishing type：Research paper (scientific journal) Publisher：(公社)日本実験動物学会

14-100日齢の雄Sprague-Dawleyラットの乳腺における経時的形態学的変化とホルモン・レセプター発現の関連について、性成熟後に出現する"oxyphilic cells(OCs)"(豊富な好酸性細胞質を有する細胞)を主体に形態学的検索を行った。肉眼的観察、Whole mount標本及びHE標本を用いた観察を行い、OCsについては透過型電子顕微鏡(TEM)を用いて精査した。更に、アンドロゲン・レセプター(AR)、エストロゲン・レセプター(ER)及びプロゲステロン・レセプター(PgR)について免疫組織学的検索を行った。肉眼的に成熟期(50-100日齢)の乳腺は褐色を帯びており、組織学的には若齢期(14-35日齢)と成熟期では構成細胞の形態が異なり、成熟期ではOCsが認められた。ER及びPgRはすべての時期で、ARは成熟期のみで発現した。OCsではAR発現が優位であり、その割合は経時的に増加した。以上の結果から成熟期の乳腺発達とAR発現は強く関連していると示唆された。また、TEMでは、OCsの細胞質に多数の脂肪滴、変形・大型化したミトコンドリア等が認められた。(著者抄録)

DOI： 10.1538/expanim.17-0134

PubMed

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J04703&link_issn=&doc_id=20180802220007&doc_link_id=130007423739&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007423739&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Kie Honjo, Taiji Hamada, Takuya Yoshimura, Seiya Yokoyama, Sohsuke Yamada, Yan-Qin Tan, Lai K Leung, Norifumi Nakamura, Yasuyo Ohi, Michiyo Higashi, Akihide Tanimoto . PCP4/PEP19 upregulates aromatase gene expression via CYP19A1 promoter I.1 in human breast cancer SK-BR-3 cells. . Oncotarget9 ( 51 ) 29619 - 29633 2018.7Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

The Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is a novel breast cancer cell expressing peptide, originally found in the neural cells as an anti-apoptotic factor, could inhibit cell apoptosis and enhance cell migration and invasion in human breast cancer cell lines. The expression of PCP4/PEP19 is induced by estrogens in estrogen receptor-positive (ER+) MCF-7 cells but also highly expressed in ER- SK-BR-3 cells. In this study, we investigated the effects of PCP4/PEP19 on aromatase gene expression in MCF-7 and SK-BR-3 human breast cancer cells. In SK-BR-3 cells but not in MCF-7 cells, PCP4/PEP19 knockdown by siRNA silencing decreased the aromatase expression in gene transcriptional level. When PCP4/PEP19 was overexpressed by CMV promoter-driven PCP4/PEP19 expressing plasmid transfection, aromatase gene transcription increased in SK-BR-3 cells. This aromatase gene transcription is mainly mediated through promoter region PI.1, which is usually active in the placental tissue but not in the breast cancer tissue. These results indicate a new function of PCP4/PEP19 that would enhance aromatase gene upregulation to supply estrogens in heterogeneous cancer microenvironment.

DOI： 10.18632/oncotarget.25651

PubMed

researchmap

Publisher：(公社)日本実験動物学会

Language：English Publisher：(公社)日本実験動物学会

researchmap

Yoshinobu Saitoh, Takao Setoguchi, Takako Yoshioka, Junichiro Nishi, Akihide Tanimoto, Setsuro Komiya . Intraoperative evaluation of polymorphonuclear leukocyte during second-stage revision surgery promote overdiagnosis of persistent periprosthetic joint infection. . Acta orthopaedica et traumatologica turcica52 ( 3 ) 191 - 195 2018.5Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The aim of this study was to evaluate whether intraoperative histopathological examination could predict the risk of relapse of infection in periprosthetic joint infections (PJI). METHODS: The study included 25 patients (14 women and 11 men, with a mean age of 67.0 years (range, 37-83 years)), who had two-staged revision surgery for a PJI. Following prosthetic removal in the first stage, all patient underwent an intraoperative histopathological examination during the second stage. The patients were divided into PMNs-positive group (≥five PMNs per high-powered field) or -negative group (<five PMNs). A relapse was defined as the occurrence of PJI. Median follow-up was 51 months (range, 32-80 months) following second-stage revision surgery. RESULTS: Intraoperative histopathological revealed that 8.0% of cases were PMNs-positive. Postoperative histopathological examination revealed that 28.0% of cases were PMNs-positive. 28.0% of cases showed discrepancy between the PMNs-positivity. Intraclass correlation coefficient indicates poor reproducibility. Infection relapse after revision surgery occurred in two cases (8.0%); both relapse cases were from the PMNs-negative group. There was no statistical relationship between the presence of PMNs in periprosthetic tissue by intraoperative or postoperative histopathological examination and relapse of infection. CONCLUSIONS: Our findings showed that intraoperative histopathological examination could not predict the relapse of infection. Intraoperative histopathological examination promotes overdiagnosis of the requirement for re-implantation of antibiotic-impregnated cement and prolonged treatment periods. LEVEL OF EVIDENCE: Level III, diagnostic study.

DOI： 10.1016/j.aott.2018.02.002

PubMed

researchmap

横山勢也, 東美智代, 谷本昭英, 米澤傑 . 【肝胆膵疾患のエピジェネティクスを学ぶ】膵疾患のエピジェネティクス膵癌におけるメチル化によるムチン発現調節 . 肝・胆・膵76 ( 5 ) 945 - 950 2018.5

横山勢也, 東美智代, 谷本昭英, 米澤傑 . 【肝胆膵疾患のエピジェネティクスを学ぶ】膵疾患のエピジェネティクス膵癌におけるメチル化によるムチン発現調節 . 肝胆膵76 ( 5 ) 945 - 950 2018.5

野元裕輔, 山筋好子, 川平尚生, 指宿敦子, 内田洋平, 多田浩一, 藤井一恭, 東裕子, 井内寛之, 宮下圭一, 大堀純一郎, 平木翼, 西正行, 谷本昭英, 金蔵拓郎 . 右前額部原発のmalignant spiradenomaの1例 . 西日本皮膚科80 ( 2 ) 164 - 165 2018.4

小倉葉月, 新田吉陽, 大井秀之, 平田宗嗣, 田上聖徳, 江口裕可, 中条哲浩, 喜島祐子, 霧島茉莉, 谷本昭英, 夏越祥次 . 急激に増大した若年性乳房悪性葉状腫瘍の1例 . 鹿児島県臨床外科学会誌29 16 - 17 2018.3

Publisher：鹿児島県臨床外科学会

症例は24歳女性で、手拳大の右乳房腫瘤が出現し、次第に小児頭大に増大した。右乳房に皮膚露出と出血を伴う腫瘍を認め、針生検にて悪性葉状腫瘍、紡錘細胞癌、間質肉腫などが疑われたため、貧血管理と手術目的で当院に緊急入院となった。右乳房に31×26×16cm大の巨大腫瘤を認めた。長径25cmにわたって腫瘍が露出しており、壊死と出血を認めた。造影CTで、右乳房に26cm大の内部不均一な腫瘤と右腋窩リンパ節の腫大を認めた。針生検病理像から悪性葉状腫瘍、紡錘細胞癌、間質肉腫が疑われたため、右乳房悪性腫瘍の術前診断で手術を施行した。術中の肉眼所見でも胸壁浸潤は認めず、腫瘍の完全切除が可能であった。病理組織学的所見では、大部分で強い核異型と多数の核分裂像を認め、悪性葉状腫瘍の診断であった。切除断端は陰性、摘出リンパ節にも転移は認めなかった。

Language：Japanese Publisher：鹿児島県臨床外科学会

researchmap

Kie Honjo, Tsubasa Hiraki, Michiyo Higashi, Hirotsugu Noguchi, Mitsuharu Nomoto, Takuya Yoshimura, Surinder K Batra, Suguru Yonezawa, Ichiro Semba, Norifumi Nakamura, Akihide Tanimoto, Sohsuke Yamada . Immunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phase. . Histology and histopathology33 ( 2 ) 201 - 213 2018.2Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：F HERNANDEZ

In mucoepidermoid carcinoma (MEC), the most common salivary gland carcinoma, there is a lack of novel prognostic markers, but post-operative early recurrence strongly affects the clinical course and a poor outcome. It is critical to predict which MEC patients are prone to develop recurrence/metastases. Mucins play pivotal roles in influencing cancer biology, thus affecting cell differentiation, adhesion, carcinoma invasion, aggressiveness and/or metastatic potential. Our aim is to elucidate the significance of expression profiles for mucins, particularly MUC4 and MUC6, and their correlations with various clinicopathological features and recurrence in salivary gland MECs. We performed immunohistochemical analyses on patients with surgically resected primary MEC using antibodies against mucin core proteins MUC4/8G7 and MUC6/CLH5 in 73 paraffin-embedded samples. Recurrence was noted in 15 of 73 (20.5%) patients. MUC4 or MUC6 expression was considered to be negative when <30% or 0% of the MEC cells showed positive staining, respectively. MUC4- and/or MUC6-negative expression respectively and variably showed a significant relationship to pathological tumor high-grade, the presence of lymphovascular invasion, lymph node metastasis and/or tumor-related death. In addition, MUC4 showed significantly negative co-expression with MUC6. Kaplan-Meier analyses revealed that not only single MUC4/6-negative expression but also the combination of both predicted significantly shorter disease-free and disease-specific survivals in MECs, especially within the first two years postoperatively. Therefore, each mucin plays a pivotal role in the pathogenesis of MEC progression. The detection of MUC4 and/or MUC6 might be a powerful parameter in the clinical management of MECs in the early postsurgical phase.

DOI： 10.14670/HH-11-913

Web of Science

PubMed

researchmap

Kaichiro Takeishi, Hiroaki Kawaguchi, Kohei Akioka, Michiko Noguchi, Emi Arimura, Masaharu Abe, Miharu Ushikai, Shinobu Okita, Akihide Tanimoto, Masahisa Horiuchi . Effects of dietary and lighting conditions on diurnal locomotor activity and body temperature in microminipigs . In Vivo32 ( 1 ) 55 - 62 2018.1Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：International Institute of Anticancer Research

The effects of dietary and lighting conditions on diurnal rhythm of locomotor activity (LA) and body temperature (BT) using four adult male microminipigs were investigated. Different feeding times, diet and lighting conditions were applied sequentially for 3 weeks in each phase as follows: Phase I: Morning mealtime, normal diet, 12-h lights on
phase II: mealtime changed to afternoon
phase III: diet changed to high-fat diet
phase IV: lighting changed to 20-h on
and phase V: phase I repeated. LA was measured by an actigraph which was worn on the body of each pig. A BT recording module (Thermochron Type-SL) was implanted in the neck subcutaneously. Phase II increased BT compared with phase I. Phase III increased LA and BT compared with phase II. Phase IV increased LA compared with phase III. LA in phase V was higher compared with phase I. These results can be extrapolated to other diurnal animals such as humans. This study provides an example of the effects of diet and lighting on biological activities in microminipigs under low-invasive procedures measuring LA and BT, leading to low variations in these measures.

DOI： 10.21873/invivo.11204

Scopus

PubMed

researchmap

　 PREV - NEXT 　

<akihide Tanimoto>

Papers - akihide Tanimoto