Faculty Profiles - akihide Tanimoto

Papers - akihide Tanimoto

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後藤優子, 山田壮亮, 霧島茉莉, 北薗育美, 平木翼, 東美智代, 畑中一仁, 谷本昭英 . 右肺静脈内に主座を置き左心房内まで達したグロムス腫瘍の稀少な1手術症例 . 診断病理35 ( 1 ) 25 - 30 2018.1

Publisher：(一社)日本病理学会

症例は32歳女性。胸部CTで右肺上葉の末梢から右上肺静脈を経て左心房内に達する数珠状の腫瘍を認め、右肺上葉切除が行われた。切除検体では最大4×2cmの白色充実性の腫瘍であった。組織学的には比較的均一な円形核を有する腫瘍細胞が充実性、シート状構造を呈し、免疫組織化学的にはvimentin、α-SMAにびまん性に強陽性、laminin、h-caldesmonは一部陽性であった。悪性度不明なグロムス腫瘍が肺静脈を経て心房内に達した症例は過去に報告がない。(著者抄録)

北薗育美, 山田壮亮, 上村豪, 霧島茉莉, 後藤優子, 平木翼, 東美智代, 田中和彦, 松山篤二, 谷本昭英 . 捺印細胞診所見の得られたPrimary pulmonary myxoid sarcoma with EWSR1-CREB1 translocationの1例 . 診断病理35 ( 1 ) 79 - 84 2018.1

Publisher：(一社)日本病理学会

症例は60歳代、女性。右肺上葉の18mm大の腫瘍が切除された。組織学的に、豊富な粘液腫状基質を背景に小型類円形〜卵円形核を有する腫瘍細胞の増殖が認められた。RT-PCRでEWSR1-CREB1融合遺伝子が検出され、primary pulmonary myxoid sarcoma with EWSR1-CREB1 translocationと診断した。捺印細胞診では、粘液状基質や炎症細胞を混じる短紡錘形から多角形の異型に乏しい細胞集塊を認め、炎症性変化との鑑別が必要であった。(著者抄録)

後藤優子, 山田壮亮, 霧島茉莉, 北薗育美, 平木翼, 東美智代, 畑中一仁, 谷本昭英 . 右肺静脈内に主座を置き左心房内まで達したグロムス腫瘍の稀少な1手術症例 . 診断病理35 ( 1 ) 25 - 30 2018.1Reviewed

Authorship：Last author Language：Japanese Publisher：(一社)日本病理学会

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北薗育美, 山田壮亮, 上村豪, 霧島茉莉, 後藤優子, 平木翼, 東美智代, 田中和彦, 松山篤二, 谷本昭英 . 捺印細胞診所見の得られたPrimary pulmonary myxoid sarcoma with EWSR1-CREB1 translocationの1例 . 診断病理35 ( 1 ) 79 - 84 2018.1Reviewed

Authorship：Last author Language：Japanese Publisher：(一社)日本病理学会

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Haesu Lee Motoyama, Sohsuke Yamada, Satoko Nakada, Nozomu Kurose, Akihide Tanimoto . Intraorbital ancient pilocytic astrocytoma of the optic nerve in neurofibromatosis type 1 patient presenting with sudden ocular pain. . SAGE open medical case reports6 2050313X18761310 2018Reviewed International journal

Language：English

Optic nerve pilocytic astrocytoma is an uncommon but well-known entity; however, intraorbital ancient pilocytic astrocytoma of the optic nerve is extremely rarely reported. To our knowledge, this is the first detailed description regarding the intraorbital ancient pilocytic astrocytoma, reported in available English literature, to date. We presented an extremely unusual neurofibromatosis type 1 case of a 17-year-old male's sudden ocular pain secondary to intraorbital pilocytic astrocytoma of the optic nerve with markedly cystic degeneration, fluid production, and hemorrhage, due to ancient and possibly ruptured glioma. Future prospective studies are required to validate the significance of intraorbital ancient pilocytic astrocytoma arising from the optic nerve and the close correlation with ruptured cystic degeneration and ocular pain, after collecting and investigating a larger number of its cases examined.

DOI： 10.1177/2050313X18761310

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有馬大智, 小宮節郎, 佐々木裕美, 嶋田博文, 永野聡, 天辰愛弓, 瀬戸口啓夫, 後藤優子, 平木翼, 谷本昭英 . 背部に発生した紡錘形細胞脂肪腫の1例 . 整形外科と災害外科67 ( 4 ) 857 - 860 2018

Publisher：西日本整形・災害外科学会

<p>【はじめに】紡錘形細胞脂肪腫spindle cell lipomaは脂肪腫の特殊型で，中年男性の後頚部，肩，背部に好発する稀な腫瘍である．【症例】70歳男性，背部皮下に弾性軟，約8 cm大の腫瘤を認めた．MRI上T2強調画像にて著明な高信号を主体とし，漸増性の増強効果を呈し内部に微小な脂肪成分を認め，分葉状の形態を呈していた．粘液型脂肪肉腫との鑑別が必要と考え，生検術を施行．肉眼的に粘液性の成分と一部線維性の組織を採取した．病理所見では粘液腫様の間質内に存在する短紡錘形の腫瘍細胞はCD34陽性，ロープ状膠原線維の存在やMDM2陰性から紡錘形細胞脂肪腫と診断し，辺縁切除術を施行した．【まとめ】紡錘形細胞脂肪腫は術前診断が難しく，他の脂肪系腫瘍である粘液型脂肪肉腫や異型脂肪腫様腫瘍との鑑別が重要である．画像所見や病理所見，臨床所見について文献的考察を加え報告する．</p>

DOI： 10.5035/nishiseisai.67.857

CiNii Research

Masahiro Sato, Kazuchika Miyoshi, Shingo Nakamura, Masato Ohtsuka, Takayuki Sakurai, Satoshi Watanabe, Hiroaki Kawaguchi, Akihide Tanimoto . Efficient Generation of Somatic Cell Nuclear Transfer-Competent Porcine Cells with Mutated Alleles at Multiple Target Loci by Using CRISPR/Cas9 Combined with Targeted Toxin-Based Selection System. . International journal of molecular sciences18 ( 12 ) 2017.12Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

The recent advancement in genome editing such a CRISPR/Cas9 system has enabled isolation of cells with knocked multiple alleles through a one-step transfection. Somatic cell nuclear transfer (SCNT) has been frequently employed as one of the efficient tools for the production of genetically modified (GM) animals. To use GM cells as SCNT donor, efficient isolation of transfectants with mutations at multiple target loci is often required. The methods for the isolation of such GM cells largely rely on the use of drug selection-based approach using selectable genes; however, it is often difficult to isolate cells with mutations at multiple target loci. In this study, we used a novel approach for the efficient isolation of porcine cells with at least two target loci mutations by one-step introduction of CRISPR/Cas9-related components. A single guide (sg) RNA targeted to GGTA1 gene, involved in the synthesis of cell-surface α-Gal epitope (known as xenogenic antigen), is always a prerequisite. When the transfected cells were reacted with toxin-labeled BS-I-B₄ isolectin for 2 h at 37 C to eliminate α-Gal epitope-expressing cells, the surviving clones lacked α-Gal epitope expression and were highly expected to exhibit induced mutations at another target loci. Analysis of these α-Gal epitope-negative surviving cells demonstrated a 100% occurrence of genome editing at target loci. SCNT using these cells as donors resulted in the production of cloned blastocysts with the genotype similar to that of the donor cells used. Thus, this novel system will be useful for SCNT-mediated acquisition of GM cloned piglets, in which multiple target loci may be mutated.

DOI： 10.3390/ijms18122610

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保坂優斗, 盛真一郎, 馬場研二, 喜多芳昭, 又木雄弘, 上之園芳一, 内門泰斗, 前村公成, 北園育美, 谷本昭英, 新地洋之, 夏越祥次 . 盲腸軸捻転症と続発性小腸軸捻転症を発症した混合性結合組織病の1例 . 日本消化器外科学会雑誌50 ( 12 ) 1008 - 1015 2017.12

Publisher：(一社)日本消化器外科学会

膠原病は結合組織の障害による消化管の運動異常により,しばしば消化管病変を合併する.症例は60歳の女性で,17年前に混合性結合組織病(mixed connective tissue disease;以下,MCTDと略記)の診断を受け,以後当院膠原病内科で加療を行っていた.腹痛を主訴に来院され,盲腸軸捻転症と診断し緊急手術を施行した.回結腸動脈を軸に360°捻転していたため,捻転解除術と盲腸固定術を行った.退院後の術後37日目に腹痛を来し,腹部CTで腸管捻転の所見を認めたため,緊急手術を施行した.捻転は解除されたが広範囲の回腸の拡張を認め,減圧処置後に腸管を切除する方針とした.初回手術から51日目に再々手術を行い,拡張し蠕動低下を認めた回腸を30cm切除した.病理検査で固有筋層の萎縮を認めた.限局した固有筋層の萎縮が限局性の蠕動低下,腸管内容物の停滞を起こし,軸捻転症が発症したものと推測した.MCTDに腸管軸捻転症の合併を認めた報告例はなく,病理所見も合わせて報告する.(著者抄録)

Sohsuke Yamada, Hiroaki Kawaguchi, Tomonobu Yamada, Xin Guo, Kei Matsuo, Taiji Hamada, Naoki Miura, Takashi Tasaki, Akihide Tanimoto . Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs. . Journal of atherosclerosis and thrombosis24 ( 11 ) 1150 - 1166 2017.11Reviewed

Language：English Publishing type：Research paper (scientific journal)

AIM: We have recently established a novel swine model for studies of atherosclerosis using MicrominipigsTM (µMPs) fed a high-fat/high-cholesterol diet (HcD). Using this swine model, we re-evaluated the effects of dietary cholic acid (CA) on serum lipid profile, atherosclerosis and hepatic injuries. METHODS: The µMPs were fed HcD supplemented with 0.7% CA (HcD＋CA) for eight weeks, and the effect of CA on serum lipoprotein levels, expression of oxidative stress markers, adiposity and lesion formation in the aorta, liver, and other organs was investigated. RESULTS: The HcD＋CA-fed group exhibited more visceral adiposity, progression of atherosclerosis and higher serum levels of oxidative stress markers than the HcD-fed group, even though they showed similar serum lipid levels. The liver demonstrated increased lipid accumulation, higher expression of oxidative stress markers, accelerated activation of foamy Kupffer cells and stellate cells, and increased hepatocyte apoptosis, indicating non-alcoholic fatty liver disease (NAFLD). Intriguingly, foamy macrophage mobilization was observed in various organs, including the reticuloendothelial system, pulmonary capillary vessels and skin very often in HcD＋CA-fed µMPs. CONCLUSION: To our knowledge, this is the first large animal model, in which visceral obesity, NAFLD and atherosclerosis are concomitantly induced by dietary manipulation. These data suggest the detrimental effects of CA, potentially through local and systemic activation of oxidative stress-induced signaling to macrophage mobilization, on the acceleration of visceral adiposity, atherosclerosis and NAFLD.

DOI： 10.5551/jat.39909

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Md Zahorul Islam, Hiroaki Kawaguchi, Naoki Miura, Noriaki Miyoshi, Emi Yamazaki-Himeno, Mitsuya Shiraishi, Atsushi Miyamoto, Akihide Tanimoto . Hypertension alters the endothelial-dependent biphasic response of bradykinin in isolated Microminipig basilar artery. . Microvascular research114 52 - 57 2017.11Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Angiotensin (Ang) II is known to promote vascular disease and hypertension, partly through its effect on vascular endothelium. Bradykinin (BK) is an endothelium-dependent agonist that induces relaxation followed by contraction of the porcine basilar artery through release of NO and PGF2α, respectively. In this study, we evaluated the effect of Ang II-induced hypertension on basilar artery responsiveness to BK in the Microminipig (MMPig). Ang II (200ng/kg/min) or vehicle was infused into MMPigs for 14days using an osmotic mini-pump and blood pressure was monitored regularly. The responsiveness of subsequently isolated basilar arteries was then measured using a micro organ bath system. MMPig basilar artery endothelial cells were cultured and stimulated with Ang II or vehicle for 48h. Mean blood pressure was significantly (P<0.05; n=5) higher in Ang II-infused MMPigs than in vehicle-infused MMPigs. In vitro, BK-induced endothelium-dependent dilation of isolated basilar artery specimens was abolished and BK-induced contraction was significantly increased (Emax: 15.85±2.42% and 56.54±2.71% of 60mM KCl in control and Ang II group respectively at 10-7M concentration of BK; P<0.01; n=5) in Ang II-infused MMPigs. Ang II stimulation of the endothelial cells significantly decreased (54.15% at 24h; P<0.05; n=three independent experiment performed in triplicate) the amount of BK-elicited NO and increased (44.27% at 24h; P<0.05; n=three independent experiment performed in triplicate) the amount of BK-elicited PGF2α. These results suggest that the decrease of NO and increase of PGF2α production from endothelial cells are responsible for cerebrovascular dysfunction in hypertension, possibly causing cerebrovascular contraction and thus increasing the risk of brain infarction.

DOI： 10.1016/j.mvr.2017.06.001

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Takashi Tasaki, Kazuhito Hatanaka, Mari Kirishima, Shun Ohnishi, Yuko Goto, Ikumi Kitazono, Tsubasa Hiraki, Sohsuke Yamada, Michiyo Higashi, Akihide Tanimoto . Aortic fibromuscular dysplasia complicated by dissection: a case report and review of literature . CARDIOVASCULAR PATHOLOGY31 41 - 46 2017.11Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Fibromuscular dysplasia (FMD) is an idiopathic, segmental, nonatherosclerotic, non-inflammatory vascular disease, which is often complicated by the occurrence of dissection. Although it is known to occur in all arteries, aortic involvement is relatively rare. To date, 33 cases of aortic FMD have been reported in available English literature, among which only three cases have been complicated by the occurrence of dissection. We describe the case of a 40-year-old woman diagnosed with aortic FMD complicated by the occurrence of a type A aortic dissection. Non-invasive imaging revealed an ascending to descending thoracic aneurysm measuring 8 cm in diameter associated with dissection. Histopathologically, a segment of the wall of the aneurysm showed architectural disorganization of the aortic wall with loss of elastic fibers, collagen deposition, and irregular proliferation of smooth muscle cells in the intima and media-features suggesting FMD. No atheromatous plaque or medial cystic degeneration was observed in the aorta. Although aortic FMD is sometimes fatal, it is often very difficult to diagnose using imaging techniques. Therefore, performing a histopathological diagnosis is very important and should be emphasized. (C) 2017 Published by Elsevier Inc.

DOI： 10.1016/j.carpath.2017.07.007

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Shuhei Ota, Tsuyoshi Sunagawa, Morikazu Shimabukuro, Youjirou Mitsumoto, Akihide Tanimoto . [Bowel Perforation in a Patient with Adult T-Cell Leukemia/Lymphoma]. . Gan to kagaku ryoho. Cancer & chemotherapy44 ( 12 ) 1494 - 1496 2017.11Reviewed

Language：Japanese Publishing type：Research paper (scientific journal)

Adult T-cell leukemia/lymphoma(ATLL)can infiltrate throughout various organs and frequently involves the gastrointestinal tract. However, bowel perforation in ATLL patients is rare. Herein, we present a case of ATLL with bowel perforation. A 75-year-old man presented with bowel distension. Computed tomography showed a large mass of the cecum. Edema and stenosis of the ascending colon was seen on colonoscopy, and tumor on the anal side of the stenosis was also found. After admission, the patient complained of abdominal pain with a peritoneal irritation sign. Free air was seen around a large mass of the cecum on computed tomography and an emergency operation was performed under the diagnosis of bowel perforation. Microscopic examination revealed bowel infiltration of ATLL. Gastrointestinal perforation can be caused by ATLL itself and is associated with a poor prognosis. The standard treatment for ATLL is chemotherapy but emergency surgery is necessary in case of perforation. It is important to observe the patient with ATLL carefully.

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Michiko Noguchi, Masaya Hirata, Hiroaki Kawaguchi, Akihide Tanimoto . Corpus luteum Regression Induced by Prostaglandin F-2 alpha in Microminipigs During the Normal Estrous Cycle . IN VIVO31 ( 6 ) 1097 - 1101 2017.11Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：INT INST ANTICANCER RESEARCH

Induction of corpus luteum regression and subsequent estrus using prostaglandin F-2 alpha (PGF(2 alpha)) in microminipigs was investigated. Microminipigs with normal estrous cycle were treated with PGF(2 alpha) as 0.75 mg (0.75 PG group, n=3) or 1.5 mg (1.5 PG group, n=4) dinoprost injected into the vulva at 24-h intervals at 10 days after the onset of estrus (D0), D1 and D2. Three microminipigs were not treated (control group). The estrous interval in the 1.5 PG group was significantly shortened compared to the control and 0.75 PG groups. Plasma progesterone levels started to decline and reached the base line in the 1.5 PG group significantly faster than in the control group. In conclusion, we demonstrate that multiple PGF(2 alpha) treatments can induce corpus luteum regression and estrous synchronization in female microminipigs.

DOI： 10.21873/invivo.11175

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大田修平, 砂川剛, 島袋盛一, 満元洋二郎, 谷本昭英 . 経過中穿孔を来した成人T細胞性白血病リンパ腫の1例 . 癌と化学療法44 ( 12 ) 1494 - 1496 2017.11

Publisher：(株)癌と化学療法社

成人T細胞性白血病リンパ腫(ATLL)は、全身諸臓器へ浸潤し、消化管へも高率に浸潤するが、穿孔を来すことはまれである。ATLLの消化管浸潤により、穿孔を来した症例を経験したため報告する。患者は腹部膨満感を主訴に受診した75歳、男性。腹部造影CTで回盲部に粗大な腫瘤を認め、下部消化管内視鏡検査では上行結腸に浮腫、狭窄があり、スコープは通過できず、上行結腸狭窄部肛門側に腫瘤を認めた。入院後、腹膜刺激症状を伴う腹痛が出現した。腹部造影CTで回盲部腫瘍周囲にfree airを認め、消化管穿孔の診断で緊急手術を施行した。術後の病理組織検査でATLLの消化管浸潤と診断された。ATLLの消化管浸潤は消化管穿孔を来すことがあり、穿孔を来した場合は予後不良である。ATLLの治療の主体は化学療法であるが、穿孔を来した場合は早急に手術が必要であり、慎重に経過をみる必要があると考えられた。(著者抄録)

大田修平, 砂川剛, 島袋盛一, 満元洋二郎, 谷本昭英 . 経過中穿孔を来した成人T細胞性白血病リンパ腫の1例 . 癌と化学療法44 ( 12 ) 1494 - 1496 2017.11Reviewed

Authorship：Last author Language：Japanese Publisher：(株)癌と化学療法社

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Takuya Yoshimura, Sohsuke Yamada, Takayuki Ishida, Kazuhiko Tanaka, Ikumi Kitazono, Kenichi Kume, Hiroshi Hijioka, Ichiro Semba, Norifumi Nakamura, Akihide Tanimoto . Cystadenocarcinoma of the minor salivary gland arising in the upper lip: A surgical case of an inadequate cytology specimen hampering conclusive diagnosis . Human Pathology: Case Reports9 64 - 68 2017.9Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Inc

Cystadenocarcinoma (CAC) of the salivary gland poses a diagnostic challenge to us, as this uncommon entity is extremely difficult to diagnose pre-operatively on an inadequate sample. However, markedly few papers have described the cytological features of CAC. An 82-year-old male presented with a history of a gradual increase in size and occasional mucous drainage from a swollen reddish nodule on the right upper lip. A retrospective examination of the cytological specimens from the drainage revealed a small number of clusters and scattered single cells of severely degenerated and mildly atypical epithelial cells with hyperchromatic dense nuclei and abundant clear cytoplasm, in a background of a large amount of mucinous material. We first interpreted this finding merely as the presence of atypical cells. However, a gross examination revealed a non-capsulated and relatively well-demarcated cystic lesion, grayish to whitish in color and measuring 13 × 9 mm in diameter, filled with mucin. A microscopic examination showed that the tumor had a central cystic cavity filled with mucinous material and was predominantly composed of the papillary proliferation of atypical columnar mucous epithelial cells with enlarged hyperchromatic nuclei, mixed with mitotic hot spots often projecting and melting into the mucinous cystic lumen, and focally involving the surrounding connective tissue. Therefore, we ultimately made a diagnosis of CAC of the minor salivary gland arising in the upper lip. Given the characteristic features of CAC, cytopathologists should be able to correctly diagnose this lesion based on multiple adequate fine needle aspiration samples.

DOI： 10.1016/j.ehpc.2016.08.006

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谷本昭英, 山田壮亮 . 【血管生物学と疾患】日常業務でよく遭遇する血管病変の最新知見粥状動脈硬化症の最新知見と病理 . 病理と臨床35 ( 8 ) 700 - 706 2017.8

Tsubasa Hiraki, Kazuhito Hatanaka, Kazunobu Sueyoshi, Yuko Goto, Ikumi Kitazono, Mari Kirishima, Sohsuke Yamada, Michiyo Higashi, Akihide Tanimoto . Unusual morphology of a pulmonary blastoma having an epithelial component with focally significant nuclear pleomorphism. . Pathology international67 ( 7 ) 370 - 372 2017.7Reviewed International journal

宿里亜李沙, 田中和彦, 窪田恵美, 竹下かおり, 西田ゆかり, 平木翼, 山田壮亮, 東美智代, 畑中一仁, 谷本昭英 . 腎細胞癌根治術後20年で甲状腺内孤立性転移を来たした1例 . 日本臨床細胞学会九州連合会雑誌48 89 - 93 2017.7

Publisher：日本臨床細胞学会-九州連合会

背景:術後長期を経た腎細胞癌の甲状腺への孤立性転移は非常に稀である。今回、我々は右腎細胞癌術後20年を経過して甲状腺内に孤立性転移を来たした症例を経験したので報告する。症例:70歳代、男性。前医のエコー検査にて甲状腺右葉内に45×41×32mm大の腫瘤を指摘され、当院を紹介受診された。穿刺吸引細胞診では、血性背景に濃縮コロイドや濾胞上皮細胞集塊に混じて、異型細胞が孤在性からシート状にごく少数認められた。異型細胞は淡明で豊富な細胞質と軽度腫大した核を有し、N/C比は小さいながらも核形不整と中心性の明瞭な核小体を認めた。異型細胞はごく少数で、且つ由来が不明であったため、「鑑別困難」(現:意義不明)と報告したところ、経過観察となっていた。その後、嗄声が出現したため再受診され、甲状腺癌による右反回神経麻痺と診断された。生検の結果、腎細胞癌の転移と判明し、CTにて周囲組織への広汎な浸潤が疑われたため、甲状腺全摘出術及び喉頭摘出術が施行された。結論:再検討では淡明細胞型腎細胞癌の細胞像であり、スクリーニング時に充分な情報があれば、腎細胞癌の転移を指摘しえた症例であった。甲状腺の単発性腫瘤であっても、病歴に留意し、腎細胞癌の転移も念頭においたスクリーニングが望まれる。(著者抄録)

宿里亜李沙, 田中和彦, 窪田恵美, 竹下かおり, 西田ゆかり, 平木翼, 山田壮亮, 東美智代, 畑中一仁, 谷本昭英 . 腎細胞癌根治術後20年で甲状腺内孤立性転移を来たした1例 . 日本臨床細胞学会九州連合会雑誌48 89 - 93 2017.7Reviewed

Authorship：Last author Language：Japanese Publisher：日本臨床細胞学会-九州連合会

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