Faculty Profiles - akihide Tanimoto

Papers - akihide Tanimoto

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早田正和, 巌谷織絵, 大井恭代, 谷本昭英 . 病理技術迅速FISH検査システムHER2 IQFISH pharmDxの有用性の検討 . 病理と臨床32 ( 5 ) 583 - 586 2014.5Reviewed

Masatatsu Yamamoto, Hiroshi Arimura, Tomoko Fukushige, Kentarou Minami, Yukihiko Nishizawa, Akihide Tanimoto, Takuro Kanekura, Masayuki Nakagawa, Shin-ichi Akiyama, Tatsuhiko Furukawa . Abcb10 Role in Heme Biosynthesis In Vivo: Abcb10 Knockout in Mice Causes Anemia with Protoporphyrin IX and Iron Accumulation . MOLECULAR AND CELLULAR BIOLOGY34 ( 6 ) 1077 - 1084 2014.3Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER SOC MICROBIOLOGY

Abcb10, member 10 of the ABC transporter family, is reportedly a part of a complex in the mitochondrial inner membrane with mitoferrin-1 (Slc25a37) and ferrochelatase (Fech) and is responsible for heme biosynthesis in utero. However, it is unclear whether loss of Abcb10 causes pathological changes in adult mice. Here, we show that Abcb10(-/-) mice lack heme biosynthesis and erythropoiesis abilities and die in midgestation. Moreover, we generated Abcb10(F/-); Mx1-Cre mice, with Abcb10 in hematopoietic cells deleted, which showed accumulation of protoporphyrin IX and maturation arrest in reticulocytes. Electron microscopy images of Abcb10(-/-) hematopoietic cells showed a marked increase of iron deposits at the mitochondria. These results suggest a critical role for Abcb10 in heme biosynthesis and provide new insights into the pathogenesis of erythropoietic protoporphyria and sideroblastic anemia.

DOI： 10.1128/MCB.00865-13

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Hirotsugu Noguchi, Sohsuke Yamada, Atsunori Nabeshima, Xin Guo, Akihide Tanimoto, Ke-Yong Wang, Shohei Kitada, Takashi Tasaki, Tatsuo Takama, Shohei Shimajiri, Hasita Horlad, Yoshihiro Komohara, Hiroto Izumi, Kimitoshi Kohno, Hidenori Ichijo, Yasuyuki Sasaguri . Depletion of Apoptosis Signal-Regulating Kinase 1 Prevents Bile Duct Ligation-Induced Necroinflammation and Subsequent Peribiliary Fibrosis . AMERICAN JOURNAL OF PATHOLOGY184 ( 3 ) 644 - 661 2014.3Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated protein kinase kinase kinase (MAP3K), is ubiquitously expressed and situated in an important upstream position of many signal transduction pathways. ASK1 plays a pivotal role in stressor-induced cell survival and inflammatory reactions. To ascertain the regulatory functions of ASK1 in bite duct ligation (BDL)-induced liver injury, we examined the net effects of ASK1 depletion on hepatic necroinflammation and/or fibrosis. We subjected C57BL/6 wild-type (WT) or ASK/-deficient (ASK(-/-)) mice to sham or BDL surgery for 14 days. In day 3 BDL animals, ASK(-/-) mice had significantly fewer bile infarcts along with more reduced interlobular or portal inflammatory infiltrate of various immune cells, including neutrophils, compared with WT mice in which ASK1 expression was markedly activated. Morphologically apoptotic hepatocytes or cholangiocytes were negligible in both the sham and BDL animals. In contrast, ASK(-/-) mice had significantly less proliferating activity of not only hepatocytes but also large cholangiocytes than WT mice. Day 14 BDL ASK(-/-) mice manifested potential antifibrogenic aspects of ASK1 deficiency, characterized by significantly fewer activated peribitiary fibrogenic cells and petibitiary fibrosis. These observations indicate that ASK1-mediated hepatic necroinfiammation and proliferation, but not apoptosis, are closely linked to Liver fibrosis and fibrogenesis. A specific ASK1 pathway blocker or inhibitor might offer a therapeutic strategy against human cholestatic diseases.

DOI： 10.1016/j.ajpath.2013.11.030

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Yamada S, Koyama T, Noguchi H, Ueda Y, Kitsuyama R, Shimizu H, Tanimoto A, Wang KY, Nawata A, Nakayama T, Sasaguri Y, Satoh T. . Marine hydroquinone zonarol prevents inflammation and apoptosis in dextran sulfate sodium-induced mice ulcerative colitis. . PLoS One9 ( 11 ) 2014.1Reviewed

Miura N, Kucho K, Noguchi M, Miyoshi N, Uchiumi T, Kawaguchi H, Tanimoto A. . Comparison of the genomic sequence of the microminipig, a novel breed of swine, with the genomic database for conventional pig. . In Vivo.28 ( 6 ) 1107 - 1111 2014.1Reviewed

Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M. . Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse. . J Mol Cell Cardiol.77 29 - 41 2014.1Reviewed

Yamaguchi T, Yamazaki T, Kawaguchi H, Tawa M, Nakamura Y, Shiota M, Osada-Oka M, Tanimoto A, Okamura T, Miura K, Iwao H, Yoshiyama M, Izumi Y. . A noninvasive metabolic syndrome model using an extremely small minipig, the microminipig. . J Pharmacol Sci.126 ( 2 ) 168 - 171 2014.1Reviewed

Yokouchi M, Nagano S, Kijima Y, Yoshioka T, Tanimoto A, Natsugoe S, Komiya S. . Solitary breast metastasis from myxoid liposarcoma. . BMC Cancer. 2014 Jul 4;14:482. doi: 10.1186/1471-2407-14-482.14 ( 482 ) 2014.1Reviewed

Hiraki T, Higashi M, Goto Y, Kitazono I, Yokoyama S, Iuchi H, Nagano H, Tanimoto A, Yonezawa S . A rare case of internal jugular vein aneurysm with massive hemorrhage in neurofibromatosis type 1. . Cardiovasc Pathol. 23 ( 4 ) 244 - 247 2014.1Reviewed

Hatanaka K, Yoshioka T, Tasaki T, Tanimoto A . The hyaline vascular type of Castleman's disease of the ovary: a case report. . Int J Surg Pathol.22 ( 7 ) 652 - 655 2014.1Reviewed

Kakimoto T, Otsuka A, Kawaguchi H, Ogata K, Tanimoto A, Kanouchi H. . Plasma homocysteine concentration in novel microminipigs. . In Vivo 28 579 - 582 2014.1Reviewed

Hamada T, Souda M, Yoshimura T, Sasaguri S, Hatanaka K, Tasaki T, Yoshioka T, Ohi Y, Yamada S, Tsutsui M, Umekita Y, Tanimoto A . Anti-apoptotic Effects of PCP4/PEP19 in Human Breast Cancer Cell Lines: A Novel Oncotarget . Oncotarget 5 6076 - 6086 2014.1Reviewed

Hatanaka K, Yoshioka T, Tasaki T, Tanimoto A. . Pulmonary rhabdomyomatous dysplasia of the newborn in neurofibromatosis type 1. . Pathol Res Pract. 210: 318-320 ( 1 ) 318 - 320 2014.1Reviewed

Kawaguchi H, Yamada T, Miura N, Ayaori M, Uto-Kondo H, Ikegawa M, Noguchi M, Wang KY, Izumi H, Tanimoto A. . Rapid Development of Atherosclerosis in the World's Smallest Microminipig fed a high-fat/high cholesterol diet: A Useful Animal Model Because of its Size and Similarity to Human Pathophysiology. . J Atheroscler Thromb. 21 ( 1 ) 186 - 203 2014.1Reviewed

Noguchi H, Yamada S, Nabeshima A, Guo X, Tanimoto A, Wang KY, Kitada S, Tasaki T, Takama T, Shimajiri S, Horlad H, Komohara Y, Izumi H, Kohno K, Ichijo H, Sasaguri Y. . Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necro-inflammation and subsequent peribiliary fibrosis. . Am J Pathol. 184 ( 1 ) 644 - 661 2014.1Reviewed

Yamamoto M, Arimura H, Fukushige T, Minami K, Nshizawa Y, Tanimoto A, Kanekura T, Nakagawa M, Akiyama SI, Furukawa T. . Abcb10 knockout mice causes anemia with protoporphyrin IX and iron accumulation: Abcb10 is essential for heme biosynthesis in vivo. . Mol Cell Biol.34 ( 1 ) 1077 - 1084 2014.1Reviewed

Akioka K, Kawaguchi H, Kitajima S, Miura N, Noguchi M, Horiuchi M, Miyoshi N, Tanimoto A. . Investigation of Necessity of Sodium Cholate and Minimal Required Amount of Cholesterol for Dietary Induction of Atherosclerosis in Microminipigs. . In Vivo. 28 ( 1 ) 81 - 90 2014.1Reviewed

Kohei Akioka, Hiroaki Kawaguchi, Sawako Kitajima, Naoki Miura, Michiko Noguchi, Masahisa Horiuchi, Noriaki Miyoshi, Akihide Tanimoto . Investigation of Necessity of Sodium Cholate and Minimal Required Amount of Cholesterol for Dietary Induction of Atherosclerosis in Microminipigs . IN VIVO28 ( 1 ) 81 - 90 2014.1Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：INT INST ANTICANCER RESEARCH

Recently we established a Microminipig (MMPig) model of atherosclerosis induced by high fat/high cholesterol (Cho) diet containing sodium cholate (SC), which is known to cause hepatotoxicity. In the present study, we investigated whether SC is necessary as well as the minimum amount of dietary Cho required to induce atherosclerosis. Experiment A: Six MMPigs were divided into three groups of two, and were fed for 12 weeks as follows: a diet containing 12% fat and 5% Cho with or without 0.7% SC, or the diet including 12% fat and 0.5% Cho with SC. Although each diet induced a similar degree of hypercholesterolemia and atherosclerosis, the liver weights and severity of fatty change in the hepatocytes were maximal in the animals fed 5% Cho and SC. Experiment B: Six MMPigs were divided into two groups of three, and fed for 18 weeks as follows: normal diet, and a diet of increasing dose of Cho (0.03, 0.1, 0.3, 0.5, 1.5 and 5%) for the initial 14 weeks and 0.5% Cho/12% fat diet for the final four weeks. Serum levels of total Cho and low-density lipoprotein-Cho reached a plateau with 0.5% Cho diet, suggesting that the minimum amount of Cho required is 0.5%. The absorption of Cho in MMPigs was enhanced by 0.5% Cho and 12% fat diet compared to the 5% Cho-alone diet. In conclusion, a diet with 0.5% Cho and 12% fat without SC appears to be sufficient to induce atherosclerosis in the MMPig.

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谷本昭英, 川口博明, 野口倫子, 三浦直樹, 大竹正剛 . 第三の家畜実験動物としてのミニブタ世界最小のマイクロミニピッグ . 病理と臨床32 ( 1 ) 92 - 96 2014.1

Md Zahorul Islam, Emi Yamazaki-Himeno, Mitsuya Shiraishi, Atsushi Miyamoto, Hiroaki Kawaguchi, Noriaki Miyoshi, Naoki Miura, Akihide Tanimoto . Angiotensin II decreases bradykinin-induced NO and increases prostaglandin F-2 alpha release from cultured Microminipig basilar arterial endothelial cells . JOURNAL OF PHARMACOLOGICAL SCIENCES124 104P - 104P 2014Reviewed

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Papers - akihide Tanimoto