Faculty Profiles - akihide Tanimoto

Papers - akihide Tanimoto

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A Tanimoto, T Sasaguri, N Arima, H Hashimoto, T Hamada, Y Sasaguri . Endometrial stromal sarcoma of the uterus with rhabdoid features . PATHOLOGY INTERNATIONAL46 ( 3 ) 231 - 237 1996.3Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：BLACKWELL SCIENCE

A case of endometrial stromal sarcoma of the uterus with rhabdoid features, occurring in a 57 year old woman is reported. Electron microscopy and immunohistochemistry revealed that the rhabdoid cells contained intermediate filaments which were positive for vimentin, cytokeratin, alpha-smooth muscle actin, and muscle specific actin, but not for myoglobin and desmin. This indicated that the tumor in this case differed somewhat from the three rhabdoid tumors and an endometrial stromal sarcoma with rhabdoid differentiation previously reported and that, therefore, these tumors were heterogeneous.

T Hamada, T Sasaguri, A Tanimoto, N Arima, S Shimajiri, T Abe, Y Sasaguri . Apoptosis of human kidney 293 cells is promoted by polymerized cadmium-metallothionein . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS219 ( 3 ) 829 - 834 1996.2Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

Transformed human kidney cells (293 cells) exposed to 12.5 to 37.5 mu M CdCl2 showed apoptosis as confirmed by characteristic electron microscopic features, a ladder on gel electrophoresis of extracted DNA, and fragmentation of nucleosomes as detected by enzyme linked immunosorbent assay (ELISA). Higher concentrations of Cd were less effective in inducing apoptosis. Furthermore, addition of the protein extract from the serum-free medium used for Cd-exposure promoted apoptosis exhibiting the same features as that after Cd-exposure. The apoptosis induced by the protein was dose-dependent. The molecular weight of the protein (Cd-protein) was shown to be 40 kDa by gel filtration. Two-dimensional electrophoresis revealed the Cd-protein as a single spot with a molecular weight of 6 kDa and pI of 4.5. Competitive ELISA showed that the Cd-protein reacted with anti-metallothionein antibody. The present findings suggest that apoptosis is induced not only by Cd itself but also by polymerized metallothionein molecules (MT) released from cells into the medium. (C) 1996 Academic Press, Inc.

DOI： 10.1006/bbrc.1996.0318

R Nakano, N Murahashi, Y Sasaguri, A Tanimoto, M Soejima, N Arima, T Hamada . Establishment and characterization of immortalized human coronary endothelial cells . BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL36 ( 4 ) 715 - 722 1995.7Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：TAYLOR & FRANCIS INC

We established an immortalized cell line from endothelial cells derived from a human coronary artery, isolated at autopsy from 76-year-old male, by transfecting the cells with origin-minus simian virus 40 DNA. These cells showed SV40 T antigen in the nuclei and Ulex europaeus I agglutinin and factor VIII-related antigen, as endothelial cell markers, in their cytoplasm. This cell line synthesized prostacyclin, tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) as well as produced the preform of matrix metalloproteinase 1, which was activated by cultivating the cells with plasminogen. These findings reveal that this immortalized endothelial cell line retains characteristics of human coronary endothelial cells, indicating that this cell line is useful for studying atherogenesis of the coronary artery.

T HAMADA, T SASAGURI, M HISAOKA, K HIRAKATA, A TANIMOTO, H NAKATA, Y SASAGURI, H HASHIMOTO . MILD EMPHYSEMA - A NOVEL METHOD USING FORMALIN-FIXED LUNGS FOR COMPUTED-TOMOGRAPHY AND PATHOLOGICAL ANALYSES . VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY426 ( 6 ) 597 - 602 1995.7Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER VERLAG

We evaluated a navel method of computed tomography (CT) analysis using formalin-fixed lungs of autopsy cases with mild emphysema. Eight formalin-inflated lungs (FILs) obtained at autopsy were examined using CT after draining off the formalin and air inflation with an air pump, and subjected to pathological study including pathological scoring of emphysema and microscopic image analysis (MIA). Satisfactory CT examination was carried out within 5 h of lung fixation. The mean alveolar area determined by MIA correlated highly with the lung volume (r=O.845) and CT score (r=0.722). This method is simple compared with conventional polyethylene glycol fixation for CT and enables CT examination of resected lungs without anxiety about biohazards.

T TAKAGISHI, Y SASAGURI, R NAKANO, N ARIMA, A TANIMOTO, H FUKUI, M MORIMATSU . EXPRESSION OF THE HISTAMINE H1 RECEPTOR GENE IN RELATION TO ATHEROSCLEROSIS . AMERICAN JOURNAL OF PATHOLOGY146 ( 4 ) 981 - 988 1995.4Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER SOC INVESTIGATIVE PATHOLOGY, INC

Histamine in serum and arterial tissue contributes to the pathogenesis of atherosclerosis and the formation of coronary artery vasospasm As the effect of histamine at a given site will be mediated by its specific receptors, we investigated by in situ hybridization and Northern blot analysis the expression and localization of human histamine H1 receptor mRNA in the arterial wall and in cultured human aortic intimal smooth muscle cells (SMC) and immortalized SMC (ISS10) and endothelial cells (SE1). In situ hybridization showed that SMC and endothelial cells expressed H1 receptor mRNA in vivo and that the expression was increased in SMC in the thickened intima of atherosclerotic foci in both the aorta and coronary artery By Northern blot analysis, we also detected histamine H1 receptor mRNA in cultured SMC, ISS10, and SE1 and found that platelet-derived growth factor stimulated SMC to increase their expression of the mRNA in vitro. These results suggest that up-regulation of histamine H1 receptor expression by platelet-derived growth factor plays an important role in the initiation and progression of cardiovascular diseases.

T HAMADA, T SASAGURI, A TANIMOTO, N ARIMA, R NAKANO, H MIYAYAMA, Y SASAGURI . OVARIAN MUCINOUS CYSTADENOCARCINOMA WITH SARCOMA-LIKE MURAL NODULES . JOURNAL OF SURGICAL ONCOLOGY58 ( 3 ) 201 - 207 1995.3Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-LISS

A rare case of ovarian mucinous cystadenocarcinoma with sarcoma-like mural nodules is reported. Macroscopically, nodular or granular lesions were scattered over the inner surface of a huge, multilocular tumor in the left ovary. The histopathological features were consistent with those of previously documented cases, except significant squamous metaplasia in the present case. The pleomorphic sarcoma-like cells showed a positive reaction for vimentin and alpha-antichymotrypsin but were negative for carcinoembryonic antigen and common epithelial membrane antigen by immunohistochemistry. Electron microscopically, the tumor cells had neither desmosomes nor secretory granules, but they possessed abundant intermediate filaments. Both immunostaining and ultrastructure suggested that the sarcoma-like nodules were derived from reactive proliferation of fibrohistiocytic cells. The fibrohistiocytic reaction seemed to occur in response to hemorrhage, because hemorrhage was reported to be associated with the mural nodules in most of the previous cases as well as ours. (C) 1995 Wiley-Liss, Inc.

K SAGAWA, M MOCHIZUKI, K MASUOKA, K KATAGIRI, T KATAYAMA, T MAEDA, A TANIMOTO, S SUGITA, T WATANABE, K ITOH . IMMUNOPATHOLOGICAL MECHANISMS OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 (HTLV-I) UVEITIS - DETECTION OF HTLV-I-INFECTED T-CELLS IN THE EYE AND THEIR CONSTITUTIVE CYTOKINE PRODUCTION . JOURNAL OF CLINICAL INVESTIGATION95 ( 2 ) 852 - 858 1995.2Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：ROCKEFELLER UNIV PRESS

The immunopathology of human T cell lymphotropic virus type 1 (HTLV-I) uveitis was addressed by using T cell clones (TCC) established from the intraocular fluid of patients with HTLV-I uveitis. Proviral DNA of HTLV-I was identified in 55 out of 94 (59%) or 13 out of 36 (36%) TCC from the ocular fluid or the peripheral blood of these patients, respectively. Most of HTLV-I-infected TCC had a CD3(+) CD4(+) CD8(-) phenotype. HTLV-I infection on TCC was confirmed by analysis of the viral mRNA, nucleotide sequence, virus-associated proteins, and virus particles. HTLV-I-infected TCC, but not HTLV-I negative TCC, constitutively produced high amounts of IL-6 (1,336 +/- 1,050 pg/ml) and TNF-alpha (289 +/- 237 pg/ml) in the absence of any stimuli. HTLVI-infected TCC from the ocular lesion also constitutively produced high amounts of IL-1 alpha (12,699 pg/ml), IL-2 (61 pg/ml), IL-3 (428 pg/ml), IL-8 (1,268 pg/ml), IL-10 (28 pg/ml ), IFN-gamma (5,095 pg/ml), and GM-CSF (2,886 pg/ml). Hydrocortisone, a drug effective in vivo for the treatment of HTLV-I uveitis, severely depressed cytokine production in vitro in most cases. In summary, the results demonstrated direct evidence of HTLV-I infection of the eye and suggest that cytokines produced by HTLV-I-infected T cells are responsible for the intraocular inflammation in patients with HTLV-I uveitis.

R Kouzuma, H Tasaki, T Komura, Y Nakashima, A Kuroiwa, A Tanimoto, O Koide . Combined treatment of probucol with diltiazem regresses atherosclerosis induced by 1% cholesterol diet in rabbit aorta . ARTERY21 ( 6 ) 337 - 351 1995Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：ARTERY PUBLISHING

To clarify whether probucol, an antioxidant, or diltiazem, a Ca2+ antagonist, favorably affect the regression of established atherosclerosis, rabbits were fed a 1% cholesterol diet for 10 weeks, then a standard diet for an additional 25 weeks (regression period). During the regression period, rabbits were grouped into a saline (S) group (n=8, 1 ml saline/d), a probucol (P) group (n=8, 1000 mg/d probucol), or a probucol and diltiazem (P+D) group (n=8, probucol 1000 mg/d in diet and diltiazem 30mg/d). We measured cholesterol in serum, lipoprotein fractions, and serum triglyceride or phospholipid concentration and found no significant differences among the three groups at 10, 15, or 35 weeks. After 10 weeks of the atherogenic diet, the ratio of macroscopic atherosclerotic lesions in aortic intima rose to 36.6 +/- 5.6%. After the regression period, the S group developed more atherosclerotic lesions (48.6 +/- 6.49%). The P+D and P groups, however, had decreased scores of 24.3 +/- 5.5% (p<0.05 vs. S) and 32.3 +/- 5.6%, respectively. Moreover, these decreased scores were well correlated with the decrease in aortic tissue lipid compositions, but not the parameters for extracellular matrices. We concluded that P+D or P therapy might be effective in regressing established atherosclerosis by removing lipid contents but not extracellular matrices.

S KATO, Y SASAGURI, S AZAGAMI, R NAKANO, T HAMADA, N ARIMA, A TANIMOTO, M MORIMATSU . AMBIENT-PRESSURE STIMULATES IMMORTALIZED HUMAN AORTIC ENDOTHELIAL-CELLS TO INCREASE DNA-SYNTHESIS AND MATRIX METALLOPROTEINASE-1 (TISSUE COLLAGENASE) PRODUCTION . VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY425 ( 4 ) 385 - 390 1994.11Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER VERLAG

In the present study, we investigated the effect of ambient pressure on [H-3]-thymidine incorporation and on the production of matrix metalloproteinase 1 (tissue collagenase/proMMP-1) using human aortic endothelial cells immortalized with simian virus 40 (SE-1). Incubation of cells at ambient pressures of 50 and 100 mmHg for 24 h slightly increased [H-3]-thymidine incorporation when directly compared with normal culture conditions. The amount of [H-3]-thymidine incorporated in SE-1 reached a maximum at 150 mmHg, while a further increase in pressure to 200 mmHg decreased incorporation. The same ambient pressure slightly stimulated human aortic intimal smooth muscle cells (SMC) to increase [3H]-thymidine incorporation but not medial SMC. Immunoblot analysis also showed that ambient pressure, ranging from 50 to 200 mmHg, like 12-O-tetradecanoyl-phorbol-13-acetate stimulated SE-1 to produce proMMP-1, an effect not seen with either intimal or medial SMC. The amount of proMMP-1 produced also reached a maximum level at 150 mmHg. We postulate that human endothelial cells are ambient pressure sensitive and that relatively lower ambient pressures play an important role in the growth of endothelial cells, while higher pressures injure endothelial cells, resulting in the initiation of atherosclerosis. This cell line may prove useful in the investigation of both the physiological and pathological roles of blood pressure on endothelial cell function.

T HAMADA, A TANIMOTO, S IWAI, H FUJIWARA, Y SASAGURI . CYTOPATHOLOGICAL CHANGES INDUCED BY CADMIUM-EXPOSURE IN CANINE PROXIMAL TUBULAR CELLS - A CYTOCHEMICAL AND ULTRASTRUCTURAL-STUDY . NEPHRON68 ( 1 ) 104 - 111 1994.9Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：KARGER

A highly sensitive cytochemical method for demonstrating intracellular Cd using 8-hydroxyquinoline was developed and applied in the cytopathological study of primary-cultured renal tubular cells from beagle kidneys. The Cd-8-hydroxyquinoline emitted a yellowish-green fluorescence which first appeared in the cytoplasm within 30 min and in the nucleus about 60-90 min after exposure to 100 mM CdCl2. It was noteworthy that intranuclear Cd was stained in the nucleolar regions. The sensitivity of the cytochemical method for Cd was estimated to be about 1.0 pg Cd/cell. Ultrastructural features of the dead cells were consistent with those of apoptosis. We conclude that Cd absorbed by proximal tubular cells rapidly reaches to the nuclei and affects nuclear as well as cytoplasmic metabolism.

Y NAKANO, MORIMOTO, I, O ISHIDA, T FUJIHIRA, A MIZOKAMI, A TANIMOTO, N YANAGIHARA, F IZUMI, S ETO . THE RECEPTOR, METABOLISM AND EFFECTS OF ANDROGEN IN OSTEOBLASTIC MC3T3-E1 CELLS . BONE AND MINERAL26 ( 3 ) 245 - 259 1994.9Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI IRELAND LTD

We investigated the androgen receptor (AR), metabolism and effects of androgens in osteoblastic MC3T3-E1 cells. AR was proved as a transcript of a IO-kb mRNA and as a 110-kDa protein. An immunocytochemical study showed that AR was located mainly in the nuclei. Specific binding of [H-3]DHT was observed in both the nuclear and cytosol fractions. MC3T3-E1 cells possessed approximately 1190 binding sites per cell and most of the sites (1150 sites) situated in the nucleus. The apparent K-d value in the nuclear fraction was 1.35 nM for [H-3]DHT binding, and it was similar to that for [H-3]testosterone. In the competition analysis, there was not much difference in the displacement of the [H-3] DHT binding from AR between the addition of radioinert DHT and testosterone. In studies of 5 alpha-reductase activity and aromatase activity of the cells, both activities were lower than the respective values in classical androgen target tissues. Androgens stimulated the incorporation of [H-3]thymidine into the cell, and DHT and testosterone had a similar potency on the cell proliferation. Thus, these results suggest testosterone itself acts mainly on the osteoblasts without conversion to DHT.

DOI： 10.1016/S0169-6009(08)80173-0

T EZAKI, T OKAMURA, Y YOSHIDA, M KODATE, T SHIRAKUSA, A TANIMOTO, R HIRATSUKA . FOREIGN-BODY GRANULOMA MIMICKING AN EXTRAHEPATICALLY GROWING LIVER-TUMOR - REPORT OF A CASE . SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY24 ( 9 ) 829 - 832 1994Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER VERLAG

We herein describe a 74-year-old woman with a foreign-body granuloma mimicking a liver tumor. Imaging studies revealed a pedunculated left lobe mass in the setting of chronic liver disease. She had a past history of a cholecystectomy as well as a previous gynecological operation. A left lateral segmentectomy was performed because of the possibility of a rupture. The dissected specimen showed a foreign-body granuloma caused by gauze. We believe this case to be a very unique granuloma, which should be kept in mind whenever making a diagnosis of a liver tumor particularly in a patient with chronic liver disease, who has a past history of abdominal surgery.

DOI： 10.1007/BF01636316

O YAMAMOTO, A TANIMOTO, H YASUDA, Y SUENAGA, M ASAHI . A COMBINED OCCURRENCE OF NEUROENDOCRINE CARCINOMA OF THE SKIN AND A BENIGN APPENDAGEAL NEOPLASM . JOURNAL OF CUTANEOUS PATHOLOGY20 ( 2 ) 173 - 176 1993.4Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：MUNKSGAARD INT PUBL LTD

A 76-year-old Japanese male presented with a subcutaneous nodule in the dorsal cubital region of the right arm. The center of the nodule showed typical features of neuroendocrine carcinoma of the skin. The peripheral portion showed epithelial islands of squamoid cells with horn cysts suggestive of benign appendageal tumor with pilar differentiation. The coexistence of two skin neoplasms in the same lesion would suggest that both tumors developed from common pluripotential stem cell.

A TANIMOTO, T HAMADA, O KOIDE . CELL-DEATH AND REGENERATION OF RENAL PROXIMAL TUBULAR CELLS IN RATS WITH SUBCHRONIC CADMIUM INTOXICATION . TOXICOLOGIC PATHOLOGY21 ( 4 ) 341 - 352 1993Reviewed

Language：English Publishing type：Doctoral thesis Publisher：SOC TOXICOLOGIC PATHOLOGISTS

Male Sprague-Dawley rats were injected subcutaneously with 0.6 mg cadmium (Cd)/kg/day for 8 wk. The subsequent changes in renal proximal tubules were studied histologically, histochemically, and ultrastructurally. The urinary and tissue Cd concentrations were determined by atomic absorption spectrophotometry. After 4 wk of exposure, apoptosis was observed predominantly in segment S3 along with epithelial regeneration in the affected tubules, and these changes gradually became more pronounced as the experimental period was prolonged. The apoptotic cells were shed into the lumen and were found to contain a large quantity of Cd. Apoptotic cells were counted in paraffin sections after various periods of exposure to Cd. Nuclear bromodeoxyuridine uptake, mitotic count, and nuclear density were used as indicators of tubular regeneration. A correlation was found between the numerical increase of apoptotic cells and the rate of urinary Cd excretion, and the rate of increase in the tissue Cd concentration had a tendency to reduce after 4 wk as the rate of urinary Cd increased. These observations suggest that apoptosis might be helpful for the efficient excretion of Cd into urine. Progressive increases in the preceding indicators of regeneration were observed. From our results, it appears that Cd-induced tubular damage, i.e., cell deletion due to apoptosis, is reversible as a result of marked epithelial regeneration. On the basis of these histological changes, the critical concentration of Cd required to produce renal tubular damage was estimated to be 600 mu g/g dry tissue.

T SASAGURI, M SOEJIMA, Y HINO, H SHIRAISHI, H DATE, M TAKASUGI, A TANIMOTO, A HORIE . SYSTEMIC NECROTIZING VASCULITIS WITH RENAL INVOLVEMENT ACCOMPANIED BY REMARKABLE EOSINOPHILIA - A CASE WITH OVERLAPPING FEATURES OF POLYARTERITIS-NODOSA AND ALLERGIC GRANULOMATOUS-ANGIITIS . JAPANESE JOURNAL OF MEDICINE30 ( 5 ) 477 - 482 1991.9Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

A 71-year-old woman was clinically suspected of allergic granulomatous angiitis (AGA) because of preceding allergic diseases including bronchial asthma, remarkable eosinophilia (14,300/mm3), mononeuritis multiplex, positive rheumatoid factor, elevated serum immunoglobulin E, and eosinophilic inflammation of the kidney. Autopsy findings, however, were characteristic of polyarteritis nodosa (PAN). Necrotizing angiitis was present in several organs except for the lung; focal and segmental glomerular lesions with crescent formation were observed in the kidney, and granuloma formation was not found. This case may be an intermediate type between PAN and AGA (an overlap syndrome) and provide useful information on the clinical entities of systemic necrotizing vasculitis.

DOI： 10.2169/internalmedicine1962.30.477

T HAMADA, S NAKANO, S IWAI, A TANIMOTO, K ARIYOSHI, O KOIDE . PATHOLOGICAL-STUDY ON BEAGLES AFTER LONG-TERM ORAL-ADMINISTRATION OF CADMIUM . TOXICOLOGIC PATHOLOGY19 ( 2 ) 138 - 147 1991Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：SOC TOXICOLOGIC PATHOLOGISTS

Histopathological, histochemical, and electron microscopic examinations were performed on beagles after a long-term oral cadmium (Cd) administration of > 8 years. Although renal atrophy was remarkable in groups receiving doses of 50 and 100 mg/kg body weight/day, bone lesions could not be demonstrated by roentgenological and histopathologic examination. It was noticed that concomitant regeneration or recovery and cell death of the epithelium occurred in the proximal convoluted tubules. The cell death was consistent with apoptosis, a special feature of cell death, which was shown to play a major part in the tubular damage of cadmium by electron microscopic examination. Fatty degeneration of the pars recta tubules was seen to show dose-dependence. The intrarenal cadmium was localized predominantly in the cytoplasm of the proximal tubular epithelium by histochemical and ultracentrifugal cell fractionation examinations. Although no remarkable changes were found in the other organs, aggregates of siderophages in the liver and focal hemorrhage in the spleen, known as spontaneous lesions, might be related to Cd intoxication. In conclusion, the present study revealed that no bone lesions occur with Cd administration in adult beagles in spite of long-term administration. An excessive cell death to regeneration or recovery in the proximal tubules might result in the renal cortical atrophy. No remarkable changes were seen in the glomeruli and distal nephrons, which were in good agreement with Cd distribution.

A. Tanimoto, T. Hamada, H. Kanesaki, K. Matsuno, O. Koide . Multiple primary cancers in a case of chronic arsenic poisoning. An autopsy report . Journal of UOEH12 ( 1 ) 89 - 99 1990Reviewed

Language：English Publishing type：Research paper (scientific journal)

This is an autopsy report of multiple primary cancers observed in a patient who had clinically been diagnosed as chronic arsenic poisoning. An 88-year-old man, non-smoker, had worked in an arsenic mine for 6 years from the age of 47. He had undergone operations for Bowen's disease and gastric cancer at ages 80 and 86, respectively. At autopsy, squamous cell carcinoma of the lung and a polypoid lesion in the piriform recess were found. Furhermore, microscopic examination revealed latent prostatic adenocarcinoma and oncocytoma in the kidney. The polypoid lesion of the piriform recess appeared to originate from the duct of the minor salivary gland in the pharynx, showing an adenoid cystic carcinoma-like pattern with squamous cell carcinoma in part. The cause of death was thought to be respiratory failure due to bronchopneumonia and pulmonary edema as well as hydrothorax, and chronic heart failure following ischemic heart diseas. Bowen's disease was followed by four internal malignant tumors, even though the etiological relation between these cancers and arsenic is not clear.

DOI： 10.7888/juoeh.12.89

T HAMADA, A TANIMOTO, M KAIDO, S MATSUMOTO, K IRIBE, O KOIDE . DIFFUSE PLEURAL RHABDOMYOSARCOMA WITH PERSISTENT PLEURAL EFFUSION . ACTA PATHOLOGICA JAPONICA39 ( 12 ) 803 - 809 1989.12Reviewed

小出紀, 海道昌宣, 谷本昭英 . Cushing病に合併した急性壊死性膵炎の一例(第30回CPC) . 臨牀と研究66 ( 4 ) 1250 - 1254 1989.4

Nakano S, Iwai S, Tanimoto A, Koide O . An ultrastructural observation of malignant mesothelioma cells in pleural effusion. . Journal of Clinical Electron Microscopy22 5 - 6 1989Reviewed

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