Faculty Profiles - ASAKAWA Akihiro

Papers - ASAKAWA Akihiro

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蔡明倫, 浅川明弘, 乾明夫 . 【栄養代謝制御における消化管生理活性ペプチドの役割】PYY・PPの食欲抑制作用と臨床応用 . 臨床消化器内科28 ( 6 ) 705 - 711 2013.5

Publisher：(株)日本メディカルセンター

先進国だけでなく,一部の発展途上国でも肥満やそれに伴う耐糖能異常,高血圧,脂質異常症などが重複するメタボリックシンドロームの患者数の増加が社会問題化しつつある.エネルギーバランスの異常が病態に大きく関与すると考えられる.グレリンやpancreatic polypeptide(PP)ペプチドファミリーなどの食欲・体重調節ペプチドを中心に病態解析が進められている.PPおよびpeptide tyrosine-tyrosine(PYY)はおもにY4あるいはY2受容体を介して摂食抑制作用を示し,体重を減少させる.最近PYY3-36がヒトにおいては恒常性維持領域だけでなく,大脳辺縁系および高次大脳皮質領域の神経活動調節にも関与することが示されている.消化管を含めた末X臓器と摂食中枢との間で行われる食欲・体重調節機構の解明が,メタボリックシンドロームの病態の解明や治療につながることが期待される.(著者抄録)

小山憲一郎, 網谷東方, 浅川明弘, 乾明夫 . 高齢者医療に必要な心身医学的知識　心身医学分野で若年の心理士が高齢者の心理的援助について悩み、学んだこと　認知行動療法の理論、技法を活かしながら . 心身医学53 ( 4 ) 325 - 333 2013.4

Publisher：(一社)日本心身医学会

若年の心理士にとって高齢者臨床にはさまざまな難しさがある。緩和ケアにおける心理療法では傾聴、共感が重要視されるが、特に死に関する不安、抑うつは非常にデリケートな問題で、その漠然とした方法論は若年の心理士にとって必要であるが、不十分であるようにも感じている。本稿では、前半で高齢者緩和ケアにおける心理的問題とそのケアについて認知行動療法をベースにレビューし、後半において筆者が担当した症例を振り返り、当時個人的に悩み、学んだことをまとめ、若年の心理士がどのようにこの領域において貢献できるかを検討している。(著者抄録)

Yagi T. . The role of zinc in the treatment of taste disorders . Recent Patents on Food, Nutrition and Agriculture5 ( 1 ) 44 - 51 2013.4Reviewed

Suzuki H. . Ghrelin and cachexia in chronic kidney disease . Pediatric Nephrology28 ( 4 ) 521 - 526 2013.4Reviewed

Ando T. . Impact of helicobacter pylori eradication on circulating adiponectin in humans . Helicobacter18 ( 2 ) 158 - 164 2013.4Reviewed

Urabe H. . Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus . Nature Communications4 1526 2013.3Reviewed

米田孝一, 浅川明弘, 乾明夫 . 日常臨床の鍵になる心身相関を探る : 食行動からのアプローチ . 日本心療内科学会誌17 ( 1 ) 5 - 9 2013.2

Amitani H. . Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle . PLoS ONE8 ( 1 ) e53913 2013.1Reviewed

ASAKAWA Akihiro, INUI Akio . Psychosomatic aspects : Role of stress and hormone in functional gastrointestinal disorder . Nihon Naika Gakkai Zasshi102 ( 1 ) 11 - 16 2013.1

米田孝一, 浅川明弘, 乾明夫 . 【内分泌・代謝疾患の心身医療】肥満症・メタボリックシンドロームの心身医学 . 心身医学53 ( 1 ) 36 - 41 2013.1

Publisher：(一社)日本心身医学会

肥満症、メタボリックシンドロームの人では、エネルギーの出入りのバランス調整が適切になされていない状態にある。食欲とストレスは密接に関連しているため、肥満症、メタボリックシンドロームの治療・予防をするうえで適切なストレスへの対処は重要である。体重調節にかかわるメカニズムを理解したうえで、患者個人を取り巻くさまざまな因子に眼を向け、一人ひとりに合ったオーダーメイドの治療法を選択していくことが重要である。(著者抄録)

Amitani H. . The role of adiponectin multimers in anorexia nervosa . Nutrition29 ( 1 ) 203 - 206 2013.1Reviewed

浅川明弘, 乾明夫 . 【機能性消化管障害(FGID):診断と治療の進歩】FGIDの基本的知識　心身医学的側面(ストレスとホルモンはどうかかわるか) . 日本内科学会雑誌102 ( 1 ) 11 - 16 2013.1

Kaimoto Kaori, Inui Akio, Asakawa Akihiro, Tsai Minglun, Ushikai Miharu, Ataka Koji, Koyama Ken-ichiro, Sato Yuki, Kato Ikuo, Fujimiya Mineko . The anorexigenic hormones and gastroduodenal motility . Journal of Psychosomatic Medicine on Digestive Diseases20 ( 1 ) 14 - 17 2013

Amitani M. . Control of food intake and muscle wasting in cachexia . International Journal of Biochemistry and Cell Biology45 ( 10 ) 2179 - 2185 2013Reviewed

Amitani Haruka, Asakawa Akihiro, Inui Akio . The Role of Adiponectin Multimers in Anorexia Nervosa(Progress of Therapy in Eating Disorder) . Japanese Journal of Psychosomatic Medicine53 ( 9 ) 826 - 833 2013

Language：Japanese Publisher：Japanese Society of Psychosomatic Medicine

Objective : Anorexia nervosa (AN) continues to be a refractory disease because of its unknown pathogenesis. The role of adiponectin in AN has not been clarified. Moreover, few reports have described the relations between adiponectin isoforms and AN in the physical and psychological states. Therefore, we measured plasma adiponectin and its isoforms levels in patients with AN to examine their roles in AN. Methods : Eighteen women participated in this study : nine patients with AN and nine age-matched healthy controls. We examined plasma adiponectin and its isoforms levels in all subjects and administered three types of psychological test to patients with AN : the Eating Disorders Inventory-2, the Maudsley Obsessional-Compulsive Inventory, and the Beck Depression Inventory-2. Results: We found that the percentage of high-molecular-weight (HMW) to total adiponectin (%HMW) was significantly low and the percentage of low-molecular-weight (LMW) to total adiponectin (%LMW) was significantly high in the AN group compared with the control group. The %HMW positively and the %LMW negatively correlated with body mass index in the entire study population. The %HMW was also positively correlated with psychological symptoms such as social insecurity or cleaning evaluated with the Eating Disorders Inventory-2 or the Maudsley Obsessional-Compulsive Inventory. Conclusions: Our study indicates that all adiponectin isoforms should be evaluated in patients with AN in addition to total adiponectin. The decreased %HMW and the increased %LMW that were correlated with the body mass index and some components of psychopathology in our patients may indicate a complex role of adiponectin isoforms in maintaining energy homeostasis and emotion during extreme malnourishment.

DOI： 10.15064/jjpm.53.9_826

CiNii Research

Koyama Ken-Ichiro, Amitani Haruka, Asakawa Akihiro, Inui Akio . Experience of a Novice Psychologist in Giving Psychological Help to Geriatric Patient in the Field of Psychosomatic Medicine : Utilizing the Techniques and Theory of Cognitive Behavioral Therapy(Psychosomatic Expertise of Medical Care for the Elderly) . Japanese Journal of Psychosomatic Medicine53 ( 4 ) 325 - 333 2013

Language：Japanese Publisher：Japanese Society of Psychosomatic Medicine

When a psychologist with little experience gives psychological support to the geriatric patients/clients in palliative care, he/she faces various difficulties, such as the age difference between the psychologist and a patient, psychosocial problems of the patients, and so on. In the field of palliative care, listening attentively and showing empathy to the patients are considered to be important methods ; however, treating patients' anxiety and depression, especially when related to death, are subtle problems. Inexperienced psychologists need an equivocal methodology, which, however, is not being practiced sufficiently, yet it seems not enough. The first half of the current article reviews the psychological problems of the geriatric patients in palliative care from the perspective of cognitive-behavioral therapy. The second half precents a summary of a case which has been a struggle and a learning experience to the author, and discusses how inexperienced psychologists can contribute to this field.

DOI： 10.15064/jjpm.53.4_325

CiNii Research

Yoneda Koichi, Asakawa Akihiro, Inui Akio . Psychosomatic Medicine for Obesity and Metabolic Syndrome(<Special Issue>Psychosomatic Medicine for Endocrinology and Metabolism) . Japanese Journal of Psychosomatic Medicine53 ( 1 ) 36 - 41 2013

Language：Japanese Publisher：Japanese Society of Psychosomatic Medicine

Patients with obesity or metabolic syndrome have a difficulty in regulating of the balance between energy intake and expenditure. Stress coping is necessary in the treatment and prevention of these diseases because appetite is related with stress. It is important to choose an order-made treatment for an individual. In this report, we focus on the lifestyle modification with understanding the mechanism of the body weight regulation.

DOI： 10.15064/jjpm.53.1_36

CiNii Research

Tsai M, Asakawa A, Amitani H, Inui A . Stimulation of leptin secretion by insulin. . Indian journal of endocrinology and metabolism16 ( Suppl 3 ) S543 - 8 2012.12Reviewed

Nakano M, Asakawa A, Inui A . Long-term correction of type 1 and 2 diabetes by central leptin gene therapy independent of effects on appetite and energy expenditure. . Indian journal of endocrinology and metabolism16 ( Suppl 3 ) S556 - 61 2012.12Reviewed

浅川明弘, 乾明夫 . 消化器疾患に対する心身医学的アプローチ　グレリンシグナルとがん性悪液質 . 日本医事新報 ( 4622 ) 84 - 90 2012.11

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Papers - ASAKAWA Akihiro