Faculty Profiles - ASAKAWA Akihiro

Papers - ASAKAWA Akihiro

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Tohgo A, Kumazawa E, Akahane K, Asakawa A, Inui A . Anticancer drugs that induce cancer-associated cachectic syndromes. . Expert review of anticancer therapy2 ( 1 ) 121 - 9 2002.2Reviewed

Ohinata K, Inui A, Asakawa A, Wada K, Wada E, Yoshikawa M . Albutensin A and complement C3a decrease food intake in mice. . Peptides23 ( 1 ) 127 - 33 2002.1Reviewed

後藤恭子, 浅川明弘, 乾明夫 . 【QOLを考慮した消化管癌治療】Cancer anorexia-cachexia syndromeの病態と治療 . 消化器科33 ( 5 ) 406 - 413 2001.11Reviewed

Ohinata K, Inui A, Asakawa A, Yoshikawa M . Novel actions of proadrenomedullin N-terminal 20 peptide (PAMP). . Peptides22 ( 11 ) 1809 - 16 2001.11

Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Fujimiya M, Katsuura G, Makino S, Fujino MA, Kasuga M . A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. . Neuroendocrinology74 ( 3 ) 143 - 7 2001.9

Asakawa A, Inui A, Yuzuriha H, Nagata T, Kaga T, Ueno N, Fujino MA, Kasuga M . Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice. . Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme33 ( 9 ) 554 - 8 2001.9

Kaga T, Inui A, Okita M, Asakawa A, Ueno N, Kasuga M, Fujimiya M, Nishimura N, Dobashi R, Morimoto Y, Liu IM, Cheng JT . Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding. . Diabetes50 ( 5 ) 1206 - 10 2001.5

Asakawa A, Inui A, Ueno N, Makino S, Fujimiya M, Fujino MA, Kasuga M . Urocortin reduces oxygen consumption in lean and ob/ob mice. . International journal of molecular medicine7 ( 5 ) 539 - 41 2001.5

Ohinata K, Inui A, Asakawa A, Wada K, Wada E, Yoshikawa M . Proadrenomedullin N-terminal 20 peptide (PAMP) inhibits food intake and gastric emptying in mice. . Peptides22 ( 4 ) 589 - 95 2001.4

Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M. . Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. . Gastroenterology120 337 - 345 2001.1Reviewed

Asakawa A, Kojima Y, Fujii E, Ohtaka M, Shimazaki R, Sato T, Nakamura T, Morozumi A, Akahane Y, Fujino MA . Case of ulcerative colitis associated with oesophageal ulcer. . The Journal of international medical research28 ( 4 ) 191 - 6 2000.7

Ohinata K, Inui A, Asakawa A, Wada K, Wada E, Yoshikawa M . Proadrenomedullin N-terminal 20 peptide (PAMP) elevates blood glucose levels via bombesin receptor in mice. . FEBS letters473 ( 2 ) 207 - 11 2000.5

Ueno N, Inui A, Asakawa A, Takao F, Tani S, Komatsu Y, Itoh Z, Kasuga M . Erythromycin improves glycaemic control in patients with Type II diabetes mellitus. . Diabetologia43 ( 4 ) 411 - 5 2000.4

Asakawa A., Inui A. . Neuropeptides as emerging targets in anorexia and cachexia . Expert Opinion on Therapeutic Targets4 ( 1 ) 73 - 87 2000.2

Language：Japanese Publisher：Expert Opinion on Therapeutic Targets

Anorexia and body weight loss are characteristic of many diseases, including cancer and AIDS. Neuropeptides play a pivotal role in the physiological mechanisms regulating food intake and body weight. Neuropeptide Y (NPY) is a key molecule of the orexigenic network for energy intake and for normal adaptive feeding response to energy deficits. Therefore, the NPY receptors (notably, Y1 and Y5) may be one of the most significant target classes for treatment of anorexia and body weight loss. In addition, several anorexigenic peptides including corticotropin-releasing factor (CRF), cholecystokinin (CCK), leptin and melanocortin (MC) are emerging as potential targets for anorexia. Antagonists for CRF 2 receptor, CCK A receptor, MC 4 receptor and leptin receptor may be useful in stimulating food intake. The development of highly specific and selective non-peptide antagonists for these receptors is awaited. Anorexia is a crucial and critical disease. Increasing knowledge of its pathophysiology could lead to innovative new medicines for anorexia-cachexia syndrome. © 2000 Ashley Publications Ltd. ISSN 1460-0412.

DOI： 10.1517/14728222.4.1.73

Scopus

Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino MA, Kasuga M . Endomorphin-1, an endogenous mu-opioid receptor-selective agonist, stimulates oxygen consumption in mice. . Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme32 ( 2 ) 51 - 2 2000.2

Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino MA, Kasuga M . Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice. . Peptides20 ( 12 ) 1445 - 8 1999.12

Ueno N, Inui A, Iwamoto M, Kaga T, Asakawa A, Okita M, Fujimiya M, Nakajima Y, Ohmoto Y, Ohnaka M, Nakaya Y, Miyazaki JI, Kasuga M. . Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice. . Gastroenterology 117 1427 - 1432 1999.1Reviewed

Asakawa A, Inui A, Ueno N, Makino S, Fujino MA, Kasuga M. . Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice. . Gastroenterology116 1287 - 1292 1999.1Reviewed

Ohtaka M, Asakawa A, Kashiwagi A, Fujino MA, Kasai H, Matsumoto Y . Pericecal appendiceal abscess with drainage during colonoscopy. . Gastrointestinal endoscopy49 ( 1 ) 107 - 9 1999.1

Momose K., Inui A., Asakawa A., Ueno N., Nakajima M., Fujimiya M., Kasuga M. . Intracerebroventricularly administered corticotropin-releasing factor inhibits food intake and produces anxiety-like behaviour at very low doses in mice . Diabetes, Obesity and Metabolism1 ( 5 ) 281 - 284 1999

Language：Japanese Publisher：Diabetes, Obesity and Metabolism

Aim: Previous studies have demonstrated that corticotropin-releasing factor (CRF) produces behavioural, physiological and immunological responses similar to those induced by stress. However, these findings have been validated largely in laboratory rats. Methods: We examined the effects of intracerebroventricular (i.c.v.) administration of CRF on anxiety and food intake in mice. Using the elevated-plus maze, we measured anxiety levels after i.c.v. CRF in mice. We also measured food intake for 2 h after i.c.v. CRF. Results: CRF increased the normal preference for the closed arms of the maze at a very low dose of 3 pmol, indicating an anxiogenic effect. CRF powerfully suppressed food intake at the doses of 3-300 pmol for over 2 h. Conclusion: Our results demonstrate that i.c.v. CRF evokes anxiogenic behaviour and suppresses feeding with the same dose-response relationships in mice. CRF may thus play a role in integrating the overall responses to stress through co-ordinated actions in the brain of this species.

DOI： 10.1046/j.1463-1326.1999.00033.x

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Papers - ASAKAWA Akihiro