研究者詳細 - 小原　恭子

論文 - 小原　恭子

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Nagai M, Okabayashi T, Akagami M, Matsuu A, Fujimoto Y, Hashem MA, Mekata H, Nakao R, Matsuno K, Katayama Y, Oba M, Omatsu T, Asai T, Nakagawa K, Ito H, Madarame H, Kawai K, Ito T, Nonaka N, Tsukiyama-Kohara K, Inoshima Y, Mizutani T, Misawa N. . Metagenomic identification, sequencing, and genome analysis of porcine hepe-astroviruses (bastroviruses) in porcine feces in Japan . Infect Genet Evol.88 104664 2021年3月査読

Nagai M., Okabayashi T., Akagami M., Matsuu A., Fujimoto Y., Hashem M.A., Mekata H., Nakao R., Matsuno K., Katayama Y., Oba M., Omatsu T., Asai T., Nakagawa K., Ito H., Madarame H., Kawai K., Ito T., Nonaka N., Tsukiyama-Kohara K., Inoshima Y., Mizutani T., Misawa N. . Metagenomic identification, sequencing, and genome analysis of porcine hepe-astroviruses (bastroviruses) in porcine feces in Japan . Infection, Genetics and Evolution88 104664 - 104664 2021年3月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Infection, Genetics and Evolution

Recently, hepe-astrovirus-like RNA viruses named bastroviruses (BastVs), have been found in human, pig, bat, and rat fecal samples. In this study, we determined nearly complete genome sequences of four BastVs in the feces of healthy pigs. Genetic characterization revealed that these porcine BastVs (PBastVs) and BastVs from other animals including humans, had the same genome organization, that is, they contained three predicted conserved domains of viral methyltransferase, RNA helicase, and RdRp in the nonstructural ORF1 and the astrovirus capsid domain in the structural ORF2. Phylogenetic analyses using RNA-dependent RNA polymerase and the capsid region revealed that PBastVs branched with bat and rat BastVs; however, the groups formed by each host were distantly related to human BastVs. Pairwise amino acid sequence comparison demonstrated that PBastVs shared 95.2–98.6% and 76.1–95.5% sequence identity among each other in the ORF1 and ORF2 regions, respectively; the sequence identities between PBastVs and BastVs from other animals were 21.4–42.5% and 9.1–20.6% in the ORF1 and ORF2 regions, respectively. This suggested that BastVs were derived from a common ancestor but evolved independently in each host population during a prolonged period. Putative recombination events were identified in the PBastV genome, suggesting that PBastVs gain sequence diversity and flexibility through recombination events. In an analysis of previously obtained metagenomic data, PBastV sequence reads were detected in 7.3% (23/315) of fecal samples from pigs indicating that PBastVs are distributed among pig populations in Japan.

DOI： 10.1016/j.meegid.2020.104664

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PubMed

Suzuki Y, Onuma H, Sato R, Sato Y, Hashiba A, Maeki M, Tokeshi M, Kayesh MEH, Kohara M, Tsukiyama-Kohara K, Harashima H. . Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition. . 330 67 - 71 2021年2月査読

Suzuki Y. . Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition . Journal of Controlled Release330 61 - 71 2021年2月査読国際誌

Kayesh M.E.H. . Recent Insights Into the Molecular Mechanism of Toll-Like Receptor Response to Dengue Virus Infection . Frontiers in Microbiology12 744233 - 744233 2021年査読国際誌

CD4, CD8b, and Cytokines Expression Profiles in Peripheral Blood Mononuclear Cells Infected with Different Subtypes of KoRV from Koalas (Phascolarctos cinereus) in a Japanese Zoo. . Viruses12 ( 12 ) 1415 2020年12月

Kayesh M.E.H. . Cd4, cd8b, and cytokines expression profiles in peripheral blood mononuclear cells infected with different subtypes of korv from koalas (Phascolarctos cinereus) in a japanese zoo . Viruses12 ( 12 ) 2020年12月査読国際誌

Ezzikouri S, Nourlil J, Benjelloun S, Kohara M, Tsukiyama-Kohara K. . Coronavirus disease 2019-Historical context, virology, pathogenesis, immunotherapy, and vaccine development. . Hum Vaccin Immunother. 16 ( 12 ) 2992 - 3000 2020年12月招待査読

Kayesh MEH, Amako Y, Hashem MA, Murakami S, Ogawa S, Yamamoto N, Hifumi T, Miyoshi N, Sugiyama M, Tanaka Y, Mizokami M, Kohara M, Tsukiyama-Kohara K. . Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA . Virus Research290 198191 2020年12月査読

Ezzikouri S. . Coronavirus disease 2019—Historical context, virology, pathogenesis, immunotherapy, and vaccine development . Human Vaccines and Immunotherapeutics16 ( 12 ) 2992 - 3000 2020年12月査読国際誌

Elmessaoudi-Idrissi M, Tsukiyama-Kohara K, Nourlil J, Kettani A, Windisch MP, Kohara M, Malik YS, Dhama K, Benjelloun S, Ezzikouri S. . Structure-guided discovery approach identifies potential lead compounds targeting M pro of SARS-CoV-2 . Virusdisease 2020年11月査読

Ezzikouri S. . Nanobodies: an unexplored opportunity to combat COVID-19 . Journal of Biomolecular Structure and Dynamics 1 - 3 2020年11月査読国際誌

Kayesh MEH, Hashem MA, Tsukiyama-Kohara K. . Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review. . Arch Virol. 165 ( 11 ) 2409 - 2417 2020年11月招待査読

Ezzikouri S, Nourlil J, Tsukiyama-Kohara K, Kohara M, El Ossmani H, Windisch MP, Benjelloun S. . Nanobodies: an unexplored opportunity to combat COVID-19 . J Biomol Struct Dyn.10 1 - 3 2020年11月査読

Kayesh M.E.H. . Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review . Archives of Virology165 ( 11 ) 2409 - 2417 2020年11月査読国際誌

Hashem MA, Maetani F, Kayesh MEH, Eiei T, Mochizuki K, Ito A, Sakurai H, Asai T, Tsukiyama-Kohara K. . Transmission of koala retrovirus from parent koalas to a joey in a Japanese zoo. . Journal of Virolgy94 ( 11 ) e0019-20 2020年5月査読

Chi Hai-Ying, Yuuki Tanaka, Tatsuro Hifumi, Ko-ichiro Shoji, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Bouchra Kitab, Takahiro Sanada, Tomoko Fujiyuki, Misako Yoneda, Hitoshi Hatai, Akira Yabuki, Noriaki Miyoshi, Chieko Kai, Michinori Kohara, Kyoko Tsukiyama-Kohara . Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew) . PLoS One15 ( 5 ) e0233232 2020年5月査読

Sayeh Ezzikouri, Mohammad Enamul Hoque Kayesh, Soumaya Benjelloun, Michinori Kohara and Kyoko Tsukiyama-Kohara . Targeting host innate and adaptive immunity to achieve the functional cure of chronic hepatitis B . Vaccines8 ( 2 ) E216 2020年5月査読

Mohammad Enamul Hoque Kayesh 1,2 , Md Abul Hashem 1, Bouchra Kitab 1 and Kyoko Tsukiyama-Kohara . Pathogenesis and Immune Response Caused by Vector-Borne and Other Viral Infections in a Tupaia Model . microorganism 2019年12月招待査読

Sanada T, Yamamoto N, Kayesh MEH, Tsukiyama-Kohara K, Hasegawa H, Miyazaki T, Takano JI, Shiogama Y, Yasutomi Y, Goh Y, Yoshida O, Hiasa Y, Kohara M. . Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response. . Biochem Biophys Res Commun.520 ( 1 ) 86 - 92 2019年11月査読

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