研究者詳細 - 小原　恭子

論文 - 小原　恭子

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Kayesh MEH, Kohara M, Tsukiyama-Kohara K . Toll-like receptor response to Zika virus infection: progress toward infection control. . Npj viruses3 ( 1 ) 20 2025年3月査読国際誌

Rashid MHO, Kayesh MEH, Hashem MA, Hifumi T, Ogawa S, Miyoshi N, Tanaka Y, Kohara M, Tsukiyama-Kohara K . Adeno-associated virus 2 CRISPR/Cas9-mediated targeting of hepatitis B virus in tree shrews. . Virus research 199550 2025年2月査読国際誌

Hifumi T., Tanaka Y., Tsukiyama-Kohara K., Miyoshi N. . Phyllodes tumor in the mammary gland of a northern tree shrew (Tupaia belangeri) . Journal of Veterinary Medical Science87 ( 4 ) 384 - 388 2025年査読国際誌

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Veterinary Medical Science

A rapidly growing mass was observed in the left third mammary gland of a 5-and-a-half-year-old intact female northern tree shrew (Tupaia belangeri). Histopathologically, the mass was composed of numerous irregularly dilated mammary ducts with a pericanalicular or intracanalicular pattern. These mammary ducts showed a leaf-like structure due to the proliferations of surrounding spindle-shaped neoplastic cells with moderate to severe nuclear atypia. We diagnosed this case as a phyllodes tumor in a mammary gland of a northern tree shrew (Tupaia belangeri), which closely resembled those occurring in the human breast histopathologically. To the best of our knowledge, this is the first report of a phyllodes tumor in the mammary gland of a northern tree shrew (Tupaia belangeri).

DOI： 10.1292/jvms.24-0444

Scopus

PubMed

Soliman AM, Mahmoud HYAH, Amer MM, Mohamed S, Hifumi T, Tsukiyama-Kohara K, Tanaka T . First detection of Colpodella spp. in Rhipicephalus annulatus and molecular characterization of piroplasmids in southern Egypt. . Frontiers in veterinary science12 1617204 2025年査読国際誌

Kayesh MEH, Kohara M, Tsukiyama-Kohara K . Innate immune sensing and vaccine strategies against West Nile virus: role of Toll-like receptors and viral evasion mechanisms. . Frontiers in microbiology16 1711088 2025年査読国際誌

Akter L, Hashem MA, Kayesh MEH, Hossain MA, Maetani F, Akhter R, Hossain KA, Rashid MHO, Sakurai H, Asai T, Hoque MN, Tsukiyama-Kohara K . A preliminary study of gene expression changes in Koalas Infected with Koala Retrovirus (KoRV) and identification of potential biomarkers for KoRV pathogenesis. . BMC veterinary research20 ( 1 ) 496 2024年10月査読国際誌

Kayesh MEH, Hashem MA, Tsukiyama-Kohara K . Epidemiology, Transmission Mode, and Pathogenesis of Chlamydia pecorum Infection in Koalas (Phascolarctos cinereus): An Overview. . Animals : an open access journal from MDPI14 ( 18 ) 2024年9月査読国際誌

Yao YG, Lu L, Ni RJ, Bi R, Chen C, Chen JQ, Fuchs E, Gorbatyuk M, Lei H, Li H, Liu C, Lv LB, Tsukiyama-Kohara K, Kohara M, Perez-Cruz C, Rainer G, Shan BC, Shen F, Tang AZ, Wang J, Xia W, Xia X, Xu L, Yu D, Zhang F, Zheng P, Zheng YT, Zhou J, Zhou JN . Study of tree shrew biology and models: A booming and prosperous field for biomedical research. . Zoological research45 ( 4 ) 877 - 909 2024年7月査読国際誌

Uno Y, Tsukiyama-Kohara K, Ishizuka M, Mizukawa H, Murayama N, Yamazaki H . Investigation of functional cytochrome P450 4A enzymes in liver and kidney of pigs, cats, tree shrews, and dogs in comparison with the metabolic capacity of human P450 4A11. . Drug metabolism and disposition: the biological fate of chemicals 2024年7月査読国際誌

Kayesh M.E.H., Kohara M., Tsukiyama-Kohara K. . Recent Insights into the Molecular Mechanisms of the Toll-like Receptor Response to Influenza Virus Infection . International Journal of Molecular Sciences25 ( 11 ) 2024年6月査読国際誌

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Molecular Sciences

Influenza A viruses (IAVs) pose a significant global threat to human health. A tightly controlled host immune response is critical to avoid any detrimental effects of IAV infection. It is critical to investigate the association between the response of Toll-like receptors (TLRs) and influenza virus. Because TLRs may act as a double-edged sword, a balanced TLR response is critical for the overall benefit of the host. Consequently, a thorough understanding of the TLR response is essential for targeting TLRs as a novel therapeutic and prophylactic intervention. To date, a limited number of studies have assessed TLR and IAV interactions. Therefore, further research on TLR interactions in IAV infection should be conducted to determine their role in host–virus interactions in disease causation or clearance of the virus. Although influenza virus vaccines are available, they have limited efficacy, which should be enhanced to improve their efficacy. In this study, we discuss the current status of our understanding of the TLR response in IAV infection and the strategies adopted by IAVs to avoid TLR-mediated immune surveillance, which may help in devising new therapeutic or preventive strategies. Furthermore, recent advances in the use of TLR agonists as vaccine adjuvants to enhance influenza vaccine efficacy are discussed.

DOI： 10.3390/ijms25115909

Scopus

PubMed

Ushirozako G, Murayama N, Tsukiyama-Kohara K, Yamazaki H, Uno Y . Novel tree shrew cytochrome P450 2Ds ( CYP2D8a and CYP2D8b ) are functional drug-metabolizing enzymes that metabolize bufuralol and dextromethorphan. . Drug metabolism and disposition: the biological fate of chemicals 2024年1月査読国際誌

Uno Y, Makiguchi M, Ushirozako G, Tsukiyama-Kohara K, Shimizu M, Yamazaki H . Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews. . Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 109835 2024年1月査読国際誌

Kayesh MEH, Nazneen H, Kohara M, Tsukiyama-Kohara K . An effective pan-serotype dengue vaccine and enhanced control strategies could help in reducing the severe dengue burden in Bangladesh-A perspective. . Frontiers in microbiology15 1423044 2024年査読国際誌

Hasan MN, Rahman MM, Husna AA, Arif M, Iwanaga T, Tsukiyama-Kohara K, Jasineviciute I, Kato D, Nakagawa T, Miura N . Elevated expression of miR-301a and its functional roles in canine oral melanoma. . Veterinary and comparative oncology 2023年12月査読国際誌

Uno Y, Minami Y, Tsukiyama-Kohara K, Murayama N, Yamazaki H . Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity. . Biochemical pharmacology 115990 2023年12月査読国際誌

Ngwe Tun MM, Nwe KM, Balingit JC, Takamatsu Y, Inoue S, Pandey BD, Urano T, Kohara M, Tsukiyama-Kohara K, Morita K . A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis. . Vaccines11 ( 12 ) 2023年12月査読国際誌

Kayesh MEH, Kohara M, Tsukiyama-Kohara K . Effects of neddylation on viral infection: an overview. . Archives of virology169 ( 1 ) 6 2023年12月査読国際誌

Akter L, Hashem MA, Rakib TM, Rashid MHO, Hossain KA, Akhter R, Utsunomiya M, Kitab B, Hifumi T, Miyoshi N, Maetani F, Tsukiyama-Kohara K . Investigation of koala retrovirus in captive koalas with pneumonia and comparative analysis of subtype distribution. . Archives of virology168 ( 12 ) 298 2023年11月査読国際誌

Ushirozako G, Murayama N, Tsukiyama-Kohara K, Yamazaki H, Uno Y . Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p-nitrophenol. . Xenobiotica; the fate of foreign compounds in biological systems 1 - 11 2023年11月査読国際誌

Hossain KA, Akhter R, Rashid MHO, Akter L, Utsunomiya M, Kitab B, Mm N, Hishiki T, Kohara M, Morita K, Tsukiyama-Kohara K . Suppression of dengue virus replication by the French maritime pine extract Pycnogenol®. . Virus research 199244 2023年10月査読国際誌

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