研究者詳細 - 小原　恭子

論文 - 小原　恭子

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Soliman AM, Mahmoud HYAH, Amer MM, Mohamed S, Hifumi T, Tsukiyama-Kohara K, Tanaka T . First detection of Rickettsia japonica in Hyalomma dromedarii ticks infesting camels from Egypt: A call for enhanced surveillance of tick-borne pathogens. . Medical and veterinary entomology 2025年9月査読国際誌

Akter L, Hashem MA, Kayesh MEH, Rakib TM, Rashid MHO, Maetani F, Tsukiyama-Kohara K . Correction: Elevated oncogene expressions in koala infected with multiple koala retrovirus subtypes: a preliminary study. . Virus genes 2025年8月査読国際誌

Kayesh MEH, Kohara M, Tsukiyama-Kohara K . Toll-like Receptor (TLR) Response in Chikungunya Virus Infection: Mechanism of Activation, Immune Evasion, and Use of TLR Agonists in Vaccine Development. . Vaccines13 ( 8 ) 2025年8月査読国際誌

Kayesh M.E.H., Kohara M., Tsukiyama-Kohara K. . Innate Immune Response to Powassan Virus Infection: Progress Toward Infection Control . Vaccines13 ( 7 ) 2025年7月査読国際誌

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Vaccines

Powassan virus is an emerging tick-borne flavivirus that poses a significant threat to human health. The outcome of Powassan virus infection is shaped by both viral factors and the host immune response. While this review aimed to examine the innate immune response, particularly toll-like receptor-mediated immune responses to Powassan virus, data specific to the immune response to Powassan virus remain scarce. Therefore, we focused on toll-like receptor responses to related flaviviruses to infer possible mechanisms of host response. Insights from both in vivo and in vitro studies are critical for guiding the development of effective therapeutic and preventive strategies. Currently, there are no clinically approved treatments or vaccines for Powassan virus, highlighting the urgent need for their development. We also highlight recent progress in POWV vaccine development, with an emphasis on the potential use of toll-like receptor agonists as adjuvants to enhance immunogenicity and improve vaccine efficacy.

DOI： 10.3390/vaccines13070754

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Akter L, Hashem MA, Kayesh MEH, Rakib TM, Rashid MHO, Maetani F, Kohara KT . Elevated oncogene expressions in koala infected with multiple koala retrovirus subtypes: a preliminary study. . Virus genes 2025年6月査読国際誌

Sanada T, Tsukiyama-Kohara K, Kohara M . Genomic characterization of hepaciviruses and pegivirus in the northern tree shrew (Tupaia belangeri). . Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 105778 2025年6月査読国際誌

Rashid MHO, Ezzikouri S, Soliman AM, Akter L, Momohara K, Hifumi T, Miyoshi N, Hishiki T, Abdel-Moneim AS, Kohara M, Tsukiyama-Kohara K . Drug repositioning: Identification of potent inhibitors of NS3 protease and NS5 RdRp for control of DENV infection. . Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie187 118104 2025年4月査読国際誌

Rashid MHO, Yasui F, Sanada T, Kono R, Honda T, Kitab B, Akter L, Utsunomiya M, Sato R, Yoshida O, Hiasa Y, Oda Y, Goh Y, Miyazaki T, Kohara M, Tsukiyama-Kohara K . Immunogenicity of an Intranasal Dual (Core and Surface)-Antigen Vaccine Against Hepatitis B Virus Enhanced by Carboxyl-Vinyl Polymer Excipients. . Vaccines13 ( 5 ) 2025年4月査読国際誌

Kayesh MEH, Kohara M, Tsukiyama-Kohara K . Effects of oxidative stress on viral infections: an overview. . Npj viruses3 ( 1 ) 27 2025年4月査読国際誌

Akhter R, Hossain KA, Kitab B, Sakoda Y, Tsukiyama-Kohara K . Common host factors for internal ribosomal entry site-mediated translation of viral genomic RNA: An investigation in foot-and-mouth disease and classical swine fever viruses. . Virus research 199570 2025年4月査読国際誌

Uno Y, Kawabata I, Ushirozako G, Tsukiyama-Kohara K, Ishizuka M, Mizukawa H, Murayama N, Yamazaki H . Exploration of functional cytochrome P450 4F enzymes in liver, intestine, and kidney from dogs, cats, pigs, and tree shrews and comparison of their metabolic capacities with human P450 4F2 and 4F12. . Biochemical pharmacology 116894 2025年3月査読国際誌

Kayesh MEH, Kohara M, Tsukiyama-Kohara K . Toll-like receptor response to Zika virus infection: progress toward infection control. . Npj viruses3 ( 1 ) 20 2025年3月査読国際誌

Rashid MHO, Kayesh MEH, Hashem MA, Hifumi T, Ogawa S, Miyoshi N, Tanaka Y, Kohara M, Tsukiyama-Kohara K . Adeno-associated virus 2 CRISPR/Cas9-mediated targeting of hepatitis B virus in tree shrews. . Virus research 199550 2025年2月査読国際誌

Hifumi T., Tanaka Y., Tsukiyama-Kohara K., Miyoshi N. . Phyllodes tumor in the mammary gland of a northern tree shrew (Tupaia belangeri) . Journal of Veterinary Medical Science87 ( 4 ) 384 - 388 2025年査読国際誌

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Veterinary Medical Science

A rapidly growing mass was observed in the left third mammary gland of a 5-and-a-half-year-old intact female northern tree shrew (Tupaia belangeri). Histopathologically, the mass was composed of numerous irregularly dilated mammary ducts with a pericanalicular or intracanalicular pattern. These mammary ducts showed a leaf-like structure due to the proliferations of surrounding spindle-shaped neoplastic cells with moderate to severe nuclear atypia. We diagnosed this case as a phyllodes tumor in a mammary gland of a northern tree shrew (Tupaia belangeri), which closely resembled those occurring in the human breast histopathologically. To the best of our knowledge, this is the first report of a phyllodes tumor in the mammary gland of a northern tree shrew (Tupaia belangeri).

DOI： 10.1292/jvms.24-0444

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Soliman AM, Mahmoud HYAH, Amer MM, Mohamed S, Hifumi T, Tsukiyama-Kohara K, Tanaka T . First detection of Colpodella spp. in Rhipicephalus annulatus and molecular characterization of piroplasmids in southern Egypt. . Frontiers in veterinary science12 1617204 2025年査読国際誌

Akter L, Hashem MA, Kayesh MEH, Hossain MA, Maetani F, Akhter R, Hossain KA, Rashid MHO, Sakurai H, Asai T, Hoque MN, Tsukiyama-Kohara K . A preliminary study of gene expression changes in Koalas Infected with Koala Retrovirus (KoRV) and identification of potential biomarkers for KoRV pathogenesis. . BMC veterinary research20 ( 1 ) 496 2024年10月査読国際誌

Kayesh MEH, Hashem MA, Tsukiyama-Kohara K . Epidemiology, Transmission Mode, and Pathogenesis of Chlamydia pecorum Infection in Koalas (Phascolarctos cinereus): An Overview. . Animals : an open access journal from MDPI14 ( 18 ) 2024年9月査読国際誌

Yao YG, Lu L, Ni RJ, Bi R, Chen C, Chen JQ, Fuchs E, Gorbatyuk M, Lei H, Li H, Liu C, Lv LB, Tsukiyama-Kohara K, Kohara M, Perez-Cruz C, Rainer G, Shan BC, Shen F, Tang AZ, Wang J, Xia W, Xia X, Xu L, Yu D, Zhang F, Zheng P, Zheng YT, Zhou J, Zhou JN . Study of tree shrew biology and models: A booming and prosperous field for biomedical research. . Zoological research45 ( 4 ) 877 - 909 2024年7月査読国際誌

Uno Y, Tsukiyama-Kohara K, Ishizuka M, Mizukawa H, Murayama N, Yamazaki H . Investigation of functional cytochrome P450 4A enzymes in liver and kidney of pigs, cats, tree shrews, and dogs in comparison with the metabolic capacity of human P450 4A11. . Drug metabolism and disposition: the biological fate of chemicals 2024年7月査読国際誌

Kayesh M.E.H., Kohara M., Tsukiyama-Kohara K. . Recent Insights into the Molecular Mechanisms of the Toll-like Receptor Response to Influenza Virus Infection . International Journal of Molecular Sciences25 ( 11 ) 2024年6月査読国際誌

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Molecular Sciences

Influenza A viruses (IAVs) pose a significant global threat to human health. A tightly controlled host immune response is critical to avoid any detrimental effects of IAV infection. It is critical to investigate the association between the response of Toll-like receptors (TLRs) and influenza virus. Because TLRs may act as a double-edged sword, a balanced TLR response is critical for the overall benefit of the host. Consequently, a thorough understanding of the TLR response is essential for targeting TLRs as a novel therapeutic and prophylactic intervention. To date, a limited number of studies have assessed TLR and IAV interactions. Therefore, further research on TLR interactions in IAV infection should be conducted to determine their role in host–virus interactions in disease causation or clearance of the virus. Although influenza virus vaccines are available, they have limited efficacy, which should be enhanced to improve their efficacy. In this study, we discuss the current status of our understanding of the TLR response in IAV infection and the strategies adopted by IAVs to avoid TLR-mediated immune surveillance, which may help in devising new therapeutic or preventive strategies. Furthermore, recent advances in the use of TLR agonists as vaccine adjuvants to enhance influenza vaccine efficacy are discussed.

DOI： 10.3390/ijms25115909

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