研究者詳細 - 大脇　哲洋

講演・口頭発表等 - 大脇　哲洋

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Sakurai T, Okumura H, Matsumoto M, Uchikado Y, Owaki T, Kita Y, Setoyama T, Omoto I, Kijima Y, Ishigami S, Natsugoe S . Endoglin (CD105) is a useful marker for evaluating microvessel density and predicting prognosis in esophageal squamous cell carcinoma. . Anticancer research 2014年7月

Sakurai T., Okumura H., Matsumoto M., Uchikado Y., Owaki T., Kita Y., Setoyama T., Omoto I., Kijima Y., Ishigami S., Natsugoe S. . Endoglin (CD105) is a useful marker for evaluating microvessel density and predicting prognosis in esophageal squamous cell carcinoma . Anticancer Research 2014年7月 Anticancer Research

記述言語：日本語

Background: Angiogenic molecular markers such as vascular endothelial growth factor and tumor microvessel density reflect prognosis of human cancers. The present study clarified the usefulness of endothelial marker endoglin (CD 105) by assessing microvessel density in esophageal squamous cell carcinoma (ESCC). Materials and Methods: We immunohistochemically investigated CD105, CD31, and vascular endothelial growth factor-A VEGF-A expression in primary esophageal squamous cell carcinoma specimens from 142 patients. Results: Microvessel density was 35.9±21.2 for CD105 and 46.3±25.4 for CD31. CD105 microvessel density was significantly associated with tumor length, tumor invasion depth, lymph node metastasis, stage, lymphatic invasion, venous invasion, and VEGF-A expression; its correlation with almost all clinicopathological parameters was stronger than CD31 microvessel density. And significantly better prognosis was achieved in patients with low, compared to high CD105, microvessel density. Conclusion: CD105 microvessel density reflected the degree of angiogenesis and prognosis in patients with esophageal squamous cell carcinoma.

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中野静雄, 夏越祥次, 衣裴勝彦, 上之園芳一, 馬場道宏, 池田直徳, 松本正隆, 奥村浩, 大脇哲洋, 愛甲孝 . EMR治療後の長期予後からみた,食道表在癌治療法の検討 . 日本消化器外科学会雑誌 2003年7月一般社団法人日本消化器外科学会

Yoshida S., Matsumoto M., Kashima S., Owaki T., Iguchi S., Inoue K., Tazuma S., Maeda T. . Emigration of regional quota graduates of Japanese medical schools to non-designated prefectures: A prospective nationwide cohort study . BMJ Open 2019年7月 BMJ Open

記述言語：日本語

Objectives: This study examined the retention of regional quota graduates of Japanese medical schools and prefecture scholarship recipients within their designated prefectures where they are obliged or expected to work and revealed the personal and regional characteristics associated with their emigration to non-designated prefectures. Regional quota and prefecture scholarship are two of the most ambitious policies ever conducted in Japan for recruiting physicians to practice in rural areas. Design: Prospective cohort study. Setting: Nationwide. Participants: Regional quota graduates with prefecture scholarship, quota graduates without scholarship and non-quota graduates with scholarship of Japanese medical schools who obtained their physician license between 2014 and 2016. Primary outcome: The emigration in 2016 of the participants from the designated prefectures. Results: Total participants were 991 physicians, three of whom were excluded due to the missing values of crucial items, leaving 988 participants for analysis (quota with scholarship 387, quota alone 358 and scholarship alone 243). The percentage of those who emigrated was 11.9% (118/988). The mean (±SD) proportion of subjects who emigrated was 11.7% (±10.3) among all prefectures and the proportion varies widely among prefectures (0%-44.4%). Multilevel logistic regression analysis showed those who received prefecture scholarship (OR 0.23; 95% CI 0.08 to 0.67) and whose designated prefecture has an ordinance-designated city (ie, large city) were less likely to emigrate (OR 0.47; 95% CI 0.24 to 0.90). In contrast, graduates from a medical school outside the designated prefecture (OR 4.20; 95% CI 2.20 to 7.67) and who have a right to postpone their obligatory service (OR 3.42; 95% CI 1.52 to 7.67) were more likely to emigrate. Conclusions: A substantial proportion of regional quota graduates and prefecture scholarship recipients emigrated to non-designated prefectures. Emigrations should be reduced by improving the potential facilitators for emigration such as discordance in location between medical school and designated prefecture.

DOI： 10.1136/bmjopen-2019-029335

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PubMed

Amitani M., Amitani H., Suzuki H., Kawazu S., Fukumoto T., Yamaguchi K., Oki T., Nitta H., Sonoda T., Uto N., Numata M., Mizuma K., Ibusuki R., Takezaki T., Owaki T., Asakawa A. . Effective learning strategies for Japanese Kampo medicine using problem-based learning and simulator training for medical students: A questionnaire survey . Traditional and Kampo Medicine 2021年8月 Traditional and Kampo Medicine

記述言語：日本語

Background: Kampo medicine was introduced into the core curriculum model of medical education in Japan in 2007, and has been taught at all 80 medical universities across the country. However, as there are differences in terms of content and between universities, Kampo medicine education needs to be standardized. Therefore, this study aimed to examine the effects of combining multiple strategies, including lectures, problem-based learning (PBL), and simulator training for the development of a standardized educational curriculum for Kampo medicine. Methods: We offered a lectures-only class (Kampo strategy-lectures [Ks-L]), a class with lectures and decoction (Ks-LD), a class with lectures, decoction, and PBL (Ks-LDP), and a class with lectures, decoction, PBL, and simulator training (Ks-LDPS). We analyzed the data from a 12-item questionnaire conducted by the Faculty Development Committee of Kagoshima University Faculty of Medicine to evaluate the curriculum. Results: Ks-LDPS was rated significantly higher than the other modules in active learning, and overall satisfaction. Conclusions: The results of this study suggest that combining multiple strategies rather than offering classes with lectures promoted a positive attitude to Kampo medicine and deep self-learning among students, thereby improving the educational effects of Kampo medicine education.

DOI： 10.1002/tkm2.1281

Scopus

Kijima Y., Yoshinaka H., Owaki T., Aikou T. . Effect of nutritional state on postoperative axillary leakage after axillary lymph node dissection in a new rat model . Surgery Today 2005年4月 Surgery Today

記述言語：日本語

Purpose. Axillary leakage after axillary lymph node dissection (ALD) in breast cancer surgery is a frequent and troublesome complication. We conducted this study to establish an experimental model of axillary leakage after ALD; to evaluate axillary leakage in different nutritional states; and to examine the effects of dietary management on axillary leakage. Methods. Twenty-eight Wistar rats were divided into two groups according to whether they were fed a high-fat diet or a low-fat diet for 14 weeks before ALD. After ALD, a suction drain was placed in the axilla and continuous suction was started. Axillary leakage was monitored for 9 days, and the drainage fluid and serum were analyzed biochemically. Results. The body weights of the two groups were not significantly different before or after ALD. The amount of cumulative drainage fluid was significantly higher on postoperative days 7 and 9 in the high-fat group. The serum phosphate lipid, total cholesterol, and free cholesterol levels, and the free cholesterol level in the drainage fluid were also significantly higher in the high-fat group. Conclusions. This model is useful for reproducing lymphatic leakage after ALD. Our findings also suggest that a low-fat diet may be advantageous for patients undergoing ALD as part of breast cancer surgery. © Springer-Verlag 2005.

DOI： 10.1007/s00595-004-2933-z

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PubMed

KIJIMA YUKO, YOSHINAKA HEIJI, OWAKI TETSUHIRO, AIKOU TAKASHI . Effect of Nutritional State on Postoperative Axillary Leakage After Axillary Lymph Node Dissection in a New Rat Model . 2005年4月

尾本至, 内門泰斗, 佐々木健, 大脇哲洋, 前村公成, 夏越祥次 . 食道癌術前治療中の経管栄養の検討 . 学会誌JSPEN 2019年9月 (一社)日本栄養治療学会

尾本至, 内門泰斗, 佐々木健, 野田昌宏, 大脇哲洋, 前村公成, 夏越祥次 . 食道癌術前治療中の経管栄養の有用性の検討 . 学会誌JSPEN 2021年1月 (一社)日本栄養治療学会

瀬ノ口奈緒, 田栗教子, 竹元明子, 深水知英, 鈴木真由美, 加治建, 出口尚寿, 尾本至, 有村愛子, 西恭宏, 永田俊行, 武田亜矢, 青木雅也, 大脇哲洋 . 術後の経過に難渋し長期間の経管栄養から経口摂取に移行できた1症例 . 学会誌JSPEN 2021年1月 (一社)日本栄養治療学会

尾本至, 内門泰斗, 佐々木健, 奥村浩, 有上貴明, 柳田茂寛, 盛真一郎, 大脇哲洋, 前村公成, 夏越祥次 . 消化器癌に対する集学的治療　術前化学療法を施行した食道癌患者の治療前栄養スコアの検討 . 日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集 2018年11月日本消化器病学会-九州支部

佐々木健, 内門泰斗, 尾本至, 奥村浩, 有上貴明, 盛真一郎, 前村公成, 大脇哲洋, 夏越祥次 . 化学放射線療法の現状と新たなる展望～制癌剤と照射法の工夫～　局所進行食道癌に対する術前DCF-RT療法 . 日本食道学会学術集会プログラム・抄録集 2018年6月 (NPO)日本食道学会

Shinden Y., Kamimura K., Hayashi N., Nomoto Y., Nagata A., Eguchi Y., Yano H., Saho H., Nakajo A., Minami K., Hirashima T., Sasaki K., Yoshinaka H., Owaki T., Tanimoto A., Nakamura M., Ohtsuka T. . Relationship between Delayed Breast Cancer Diagnosis and Behavioral Economic Factors and Personality Characteristics . Asian Pacific Journal of Cancer Prevention 2023年 Asian Pacific Journal of Cancer Prevention

記述言語：日本語

Background: Delays in breast cancer diagnosis can allow the disease to progress to an incurable stage. However, factors that cause patients to delay seeking treatment are unclear. In this study, we aimed to identify behavioral economic factors and personality characteristics of patients with breast cancer who had a delayed diagnosis. Methods: We analyzed questionnaires completed by 41 patients with breast cancer. A delayed diagnosis was defined if the time between the first symptom and the medical visit was more than 6 months. Results: We found 11 patients who had a delayed diagnosis. The significant characteristics associated with patients with breast cancer who had delayed diagnosis were: (i) less experience with breast cancer screening; (ii) progressive disease stage; and (iii) low time and future time preference. We found no significant behavioral economic factors other than time preference, and personality that differed between patients with breast cancer who did and did not have a delayed diagnosis. Conclusion: Low time preference rate is a characteristic of patients with breast cancer who had a delayed diagnosis.

DOI： 10.31557/APJCP.2023.24.10.3437

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PubMed

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講演・口頭発表等 - 大脇 哲洋

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講演・口頭発表等 - 大脇　哲洋