研究者詳細 - 大脇　哲洋

講演・口頭発表等 - 大脇　哲洋

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Owaki T., Yoshinaka H., Ehi K., Uenosono Y., Kijima Y., Natsugoe S., Aikou T. . Lymphatic stream from a breast tumor to a sentinel node in the parasternal node basin: Consideration of two cases with internal mammary node metastases . European Journal of Radiology Extra 2004年7月 European Journal of Radiology Extra

記述言語：日本語

Prior to worldwide acceptance of the sentinel lymph node concept, internal mammary node dissection was regarded as unnecessary for diagnosis of breast cancer. More recently, the impact of internal mammary nodes dissection on the survival of breast cancer patients has come under scrutiny. We have encountered important breast cancer cases involving lymphatic streams that go from the tumor to both the internal mammary chain and axillary node basin simultaneously. Moreover, a lymphatic stream was found to go from the breast tumor to the internal mammary chain via intra-mammary gland lymph nodes. These cases indicate the dual importance of internal mammary sentinel node dissection as well as axillary sentinel node dissection. © 2004 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrex.2004.03.007

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吉留伸郎, 草野力, 実操二, 池田直穂, 山本誠司, 大脇哲洋, 小代正隆, 愛甲孝 . IV-17 6日後に大量出血をきたした奇形血管を有する食道ポリープの一例 . 日本消化器外科学会雑誌 1998年2月一般社団法人日本消化器外科学会

Kairupan T.S., Ibusuki R., Kheradmand M., Sagara Y., Mantjoro E.M., Nindita Y., Niimura H., Kuwabara K., Ogawa S., Tsumematsu-Nakahata N., Nerome Y., Owaki T., Matsushita T., Maenohara S., Yamaguchi K., Takezaki T. . Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population . Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ 2017年日本疫学会

記述言語：英語

Background: An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases. Method: We selected 2180 sub-cohort subjects aged 35-69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-α, IL-10, and NF-κB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases. Results: HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-a 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-κB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18-7.77). Conclusion: The present study found the interaction between TNF-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.

DOI： 10.1016/j.je.2016.08.017

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PubMed

Natsugoe S., Okumura H., Matsumoto M., Uchikado Y., Setoyama T., Yokomakura N., Uenosono Y., Ishigami S., Owaki T., Aikou T. . Individualization of lymphadenectomy in superficial esophageal squamous cell cancer . Esophagus 2006年7月 Esophagus

記述言語：日本語

Background. As the result of the development of imaging means, the incidence of discovery of superficial esophageal squamous cell cancer (ESCC) has recently increased. Various treatment methods such as endoscopic mucosal resection and reduction of lymphadenectomy have been performed to preserve the quality of life. Because lymph node metastasis occurs even in the early stage of esophageal cancer, we should carefully select the treatment method, including lymphadenectomy. Methods. We analyzed the distribution of solitary lymph metastasis of 27 superficial esophageal cancers. To analyze the distribution of micrometastasis, a total of 1542 lymph nodes obtained from 46 patients with pN0 submucosal cancer were immunohistochemically examined by cytokeratin antibody. Sentinel node mapping was performed in 23 patients with clinical T1 tumors. Results. The location of lymph node metastasis in the 22 patients with solitary lymph metastasis in superficial cancer was limited to recurrent nerve nodes in the upper thoracic esophagus, recurrent nerve nodes, paraesophageal nodes, or perigastric nodes in the middle or lower thoracic esophagus. For eight patients with lymph node micrometastasis in pN0 patients with superficial esophageal cancer, the locations of micrometastasis were similar to those of solitary metastasis. In sentinel node mapping, all nodal metastasis was included in sentinel nodes with a single exception. Conclusions. Individual lymphadenectomy in superficial ESCC will be established using methods such as analysis of past data, clinical diagnosis of lymph node metastasis by imaging, and sentinel node navigation surgery, including the diagnosis of micrometastasis. © Japan Esophageal Society and Springer-Verlag 2006.

DOI： 10.1007/s10388-006-0070-z

Scopus

Uchikado Y., Okumura H., Ishigami S., Setoyama T., Matsumoto M., Owaki T., Kita Y., Natsugoe S. . Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer . Gastric Cancer 2011年3月 Gastric Cancer

記述言語：日本語

Background: The expression of E-cadherin correlates with the progression and metastasis of gastric cancer. Slug, a member of the snail family of transcriptional factors, is a newly identified factor that represses transcription of the E-cadherin gene. The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in gastric cancer. Methods: Immunohistochemistry was used to investigate the expression of E-cadherin and Slug proteins in 164 patients with gastric cancer. The relationships between the expression of these proteins and clinicopathological factors, including prognosis, were analyzed. Results: Positive expression of E-cadherin and Slug was observed in 43.9 and 29.9% of cases, respectively. Tumors with reduced E-cadherin or positive Slug expression had greater extent of lymph node metastasis, lymphatic invasion, and venous invasion, and were at a worse stage than the tumors with preserved E-cadherin or negative Slug expression. Slug expression was significantly correlated with reduced E-cadherin expression; 37 of the 49 (75.5%) tumors with positive Slug expression had reduced E-cadherin expression (P = 0.0008). Patients with reduced E-cadherin expression or positive Slug expression had poor clinical outcomes. In the group with preserved E-cadherin expression, the 5-year survival rate was better for patients who were negative for Slug expression than for those who were positive for Slug expression (P = 0.0001). However, multivariate analysis indicated that E-cadherin expression and Slug expression were not independent prognostic factors. Conclusions: Evaluation of not only the expression of E-cadherin, but also the coexpression of E-cadherin and Slug in patients with preserved E-cadherin expression would be useful for predicting malignant properties of gastric cancer. © 2011 The International Gastric Cancer Association and The Japanese Gastric Cancer Association.

DOI： 10.1007/s10120-011-0004-x

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PubMed

Yokomakura N, Natsugoe S, Okumura H, Ikeda R, Uchikado Y, Mataki Y, Takatori H, Matsumoto M, Owaki T, Ishigami S, Aikou T . Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma. . Oncology reports 2007年9月

Yokomakura N., Natsugoe S., Okumura H., Ikeda R., Uchikado Y., Mataki Y., Takatori H., Matsumoto M., Owaki T., Ishigami S., Aikou T. . Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma . Oncology Reports 2007年9月 Oncology Reports

記述言語：日本語

Chemoradiation therapy (CRT), a combination of X-ray irradiation and anticancer agents as a radiosensitizer, has been found to be an effective treatment for esophageal cancer and has been linked to p53 genetics. The p53 gene family regulates cell-cycle arrest, apoptosis and DNA damage repair. A recently identified ribonucleotide reductase, p53R2, is directly regulated by p53 in the supply of nucleotides for repairing damaged DNA. In the present study, we investigated the improvement in radiosensitivity of human esophageal squamous cell carcinoma (ESCC) cell lines using p53R2 small interfering RNA (siRNA). p53R2 expression in ESCC cells (TE-8) with or without transfection of p53R2 siRNA was examined by Western blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). The radiosensitivity of TE-8 cells was also measured by cell survival assay. In addition, we investigated the relationship between the expression of p53R2 mRNA in the biopsy specimens of untreated primary tumors and the efficacy of CRT, using RT-PCR. The expression of p53R2 was amplified after X-ray irradiation (14 Gy) and diminished after X-ray irradiation following the transfection of p53R2 siRNA in TE-8 cells. The radiosensitivity of the TE-8 cells significantly improved following the transfection of p53R2 siRNA. In the clinical study, a significantly lower p53R2 mRNA expression was detected in the effective response cases. We demonstrated that p53R2 is associated with the radiosensitivity of ESCC cell lines, and that p53R2 expression is reduced after X-ray irradiation following the transfection of p53R2 siRNA. This protocol could potentially improve the efficacy of radiation therapy.

DOI： 10.3892/or.18.3.561

Scopus

Omoto I, Matsumoto M, Uchikado Y, Kita Y, Sakurai T, Sasaki K, Setoyama T, Okumura H, Owaki T, Ishigami S, Natsugoe S . Immunohistochemical evidence of association between ghrelin expression and tumor growth in esophageal carcinoma. . Anticancer research 2014年6月

Omoto I., Matsumoto M., Uchikado Y., Kita Y., Sakurai T., Sasaki K., Setoyama T., Okumura H., Owaki T., Ishigami S., Natsugoe S. . Immunohistochemical evidence of association between ghrelin expression and tumor growth in esophageal carcinoma . Anticancer Research 2014年6月 Anticancer Research

記述言語：日本語

Background: Ghrelin, an orexigenic peptide, is primarily produced and secreted by the gastrointestinal tract. As far as we are aware of, there is no evidence of ghrelin expression in esophageal squamous cell carcinoma (ESCC). Materials and Methods: Two hundred and ten patients with ESCC who underwent surgical resection were enrolled in this study. We immunohistochemically investigated ghrelin expression in primary ESCC specimens and analyzed the relationship with clinicopathological factors. Results: High ghrelin expression was observed in 61 patients (29.0%). Depth of tumor invasion and histological differentiation were statistically associated with ghrelin expression. As for depth of tumor invasion, the deeper it was, the higher was the expression of ghrelin. Well-differentiated tumors had a significantly higher proportion of ghrelin-expressing cells than other types. Conclusion: Ghrelin expression correlated with tumor depth and tumor differentiation, suggesting an important role of ghrelin in tumor growth in ESCC.

Scopus

Kijima Y., Yoshinaka H., Owaki T., Funasako Y., Aikou T. . Immediate reconstruction using inframammary adipofascial flap of the anterior rectus sheath after partial mastectomy . American Journal of Surgery 2007年6月 American Journal of Surgery

記述言語：日本語

Treatment of early breast cancer using breast conservative therapy (BCT) usually ensures local control and acceptable cosmetic results. To repair defects caused by partial mastectomy in the lower region of the breast, some reconstruction should be used. We developed a procedure involving the cranial based adipofascial (anterior rectus sheath) flap from immediately below the inframammary area for the reconstruction of defect due to partial mastectomy for patients with early breast cancer. In this procedure, a skin incision is made at the inframammary line, and the inframammary skin area is undermined. A tongue shaped flap composed of the subcutaneous fat and the anterior sheath of rectus abdominis muscle is pulled up and a C-shaped flap is rotated, gathered, and inserted to reconstruct the breast defect. © 2007 Excerpta Medica Inc. All rights reserved.

DOI： 10.1016/j.amjsurg.2006.06.052

Scopus

PubMed

喜島祐子, 吉中平次, 大脇哲洋, 愛甲孝 . 遊離真皮脂肪片移植による乳房温存術後一期的再建 . 日本臨床外科学会雑誌 2005年日本臨床外科学会

記述言語：日本語

乳房内側領域病変に対する乳房温存療法において,とくに乳房の小さい女性の場合,乳腺欠損部の補填が難しく,著しい術後変形をきたすことがある.内側領域の乳癌4症例に対し乳房温存術を行い,一期的に下腹部より採取した遊離真皮脂肪片による自家移植・補填を行い良好な結果を得た.術後経過観察中の理学所見(超音波検査, CT)より,移植片周囲に新生血管が増生していることが確認された.一般外科医にも習得可能な簡便な方法であり,乳房温存術後の整容性を保持するために有用な方法と思われる.

DOI： 10.3919/jjsa.66.7

馬場政道, 中野静雄, 大脇哲洋, 上之園芳一, 馬場道宏, 草野力, 夏越祥次, 愛甲孝 . III-6-2.高度進行食道癌における照射・化学療法の意義 . 日本消化器外科学会雑誌 2002年9月一般社団法人日本消化器外科学会

山本誠司, 草野力, 小代正隆, 吉留伸郎, 大脇哲洋, 池田直徳, 愛甲孝 . III-227 紋拒性イレウスとSIRSの関連について . 日本消化器外科学会雑誌 1998年2月一般社団法人日本消化器外科学会

池田直徳, 吉留伸郎, 大脇哲洋, 山本誠司, 草野力, 小代正隆, 愛甲孝 . II-130 初回破裂1年6ヶ月後に腹腔内出血により再発が確認された肝細胞癌の1例 . 日本消化器外科学会雑誌 1998年2月一般社団法人日本消化器外科学会

中野静雄, 馬場政道, 大脇哲洋, 崎田浩徳, 草野力, 夏越祥次, 愛甲孝 . II-1-4.表在食道癌に対するEMR治療例の長期予後の検討(第55回日本食道疾患研究会) . 日本消化器外科学会雑誌 2002年9月一般社団法人日本消化器外科学会

大脇哲洋, 馬場政道, 吉中平次, 夏越祥次, 坂元史典, 中野静雄, 島田麻里, 草野力, 福元俊孝, 愛甲孝 . I-2-3.超音波内視鏡(EUS)による食道表在癌の深達度診断(示説)(第55回日本食道疾患研究会) . 日本消化器外科学会雑誌 2002年9月一般社団法人日本消化器外科学会

草野力, 吉留伸郎, 大脇哲洋, 山本誠司, 池田直徳, 小代正隆, 愛甲孝 . Hyperdynamic循環管理によるARDS対策 . 日本外科学会雑誌 1998年3月一般社団法人日本外科学会

大脇哲洋, 根路銘安仁, 新村英士, 嶽崎俊郎, 村永文学, 夏越祥次 . HP-211-5 離島へき地における外科加療後のフォローと問題点とその対策(外科臨床2,ハイブリッドポスター,第109回日本外科学会定期学術集会) . 日本外科学会雑誌 2009年2月一般社団法人日本外科学会

内門泰斗, 奥村浩, 松本正隆, 瀬戸山徹郎, 佐々木健, 桜井俊秀, 喜島祐子, 北薗正樹, 大脇哲洋, 柳正和, 石神純也, 新地洋之, 上野真一, 夏越祥次 . HP-180-6 EMT関連タンパクSnail, SlugはpN 0食道癌の予後と関連する(食道(浸潤・転移),ハイブリッドポスター,第109回日本外科学会定期学術集会) . 日本外科学会雑誌 2009年2月一般社団法人日本外科学会

櫻井俊秀, 奥村浩, 松本正隆, 瀬戸山徹郎, 内門泰斗, 佐々木健, 尾本至, 大脇哲洋, 石神純也, 夏越祥次 . HP-100-1 食道癌におけるオートファジーマーカーLC-3発現の意義(食道(発癌・悪性度2),ハイブリッドポスター,第109回日本外科学会定期学術集会) . 日本外科学会雑誌 2009年2月一般社団法人日本外科学会

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講演・口頭発表等 - 大脇 哲洋

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講演・口頭発表等 - 大脇　哲洋