研究者詳細 - 大脇　哲洋

講演・口頭発表等 - 大脇　哲洋

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内門泰斗, 奥村浩, 尾本至, 喜多芳昭, 大脇哲洋, 夏越祥次 . 【食道手術-合併症対処の各施設の工夫-】術中・術後合併症の予防と対処　当施設の工夫　反回神経麻痺　当施設の予防と対策 . 手術 2015年6月金原出版(株)

喜多芳昭, 馬場研二, 盛真一郎, 井出迫俊彦, 内門泰斗, 有上貴明, 上之園芳一, 奥村浩, 前村公成, 大脇哲洋, 石神純也, 中川昌之, 夏越祥次 . S状結腸を用いた代用腟に発生した粘液癌の1例 . 日本癌治療学会誌 2015年9月 (一社)日本癌治療学会

鶴田祐介, 奥村浩, 内門泰斗, 恵浩一, 伊地知哲也, 尾本至, 喜多芳昭, 石神純也, 大脇哲洋, 夏越祥次 . ESDとサルベージ手術により喉頭温存した頸部食道を含む多発表在癌の1例 . 日本食道学会学術集会プログラム・抄録集 2015年7月 (NPO)日本食道学会

岩穴口孝, 宇都由美子, 大脇哲洋 . EBMの推進のための診療支援ツールと病院情報システムの連携と評価 . 日本診療情報管理学会学術大会抄録集 2021年8月日本診療情報管理学会

佐々木健, 内門泰斗, 尾本至, 浦田正和, 奥村浩, 大脇哲洋, 有上貴明, 上之園芳一, 前村公成, 夏越祥次 . 7.5MHzリニア型超音波専用機による食道癌術前リンパ節転移診断 . 日本消化器外科学会雑誌 2017年10月 (一社)日本消化器外科学会

下之薗将貴, 奥村浩, 内門泰斗, 恵浩一, 喜多芳昭, 上之園芳一, 有上貴明, 大脇哲洋, 石神純也, 夏越祥次 . 3群以上の遠位リンパ節転移を認めた食道粘膜癌症例の検討 . 日本消化器外科学会総会 2015年7月 (一社)日本消化器外科学会

松本正隆, 夏越祥次, 瀬戸山徹郎, 花園幸一, 奥村浩, 大脇哲洋, 愛甲孝 . O-2-13 悪性腫瘍の血管新生・リンパ管新生を標的とした治療戦略(症例1,一般演題(口演),第62回日本消化器外科学会定期学術総会) . 日本消化器外科学会雑誌 2007年7月一般社団法人日本消化器外科学会

瀬戸山徹郎, 夏越祥次, 松本正隆, 奥村浩, 内門泰斗, 佐々木健, 櫻井俊秀, 石神純也, 大脇哲洋, 愛甲孝 . O-1-332 根治切除後再発食道癌に対する治療方針の選択(食道再発1,一般演題(口演),第63回日本消化器外科学会総会) . 日本消化器外科学会雑誌 2008年7月一般社団法人日本消化器外科学会

花園幸一, 夏越祥次, 松本正隆, 奥村浩, 瀬戸山徹郎, 喜多芳昭, 内門泰斗, 佐々木健, 大脇哲洋, 愛甲孝 . O-1-14 高齢者食道癌に対する治療方針(切除vsCRT)の検討(高齢者食道癌2,一般演題(口演),第62回日本消化器外科学会定期学術総会) . 日本消化器外科学会雑誌 2007年7月一般社団法人日本消化器外科学会

佐々木健, 夏越祥次, 石神純也, 松本正隆, 奥村浩, 瀬戸山徹郎, 内門泰斗, 櫻井俊秀, 大脇哲洋, 愛甲孝 . O-1-136 食道扁平上皮癌のTwistとE-cadherinの発現の意義(食道研究1,一般演題(口演),第63回日本消化器外科学会総会) . 日本消化器外科学会雑誌 2008年7月一般社団法人日本消化器外科学会

Okumura H, Kita Y, Yokomakura N, Uchikado Y, Setoyama T, Sakurai H, Omoto I, Matsumoto M, Owaki T, Ishigami S, Natsugoe S . Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma. . Anticancer research 2010年12月

Okumura H., Kita Y., Yokomakura N., Uchikado Y., Setoyama T., Sakurai H., Omoto I., Matsumoto M., Owaki T., Ishigami S., Natsugoe S. . Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma . Anticancer Research 2010年12月 Anticancer Research

記述言語：日本語

Background: The 14-3-3 sigma gene is transcriptionally activated by p53 after DNA damage and facilitates DNA repair during G2 arrest. The present study analyzed the clinical significance of 14-3-3 sigma expression in esophageal squamous cell carcinoma. Patients and Methods: The relationship between 14-3-3 sigma and p53 expressions was investigated immunohistochemically in surgical specimens of primary tumors from 248 patients with esophageal squamous cell carcinoma. Results: The positive expression rates of cytoplasmic and nuclear14-3-3 sigma were 61.7% and 41.9%, respectively. There was no correlation between 14-3-3 sigma and p53 expression. Positive expression of nuclear 143-3 sigma was significantly correlated with depth of invasion, stage, lymphatic invasion, and poor prognosis. Multivariate analysis indicated that negative expression of nuclear 14-3-3 sigma was an independent prognostic factor. Conclusion: Evaluation of the expression of nuclear 14-3-3 sigma proteins may be useful in predicting the outcome in patients with esophageal squamous cell carcinoma.

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Kawasaki Y., Okumura H., Uchikado Y., Kita Y., Sasaki K., Owaki T., Ishigami S., Natsugoe S. . Nrf2 is useful for predicting the effect of chemoradiation therapy on esophageal squamous cell carcinoma . Annals of Surgical Oncology 2014年7月 Annals of Surgical Oncology

記述言語：日本語

Background: The transcription factor NF-E2-related factor 2 (Nrf2) was originally identified to be a critical regulator of intracellular antioxidants and phase II detoxification enzymes. Recent studies have shown that high Nrf2 expression gives cancer cells an advantage for survival from anticancer chemotherapy and radiation therapy. The aims of this retrospective study were to examine the expression of Nrf2 in biopsy specimens of esophageal squamous cell carcinoma (ESCC) and to evaluate whether such expression is useful for predicting the response to chemoradiation therapy (CRT). Methods: A total of 46 patients with ESCC who received curative surgery after CRT from 1997 to 2011 were enrolled in the current study. Nrf2 expression in the biopsy specimens before CRT was examined immunohistochemically using anti-Nrf2 antibody. The correlations between Nrf2 expression and clinical factors and histological and clinical response to CRT were analyzed. Results: The rate of Nrf2-positive expression was 39 %. Both clinically and histologically, significant correlations were found between positive Nrf2 expression and unfavorable response to CRT. Furthermore, Nrf2 was significantly correlated with clinical lymph node metastases and patients' postoperative outcomes. Multivariate analysis showed that Nrf2 expression status was an independent prognostic factor. Conclusions: Nrf2 expression was found to be closely related to the effect of CRT and could predict the CRT outcome in patients with ESCC. © 2014 Society of Surgical Oncology.

DOI： 10.1245/s10434-014-3600-2

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PubMed

Natsugoe S., Matsumoto M., Okumura H., Ishigami S., Uenosono Y., Owaki T., Takao S., Aikou T. . Multiple primary carcinomas with esophageal squamous cell cancer: Clinicopathologic outcome . World Journal of Surgery 2005年1月 World Journal of Surgery

記述言語：日本語

The incidence of multiple primary carcinomas (MPCs) associated with esophageal cancer has increased. The purpose of this study was to analyze clinicopathologic findings for MPC and for only esophageal cancer (OEC). Of 157 patients with MPCs, 60 had synchronous cancer and 97 metachronous cancer. Another 42 patients had antecedent esophageal cancer (AEC), and 55 patients had subsequent esophageal cancer (SEC). We retrospectively analyzed the clincopathologic findings for patients in these categories. The incidence of early-stage carcinoma was higher in patients with MPCs than in those with an OEC. Of patients with MPCs, those with metachronous cancer had a higher rate of early-stage carcinoma than those with synchronous cancer. The 5-year survival rates were not significantly different for MPC and OEC patients. Patients with metachronous cancer had a significantly better prognosis than those with synchronous cancer (p = 0.017); and in the metachronous cancer group the prognosis was significantly better for patients with AEC than for those with SEC (p = 0.0005). Meticulous follow-up after treatment of a first cancer should be required to detect other early-stage carcinomas. © 2004 by the Société Internationale de Chirurgie.

DOI： 10.1007/s00268-004-7525-y

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PubMed

花園幸一, 夏越祥次, 奥村浩, 松本正隆, 内門泰斗, 瀬戸山徹郎, 大脇哲洋, 愛甲孝 . MS-1-2 cT4食道癌に対する化学放射線療法の検討(cT4食道癌の治療,ミニシンポジウム1,第61回日本消化器外科学会定期学術総会) . 日本消化器外科学会雑誌 2006年7月一般社団法人日本消化器外科学会

Nagata A, Shinden Y, Nomoto Y, Saho H, Nakajo A, Minami K, Kumagae Y, Kirishima M, Owaki T, Ohtsuka T . Metastasis of breast cancer to the right kidney with a tumor thrombus in the inferior vena cava: a case report. . Surgical case reports 2022年1月

Sakita H., Okumura H., Ishigami S., Matsumoto M., Uchikado Y., Setoyama T., Arigami T., Uenosono Y., Kijima Y., Owaki T., Shinchi H., Ueno S., Natsugoe S. . Metachronous esophageal squamous cell cancer after gastrectomy for gastric cancer . Esophagus 2013年9月 Esophagus

記述言語：日本語

Background: The clinical and biological characteristics of metachronous esophageal squamous cell cancer (ESCC) after gastrectomy for gastric cancer have yet to be sufficiently elucidated. The aim of the present study was to examine carcinogenesis in such patients. Methods: Subjects comprised 11 patients with metachronous carcinoma in whom ESCC occurred after gastric cancer (metachronous ESCC), 9 patients with simultaneously occurring gastric cancer and ESCC (simultaneous ESCC) and 52 patients with ESCC alone. We investigated the clinicopathological findings and biological properties using p53, p21 and cyclin D1 expression. Results: The positive rate for the intraepithelial spread of tumor was higher for metachronous ESCC than for simultaneous ESCC (p < 0.05). The number of dysplastic lesions in metachronous ESCC, simultaneous ESCC and ESCC alone was 56, 41 and 44, respectively. The rate of positive p53 expression in dysplasia was significantly higher for metachronous ESCC than for ESCC alone (p = 0.03). Conclusions: Positive expression of p53 was found in not only the primary tumor, but also intraepithelial neoplasia around the tumor in metachronous ESCC. Chronic gastroesophageal reflux due to gastrectomy may be involved in the process of carcinogenesis in addition to environmental and genetic factors for metachronous ESCC. Further studies of a larger number of patients with metachronous ESCC and a history of gastrectomy are warranted. © 2013 The Japan Esophageal Society and Springer Japan.

DOI： 10.1007/s10388-013-0371-y

Scopus

Owaki T., Kusano C., Ojiro M., Aikou T. . Massive bleeding from Dieulafoy's lesion of the small intestine in a child - Therapy for the bleeding from gastrointestinal tract out of endoscopic observation . Digestive Surgery 2002年9月 Digestive Surgery

記述言語：日本語

Dieulafoy's lesion is recognized as a submucosal artery associated with a minute mucosal defect and a rare cause of severe gastrointestinal hemorrhage. Especially, that of distal jejunum or ileum is extraordinarily rare. It is very difficult to detect the lesion in these parts. We experienced massive bleeding from Dieulafoy's lesion of the distal jejunum in a 12-year-old girl. Preoperative angiography and intraoperative palpation detected the point of bleeding. She was rescued by partial jejunectomy. Compiled reports suggested that careful palpation was useful for detection of the location of the bleeding point, which was enhanced as vascular dilatation by the angiogram, during the operation comparatively. Copyright© 2002 S. Karger AG, Basel.

DOI： 10.1159/000064571

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PubMed

喜島祐子, 大脇哲洋, 吉中平次, 愛甲孝, 金子洋一 . 鹿児島県におけるマンモグラフィ併用集団検診 : 検診における視触診の意義 : MMG単独検診の可能性 . 日本乳癌検診学会誌 = Journal of Japan Association of Breast Cancer Screening 2003年6月

喜島祐子, 大脇哲洋, 吉中平次, 愛甲孝, 金子洋一 . 検診における視・触診の意義　　（６）　　鹿児島県におけるマンモグラフィ併用集団検診―検診における視触診の意義：　　ＭＭＧ単独検診の可能性― . 日本乳癌検診学会誌 2003年特定非営利活動法人　日本乳癌検診学会

記述言語：日本語

鹿児島県でのマンモグラフィ併用乳癌検診の結果を人的労力・経済効果の面からも検討した。40歳以上の女性にマンモグラフィ併用検診を導入した平成12, 13年度の癌発見率は0.16%, 0.18%と高率であった。年代別にみると, マンモグラフィ併用検診は40歳代においても有用であり, 早期発見に寄与していた。<BR>平成13年度の結果を用いて, 乳癌患者1名を発見するために要した費用を概算すると, マンモグラフィ検診では1,461,432円であった。同様にマンモグラフィ偽陰性例を発見するのに要した金額は1名あたり15,249,950円であった。さらに, 視触診を行うために派遣された医師ののべ人数は340人に及んだ。マンモグラフィ単独検診のモデル事業では1,945人から3人の癌が発見された (癌発見率0.15%) 。<BR>人的労力・経済効率・受診率向上などの面で, マンモグラフィ単独検診の可能性が示唆された。

DOI： 10.3804/jjabcs.12.157

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講演・口頭発表等 - 大脇 哲洋

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講演・口頭発表等 - 大脇　哲洋