研究者詳細 - 大脇　哲洋

講演・口頭発表等 - 大脇　哲洋

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草野力, 吉留伸郎, 大脇哲洋, 山本誠司, 池田直徳, 小代正隆, 春田隆秀, 愛甲孝 . W-4-2 透析を要する腹部手術例の周術期管理 (<ワークショップ4> 消化器外科手術と腎透析(適応, 手術時期ならびに手術成績)) . 日本消化器外科学会雑誌 1998年2月一般社団法人日本消化器外科学会

中条哲浩, 白尾一定, 中野静雄, 大脇哲洋, 夏越祥次, 愛甲孝 . VS-7-8 鏡視下甲状腺切除術における鋼線筋鉤の有用性(第108回日本外科学会定期学術集会) . 日本外科学会雑誌 2008年4月一般社団法人日本外科学会

大脇哲洋, 中野静雄, 益満幸一郎, 吉中平次, 愛甲孝 . VP-60 鏡視下甲状腺切除の問題点とその対策 . 日本外科学会雑誌 2000年3月一般社団法人日本外科学会

大脇哲洋, 吉中平次 . 手術室関連設備の海外の動向(<特集>海外における医科器械の最新動向) . 医科器械学 2006年2月一般社団法人日本医療機器学会

喜多芳昭, 松本正隆, 内門泰斗, 奥村浩, 大脇哲洋, 夏越祥次 . 臨床報告一期的縫合閉鎖が有効であった食道穿孔の2例 . 臨床外科 2012年5月株式会社医学書院

Okumura H., Uchikado Y., Omoto I., Kita Y., Sasaki K., Arigami T., Uenosono Y., Matsushita D., Hiraki Y., Owaki T., Ishigami S., Natsugoe S. . The usefulness of neoadjuvant chemoradiation therapy for locally advanced esophageal cancer with multiple lymph-node metastases . Annals of Surgical Oncology 2014年9月 Annals of Surgical Oncology

記述言語：日本語

Background. The prognosis of patients with esophageal squamous-cell cancer (ESCC) and multiple lymph-node metastases is quite poor. We examined whether neoadjuvant chemoradiation therapy (CRT) has a beneficial effect in such patients. Methods. A total of 50 consecutive patients with T3-4 tumors and without organ metastases were prospectively enrolled. Of those patients, 20, who had four or more nodal metastases, underwent neoadjuvant CRT (CRT group), and the remaining 30 patients, who had three or fewer nodal metastases, underwent surgery alone (surgery group). CRT consisted of 5-fluorouracil plus cisplatin and 40 Gy of radiation. The groups' clinical outcomes were compared. Results. Surgery was performed in 48 patients: all enrolled patients except for 2 who had organ metastasis after CRT. In the CRT group, the number of patients with pathological complete response was observed in 8 patients (44 %), mean nodal metastases number was changed from 8.2 to 2.6 and 9 patients had pN0. The 3-year survival rate was 76 % in the CRT group (4 patients relapsed) and 68 % in the surgery group (8 patients relapsed), which is not a statistically significant difference (P = 0.61). Conclusions. Neoadjuvant CRT is beneficial for locally advanced ESCC with four or more lymph-node metastases. © 2014 Society of Surgical Oncology.

DOI： 10.1245/s10434-014-3688-4

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Owaki T, Nakano S, Arimura K, Aikou T . The ultrasonic coagulating and cutting system injures nerve function. . Endoscopy 2002年7月

Owaki T., Nakano S., Arimura K., Aikou T. . The ultrasonic coagulating and cutting system injures nerve function . Endoscopy 2002年7月 Endoscopy

記述言語：日本語

Background: Although, many surgeons have used ultrasonic coagulating and cutting systems and shears (LCS) when carrying out endoscopic thyroidectomies and parathyroidectomies, in our experience some patients had temporary paralysis of the recurrent laryngeal nerve (RLN) after these operations. We had sometimes noticed that the heat of the blade of the LCS was increased just after use; therefore, we designed an RLN model, and investigated the damage to the RLN which could be attributed to the heat of the LCS. Methods: We investigated the effects of the heat of the LCS blade on rat femoral and sciatic nerves, using temperature measurement, histological examination and evoked electromyography. Results: The temperature of the LCS blade exceeded 150°C after 30 seconds when it was not used for cutting. When we used the LCS to cut rat muscle or fat tissue, the temperature of the blade exceeded 100°C after 20 seconds. There was no damage to the nerve histologically when the LCS was used for less than 20 seconds at a distance of 3 mm. Electrophysiological study showed that touching the nerve with the LCS blade after only 5 seconds of use resulted in damage to the nerve. Conclusions: Our results suggest that the RLN should not be touched directly with the blade just after it has been used, and that it is possible to use the LCS at a distance of 3 mm from the RLN for less than 20 seconds at level 3. In order to maintain these distances, the RLN must be endoscopically visualized during surgery of the neck.

DOI： 10.1055/s-2002-33221

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奥村浩, 内門泰斗, 喜多芳昭, 尾本至, 惠浩一, 林直樹, 大脇哲洋, 石神純也, 夏越祥次 . 全身状態に基づいた食道破裂・穿孔症例の治療法の検討 . 日本腹部救急医学会雑誌 2015年日本腹部救急医学会

記述言語：日本語

目的：食道破裂・穿孔の適切な治療方針を検討すること。対象と方法：2004年7月から2013年6月に当科で診療した食道破裂・穿孔症例の特徴を検討した。結果：食道破裂・穿孔症例は10例であった。来院時ショック状態の3症例は下部食道の破裂で胸水貯留，白血球低下を伴い，2例にドレナージとステント挿入，1例にドレナージ後二期的経裂孔手術が施行された。非ショックの7症例では，胸水貯留が1例，白血球低下症例は認められず，4例に手術，3例に保存的加療がなされた。ショック群の在院日数が有意に長期であったが，在院死亡例はみられなかった。結論：来院時ショック状態の食道破裂症例に対しては，ドレナージを主体とし，ステント挿入も考慮した保存的治療を行い，手術は二期的に計画することが勧められる。

DOI： 10.11231/jaem.35.043

Amitani M., Amitani H., Sloan R.A., Suzuki H., Sameshima N., Asakawa A., Nerome Y., Owaki T., Inui A., Hoshino E. . The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo . Frontiers in Pharmacology 2015年 Frontiers in Pharmacology

記述言語：日本語

Complementary and alternative medicine (CAM) including Japanese Kampo is known to have anticancer potential. An increasing number of cancer survivors are using CAM for disease prevention, immune system enhancement, and symptom control. Although there have been abundant previous clinical reports regarding CAM, scientific investigations aimed at acquiring quantifiable results in clinical trials, as well as basic research regarding CAM, have only recently been undertaken. Recent studies suggest that CAM enhancement of immune function is related to cytokines. This review provides a translational aspect of CAM, particularly Hozai in Kampo from both scientific and clinical points of view for further development of CAM for cancer treatment.

DOI： 10.3389/fphar.2015.00150

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Natsugoe S., Okumura H., Matsumoto M., Uchikado Y., Setoyama T., Uenosono Y., Ishigami S., Owaki T., Aikou T. . The role of salvage surgery for recurrence of esophageal squamous cell cancer . European Journal of Surgical Oncology 2006年6月 European Journal of Surgical Oncology

記述言語：日本語

Aim: A consensus treatment strategy for recurrent esophageal squamous cell cancer (ESCC) has not been established. The purpose of the present study was to analyse the mode of recurrence, and evaluate the role of surgical salvage treatment in recurrence of ESCC. Methods: Recurrence was detected in 131 of 367 consecutive patients with ESCC. We retrospectively analysed the mode of recurrence and treatment for recurrence. Recurrence was divided into four types; lymph node, hematogeneous, mixed and local. Treatments were classified into four groups; chemotherapy alone (C group), radiation therapy±chemotherapy (R group), surgery±other therapy (S group), and no therapy (N group). Results: Of the 131 recurrences, the number of patients with lymph node, hematogeneous, mixed and local recurrence was 43, 44, 40 and 4, respectively. The number of patients in the C, R, S, N groups was 35, 35, 24 and 37, respectively. Of the 24 patients who received surgical treatment for recurrence, the number of patients with lymph node, hematogeneous, mixed and local recurrence was 11, 6, 6 and 1, respectively. The number of lesions in hematogeneous recurrence was 2 or less. The survival rate from recurrence to death in the C, R, S and N groups was 0, 3.9, 6.7 and 0%, respectively. A statistically significant difference was found in these groups (p<0.0001). Conclusions: Salvage surgery is one of the useful treatment tools for resectable metastatic lesions. In such cases, the number of lesions, recurrent sites and effectiveness of chemotherapy and/or radiotherapy should be carefully evaluated. © 2006 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ejso.2006.02.014

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Amitani M., Amitani H., Cheng K.C., Kairupan T.S., Sameshima N., Shimoshikiryo I., Mizuma K., Rokot N.T., Nerome Y., Owaki T., Asakawa A., Inui A. . The role of ghrelin and ghrelin signaling in aging . International Journal of Molecular Sciences 2017年7月 International Journal of Molecular Sciences

記述言語：日本語

With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important role in the mechanism of longevity mediated by calorie restriction. In this review, we will discuss the role of orexigenic peptides with a particular focus on ghrelin. We conclude that the ghrelin-growth hormone secretagogue-R signaling pathway may play an important role in the anti-aging mechanism.

DOI： 10.3390/ijms18071511

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網谷真理恵, 浅川明弘, 網谷東方, 根路銘安仁, 大脇哲洋, 乾明夫 . 理論から検討するプライマリ・ケア領域での心身医学の重要性 . 心身医学 2016年一般社団法人日本心身医学会

記述言語：日本語

<p>プライマリ・ケアと心身医学には, ｢全人的医療｣を目指すという患者への診療姿勢, ｢ヘルスプロモーション｣, ｢メンタルヘルスケア｣など, 共通して重視している側面がある. プライマリ・ケアにおける心身医学の役割を考察することは, 心身医学のあり方を見つめなおし, 今後の心身医学の啓蒙と発展への助力となると考える. また漠然とした認識ではなく, 必要な学習項目を挙げて, プライマリ・ケアと心身医学の共通点と相違点を整理することで, 心身医学が重視しているプライマリ・ケアに必要な理論体系についても考察する.</p>

DOI： 10.15064/jjpm.56.11_1104

Sakurai T., Okumura H., Matsumoto M., Uchikado Y., Setoyama T., Omoto I., Owaki T., Maemura K., Ishigami S., Natsugoe S. . The expression of LC-3 is related to tumor suppression through angiogenesis in esophageal cancer . Medical Oncology 2013年12月 Medical Oncology

記述言語：日本語

Autophagy is important in the development and remodeling of cells. It is required for cellular adaptation to nutrient deprivation and elimination of damaged organelles. Recently, autophagy has been implicated in carcinogenesis and metastasis. We hypothesized that autophagy-related proteins are initiated until nutrition is supplied by angiogenesis. We evaluated the clinicopathological significance of LC3, an autophagic marker, and its relationship to angiogenesis in patients with esophageal squamous cell carcinoma (ESCC). We immunohistochemically investigated the expression of LC3 as well as endoglin (CD105), a microvessel marker, and vascular endothelial growth factor A (VEGF-A) in 142 patients with ESCC. The high, moderate, and low expression rates of LC3 were 40, 31, and 29 %. LC3 expression inversely correlated with depth of invasion, lymph node metastasis, lymphatic invasion, MVD, VEGF-A expression, and poor prognosis. The overall survival rate was better in patients with high LC3 expression compared to patients with low LC3 expression. We demonstrate that low LC3 expression is related to tumor development as facilitated by angiogenesis and that alteration in LC3 expression is closely related to prognosis. Expression of LC3 proteins is a useful marker for determining tumor prognostic behavior in patients with ESCC. © 2013 The Author(s).

DOI： 10.1007/s12032-013-0701-x

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Amitani M., Amitani H., Owaki T., Monuki T., Adachi S., Kawazu S., Fukumoto T., Suzuki H., Yoshimura T., Mizuma K., Nishida Y., Watanabe H., Hirose M., Funakoshi K., Ota K., Murotani K., Asakawa A. . The Effect of Mindfulness Yoga in Children With School Refusal: A Study Protocol for an Exploratory, Cluster-Randomized, Open, Standard Care-Controlled, Multicenter Clinical Trial . Frontiers in Public Health 2022年7月 Frontiers in Public Health

記述言語：日本語

Background: School refusal occurs in about 1–2% of young people. Anxiety and depression are considered to be the most common emotional difficulties for children who do not attend school. However, at present, no definitive treatment has been established for school refusal, although interventions such as cognitive behavioral therapy have been used. This paper reports a protocol for a cluster-randomized controlled trial of a mindfulness yoga intervention for children with school refusal. Methods: This study is a multicenter, exploratory, open cluster-randomized controlled trial. This study will recruit children aged 10–15 years with school refusal. After a 2-week baseline, participants for each cluster will be randomly assigned to one of two groups: with or without mindfulness yoga for 4 weeks. Mindfulness yoga will be created for schoolchildren for this protocol and distributed to the participants on DVD. The primary outcome is anxiety among children with school refusal using the Spence Children's Anxiety Scale-Children. Discussion: For this study, we developed a mindfulness yoga program and protocol, and examine whether mindfulness yoga can improve anxiety in children with school refusal. Our mindfulness yoga program was developed based on the opinions of children of the same age, and is a program that children can continue to do every day without getting bored. In this way, we believe that we can contribute to the smooth implementation of support to reduce the anxiety of children with school refusal, and to the reduction of the number of children who refuse to go to school.

DOI： 10.3389/fpubh.2022.881303

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小代正隆, 草野力, 吉留伸郎, 大脇哲洋, 山本誠司, 池田直徳, 山角健介, 愛甲孝 . 色素沈着, 潰瘍を呈した慢性静脈不全症例の治療経験 . 静脈学 1998年10月

Kijima Y., Owaki T., Yoshinaka H., Aikou T. . Synchronous bilateral breast cancer with Paget's disease and invasive ductal carcinoma: Report of a case . Surgery Today 2003年8月 Surgery Today

記述言語：日本語

We report a case of synchronous bilateral breast cancer with Paget's disease and invasive ductal carcinoma. A 60-year-old Japanese woman presented with an 8-month history of discharge from the left nipple with eczema and itching. Mammography showed grouped fine calcification in the right breast, which was highly suggestive of right breast carcinoma with an intraductal component. Ultrasonography did not reveal any mass lesions in the bilateral breasts, and computed tomography and bone scintigraphy showed no site of distant metastasis. We performed a modified radical mastectomy for Paget's disease in the left breast and breast-conserving surgery for ductal carcinoma in the right breast. The histological diagnosis was Paget's disease in the left breast and invasive ductal carcinoma with a predominant intraductal component in the right breast. There was no metastasis in any of the 24 left axillary lymph nodes resected. We also gave her postoperative adjuvant chemoendocrine therapy, comprised of tamoxifen (20mg) and UFT (uracil/tegafur) (400mg) daily. The patient has been disease-free for 4 years since her operation.

DOI： 10.1007/s00595-003-2549-8

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KIJIMA YUKO, OWAKI TETSUHIRO, YOSHINAKA HEIJI, AIKOU TAKASHI . Synchronous Bilateral Breast Cancer with Paget's Disease and Invasive Ductal Carcinoma : Report of a Case . Surg Today 2003年8月

奥村浩, 夏越祥次, 松本正隆, 大脇哲洋, 有留邦明, 中条哲浩, 上之園芳一, 花園幸一, 愛甲孝 . SY-6-2 食道胃接合部癌に対する外科治療(食道胃接合部癌に対する外科治療-経食道裂孔vs経開胸開腹-,シンポジウム6,第61回日本消化器外科学会定期学術総会) . 日本消化器外科学会雑誌 2006年7月一般社団法人日本消化器外科学会

松本正隆, 内門泰斗, 喜多芳昭, 尾本至, 櫻井俊秀, 瀬戸山徹郎, 奥村浩, 大脇哲洋, 石神純也, 夏越群次 . SY-5-4 胸部食道癌に対する外科治療の限界(シンポジウム(5)食道癌に対する外科治療の限界,シンポジウム,第110回日本外科学会定期学術集会) . 日本外科学会雑誌 2010年3月一般社団法人日本外科学会

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<大脇 哲洋>

講演・口頭発表等 - 大脇 哲洋

<大脇　哲洋>

講演・口頭発表等 - 大脇　哲洋