研究者詳細 - 牧迫　飛雄馬

論文 - 牧迫　飛雄馬

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Hirase T, Okita M, Nakai Y, Akaida S, Shono S, Makizako H . Pain and physical activity changes during the COVID-19 state of emergency among Japanese adults aged 40 years or older: A cross-sectional study. . Medicine100 ( 41 ) e27533 - e27533 2021年10月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Medicine

ABSTRACT: Understanding the relationship between pain and physical activity (PA) levels is beneficial for maintaining good health status. However, the impact of pain on changes in PA during the coronavirus disease 2019 (COVID-19) pandemic is unknown. The purpose of this study was to examine whether PA levels pre-, during, and post-COVID-19 state of emergency differ between Japanese adults who had pain after the COVID-19 state of emergency and those who did not.Data were collected from a cross-sectional online survey conducted between October 19 and 28, 2020. The analytic sample consisted of 1967 Japanese adults aged ≥40 years who completed the online survey. Participants completed questionnaires on the presence of pain and duration of PA, defined as the total PA time per week based on activity frequency and time. Participants were asked to report their PA at 3 time points: October 2019 (before the COVID-19 pandemic), April 2020 (during the COVID-19 state of emergency), and October 2020 (after the COVID-19 state of emergency).Among participants aged ≥60 years who reported pain in October 2020, the total PA time was significantly lower than participants who did not report having pain. Furthermore, the total PA time in April 2020 was significantly lower than that in October 2019; however, no significant difference in total PA time was observed between April and October 2020. Among participants aged 40 to 59 years, no significant differences were observed in total PA times at the 3 time points between those with and without pain. In addition, the total PA time in October 2020 significantly increased compared to that in April 2020, although it significantly decreased in April 2020 compared to October 2019.This study suggests that older adults with pain have lower PA levels after the COVID-19 state of emergency.

DOI： 10.1097/MD.0000000000027533

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PubMed

立石麻奈, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 赤井田将真, 和田あゆみ, 佐藤菜々, 窪薗琢郎, 大石充 . 転倒歴を有さない地域在住高齢女性における転倒恐怖感と身体活動量との関連 . 日本老年医学会雑誌58 ( 4 ) 663 - 663 2021年10月

赤井田将真, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 立石麻奈, 田平隆行, 竹中俊宏, 窪薗琢郎, 大石充 . 地域在住高齢者における自動車事故歴と転倒歴との関連 . 日本老年医学会雑誌58 ( 4 ) 663 - 663 2021年10月

牧迫飛雄馬, 窪薗琢郎, 大石充 . 【日本における高齢者コホート研究の成果と現状】垂水研究 . 老年内科4 ( 4 ) 405 - 409 2021年10月

Jujo K. . Impact of social frailty in hospitalized elderly patients with heart failure: A fragile-hf registry subanalysis . Journal of the American Heart Association10 ( 17 ) e019954 2021年9月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of the American Heart Association

BACKGROUND: Frailty is conceptualized as an accumulation of deficits in multiple areas and is strongly associated with the prognosis of heart failure (HF). However, the social domain of frailty is less well investigated. We prospectively evaluated the clinical characteristics and prognostic impact of social frailty (SF) in elderly patients with HF. METHODS AND RESULTS: FRAGILE-HF (prevalence and prognostic value of physical and social frailty in geriatric patients hospitalized for heart failure) is a multicenter, prospective cohort study focusing on patients hospitalized for HF and aged ≥65 years. We defined SF by Makizako’s 5 items, which have been validated as associated with future disability. The primary end point was a composite of all-cause death and rehospitalization because of HF. The impact of SF on all-cause mortality alone was also evaluated. Among 1240 enrolled patients, 825 (66.5%) had SF. During the 1-year observation period after discharge, the rates of the combined end point and all-cause mortality were significantly higher in patients with SF than in those without SF (Log-rank test: both P < 0.05). SF remained as significantly associated with both the combined end point (hazard ratio, 1.30; 95% CI, 1.02–1.66; P = 0.038) and all-cause mortality (hazard ratio, 1.53; 95% CI, 1.01–2.30; P = 0.044), even after adjusting for key clinical risk factors. Furthermore, SF showed significant incremental prognostic value over known risk factors for both the combined end point (net-reclassification improvement: 0.189, 95% CI, 0.063–0.316, P = 0.003) and all-cause mortality (net-reclassification improvement: 0.234, 95% CI, 0.073–0.395, P = 0.004). CONCLUSIONS: Among hospitalized geriatric patients with HF, two thirds have SF. Evaluating SF provides additive prognostic information in elderly patients with HF. REGISTRATION: URL: https://upload.umin.ac.jp/. Unique identifier: UMIN000023929.

DOI： 10.1161/JAHA.120.019954

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PubMed

牧迫飛雄馬 . 書評 -太田　進,藤田玲美,大古拓史(著)-｢動画でわかる運動器理学療法臨床実習スキル｣ . 理学療法ジャーナル55 ( 7 ) 778 - 778 2021年7月

牧迫飛雄馬, 赤井田将真 . 【認知症-最近の動向】認知機能低下に対する運動療法の効果 . カレントテラピー39 ( 7 ) 656 - 661 2021年7月

記述言語：日本語出版者・発行元：(株)ライフメディコム

身体活動の不足は、認知症の発症や認知機能の低下に強く関連するため、身体活動を向上させて活動的なライフスタイルを確立することは、認知機能の低下を抑制するために重要な要因である。定期的な運動習慣を有する高齢者では、将来の認知症発症のリスクが軽減され、運動介入による認知機能低下の抑制に対する効果が期待される。特に、有酸素運動を中心とした身体活動の向上は、認知症の発症の予防や遅延に効果が期待されている。認知機能の維持・改善に対するより効果的な運動療法においては、運動による身体活動の促進のみではなく、知的な刺激が伴う活動を付加することが推奨される。高齢期における認知機能の低下を抑制するためには、一時的な運動療法にとどまらず、習慣化できるようにいかに支援するかも重要なポイントとなる。(著者抄録)

谷口善昭, 牧迫飛雄馬, 富岡一俊, 中井雄貴, 佐藤菜々, 和田あゆみ, 木山良二, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係 . 日本サルコペニア・フレイル学会誌5 ( 1 ) 96 - 103 2021年6月

記述言語：日本語出版者・発行元：一般社団法人日本サルコペニア・フレイル学会

［目　的］ 地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係を明らかにする。 ［方　法］ 地域での健康チェックに参加した高齢女性265名を分析対象とした。骨粗鬆症の有無，身体・認知・社会的フレイルを評価し，身体・社会的フレイルに関しては，プレフレイルとフレイルを合わせてプレフレイル以上とした。骨粗鬆症を従属変数とし，身体的プレフレイル以上，認知的フレイル，社会的プレフレイル以上を独立変数としたロジスティック回帰分析を行い，さらに前期・後期高齢女性に分けてオッズ比を算出した。 ［結　果］ 年齢，内服数，教育歴，BMI，関節リウマチの有無，呼吸器疾患の有無で傾向スコアを算出し，傾向スコアで調整したロジスティック回帰分析の結果，後期高齢女性において骨粗鬆症と社会的プレフレイル以上が関連していた（オッズ比3.14，95％ CI1.25-7.93，p＝0.02）。 ［結　論］ 地域在住後期高齢女性において，社会的フレイルは骨粗鬆症のリスクを高める可能性がある。

DOI： 10.69303/jjasf.5.1_96

CiNii Research

Makino K, Lee S, Bae S, Chiba I, Harada K, Katayama O, Shinkai Y, Makizako H, Shimada H . Prospective Associations of Physical Frailty With Future Falls and Fear of Falling: A 48-Month Cohort Study. . Physical therapy101 ( 6 ) 2021年6月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Physical therapy

Objective: The present study aimed to examine the prospective associations of physical frailty with future falls and fear of falling (FOF) among community-dwelling older adults. Methods: A prospective cohort study with a 48-month follow-up was conducted in a Japanese community. Participants were 2469 community-dwelling older adults aged 65 years or older who completed baseline and follow-up assessments at intervals of 48 ± 2 months. Primary outcomes were recent falls (defined as at least one fall within the past year) and FOF (determined by response to "Are you afraid of falling?") at follow-up survey. Physical frailty, operationalized by the frailty phenotype (slowness, weakness, exhaustion, weight loss, and low activity) based on the criteria of the Japanese version of the Cardiovascular Health Study (J-CHS), was also assessed as a predictor of future falls and FOF. Results: Multivariable logistic regression showed that prefrailty or frailty increase the risk of not only future falls (odds ratio [OR]: 1.57; 95% CI = 1.20-2.05) but also FOF (OR: 1.33; 95%CI = 1.05-1.69). In addition, the relationship between baseline frailty status and future falls remained significant after adjusting for baseline FOF (OR: 1.55; 95% CI = 1.19-2.02), and the relationship between baseline frailty status and future FOF also remained significant after adjusting for baseline falls (OR: 1.32; 95% CI = 1.04-1.68). Conclusions: Frailty status may predict future falls and FOF among community-dwelling older adults. Strategies to prevent frailty may be beneficial to prevent not only future falls but also future FOF in a community setting. Impact: Falls and FOF have a close relationship but a different clinical meaning. Older adults with physical frailty may require monitoring as high risk not only for falls but also for FOF.

DOI： 10.1093/ptj/pzab059

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西田裕紀子, 牧迫飛雄馬, 鄭丞媛, 大塚礼, 藤原佳典, 北村明彦, 鈴木宏幸, 渡辺修一郎, 近藤克則, 島田裕之, 鈴木隆雄 . 地域在住高齢者の認知機能の時代的推移長寿コホートの総合的研究(ILSA-J)より . 老年社会科学43 ( 2 ) 163 - 163 2021年6月

谷口善昭, 牧迫飛雄馬, 富岡一俊, 中井雄貴, 佐藤菜々, 和田あゆみ, 木山良二, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係 . 日本サルコペニア・フレイル学会雑誌5 ( 1 ) 96 - 103 2021年6月

記述言語：日本語出版者・発行元：(一社)日本サルコペニア・フレイル学会

[目的]地域在住高齢女性における骨粗鬆症と身体・認知・社会的フレイルとの関係を明らかにする。[方法]地域での健康チェックに参加した高齢女性265名を分析対象とした。骨粗鬆症の有無、身体・認知・社会的フレイルを評価し、身体・社会的フレイルに関しては、プレフレイルとフレイルを合わせてプレフレイル以上とした。骨粗鬆症を従属変数とし、身体的プレフレイル以上、認知的フレイル、社会的プレフレイル以上を独立変数としたロジスティック回帰分析を行い、さらに前期・後期高齢女性に分けてオッズ比を算出した。[結果]年齢、内服数、教育歴、BMI、関節リウマチの有無、呼吸器疾患の有無で傾向スコアを算出し、傾向スコアで調整したロジスティック回帰分析の結果、後期高齢女性において骨粗鬆症と社会的プレフレイル以上が関連していた(オッズ比3.14、95%CI1.25-7.93、p=0.02)。[結論]地域在住後期高齢女性において、社会的フレイルは骨粗鬆症のリスクを高める可能性がある。(著者抄録)

佐藤菜々, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 和田あゆみ, 木山良二, 堤本広大, 窪薗琢郎, 竹中俊宏, 大石充 . 地域在住高齢者における社会参加とサルコペニアとの関連 . 日本サルコペニア・フレイル学会雑誌5 ( 1 ) 73 - 80 2021年6月

記述言語：日本語出版者・発行元：(一社)日本サルコペニア・フレイル学会

[目的]地域在住高齢者における社会参加とサルコペニアとの関連を明らかにすることを目的とした。[方法]地域コホート研究(垂水研究2018)に参加した65歳以上の地域在住高齢者859名のうち、脳卒中等の既往歴のない751名を分析対象とした。Asian Working Group for Sarcopenia2019に基づいてサルコペニアの有無、またJST版活動能力指標の社会参加に関する4項目より社会参加の状況を評価した。[結果]サルコペニアを有する者では、社会参加得点が有意に低値であった(p<0.001)。従属変数をサルコペニアの有無、独立変数を社会参加得点としたロジスティック回帰分析の結果、社会参加とサルコペニアに有意な関連を認めた(オッズ比0.83、95%信頼区間0.71-0.97)(共変量:年齢、性別、教育歴、服薬数、転倒歴、運動習慣、うつ傾向、認知機能)。[結論]地域在住高齢者の社会参加状況はサルコペニアと関連することが示唆された。(著者抄録)

丸田道雄, 牧迫飛雄馬, 池田由里子, 韓こう煕, 中村篤, 宮田浩紀, 下木原俊, 大勝巌, 大勝秀樹, 田平隆行 . 地域在住高齢者が重要とする活動の満足度と抑うつ症状の関連 . 日本作業療法研究学会雑誌24 ( 1 ) 62 - 63 2021年5月

赤井田将真, 牧迫飛雄馬, 中井雄貴, 富岡一俊, 谷口善昭, 和田あゆみ, 佐藤菜々, 丸田道雄, 田平隆行 . 地域在住高齢者における意味のある活動の満足度とフレイルの関係 . 日本作業療法研究学会雑誌24 ( 1 ) 76 - 76 2021年5月

Nakamura M, Hamada T, Tanaka A, Nishi K, Kume K, Goto Y, Beppu M, Hijioka H, Higashi Y, Tabata H, Mori K, Mishima Y, Uchino Y, Yamashiro K, Matsumura Y, Makizako H, Kubozono T, Tabira T, Takenaka T, Ohishi M, Sugiura T . Association of Oral Hypofunction with Frailty, Sarcopenia, and Mild Cognitive Impairment: A Cross-Sectional Study of Community-Dwelling Japanese Older Adults. . Journal of clinical medicine10 ( 8 ) 2021年4月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Clinical Medicine

Oral hypofunction is a new concept that addresses the oral function of older adults. Few studies have investigated the relationship between oral hypofunction and general health conditions such as frailty, sarcopenia, and mild cognitive impairment. This paper explores these relationships in a large-scale, cross-sectional cohort study. The relationships of oral hypofunction with frailty, sarcopenia, and mild cognitive impairment were examined using data from 832 individuals who participated in the 2018 health survey of the residents of Tarumizu City, Kagoshima Prefecture, Japan. Individuals with frailty, sarcopenia, and mild cognitive impairment had significantly higher rates of oral hypofunction. Frailty was independently associated with deterioration of the swallowing function (odds ratio 2.56; 95% confidence interval, 1.26–5.20), and mild cognitive impairment was independently associated with reduced occlusal force (odds ratio 1.48; 95% confidence interval, 1.05–2.08) and decreased tongue pressure (odds ratio 1.77; 95% confidence interval, 1.28–2.43). There was no independent association found between sarcopenia and oral function. In conclusion, early intervention for related factors such as deterioration of the swallowing function in frailty, reduced occlusal force, and decreased tongue pressure in mild cognitive impairment could lead to the prevention of general hypofunction in older adults.

DOI： 10.3390/jcm10081626

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牧迫飛雄馬 . 特集整形外科疾患の運動療法-最近の進歩サルコペニアに対する運動療法 . 整形･災害外科64 ( 4 ) 457 - 464 2021年4月

Kume Y. . Polypharmacy and Lack of Joy Are Related to Physical Frailty among Northern Japanese Community-Dwellers from the ORANGE Cohort Study . Gerontology67 ( 2 ) 184 - 193 2021年4月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Gerontology

Introduction: A prevalence of frailty is gradually increasing with the progress of aging in Japan, and critical challenges regarding early diagnosis and prevention of frailty were necessary in community. Although previous studies have well documented the characteristics of physical disability, there is limited information on frail state differences among older adults in Japanese rural areas. The aim of our cross-sectional observational study was to clarify the association of frail status in northern Japanese community-dwellers aged 65 or more. Methods: 345 participants were recruited from 2018 to 2020, and after getting informed consent from each participant, assessments and outcomes were evaluated according to the ORANGE protocol. We applied the frailty index of Gerontology-the Study of Geriatric Syndromes (NCGG-SGS) to classify frailty status by collecting data of demographics and psychosocial status using the Kihon checklist (KCL) and cognitive domains used by the National Center for Geriatrics and Gerontology-Functional Assessment Tool (NCGG-FAT). Results: Our subjects included 313 older adults divided into 138 robust, 163 prefrail, and 12 frail. For statistical analysis, we found that the frail group had a lower educational duration, worsened KCL items, lower cognitive functions, and a tendency toward depression compared to the other groups. Moreover, physical frailty and cognitive decline were related, and polypharmacy and a lack of joy in daily life were explanatory variables of frail status. Conclusions: We suggest that KCL is important for frail discrimination, and in order to prevent physical frailty, our community should take care of not only exercise and nutrition but also cognitive functioning and depressive tendencies. In particular, polypharmacy and the presence of fun in your life are possible to be related to frailty.

DOI： 10.1159/000511986

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PubMed

Kubozono T. . The relationship between home blood pressure measurement and room temperature in a Japanese general population . Hypertension Research44 ( 4 ) 454 - 463 2021年4月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Hypertension Research

Blood pressure (BP) is influenced by various factors, and it is known that temperature and BP have a negative relationship. However, few reports have examined the relationship between BP and temperature throughout the day in the same participant over time. Therefore, this study aimed to investigate the relationship between BP and temperature in the morning and evening in the same participants during a time period of ~1 year. In total, 401 participants, who participated in a community-based health checkup survey in Tarumizu, Japan, were enrolled. Five participants were excluded due to missing data. All participants measured their BP and the room temperature at home using a blood pressure monitor (HEM-9700T, OMRON Healthcare, Kyoto, Japan). The mean systolic BP (SBP) and diastolic BP (DBP) in the morning were significantly higher than the mean of the measurements taken in the evening (SBP: morning vs. evening 128 ± 15 mmHg vs. 122 ± 14 mmHg, P < 0.0001; DBP: morning vs. evening 77 ± 10 mmHg vs. 72 ± 8 mmHg, P < 0.0001). Using a linear mixed model with participants as a random effect, SBP and DBP were significantly associated with temperature in both the morning and evening. In the morning, in almost every month except July, a significant association between SBP and temperature was observed. However, there was a significant relationship between evening BP and temperature in all months. In conclusion, BP was significantly related to temperature in both the morning and evening during the year-long study. Furthermore, BP and temperature were significantly associated in all months except morning measurements in July.

DOI： 10.1038/s41440-020-00564-3

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PubMed

Kobozono Takuro, Akasaki Yuichi, Kawasoe Shin, Ojima Satoko, Kawabata Takeko, Makizako Hyuma, Kuwahata So, Takenaka Toshihiro, Maeda Mayuka, Ohno Mayu, Kijimuta Mika, Fujiwara Seisuke, Miyagawa Ken, Ohishi Mitsuru . The relationship between home blood pressure measurement and room temperature in a Japanese general population(和訳中) . Hypertension Research44 ( 4 ) 454 - 463 2021年4月

記述言語：英語出版者・発行元：Nature Publishing Group

朝夕に自宅で測定した血圧と、同時に記録した室温との関係性を調査した。地域健康診断を受診した参加者395名(男性136名、女性259名、平均71±8歳)を被験者とし、血圧モニターを使用して自宅で血圧と室温を測定した。平均収縮期血圧(SBP)と拡張期血圧(DBP)は、それぞれ139±18mmHgと80±11mmHgで、191名が降圧薬を使用していた。朝のSBPとDBPは、夕方の平均測定値の平均よりも有意に高かった。変量効果としての家庭血圧と室温との関連を検討した線形混合モデルでは、SBPとDBPは朝夕両方の気温と有意に関連していた。7月以外の月の朝においてSBPと気温の間に有意な関連が観察されたが、夕方の血圧と気温の間には全ての月で有意な関連がみられた。血圧は、1年間の研究期間中、朝夕の両方で気温と有意に関連していた。また気温は7月の朝の血圧測定値を除き、全ての月で血圧に有意に影響していた。

Makizako Hyuma, Nakai Yuki, Shiratsuchi Daijo, Akanuma Tomomi, Yokoyama Kaori, Matsuzaki-Kihara Yuriko, Yoshida Hiroto . COVID-19緊急事態宣言下での日本人後期高齢者における体力低下および認知機能低下の認識(Perceived declining physical and cognitive fitness during the COVID-19 state of emergency among community-dwelling Japanese old-old adults) . Geriatrics & Gerontology International21 ( 4 ) 364 - 369 2021年4月

記述言語：英語出版者・発行元：John Wiley & Sons Australia, Ltd

2020年7月に北海道美唄市在住の地域在住後期高齢者1112名を対象として、COVID-19緊急事態宣言下での体力・認知機能低下の認識に関する質問紙調査を郵送法により実施した。調査項目は、年齢、性別、居住形態、病歴、ポリファーマシー、高齢者うつ尺度、体力低下や認知機能低下の認識の有無、緊急事態宣言前の運動教室への参加状況、緊急事態宣言下での運動習慣(週に2回以上、30分以上)や日常生活リズムの乱れの有無などとした。774名(女性433名、平均83.3±4.4歳)を解析対象とした。その結果、COVID-19緊急事態下で体力低下を認識していたのは339名(43.8%)、認知機能低下を認識していたのは259名(33.5%)であった。潜在的交絡因子を調整した多変量ロジスティック回帰モデルの結果、COVID-19緊急事態宣言下での運動習慣は体力低下の認識の低さと有意に関連していた。また、COVID-19緊急事態宣言下での日常生活リズムの乱れは、体力低下および認知機能低下の認識が高いことと有意に関連していた。

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