Faculty Profiles - MIURA Naoki

Papers - MIURA Naoki

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Kawaguchi H, Yamada T, Miura N, Ayaori M, Uto-Kondo H, Ikegawa M, Noguchi M, Wang KY, Izumi H, Tanimoto A. . Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet. . J Atheroscler Thromb21 ( 3 ) 186 - 203 2014.3Reviewed

Murata D. Sogawa T. Tokunaga S. Iwanaga T. Kawaguchi H. Miyoshi N. Momoi Y. Fujiki M. Miura N*（*Corresponding author）. . Ganglion cysts arising from a canine stifle joint. . J Vet Med Sci76 ( 3 ) 457 - 459 2014.3Reviewed

Murata Daiki, Sogawa Takeshi, Tokunaga Satoshi, Iwanaga Tomoko, Kawaguchi Hiroaki, Miyoshi Noriaki, Momoi Yasuyuki, Fujiki Makoto, Miura Naoki . 犬の後膝関節に生じたガングリオン嚢胞(Ganglion Cysts Arising from a Canine Stifle Joint) . The Journal of Veterinary Medical Science76 ( 3 ) 457 - 459 2014.3Reviewed International journal

Kawaguchi Hiroaki, Yamada Tomonobu, Miura Naoki, Ayaori Makoto, Uto-Kondo Harumi, Ikegawa Masaya, Noguchi Michiko, Wang Ke-Yong, Izumi Hiroyuki, Tanimoto Akihide . 高脂肪/高コレステロール食を与えた世界最小のマイクロミニブタにおける動脈硬化の急速な進行　そのサイズとヒトの病態生理学との類似性ゆえに有用な動物モデル(Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet: A Useful Animal Model Due to its Size and Similarity to Human Pathophysiology) . Journal of Atherosclerosis and Thrombosis21 ( 3 ) 186 - 203 2014.3Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：(一社)日本動脈硬化学会

生後3ヵ月で体重が僅か5kgの世界最小のマイクロミニブタ(MMP)を用いて脂質異常症誘発性動脈硬化の動物モデルを開発し、脂質代謝とアテローム形成に関するヒトとの類似性について調べた。MMPにコール酸以外のコレステロールを0.2%以上含む高脂肪/高コレステロール食を8週間与えたところ、高コレステロール血症となり、動脈硬化を発症した。血清のLDL-C値とLDL画分の割合は著しく増加し、LDL受容体とHMG-CoA還元酵素の肝発現は協調的に減少した。MMPの血清よりコレステロール輸送に逆の働きを及ぼすコレステリルエステル転送蛋白質活性を検出した。Niemann-Pick C1様1蛋白は肝臓と小腸で発現したが、肝性apoB mRNA編集酵素は発現しなかった。ヒトと同様、そしてマウスとは対照的に、肝性リパーゼ活性の大半は肝臓に局在していた。

Akioka K, Kawaguchi H, Kitajima S, Miura N, Noguchi M, Horiuchi M, Miyoshi N, Tanimoto A. . Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs. . In Vivo28 ( 1 ) 81 - 90 2014.1Reviewed

Hosokawa K. Ohnishi T. Sameshima H. Miura N. Koide T. Maruyama I. Tanaka KA. . Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model. . PLoS One9 ( 1 ) e86491 2014.1Reviewed

Hosokawa K. Ohnishi T. Miura N. Sameshima H. Koide T. Tanaka KA. Maruyama I. . Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions. . Thromb Res133 ( 1 ) 66 - 72 2014.1Reviewed

Md Zahorul Islam, Emi Yamazaki-Himeno, Mitsuya Shiraishi, Atsushi Miyamoto, Hiroaki Kawaguchi, Noriaki Miyoshi, Naoki Miura, Akihide Tanimoto . Angiotensin II decreases bradykinin-induced NO and increases prostaglandin F-2 alpha release from cultured Microminipig basilar arterial endothelial cells . JOURNAL OF PHARMACOLOGICAL SCIENCES124 104P - 104P 2014Reviewed International journal

Kawaguchi, H., Yamada, T., Miura, N., Ayaori, M., Uto-Kondo, H., Ikegawa, M., Noguchi, M., Wang, K.-Y., Izumi, H., Tanimoto, A. . Rapid development of atherosclerosis in the world's smallest microminipig fed a high-fat/high-cholesterol diet: A useful animal model due to its size and similarity to human pathophysiology . Journal of Atherosclerosis and Thrombosis21 ( 3 ) 186 - 203 2014Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN ATHEROSCLEROSIS SOC

Aim: Experimental studies of human atherogenesis require an appropriate animal model that mimics human physiology and pathology. Because swine physiology is similar to human physiology, we developed a hyperlipidemia-induced atherosclerosis model using the recently developed world's smallest Microminipig (TM).
Methods: These animals weigh only 5 kg at 3 months of age, much smaller than any other miniature pig. We found that the administration of a high-fat/high-cholesterol diet containing at least 0.2% cholesterol without cholic acid for as little as eight weeks induces hypercholesterolemia and subsequent atherosclerosis in these animals.
Results: The serum levels of low-density lipoprotein cholesterol (LDL-C) and the percent distribution of cholesterol in the LDL fractions were markedly increased. The hepatic expression of LDL receptor and hydroxymethylglutaryl-CoA reductase was coordinately decreased. The cholesteryl ester transfer protein activity, which plays a role in reverse cholesterol transport, was detected in the serum of the Microminipigs. Niemann-Pick C1-like 1 protein was expressed in both the liver and small intestine; however, hepatic apoB mRNA editing enzyme was not expressed. As in humans, and in contrast to that observed in mice, most of the hepatic lipase activity was localized in the liver. These results suggest that the hyperlipidemia-induced gene expression profile linked to cholesterol homeostasis and atherogenesis is similar in Microminipigs and humans.
Conclusion: We conclude that the characteristics of the Microminipig, including its easy handling size, make it an appropriate model for studies of atherosclerosis and related conditions.

DOI： 10.5551/jat.21246

Tasaki Yumi, Miura Naoki, Iyori Keita, Nishifuji Koji, Endo Yasuyuki, Momoi Yasuyuki . バベシア症の犬における血管炎様変化を伴う全身脱毛症(Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis) . The Journal of Veterinary Medical Science75 ( 10 ) 1367 - 1369 2013.10Reviewed International journal

Miura N, Furukawa M, Magari Y, Momoi Y. . Cross-Reactivity of the Anti-Human D-Dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products. . J Vet Med Sci.75 ( 7 ) 963 - 966 2013.7Reviewed

Miura Naoki, Furukawa Makoto, Magari Yasuo, Momoi Yasuyuki . 抗ヒトDダイマーモノクローナル抗体1C9-6F10の犬フィブリン分解産物との交差反応性(Cross-Reactivity of the Anti-Human D-dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products) . The Journal of Veterinary Medical Science75 ( 7 ) 963 - 966 2013.7Reviewed International journal

Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Shameshima H, Miyoshi N, Tanimoto A, Maruyama I . Coagulation activity and white thrombus formation in the microminipig. . In vivo27 ( 3 ) 357 - 361 2013.5Reviewed

Kawaguchi H*, Yamada T*, Miura N(* Equal contribution), Noguchi M, Izumi H, Miyoshi N, Tanimoto A. . Sex Differences in Serum Lipid Profile in Novel Microminipigs. . In Vivo.27 ( 5 ) 617 - 621 2013.5Reviewed

Yoshikawa T, Takahashi Y, Kawaguchi H, Utsunomiya S, Miura N, Izumi H, Miyoshi N, Tanimoto A. . A dermal phototoxicity study following intravenous infusion administration of ciprofloxacin hydrochloride in the novel microminipigs. . Toxicologic pathology41 ( 1 ) 109 - 113 2013.1Reviewed

Hosokawa K, Ohnishi T, Sameshima H, Miura N, Ito T, Koide T, Maruyama I. . nalysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions. . Thromb Haemost109 ( 1 ) 102 - 111 2013.1Reviewed

岩永朋子, 関屋仁, 三浦直樹, 桃井康行. . 咳嗽失神が認められた犬の1例. . 鹿児島県獣医師会会報52 21 - 22 2013.1

Kikuchi K, Miura N, Kawahara KI, Murai Y, Morioka M, Lapchak PA, Tanaka E . Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke. . Biomedical reports1 ( 1 ) 7 - 12 2013.1Reviewed International journal

Tasaki Y, Miura N, Iyori K, Nishifuji K, Endo Y, Momoi Y . Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis. . J Vet Med Sci75 ( 10 ) 1367 - 1369 2013Reviewed

Miyamoto Atsushi, Islam Md. Zahorul, Kawaguchi Hiroaki, Miura Naoki, Yamzaki-Himeno Emi, Shiraishi Mitsuya, Miyoshi Noriaki, Tanimoto Akihide . Effect of continuous intravenous infusion of angiotensin II on Microminipig basilar arterial responsiveness . JOURNAL OF PHARMACOLOGICAL SCIENCES121 22P 2013Reviewed International journal

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Papers - MIURA Naoki