Faculty Profiles - MIURA Naoki

Papers - MIURA Naoki

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山﨑裕毅, 川畑貴裕, 澤真理子, 賴昱璋, 矢吹映, 三浦直樹 . 縦隔型T細胞性リンパ腫を呈した若齢犬の1例 . 日本獣医師会雑誌　69 ( 6 ) 333 - 338 2016.8縦隔型T細胞性リンパ腫を呈した若齢犬の1例Reviewed

藤川拓郎, 永野理樹, 和田三枝, 齋藤靖生, 乙丸孝之介, 三浦直樹, 藤木誠, 窪田力 . 娩出時肋骨骨折に起因した気管狭窄による呼吸不全子牛の8症例. . 日本獣医師会雑誌　69 ( 5 ) 267 - 270 2016.6娩出時肋骨骨折に起因した気管狭窄による呼吸不全子牛の8症例.Reviewed

川口博明, 笹竹洋, 野口倫子, 秋岡幸兵, 三浦直樹, 武石嘉一朗, 堀内正久, 谷本昭英 . 犬の輸送ストレス軽減のための新規鍼治療の試み. . 日本獣医師会雑誌　69 ( 3 ) 143 - 146 2016.4犬の輸送ストレス軽減のための新規鍼治療の試み.Reviewed

Morishita S, Kawaguchi H, Ono T, Miura N, Murakoshi M, Sugiyama K, Kato H, Tanimoto A, Nishino H. . Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs. . Biosci Biotechnol Biochem.80 ( 2 ) 295 - 303 2016.2Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs.Reviewed

Morishita Satoru, Kawaguchi Hiroaki, Ono Tomoji, Miura Naoki, Murakoshi Michiaki, Sugiyama Keikichi, Kato Hisanori, Tanimoto Akihide, Nishino Hoyoku . マイクロミニブタにおいて、腸溶性ラクトフェリンは高脂肪高コレステロール食による高コレステロール血症と粥状動脈硬化症の進行を減弱させる(Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs) . Bioscience, Biotechnology, and Biochemistry80 ( 2 ) 295 - 303 2016.2マイクロミニブタにおいて、腸溶性ラクトフェリンは高脂肪高コレステロール食による高コレステロール血症と粥状動脈硬化症の進行を減弱させる(Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs)Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：(公社)日本農芸化学会

マイクロミニブタに8週間腸溶性ラクトフェリン(eLF)を経口摂取させたところ、高脂肪高コレステロール食(HFCD)による血清の総コレステロール値とLDL-コレステロール値の上昇が著しく減弱したが、HDL-コレステロールは変化しなかった。血管の組織検査より、eLFにより全身の粥状動脈硬化の進行が阻害されていた。eLF投与に特徴的な肝臓の遺伝子による経路分析では、ステロイド生合成経路に有意な変化が起こり、これらの遺伝子はすべて上方制御されていた。すなわち、HFCDにより阻害されたコレステロール合成がeLFにより回復したことが示唆された。以上より、eLFはHFCDによるコレステロール代謝異常からホメオスタシスを防御することにより、高コレステロール血症と粥状動脈硬化症を防ぐことが示唆された。

山崎裕毅, 川畑貴裕, 頼いく璋, 三浦直樹 . 症例から学ぶシリーズ　縦隔型T細胞性リンパ腫を呈した若齢犬の1例 . Joncol: Japanese Journal of Veterinary Clinical Oncology12 ( 1 ) 99 - 102 2016.1症例から学ぶシリーズ　縦隔型T細胞性リンパ腫を呈した若齢犬の1例Reviewed International journal

KAWAGUCHI Hiroaki, SASATAKE Yo, NOGUCHI Michiko, AKIOKA Kohei, MIURA Naoki, TAKEISHI Ka-ichiro, HORIUCHI Masahisa, TANIMOTO Akihide . Study of a Novel Acupuncture Treatment for Canine Transportation Stress . Journal of the Japan Veterinary Medical Association69 ( 3 ) 143 - 146 2016Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Veterinary Medical Association

In recent years, animals are increasingly being transported by vehicle. The mitigation of stress animals aresubjected to while being transported by vehicle is desirable from the perspective of animal welfare. Weinvestigated the potential of acupuncture, which has fewer side effects than drug therapy, as a means fortreating canine transportation stress. Eleven dogs which had exhibited motion sickness symptoms duringtransportation (vomiting, salivation, and a reduced amount of spontaneous activity) underwent an easy-to-applyacupuncture treatment. Short, ultra-thin circular transdermal needles were applied to locations correspondingto acupoints on the apical area of both ears, which are identified as Erjian Points 1 to 3 (“Jisen” in Japanese) intraditional oriental medicine. Motion sickness symptoms were suppressed in the treated dogs the next timethey were transported. We consider acupuncture to be a promising potential therapeutic strategy in veterinarymedicine.

DOI： 10.12935/jvma.69.143

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J01104&link_issn=&doc_id=20160318440004&doc_link_id=10.12935%2Fjvma.69.143&url=https%3A%2F%2Fdoi.org%2F10.12935%2Fjvma.69.143&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

YAMAZAKI Hiroki, KAWABATA Takahiro, SAWA Mariko, LAI Yu-Chang, YABUKI Akira, MIURA Naoki . A Rare Case of Mediastinal T-Cell Lymphoma in a Juvenile Dog . Journal of the Japan Veterinary Medical Association69 ( 6 ) 333 - 338 2016Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Veterinary Medical Association

Mediastinal mass and hepatomegaly were detected by computed tomography in a 10-month-old Miniature Dachshund presenting with dyspnea. The dog was diagnosed as mediastinal T-cell lymphoma with liver invasion by cytological and clonality examination. Multidrug therapy (UW-25) was not effective for the dog. As a second-line therapy, a combination treatment of toceranib phosphate and CCNU was performed based on the expression profiling of multidrug resistance genes and angiogenic genes by qRT-PCR analysis, resulting in an improved condition. However, the dog died from dyspnea at 36 days after first examination. T-cell lymphoma was confirmed by necropsy.

DOI： 10.12935/jvma.69.333

FUJIKAWA Takuro, NAGANO Masaki, WADA Mie, SAITOU Yasuo, OTOMARU Kounosuke, MIURA Naoki, FUJIKI Makoto, KUBOTA Chikara . Consideration of Diagnosis and Surgical Treatment of Tracheal Stenosis Caused by Rib Fracture in Calves . Journal of the Japan Veterinary Medical Association69 ( 5 ) 267 - 270 2016Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Veterinary Medical Association

Eight Japanese black calves (14‐65 days old) with severe respiration insufficiency due to tracheal stenosis by rib fractures at the calving were brought to Kagoshima University Veterinary Teaching Hospital. At the first visit (NOSAI), all calves had common symptoms of coughing and wheezing sounds. All calves were towed at the time of calving. In x-ray and computed-tomography (CT) examinations, the 1st to 6th right and/or left ribs were fractured and tracheal stenosis was observed. Surgical treatment was conducted in all cases to remove the 1st to 3rd fractured ribs on one side that compressed the trachea. The respiratory condition of all calves improved from the day after surgical relocation and had completely reversed by the 14th postoperative day. From the above, CT examination was found to be useful for diagnosing tracheal stenosis due to rib fracture while removing the fractured ribs on one side is effective surgical treatment.

DOI： 10.12935/jvma.69.267

Kohyama M, Yabuki A, Kawasaki Y, Kawaguchi H, Miura N, Kitano Y, Onitsuka T, Rahman MM,Miyoshi N, Yamato O. . GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog. . J Am Anim Hosp Assoc51 ( 6 ) 396 - 400 2015.11GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog.Reviewed

Otomaru K, Fujikawa T, Saito Y, Ando T, Obi T, Miura N, Kubota C. . Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography . Journal of Veterinary Medical Science. 77 ( 9 ) 1191 - 1193 2015.9Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomographyReviewed

Otomaru Konosuke, Fujikawa Takuro, Saito Yasuo, Ando Takaaki, Obi Takeshi, Miura Naoki, Kubota Chikara . 未経産牛における腹腔内嚢胞のコンピュータ断層撮影による診断(Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography) . The Journal of Veterinary Medical Science77 ( 9 ) 1191 - 1193 2015.9未経産牛における腹腔内嚢胞のコンピュータ断層撮影による診断(Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography)Reviewed International journal

Noguchi M, Miura N, Ando T, Kubota C, Hobo S, Kawaguchi H, Tanimoto A. . Profiles of reproductive hormone in the microminipig during the normal estrous cycle. . In Vivo29 ( 1 ) 17 - 22 2015.1Profiles of reproductive hormone in the microminipig during the normal estrous cycle.Reviewed

Murata D, Miyakoshi D, Hatazoe T, Miura N, Tokunaga S, Fujiki M, Nakayama K, Misumi K. . Multipotency of equine mesenchymal stem cells derived from synovial fluid. . Vet J.202 ( 1 ) 53 - 61 2014.10Multipotency of equine mesenchymal stem cells derived from synovial fluid.Reviewed

Kawaguchi H, Yamada T, Miura N, Ayaori M, Uto-Kondo H, Ikegawa M, Noguchi M, Wang KY, Izumi H, Tanimoto A. . Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet. . J Atheroscler Thromb21 ( 3 ) 186 - 203 2014.3Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet.Reviewed

Murata D. Sogawa T. Tokunaga S. Iwanaga T. Kawaguchi H. Miyoshi N. Momoi Y. Fujiki M. Miura N*（*Corresponding author）. . Ganglion cysts arising from a canine stifle joint. . J Vet Med Sci76 ( 3 ) 457 - 459 2014.3 Ganglion cysts arising from a canine stifle joint.Reviewed

Kawaguchi Hiroaki, Yamada Tomonobu, Miura Naoki, Ayaori Makoto, Uto-Kondo Harumi, Ikegawa Masaya, Noguchi Michiko, Wang Ke-Yong, Izumi Hiroyuki, Tanimoto Akihide . 高脂肪/高コレステロール食を与えた世界最小のマイクロミニブタにおける動脈硬化の急速な進行　そのサイズとヒトの病態生理学との類似性ゆえに有用な動物モデル(Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet: A Useful Animal Model Due to its Size and Similarity to Human Pathophysiology) . Journal of Atherosclerosis and Thrombosis21 ( 3 ) 186 - 203 2014.3高脂肪/高コレステロール食を与えた世界最小のマイクロミニブタにおける動脈硬化の急速な進行　そのサイズとヒトの病態生理学との類似性ゆえに有用な動物モデル(Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet: A Useful Animal Model Due to its Size and Similarity to Human Pathophysiology)Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：(一社)日本動脈硬化学会

生後3ヵ月で体重が僅か5kgの世界最小のマイクロミニブタ(MMP)を用いて脂質異常症誘発性動脈硬化の動物モデルを開発し、脂質代謝とアテローム形成に関するヒトとの類似性について調べた。MMPにコール酸以外のコレステロールを0.2%以上含む高脂肪/高コレステロール食を8週間与えたところ、高コレステロール血症となり、動脈硬化を発症した。血清のLDL-C値とLDL画分の割合は著しく増加し、LDL受容体とHMG-CoA還元酵素の肝発現は協調的に減少した。MMPの血清よりコレステロール輸送に逆の働きを及ぼすコレステリルエステル転送蛋白質活性を検出した。Niemann-Pick C1様1蛋白は肝臓と小腸で発現したが、肝性apoB mRNA編集酵素は発現しなかった。ヒトと同様、そしてマウスとは対照的に、肝性リパーゼ活性の大半は肝臓に局在していた。

Murata Daiki, Sogawa Takeshi, Tokunaga Satoshi, Iwanaga Tomoko, Kawaguchi Hiroaki, Miyoshi Noriaki, Momoi Yasuyuki, Fujiki Makoto, Miura Naoki . 犬の後膝関節に生じたガングリオン嚢胞(Ganglion Cysts Arising from a Canine Stifle Joint) . The Journal of Veterinary Medical Science76 ( 3 ) 457 - 459 2014.3犬の後膝関節に生じたガングリオン嚢胞(Ganglion Cysts Arising from a Canine Stifle Joint)Reviewed International journal

Akioka K, Kawaguchi H, Kitajima S, Miura N, Noguchi M, Horiuchi M, Miyoshi N, Tanimoto A. . Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs. . In Vivo28 ( 1 ) 81 - 90 2014.1Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs.Reviewed

Hosokawa K. Ohnishi T. Sameshima H. Miura N. Koide T. Maruyama I. Tanaka KA. . Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model. . PLoS One9 ( 1 ) e86491 2014.1Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model.Reviewed

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Papers - MIURA Naoki