Faculty Profiles - MIURA Naoki

Papers - MIURA Naoki

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Amitani, S., Miyahara, K., Sohara, H., Kakura, H., Koga, M., Moriyama, Y., Taira, A., Nagano, S.-I., Miura, N., Misumi, K., Sakamoto, H. . Experimental His-bundle pacing: Histopathological and electrophysiological examination . PACE - Pacing and Clinical Electrophysiology22 ( 4 I ) 562 - 566 1999Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

His-bundle pacing gives a more physiological ventricular contraction in comparison to right ventricular apical pacing. However the problems of lead fixation and stability of long-term His-bundle pacing are yet unsolved. We used six adult beagles, in which a screw-in lead was anchored in the His- bundle region for observation of the pacing conditions and histopathologic changes of the conduction system over the course of 2 months. In the results, a satisfactory fixation was obtained using a conventional screw-in lead and no histological influence on the conduction system was observed. The pacing threshold at the time of implantation was 1.15 ± 0.69V (3.23 ± 3.08 mA) in the pulse width of 0.5 ms. R wave amplitude, the impedance and slew rate were 7.28 ± 2.04 mV, 409 ± 102 Ohm, and 0.65 ± 0.41 V/s, respectively. Two months later, these parameters changed to 2.83 ± 1.06 V (10.4 ± 5.71 mA), 5.63 ± 1.62 mV, 310 ± 71.3 Ohm, and 0.49 ± 0.22 V/s, respectively. These results suggest the feasibility of clinical application of permanent His- bundle pacing.

DOI： 10.1111/j.1540-8159.1999.tb00497.x

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藤木誠, 三浦直樹, 三角一浩, 坂本絋 . 麻酔モニター(BP-508)の終末呼気二酸化炭素分圧と平均動脈圧に対するイヌでの有効性 . 獣医麻酔外科学雑誌 = Japanese journal of veterinary anesthesia & surgery29 55 1998.10Reviewed International journal

KAMIMURA Shunichi, HASHINOKUCHI Tetsu, USHINOHAMA Kanji, MIURA Naoki, HAMANA Katsumi, SAKAMOTO Hiroshi . A Clinical Case of Bladder Rupture Occurring in a New-Born Japanese Black Calf . Journal of the Japan Veterinary Medical Association51 ( 5 ) 246 - 248 1998.5Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Veterinary Medical Association

A 15-day-old female calf complaining urinary obstruction and hematuria, was diagnosed as bladder rupture by positive-contrast cystography and ultrasonography. Through a posterior ventral midline incision one third of bladder containing ruptured devitalized tissue was debrided, resulting in recovery after operation. The case was suspected to be due to urachal anomaly type 2, a vesicourachal diverticulum.

DOI： 10.12935/jvma1951.51.246

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Sakamoto, H., Kirihara, H., Fujiki, M., Miura, N., Misumi, K. . The Effects of Medetomidine on Maternal and Fetal Cardiovascular and Pulmonary Function, Intrauterine Pressure and Uterine Blood Flow in Pregnant Goats . Experimental Animals46 ( 1 ) 67 - 73 1997.1Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：International Press Editing Centre Incorporation

To investigate the effects of medetomidine on late pregnant goats, medetomidine induced changes in maternal or fetal circulation and acid-base balance, as well as changes in intrauterine pressure (IUP) and uterine blood flow (UBF), were studied. Intramuscular administration of medetomidine (40 μg/kg b.w.) decreased the heart rate (HR) and arterial blood pressure (ABP) of the mother, and the change in HR was significant statistically (p&lt
0.05). In the fetus, HR and ABP showed a transient decrease and increase (p&lt
0.05), respectively. A decrease in maternal arterial blood pH and oxygen partial pressure (PO2) and an increase in carbon dioxide partial pressure (PCO2) were recorded alter the injection, but none was significant. In the fetus, arterial blood PO2 decreased significantly (p&lt
0.05) after 5 min of administration, and a significant metabolic acidemia supported by a decrease in base excess was observed. Within 1 to 4 min after the administration of medetomidine, IUP began to rise and remained high for 10 to 14 min. Thereafter, the rise in IUP was frequent and periodical. After the injection, UBF significantly (p&lt
0.05) decreased, and the fall in UBF was associated with a rise in IUP. The maternal and fetal serum medetomidine concentration increased remarkably after the injection of medetomidine into the mother. These observations in late pregnant goats suggested that medetomidine induced a decrease in maternal cardiac output, a decrease in UBF arising from the induction of uterine contractions, and transplacental medetomidine can have a suppressive effect on the fetus.

DOI： 10.1538/expanim.46.67

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