Faculty Profiles - Kyoko (Tsukiyama-)Kohara

Papers - Kyoko (Tsukiyama-)Kohara

Division display 101 - 120 of about 149 ／ All the affair displays >>

Kitab, B., Kohara, M., Tsukiyama-Kohara, K. . Experimental in vitro and in vivo systems for studying the innate immune response during dengue virus infections. . Arch Virol.163 ( 7 ) 1717 - 1726 2018.7Reviewed

Kyoko Tsukiyama-Kohara, Michinori Kohara . Hepatitis C Virus: Viral Quasispecies and Genotype . International Journal of Molecular Sciences19 ( 23 ) 1 - 8 2017.12Invited Reviewed

Kyoko Tsukiyama-Kohara, Michinori Kohara . Hepatitis C Virus: Viral Quasispecies and Genotypes. . International journal of molecular sciences19 ( 1 ) 2017.12Reviewed International journal

Language：English Publishing type：Research paper (scientific journal)

Hepatitis C virus (HCV) mainly replicates in the cytoplasm, where it easily establishes persistent infection, resulting in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Due to its high rate of mutation, HCV forms viral quasispecies, categorized based on the highly variable regions in the envelope protein and nonstructural 5A protein. HCV possesses seven major genotypes, among which genotype 1 is the most prevalent globally. The distribution of HCV genotypes varies based on geography, and each genotype has a different sensitivity to interferon treatment. Recently-developed direct-acting antivirals (DAAs), which target viral proteases or polymerases, mediate drastically better antiviral effects than previous therapeutics. Although treatment with DAAs has led to the development of drug-resistant HCV mutants, the most recently approved DAAs show improved pan-genomic activity, with a higher barrier to viral resistance.

DOI： 10.3390/ijms19010023

Scopus

PubMed

Nze-Nkogue C, Horie M, Fujita S, Inoue E, Akomo-Okoue EF, Ozawa M, Ngomanda A, Yamagiwa J, Tsukiyama-Kohara K. . Identification and molecular characterization of novel primate bocaparvoviruses from wild western lowland gorillas of Moukalaba-Doudou National Park, Gabon. . Infect Genet Evol.53 30 - 37 2017.9Reviewed

Chimene NZE NKOGUE . Epidemiological study of viruses infecting western lowland gorillas in Moukalaba-Doudou National Park (Gabon) . 2017.9Reviewed

Kayesh MEH, Ezzikouri S, Chi H, Sanada T, Hayashi, Y., Rebbani, K., Kitab, B., Matuu, A., Miyoshi, N., Hishima, T., Kohara, M., Tsukiyama-Kohara, K. . Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri. . Scientific Reports7 ( 1 ) 9848 - 9861 2017.8Reviewed

Kayesh ME*, Kitab B*, Sanada T, Hayasaka D, Morita K, Kohara M, Tsukiyama-Kohara K . Susceptibility of tupaia cells to dengue virus infection and their initial immune response. . Infection Genetics and Evolution51 203 - 210 2017.7Reviewed

KAYESH MEH, EZZIKOURI S, CHI H, SANADA T, YAMAMOTO N, KITAB B, HARAGUCHI T, MATUYAMA R, NKOGUE CN, HATAI H, MIYOSHI N, MURAKAMI S, TANAKA Y, TAKANO J, SHIOGAMA Y, YASUTOMI Y, KOHARA M, TSUKIYAMA-KOHARA K. . Interferon-β response is impaired by hepatitis B virus infection in Tupaia belangeri. . VIRUS RESEARCH237 47 - 57 2017.6Reviewed

Tokunaga Y, Osawa Y, Ohtsuki T, Hayashi Y, Yamaji K, Yamane D, Hara M, Munekata K, Tsukiyama-Kohara K, Hishima T, Kojima S, Kimura K, Kohara M. . Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model. . Sci Rep.7 ( 1 ) 325 2017.3Reviewed

Chime`ne Nze Nkogue, Masayuki Horie, Shiho Fujita, Michiko Ogino, Yuki Kobayashi, Keijiro Mizukami, Tatsunori Masatani, Sayeh Ezzikouri, Aya Matsuu, Tetsuya Mizutani, Makoto Ozawa, Osamu Yamato, Alfred Ngomanda, Juichi Yamagiwa, Kyoko Tsukiyama-Kohara . Molecular epidemiological study of adenovirus infecting western lowland gorillas and humans in and around Moukalaba-Doudou National Park (Gabon) . Virus Genes52 ( 5 ) 671 - 678 2016.10Reviewed

Sayeh Ezzikouri, Fatima Zahra Jadid, Salsabil Hamdi, Kyoko Tsukiyama-Kohara, Soumaya Benjelloun . Supplementation of Pycnogenol to conventional treatment may improve type 2 diabetes-associated with Hepatitis C Therapy . Journal of Clinical and Translational Hepatology4 ( 3 ) 228 - 233 2016.9Reviewed

Takahisa Kouwaki, Yoshimi Fukushima, Takuji Daito, Naoki Yamamoto, Edin J Mifsud, Chean Ring Leong, Kyoko Tsukiyama-Kohara, Michinori Kohara, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi . Exosome RNA Released by Hepatocytes Regulates Innate Immune Responses to Hepatitis B Virus Infection . Frontiers in Immunology7 335 2016.8Reviewed

Hai-Ying C, Nagano K, Ezzikouri S, Yamaguchi C, Kayesh ME, Rebbani K, Kitab B, Nakano H, Kouji H, Kohara M, Tsukiyama-Kohara K. . Establishment of an intermittent cold stress model using Tupaia belangeri and evaluation of compound C737 targeting neuron-restrictive silencer factor. . Exp. Anim.65 ( 3 ) 285 - 292 2016.7Reviewed

Rebban, K & iTsukiyama-Kohara, K. . HCV-Induced Oxidative Stress: Battlefield-Winning Strategy . Oxidative Medicine and Cellular Longevity2016 ( 2016 ) 7425628 2016.5Invited Reviewed

Kanda T, Ozawa M, Tsukiyama-Kohara K . IRES-mediated translation of foot-andmouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals . BMC Veterinary Research12 66 2016.3Reviewed

Sanada, T., Tsukiyama-Kohara, K., Yamamoto, N., Ezzikouri, S., Benjelloun, S., Murakami, S., Tanaka, Y., Tateno, C., Kohara, M. . Property of hepatitis B virus replication in tupaia belangeri hepatocytes . BBRC8 ( 469 ) 229 - 235 2016.1Reviewed

Khadija Rhebbani, Kyoko Tsukiyama-Kohara . DHCR24:A Novel HCC Biomaker at a Glance . Clinical Microbiology4 ( 6 ) 1000228 2015.12Invited Reviewed

Masatani T, Ozawa M, Yamada K, Ito N, Horie M, Matsuu A, Okuya K, Tsukiyama-Kohara K, Sugiyama M, Nishizono A. . Contribution of the interaction between rabies virus P protein and IKKε to the inhibition of type I interferon induction signaling. . J Gen. Virol. 2015.12Reviewed

Ohtsuki T, Kimura K, Tokunaga Y, Tsukiyama-Kohara K, Tateno C, Hayashi Y, Hishima T, Kohara M. . M2 macrophages play critical roles in progression of inflammatory liver disease in hepatitis C virus transgenic mice. . J Virol.14 ( 90 ) 307 - 309 2015.10Reviewed

Okuya K, Kawabata T, Nagano K, Tsukiyama-Kohara K, Kusumoto I, Takase K, Ozawa M. . Isolation and characterization of influenza A viruses from environmental water at an overwintering site of migratory birds in Japan. . Arch Virol. 2015.9Reviewed

　 PREV - NEXT 　

<Kyoko (Tsukiyama-)Kohara>

Papers - Kyoko (Tsukiyama-)Kohara