研究者詳細 - 谷本　昭英

論文 - 谷本　昭英

分割表示 561 件中 421 - 440 件目／全件表示 >>

Noriaki Miyoshi, Masahisa Horiuchi, Yoshinori Inokuchi, Yoko Miyamoto, Naoki Miura, Satatoshi Tokunaga, Makoto Fujiki, Yasukatsu Izumi, Hiroaki Miyajima, Ryoichi Nagata, Kazuhiro Misumi, Toru Takeuchi, Akihide Tanimoto, Nobuhiro Yasuda, Hiroki Yoshida, Hiroaki Kawaguchi . Novel Microminipig Model of Atherosclerosis by High Fat and High Cholesterol Diet, Established in Japan . IN VIVO24 ( 5 ) 671 - 680 2010年9月査読

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：INT INST ANTICANCER RESEARCH

Novel atherosclerotic lesions were induced in the Microminipig (MMP, registered with the Japanese Ministry of Agriculture, Forestry and Fisheries as a novel variety of swine), the smallest pig available for experimental use, by feeding a high fat (12%) and high cholesterol (5%) diet (HFCD) with sodium cholate (SC, 0.7%) (HFCD/SC) for three months. Three MMPs were used: a male fed with normal diet (M-ND), and a male and an ovariectomized female fed with HFCD/SC (M-HFCD/SC and Fx-HFCD/SC). HFCD/SC induced hypercholesterolemia accompanied by an increase in serum total cholesterol (T-Cho), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and cholesterol ester (CE) from the first week. Serum levels of T-Cho, LDL-C and CE reached a maximum in two to three weeks, and HDL-C gradually increased during the experimental period (duration). Serum lipoprotein analysis showed a dominant LDL-C fraction, as seen in humans, in all three MMPs. Body weight gain in the MMPs fed with HFCD/SC was greater than in the animal fed with M-ND. At the end of the experiment, computed tomography scans of conscious animals showed increases in subcutaneous and abdominal fat in those fed with HFCD/SC, suggesting the induction of obesity. Atherosclerotic lesions in systemic arteries (including external and internal iliac arteries, abdominal aorta, coronary artery, cerebral arterial circle), fatty changes, and foamy cell infiltration in the liver and spleen were histopathologically observed in the MMPs fed with HFCD/SC. Atherosclerosis and the pathological findings induced by HFCD/SC in MMPs were similar to the pathological changes associated with human atherosclerosis, suggesting that the MMP has the potential to be a suitable animal model for human atherosclerosis.

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Yatera Y, Shibata K, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Toyohira Y, Wang KY, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M . Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet. . Cardiovascular research87 ( 4 ) 675 - 682 2010年9月査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：INT INST ANTICANCER RESEARCH

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Wang KY, Tanimoto A, Yamada S, Guo X, Ding Y, Watanabe T, Watanabe T, Kohno K, Hirano K, Tsukada H, Sasaguri Y . Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. . The American journal of pathology177 ( 2 ) 713 - 723 2010年8月査読国際誌

Matsuura Y, Kitajima M, Hachisuga T, Tanimoto A, Okura N, Kihara I . Malignant mixed müllerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings. . The journal of obstetrics and gynaecology research36 ( 4 ) 907 - 911 2010年8月査読国際誌

王克よう, 谷本昭英, 笹栗靖之 . 細胞外マトリックスと動脈硬化 . 産業医科大学雑誌32 ( 2 ) 195 - 203 2010年6月

出版者・発行元：産業医科大学

動脈壁の細胞外マトリックスは、主に血管平滑筋細胞から作られる。動脈硬化病変においては、とくにI、III、IV、V、VIII型コラーゲンとエラスチンの高発現が確認されている。細胞外マトリックス分解に中心的役割を果たす酵素としてマトリックスメタロプロテアーゼ(matrix metalloproteinase;MMP)が知られており、動脈硬化の発症と進展、動脈瘤の発生と破裂、粥腫の不安定性などにMMPは関連している。MMP1、2、3、7、9、12、MT1-MMPなど多くのMMPが動脈脈壁に発現しており、主たるMMPの産生細胞は血管平滑筋細胞と動脈硬化病変に浸潤したマクロファージである。本総説では動脈硬化病変と細胞外マトリックスおよびその分解酵素でありMMPの関連について詳述する。(著者抄録)

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J00526&link_issn=&doc_id=20100622060006&doc_link_id=110007618648&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F110007618648&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Hatanaka K, Tanimoto A, Umekita Y, Yoshioka T, Kanekura T . Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report. . Diagnostic pathology5 42 - 42 2010年6月査読国際誌

Yoshioka T, Harada M, Umekita Y, Taguchi S, Higashi M, Nakamura D, Suzuki S, Tanimoto A . Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. . Pathology international60 ( 4 ) 326 - 329 2010年4月査読国際誌

王克よう, 谷本昭英, 笹栗靖之 . 動脈硬化病変におけるヒスタミンの役割 . 産業医科大学雑誌32 ( 1 ) 63 - 71 2010年3月

出版者・発行元：産業医科大学

ヒスタミンは、ヒスチジン脱炭酸酵素によってL-ヒスチジンから合成され、炎症、アレルギー、胃酸分泌、神経伝達といった生体反応を調節する生体アミンである。動脈硬化病変では、マクロファージ由来の泡沫細胞から産生されたヒスタミンは、血管平滑筋、血管内皮、炎症細胞に特異的ヒスタミン受容体を介して作用し、炎症反応に関わる多くの分子の発現を調節している。動脈硬化病変の形成と進展には、ヒスタミンネットワークによる慢性炎症反応の制御システムが関与している。(著者抄録)

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J00526&link_issn=&doc_id=20100308220005&doc_link_id=110007588849&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F110007588849&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Morisada N, Nomura M, Nishii H, Furuno Y, Sakanashi M, Sabanai K, Toyohira Y, Ueno S, Watanabe S, Tamura M, Matsumoto T, Tanimoto A, Sasaguri Y, Shimokawa H, Kusuhara K, Yanagihara N, Shirahata A, Tsutsui M. . Complete Disruption of All Nitric Oxide Synthase Genes Causes Markedly Accelerated Renal Lesion Formation Following Unilateral Ureteral Obstruction in Mice In Vivo. . J Pharmacol Sci.114 379 - 389 2010年査読

Yoshioka T, Harada M, Umekita Y, Taguchi S, Higashi M, Nakamura D, Suzuki S, Tanimoto A. . Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. . Pathol Int.60 326 - 329 2010年査読

Hatanaka K, Tanimoto A, Umekita Y, Yoshioka T, Kanekura T. . Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report. . Diagn Pathol.5 42 2010年査読

Matsuura Y, Kitajima M, Hachisuga T, Tanimoto A, Okura N, Kihara I. . Malignant mixed mullerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings. . J Obstet Gynaecol Res.36 907 - 911 2010年査読

Zenmyo M, Tanimoto A, Sakakima H, Yokouchi M, Nagano S, Yamamoto T, Ishido Y, Komiya S, Ijiri K. . Gadd45beta expression in chondrosarcoma: A pilot study for diagnostic and biological implications in histological grading. . Diagn Pathol.13 69 2010年査読

Zenmyo M, Ishido Y, Terahara M, Yamamoto T, Tanimoto A, Komiya S, Ijiri K. . Intramedullary subependymoma of the cervical spinal cord: a case report with immunohistochemical study. . Int J Neurosci.120 676 - 679 2010年査読

Bakhtiar Y, Arita K, Hirano H, Habu M, Fujio S, Kitajima S, Tanimoto A. 2010, 50: 1023-1026 . Prolactin-producing pituitary adenoma with abundant spherical amyloid deposition masquerading as extensive calcification. . Neurol Med Chir (Tokyo). 50 1023 - 1026 2010年査読

Yatera Y, Shibata K, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Toyohira Y, Wang KY, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. . Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet. . Cardiovasc Res.87 675 - 682 2010年査読

Ding Y, Yamada S, Wang KY, Shimajiri S, Guo X, Tanimoto A, Murata Y, Kitajima S, Watanabe T, Izumi H, Kohno K, Sasaguri Y. . Overexpression of Peroxiredoxin 4 Protects Against High-Dose Streptozotocin-Induced Diabetes by Suppressing Oxidative Stress and Cytokines in Transgenic mice. . Antioxid Redox Signal13 1477 - 1490 2010年査読

Wang KY*, Tanimoto A* (*equal contribution), Yamada S, Guo X, Ding Y, Watanabe T, Watanabe T, Kohno K, Hirano KI, Tsukada H, Sasaguri Y. . Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors. Model for Nonalcoholic Steatohepatitis in Mice. . Am J Pathol. 2010177 713 - 723 2010年査読

Izumi H, Wakasugi T, Shimajiri S, Tanimoto A, Sasaguri Y, Kashiwagi E, Yasuniwa Y, Akiyama M, Han B, Wu Y, Uchiumi T, Arao T, Nishio K, Yamazaki R, Kohno K. . Role of ZNF143 in tumor growth through transcriptional regulation of DNAreplication and cell-cycle-associated genes. . Cancer Sci.101 2538 - 2545 2010年査読

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