Faculty Profiles - KOSAI Ken-ichiro

Papers - KOSAI Ken-ichiro

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Tada T, Nguyen JB, Hitoshi Y, Watson NP, Dunn JF, Ohara S, Nagano S, Kosai K, Israel MA. . Diffuse Encephaloventriculitis and Substantial Leukoencephalopathy after Intraventricular Administration of Recombinant Adenovirus . Neurol Res27 378 - 386 2005.6Reviewed

Nagano S, Oshika H, Fujiwara H, Komiya S, Kosai K. . An Efficient Construction of Conditionally Replicating Adenoviruses that Target Tumor Cells with Multiple Factors . Gene Ther12 1385 - 1393 2005.5Reviewed

Okada H, Takemura G, Kosai K, Li Y, Takahashi T, Esaki M, Yuge K, Miyata S, Maruyama R, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H. . Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure . Circulation111 2430 - 2437 2005.5Reviewed

Ushikoshi H, Takahashi T, Chen X, Khai NC, Esaki M, Goto K, Takemura G, Maruyama R, Minatoguchi S, Fujiwara T, Nagano S, Yuge K, Kawai T, Murofushi Y, Fujiwara H, Kosai K. . Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes . Lab Invest85 862 - 873 2005.4Reviewed

神囿淳一，永野聡，小宮節郎，小戝健一郎 . Survivin依存性増殖制御型アデノウイルスを用いた骨軟部腫瘍に対する遺伝子治療法の開発 . 日本整形外科学会誌79 ( 8 ) S896 - S896 2005

Li Y, Takemura G, Kosai K, Takahashi T, Okada H, Miyata S, Yuge K, Nagano S, Esaki M, Khai NC, Goto K, Mikami A, Maruyama R, Minatoguchi S, Fujiwara T Fujiwara H. . Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure . Circ.Res95 27 - 36 2004.8Reviewed

Kawai T, Takahashi T, Esaki M, Ushikoshi H, Nagano S, Fujiwara H, Kosai K. . Efficient cardiomyogeneic differentiation of embryonic stem cell by FGF-2 and BMP-2 . Circ. J68 691 - 702 2004.7Reviewed

Hisaka Y, Ieda M, Nakamura T, Kosai K, Ogawa S, Fukuda K. . Powerful and controllable angiogenesis by using gene-modified cells expressing human hepatocyte growth factor and thymidine kinase . J Am Coll Cardiol43 1915 - 1922 2004.5Reviewed

Iida SI, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H. . Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G(1) tetraploidy checkpoint function . Oncogene23 5266 - 5274 2004.5Reviewed

Minatoguchi S, Takemura G, Chen XH, Wang N, Uno Y, Koda M, Arai M, Misao Y, Lu C, Suzuki K, Goto K, Komada A, Takahashi T, KosaiI57:I58 K, Fujiwara T, Fujiwara H. . Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment . Circulation109 2572 - 2580 2004.5Reviewed

Nagano S, Yuge K, Fukunaga M, Terazaki Y, Fujiwara H, Komiya S, Kosai K. . Gene Therapy eradicating distant disseminated micro-metastases by optimal cytokine expression in the primary lesion only -novel concepts for successful cytokine gene therapy . Int. J. Oncol24 549 - 558 2004.3Reviewed

Ikoma T, Takahashi T, Nagano S, Li Y-M, Ohno Y, Ando K, Fujiwara T, Fujiwara H and Kosai K. . A definitive role of RhoC in metastasis of orthotopic lung cancer in mice . Clin Cancer Res 2004.2

神囿淳一，永野聡，小宮節郎，小戝健一郎 . 癌特異的増殖制御型アデノウイルスベクターを用いた骨軟部腫瘍に対する遺伝子治療 . 日本整形外科学会誌78 ( 6 ) S682 - S682 2004

Li Y, Takemura G, Kosai K, Yuge K, Nagano S, Esaki M, Goto K, Takahashi T, Hayakawa K, Koda M, Kawase Y, Maruyama R, Okada H, Minatoguchi S, Mizuguchi H, Fujiwara T, Fujiwara H. . Postinfarct treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice . Circulation 2003.4

Himeno W, Akagi T, Furui A, Maeno Y, Ishii M, Kosai K, Murohara T, Kato H. . Increased angiogenic growth factor in cyanotic congenital heart disease . Pediatr Cardiol24 ( 2 ) 127 - 132 2003.3

Terazaki Y, Yano S, Yuge K, Nagano S, Fukunaga M, Guo ZS, Komiya S, Shirouzu K, Kosai, K. . An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice . Hepatology37 ( 1 ) 155 - 163 2003.1

Tsuneoka M, Umata T, Kimura H, Koda Y, Nakajima M, Kosai K, Takahashi T, Takahashi Y, Yamamoto A. . c-myc induces autophagy in rat 3Y1 fibroblast cells . Cell Struct Funct. 2003

Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, Kohara M, Yoshimura A. . Activation of STAT3 by the Hepatitis C virus core protein leads to cellular transformation . J. Exp. Med196 ( 5 ) 641 - 653 2002.9

Aoyama T, Takemura G, Maruyama R, Kosai K, Takahashi T, Koda M, Hayakawa K, Kawase Y, Minatoguchi S, Fujiwara H. . Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes . Cardiovasc Res55 ( 4 ) 787 - 798 2002.9

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